{"id":"https://openalex.org/W2346211751","doi":"https://doi.org/10.1016/j.jid.2016.03.017","title":"Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma","display_name":"Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma","publication_year":2016,"publication_date":"2016-05-08","ids":{"openalex":"https://openalex.org/W2346211751","doi":"https://doi.org/10.1016/j.jid.2016.03.017","mag":"2346211751","pmid":"https://pubmed.ncbi.nlm.nih.gov/27160068"},"language":"en","primary_location":{"id":"doi:10.1016/j.jid.2016.03.017","doi":"https://doi.org/10.1016/j.jid.2016.03.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2016.03.017","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jid.2016.03.017","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008667539","display_name":"William E. Lowry","orcid":"https://orcid.org/0000-0003-2932-2276","observed_orcids":["https://orcid.org/0000-0003-2932-2276"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210150380","display_name":"Broad Center","ror":"https://ror.org/04tbrah05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150380"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William E. Lowry","raw_affiliation_strings":["Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA; Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA. Electronic address: blowry@ucla.edu","Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA","Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA","Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA","Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA; Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA. Electronic address: blowry@ucla.edu","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210150380"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000561276","display_name":"Aimee Flores","orcid":"https://orcid.org/0000-0002-3112-8934","observed_orcids":["https://orcid.org/0000-0002-3112-8934"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4210150380","display_name":"Broad Center","ror":"https://ror.org/04tbrah05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210150380"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aimee Flores","raw_affiliation_strings":["Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA; Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA","Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA","Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA","Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA; Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli and Edythe Broad Center for Regenerative Medicine, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210150380"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101789455","display_name":"Andrew C. White","orcid":"https://orcid.org/0000-0002-5436-5377","observed_orcids":["https://orcid.org/0000-0002-5436-5377"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew C. White","raw_affiliation_strings":["Cornell University Stem Cell Program, Cornell University, Ithaca, New\u00a0York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell University Stem Cell Program, Cornell University, Ithaca, New\u00a0York, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008667539"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4210150380","https://openalex.org/I4390039293"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.2611,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.2529077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"136","issue":"8","first_page":"1543","last_page":"1548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.3970000147819519,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.2890999913215637,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.05460000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/oncogenic-ras-mutations","display_name":"oncogenic Ras mutations","score":0.7160000205039978},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6980000138282776},{"id":"https://openalex.org/keywords/hair-follicle-stem-cells","display_name":"hair follicle stem cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/epidermal-cell-types","display_name":"epidermal cell types","score":0.49799999594688416},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6118461489677429},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5780799984931946},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.5672287940979004},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5262431502342224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5065327882766724},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4933890402317047},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48922109603881836},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.4876190721988678},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4473692774772644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3382980525493622},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2809861898422241},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2615066170692444},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21472454071044922},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18788644671440125},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.06895244121551514}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jid.2016.03.017","doi":"https://doi.org/10.1016/j.jid.2016.03.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2016.03.017","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},{"id":"pmid:27160068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27160068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of investigative dermatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jid.2016.03.017","doi":"https://doi.org/10.1016/j.jid.2016.03.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jid.2016.03.017","pdf_url":null,"source":{"id":"https://openalex.org/S28607811","display_name":"Journal of Investigative Dermatology","issn_l":"0022-202X","issn":["0022-202X","1523-1747"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Investigative Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3139846897","display_name":"Identification and characterization of cancer cells of origin in the epidermis","funder_award_id":"R01AR057409","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W332047183","https://openalex.org/W1510438272","https://openalex.org/W1918810853","https://openalex.org/W1922428981","https://openalex.org/W1964818845","https://openalex.org/W1974676367","https://openalex.org/W1979627083","https://openalex.org/W1981634986","https://openalex.org/W1983910789","https://openalex.org/W1986404157","https://openalex.org/W1992329875","https://openalex.org/W1993358791","https://openalex.org/W1995004385","https://openalex.org/W1995434582","https://openalex.org/W1997509648","https://openalex.org/W2000477644","https://openalex.org/W2012877571","https://openalex.org/W2020969391","https://openalex.org/W2021302907","https://openalex.org/W2021689495","https://openalex.org/W2023936521","https://openalex.org/W2024150672","https://openalex.org/W2027275966","https://openalex.org/W2038858817","https://openalex.org/W2043933428","https://openalex.org/W2044168765","https://openalex.org/W2047789962","https://openalex.org/W2047926803","https://openalex.org/W2050389860","https://openalex.org/W2062210994","https://openalex.org/W2062312459","https://openalex.org/W2065299060","https://openalex.org/W2070081201","https://openalex.org/W2070471604","https://openalex.org/W2080155427","https://openalex.org/W2080628861","https://openalex.org/W2082097084","https://openalex.org/W2084773215","https://openalex.org/W2085073389","https://openalex.org/W2093937463","https://openalex.org/W2101183670","https://openalex.org/W2126091128","https://openalex.org/W2127292451","https://openalex.org/W2128537223","https://openalex.org/W2129617079","https://openalex.org/W2134674923","https://openalex.org/W2150138958","https://openalex.org/W2153027227","https://openalex.org/W2155461614","https://openalex.org/W2157036356","https://openalex.org/W2157466346","https://openalex.org/W2161092951","https://openalex.org/W2163570379","https://openalex.org/W2173159263","https://openalex.org/W2341262906","https://openalex.org/W2402296033","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W1997509648","https://openalex.org/W2312671547","https://openalex.org/W2000477644","https://openalex.org/W2341262906","https://openalex.org/W2047926803","https://openalex.org/W4242777689","https://openalex.org/W2564436319","https://openalex.org/W2314598629","https://openalex.org/W2342760745","https://openalex.org/W2077044260"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}