{"id":"https://openalex.org/W2346200484","doi":"https://doi.org/10.1523/jneurosci.3919-15.2016","title":"The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis","display_name":"The Proinflammatory Cytokine Interleukin 18 Regulates Feeding by Acting on the Bed Nucleus of the Stria Terminalis","publication_year":2016,"publication_date":"2016-05-04","ids":{"openalex":"https://openalex.org/W2346200484","doi":"https://doi.org/10.1523/jneurosci.3919-15.2016","mag":"2346200484","pmid":"https://pubmed.ncbi.nlm.nih.gov/27147667","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6218159"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.3919-15.2016","doi":"https://doi.org/10.1523/jneurosci.3919-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3919-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/18/5170.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/36/18/5170.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059422595","display_name":"Walter G. Francesconi","orcid":"https://orcid.org/0000-0002-8806-9023","observed_orcids":["https://orcid.org/0000-0002-8806-9023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Francesconi","raw_affiliation_strings":["Molecular and Cellular Neuroscience Department and wfranc@scripps.edu bconti@scripps.edu","1Molecular and Cellular Neuroscience Department and"],"raw_orcid":"https://orcid.org/0000-0002-8806-9023","affiliations":[{"raw_affiliation_string":"Molecular and Cellular Neuroscience Department and wfranc@scripps.edu bconti@scripps.edu","institution_ids":[]},{"raw_affiliation_string":"1Molecular and Cellular Neuroscience Department and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034217257","display_name":"Manuel S\u00e1nchez-Alavez","orcid":"https://orcid.org/0000-0002-8164-8452","observed_orcids":["https://orcid.org/0000-0002-8164-8452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel S\u00e1nchez-Alavez","raw_affiliation_strings":["Molecular and Cellular Neuroscience Department and Department of Chemical Physiology, and","1Molecular and Cellular Neuroscience Department and","2Department of Chemical Physiology, and"],"raw_orcid":"https://orcid.org/0000-0002-8164-8452","affiliations":[{"raw_affiliation_string":"Molecular and Cellular Neuroscience Department and Department of Chemical Physiology, and","institution_ids":[]},{"raw_affiliation_string":"1Molecular and Cellular Neuroscience Department and","institution_ids":[]},{"raw_affiliation_string":"2Department of Chemical Physiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012923877","display_name":"Fulvia Berton","orcid":"https://orcid.org/0000-0002-9046-0056","observed_orcids":["https://orcid.org/0000-0002-9046-0056"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fulvia Berton","raw_affiliation_strings":["Department of Chemical Physiology, and Department of Biology, University of Pisa, Italy","2Department of Chemical Physiology, and","3Department of Biology, University of Pisa, Italy,"],"raw_orcid":"https://orcid.org/0000-0002-9046-0056","affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology, and Department of Biology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"2Department of Chemical Physiology, and","institution_ids":[]},{"raw_affiliation_string":"3Department of Biology, University of Pisa, Italy,","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009770199","display_name":"Silvia Alboni","orcid":"https://orcid.org/0000-0002-2332-3166","observed_orcids":["https://orcid.org/0000-0002-2332-3166"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Alboni","raw_affiliation_strings":["Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and"],"raw_orcid":"https://orcid.org/0000-0002-2332-3166","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041114001","display_name":"Cristina Benatti","orcid":"https://orcid.org/0000-0003-0236-9525","observed_orcids":["https://orcid.org/0000-0003-0236-9525"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Benatti","raw_affiliation_strings":["Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and"],"raw_orcid":"https://orcid.org/0000-0003-0236-9525","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037892375","display_name":"Simone Mori","orcid":"https://orcid.org/0000-0002-0793-7045","observed_orcids":["https://orcid.org/0000-0002-0793-7045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simone Mori","raw_affiliation_strings":["Department of Chemical Physiology, and","2Department of Chemical Physiology, and"],"raw_orcid":"https://orcid.org/0000-0002-0793-7045","affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology, and","institution_ids":[]},{"raw_affiliation_string":"2Department of Chemical Physiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082452827","display_name":"William Nguyen","orcid":"https://orcid.org/0000-0002-3984-2390","observed_orcids":["https://orcid.org/0000-0002-3984-2390","https://orcid.org/0000-0003-1092-4859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Nguyen","raw_affiliation_strings":["Department of Chemical Physiology, and","2Department of Chemical Physiology, and"],"raw_orcid":"https://orcid.org/0000-0003-1092-4859","affiliations":[{"raw_affiliation_string":"Department of Chemical Physiology, and","institution_ids":[]},{"raw_affiliation_string":"2Department of Chemical Physiology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001234489","display_name":"Eric P. Zorrilla","orcid":"https://orcid.org/0000-0003-2288-7899","observed_orcids":["https://orcid.org/0000-0003-2288-7899"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Zorrilla","raw_affiliation_strings":["CNAD, The Scripps Research Institute, La Jolla, California","5CNAD, The Scripps Research Institute, La Jolla, California,"],"raw_orcid":"https://orcid.org/0000-0003-2288-7899","affiliations":[{"raw_affiliation_string":"CNAD, The Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"5CNAD, The Scripps Research Institute, La Jolla, California,","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028698640","display_name":"Gianluca Moroncini","orcid":"https://orcid.org/0000-0002-0380-0105","observed_orcids":["https://orcid.org/0000-0002-0380-0105"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Moroncini","raw_affiliation_strings":["Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche, Ancona, Italy","6Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"],"raw_orcid":"https://orcid.org/0000-0002-0380-0105","affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]},{"raw_affiliation_string":"6Dipartimento di Scienze Cliniche e Molecolari, Universit\u00e0 Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fabio Tascedda","orcid":"https://orcid.org/0000-0002-0958-7333","observed_orcids":["https://orcid.org/0000-0002-0958-7333"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Tascedda","raw_affiliation_strings":["Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and"],"raw_orcid":"https://orcid.org/0000-0002-0958-7333","affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"4Department of Life Sciences, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy, and","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086290614","display_name":"Bruno Conti","orcid":"https://orcid.org/0000-0002-9185-5201","observed_orcids":["https://orcid.org/0000-0002-9185-5201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Conti","raw_affiliation_strings":["Molecular and Cellular Neuroscience Department and Department of Chemical Physiology, and wfranc@scripps.edu bconti@scripps.edu","1Molecular and Cellular Neuroscience Department and","2Department of Chemical Physiology, and"],"raw_orcid":"https://orcid.org/0000-0002-9185-5201","affiliations":[{"raw_affiliation_string":"Molecular and Cellular Neuroscience Department and Department of Chemical Physiology, and wfranc@scripps.edu bconti@scripps.edu","institution_ids":[]},{"raw_affiliation_string":"1Molecular and Cellular Neuroscience Department and","institution_ids":[]},{"raw_affiliation_string":"2Department of Chemical Physiology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1977,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.910556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"36","issue":"18","first_page":"5170","last_page":"5180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bed-nucleus-of-the-stria-terminalis","display_name":"bed nucleus of the stria terminalis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.824999988079071},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sickness-behavior","display_name":"sickness behavior","score":0.5130000114440918},{"id":"https://openalex.org/keywords/il-18-receptor","display_name":"IL-18 receptor","score":0.875},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lateral-hypothalamus","display_name":"lateral hypothalamus","score":0.9599999785423279},{"id":"https://openalex.org/keywords/disinhibition","display_name":"disinhibition","score":0.7459999918937683},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.753000020980835},{"id":"https://openalex.org/keywords/extended-amygdala","display_name":"extended amygdala","score":0.7910000085830688},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.8019999861717224},{"id":"https://openalex.org/keywords/eating-disorders","display_name":"eating disorders","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C2778652331","wikidata":"https://www.wikidata.org/wiki/Q3122152","display_name":"Stria terminalis","level":3,"score":0.9460368156433105},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7686315774917603},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.6935316920280457},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.5804175138473511},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5564207434654236},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5392929315567017},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4907032251358032},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4781290590763092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44519031047821045},{"id":"https://openalex.org/C2780148200","wikidata":"https://www.wikidata.org/wiki/Q7452044","display_name":"Septal nuclei","level":3,"score":0.43068674206733704},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.42933428287506104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41943198442459106},{"id":"https://openalex.org/C2780948618","wikidata":"https://www.wikidata.org/wiki/Q5421874","display_name":"Extended amygdala","level":4,"score":0.41552338004112244},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41522878408432007},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.41329193115234375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4109204113483429},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3797042667865753},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.2372264862060547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12434929609298706},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.07095438241958618}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007026","descriptor_name":"Hypothalamic Area, Lateral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012686","descriptor_name":"Septal Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020382","descriptor_name":"Interleukin-18","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053727","descriptor_name":"Interleukin-18 Receptor alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053727","descriptor_name":"Interleukin-18 Receptor alpha Subunit","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1523/jneurosci.3919-15.2016","doi":"https://doi.org/10.1523/jneurosci.3919-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3919-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/18/5170.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5176887","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6218159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6218159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6218159","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:27147667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27147667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:iris.univpm.it:11566/239893","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11566/239893","pdf_url":"http://www.jneurosci.org/content/36/18/5170.full.pdf","source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/1089902","doi":null,"is_oa":true,"landing_page_url":"https://www.jneurosci.org/content/36/18/5170/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unimore.it:11380/1102730","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1102730","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.3919-15.2016","doi":"https://doi.org/10.1523/jneurosci.3919-15.2016","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.3919-15.2016","pdf_url":"https://www.jneurosci.org/content/jneuro/36/18/5170.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2509907212","display_name":"Brain interleukin-18 control of food intake and energy expenditure","funder_award_id":"R01DK094026","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2658086992","display_name":"Role of the IL-13 system in dopaminergic cell death","funder_award_id":"R01NS085155","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2346200484.pdf","grobid_xml":"https://content.openalex.org/works/W2346200484.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W907340482","https://openalex.org/W1522048223","https://openalex.org/W1542136448","https://openalex.org/W1597278618","https://openalex.org/W1648832798","https://openalex.org/W1657691208","https://openalex.org/W1912027123","https://openalex.org/W1963714080","https://openalex.org/W1966613107","https://openalex.org/W1971994650","https://openalex.org/W1972489844","https://openalex.org/W1976763631","https://openalex.org/W1977521403","https://openalex.org/W1980267862","https://openalex.org/W1983231052","https://openalex.org/W1984109440","https://openalex.org/W1986550451","https://openalex.org/W1991427938","https://openalex.org/W2003542304","https://openalex.org/W2006516339","https://openalex.org/W2008100712","https://openalex.org/W2012968633","https://openalex.org/W2013812773","https://openalex.org/W2019584232","https://openalex.org/W2020793513","https://openalex.org/W2023989159","https://openalex.org/W2024922001","https://openalex.org/W2029029038","https://openalex.org/W2029988864","https://openalex.org/W2031520642","https://openalex.org/W2036274005","https://openalex.org/W2040290427","https://openalex.org/W2044857185","https://openalex.org/W2047612148","https://openalex.org/W2047641968","https://openalex.org/W2049183025","https://openalex.org/W2051050975","https://openalex.org/W2054740083","https://openalex.org/W2057605801","https://openalex.org/W2060968640","https://openalex.org/W2061478482","https://openalex.org/W2061731591","https://openalex.org/W2066986387","https://openalex.org/W2067589373","https://openalex.org/W2069204309","https://openalex.org/W2069635498","https://openalex.org/W2072328958","https://openalex.org/W2079679184","https://openalex.org/W2080423414","https://openalex.org/W2080461489","https://openalex.org/W2083926404","https://openalex.org/W2088820747","https://openalex.org/W2090318357","https://openalex.org/W2102268999","https://openalex.org/W2112927743","https://openalex.org/W2115119251","https://openalex.org/W2117361576","https://openalex.org/W2120987567","https://openalex.org/W2124796787","https://openalex.org/W2138091294","https://openalex.org/W2139117581","https://openalex.org/W2143066408","https://openalex.org/W2148895573","https://openalex.org/W2150268563","https://openalex.org/W2156466346","https://openalex.org/W2158128209","https://openalex.org/W2314721400","https://openalex.org/W2321134387","https://openalex.org/W3021526609","https://openalex.org/W4297968506","https://openalex.org/W6843817080"],"related_works":["https://openalex.org/W2091719346","https://openalex.org/W941022928","https://openalex.org/W2163779081","https://openalex.org/W2226422858","https://openalex.org/W2949189204","https://openalex.org/W2087658385","https://openalex.org/W2962010475","https://openalex.org/W2212643815","https://openalex.org/W2015209202","https://openalex.org/W2316193704"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,125,306],"proinflammatory":[2,258],"cytokine":[3],"IL-18":[4,30,74,88,112,128,170,200,221,229,304],"has":[5],"central":[6],"anorexigenic":[7,266,284],"effects":[8,126],"and":[9,82,95,131,186,253,270,311],"was":[10],"proposed":[11],"to":[12,14,55,61,298],"contribute":[13],"loss":[15],"of":[16,39,43,50,71,86,127,175,199,237,246,264,272,290,294,314,322],"appetite":[17,247],"observed":[18,133],"during":[19,248],"sickness.":[20],"Here":[21,277],"we":[22,278],"tested":[23],"in":[24,79,106,134,139,150,189,195,210],"the":[25,27,40,44,62,72,80,115,151,162,173,190,204,235,291,295,303,320],"mouse":[26],"hypothesis":[28],"that":[29,68,83,111,156,228,280,316],"can":[31,171,192,286],"decrease":[32],"food":[33,96,196,300],"intake":[34,97,301],"by":[35,203,233],"acting":[36],"on":[37,118,165,288],"neurons":[38,120,147,178,211,289],"bed":[41,292],"nucleus":[42,293],"stria":[45,296],"terminalis":[46,297],"(BST),":[47],"a":[48,122,154,180,251,309,312],"component":[49],"extended":[51],"amygdala":[52],"recently":[53],"shown":[54],"influence":[56],"feeding":[57,232],"via":[58,302],"its":[59],"projections":[60],"lateral":[63],"hypothalamus":[64],"(LH).":[65],"We":[66],"found":[67],"both":[69],"subunits":[70],"heterodimeric":[73],"receptor":[75],"are":[76,129,260],"highly":[77],"expressed":[78],"BST":[81,107,119,238],"local":[84],"injection":[85],"recombinant":[87],"(50":[89],"ng/ml)":[90],"significantly":[91],"reduced":[92],"c-fos":[93],"activation":[94],"for":[98,215,319],"at":[99],"least":[100],"6":[101],"h.":[102],"Electrophysiological":[103],"experiments":[104],"performed":[105],"brain":[108],"slices":[109],"demonstrated":[110],"strongly":[113],"reduces":[114],"excitatory":[116,163,185],"input":[117,164],"through":[121,179],"presynaptic":[123],"mechanism.":[124,182],"cell-specific":[130],"were":[132,148,201,208],"Type":[135,140,145,166,239],"III":[136,146,167,240],"but":[137],"not":[138],"I/II":[141],"neurons.":[142,160,242],"Interestingly,":[143],"IL-18-sensitve":[144],"recorded":[149],"juxtacapsular":[152],"BST,":[153],"region":[155],"contains":[157],"BST-LH":[158],"projecting":[159],"Reducing":[161],"GABAergic":[168,241],"neurons,":[169],"increase":[172],"firing":[174],"glutamatergic":[176],"LH":[177,191],"disinhibitory":[181],"Imbalance":[183],"between":[184],"inhibitory":[187],"activity":[188,236],"induce":[193],"changes":[194],"intake.":[197],"Effects":[198],"mediated":[202],"IL-18R":[205],"because":[206],"they":[207],"absent":[209],"from":[212],"animals":[213],"null":[214],"IL-18R\u03b1":[216],"(Il18ra(-/-)),":[217],"which":[218],"lack":[219],"functional":[220],"receptors.":[222],"In":[223],"conclusion,":[224],"our":[225],"data":[226],"show":[227,279],"may":[230],"inhibit":[231],"inhibiting":[234],"SIGNIFICANCE":[243],"STATEMENT:":[244],"Loss":[245],"sickness":[249],"is":[250],"common":[252],"often":[254],"debilitating":[255],"phenomenon.":[256],"Although":[257],"cytokines":[259],"recognized":[261],"as":[262],"mediators":[263],"these":[265],"effects,":[267],"their":[268],"mechanism":[269],"sites":[271],"action":[273,315],"remain":[274],"poorly":[275],"understood.":[276],"interleukin":[281],"18,":[282],"an":[283],"cytokine,":[285],"act":[287],"reduce":[299],"receptor.":[305],"findings":[307],"identify":[308],"site":[310],"mode":[313],"indicate":[317],"targets":[318],"treatment":[321],"cachexia":[323],"or":[324],"other":[325],"eating":[326],"disorders.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
