{"id":"https://openalex.org/W23461526","doi":null,"title":"Swelling-restricted minimatrices for controlled release of drugs. Preliminary in-vivo studies.","display_name":"Swelling-restricted minimatrices for controlled release of drugs. Preliminary in-vivo studies.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W23461526","mag":"23461526","pmid":"https://pubmed.ncbi.nlm.nih.gov/2635916"},"language":"en","primary_location":{"id":"pmid:2635916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2635916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bollettino chimico farmaceutico","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053035943","display_name":"Carla Marcella Caramella","orcid":"https://orcid.org/0000-0002-1261-1525","observed_orcids":["https://orcid.org/0000-0002-1261-1525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Caramella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035322997","display_name":"Franca Ferrari","orcid":"https://orcid.org/0000-0002-2548-5249","observed_orcids":["https://orcid.org/0000-0002-2548-5249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Ferrari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023781229","display_name":"Maria Cristina Bonferoni","orcid":"https://orcid.org/0000-0002-1194-9372","observed_orcids":["https://orcid.org/0000-0002-1194-9372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Bonferoni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055197573","display_name":"Andrea Gazzaniga","orcid":"https://orcid.org/0000-0002-4962-3685","observed_orcids":["https://orcid.org/0000-0002-4962-3685"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Gazzaniga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109853637","display_name":"M.E. Sangalli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M E Sangalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055804216","display_name":"Ubaldo Conte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Conte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086869912","display_name":"Mario De Bernardi Di Valserra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M De Bernardi di Valserra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068478774","display_name":"Fausto Feletti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Feletti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00190718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"128","issue":"10","first_page":"310","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.7935000061988831,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.19269999861717224,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8339999914169312},{"id":"https://openalex.org/keywords/diltiazem-hydrochloride","display_name":"diltiazem hydrochloride","score":0.9100000262260437},{"id":"https://openalex.org/keywords/ph-dependent-solubility","display_name":"pH-dependent solubility","score":0.9020000100135803},{"id":"https://openalex.org/keywords/film-thickness","display_name":"film thickness","score":0.8270000219345093},{"id":"https://openalex.org/keywords/in-vivo-pharmacokinetics","display_name":"in vivo pharmacokinetics","score":0.7710000276565552},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/modified-release-tablets","display_name":"modified release tablets","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8637135624885559},{"id":"https://openalex.org/C2909111407","wikidata":"https://www.wikidata.org/wiki/Q422229","display_name":"Diltiazem hydrochloride","level":4,"score":0.8011430501937866},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.6439966559410095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4770997166633606},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4718347191810608},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4696813225746155},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.45954200625419617},{"id":"https://openalex.org/C2781448156","wikidata":"https://www.wikidata.org/wiki/Q1570182","display_name":"Coating","level":2,"score":0.45199280977249146},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4375718832015991},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41991904377937317},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41725432872772217},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3469279706478119},{"id":"https://openalex.org/C2776741139","wikidata":"https://www.wikidata.org/wiki/Q422229","display_name":"Diltiazem","level":3,"score":0.2446337640285492},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.20758014917373657},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1955806016921997},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10052052140235901},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.09445565938949585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09197002649307251},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005079","descriptor_name":"Excipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2635916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2635916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bollettino chimico farmaceutico","raw_type":"Journal Article"},{"id":"mag:23461526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2635916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1571002090","https://openalex.org/W1598120424","https://openalex.org/W1788270085","https://openalex.org/W1965011519","https://openalex.org/W1966089448","https://openalex.org/W1971141332","https://openalex.org/W1971363227","https://openalex.org/W1972753567","https://openalex.org/W1978845922","https://openalex.org/W1984462272","https://openalex.org/W1989099144","https://openalex.org/W1995018997","https://openalex.org/W1996373995","https://openalex.org/W1999758583","https://openalex.org/W2000476709","https://openalex.org/W2005385266","https://openalex.org/W2008318526","https://openalex.org/W2009672923","https://openalex.org/W2013044366","https://openalex.org/W2013098961","https://openalex.org/W2015778975","https://openalex.org/W2019042756","https://openalex.org/W2019798398","https://openalex.org/W2021492058","https://openalex.org/W2024523807","https://openalex.org/W2026432782","https://openalex.org/W2028145556","https://openalex.org/W2031903601","https://openalex.org/W2033714885","https://openalex.org/W2037254727","https://openalex.org/W2038689088","https://openalex.org/W2043969268","https://openalex.org/W2050715617","https://openalex.org/W2062173809","https://openalex.org/W2065196337","https://openalex.org/W2069120880","https://openalex.org/W2069706627","https://openalex.org/W2070284066","https://openalex.org/W2073744102","https://openalex.org/W2077533234","https://openalex.org/W2079730632","https://openalex.org/W2082049624","https://openalex.org/W2083043782","https://openalex.org/W2085821414","https://openalex.org/W2089343859","https://openalex.org/W2096687705","https://openalex.org/W2099463759","https://openalex.org/W2099505231","https://openalex.org/W2099652155","https://openalex.org/W2100171635","https://openalex.org/W2100744126","https://openalex.org/W2102291177","https://openalex.org/W2102309115","https://openalex.org/W2102919055","https://openalex.org/W2112146495","https://openalex.org/W2113442276","https://openalex.org/W2113565188","https://openalex.org/W2114906083","https://openalex.org/W2116403399","https://openalex.org/W2121586764","https://openalex.org/W2123401857","https://openalex.org/W2126877640","https://openalex.org/W2130517142","https://openalex.org/W2132736409","https://openalex.org/W2133907938","https://openalex.org/W2135844248","https://openalex.org/W2145452721","https://openalex.org/W2154897217","https://openalex.org/W2163534065","https://openalex.org/W2165125541","https://openalex.org/W2166056797","https://openalex.org/W2167485345","https://openalex.org/W2168052860","https://openalex.org/W4243620710"],"related_works":["https://openalex.org/W2021970719","https://openalex.org/W2030953617","https://openalex.org/W1963533328","https://openalex.org/W2153334445","https://openalex.org/W2143364144","https://openalex.org/W1984411874","https://openalex.org/W2914353999","https://openalex.org/W7220745379","https://openalex.org/W1973058058","https://openalex.org/W2624387712"],"abstract_inverted_index":{"A":[0],"preliminary":[1],"in-vivo":[2,46,59,75],"study":[3],"was":[4,78,94],"performed":[5,110],"on":[6,58,80],"a":[7,40,56,71,81],"new":[8],"modified":[9],"release":[10,132],"system":[11,17],"which":[12,77],"contained":[13],"diltiazem":[14],"hydrochloride.":[15],"The":[16,30,74,92,118],"consisted":[18],"of":[19,34,54,106,113,124,151],"swellable":[20],"minimatrices":[21,62],"that":[22,121],"were":[23,68,109],"coated":[24],"with":[25,43,64],"an":[26,99],"acrylic":[27],"polymeric":[28],"film.":[29],"film":[31,66,125,154],"thickness,":[32],"because":[33],"its":[35],"pH-dependent":[36],"solubility,":[37],"might":[38],"represent":[39],"critical":[41],"variable":[42,57],"regard":[44],"to":[45,50,129,148,156],"release.":[47],"In":[48],"order":[49,128],"evaluate":[51],"the":[52,122,131,145,149,153],"influence":[53],"such":[55],"behaviour,":[60],"two":[61,90],"formulations":[63],"differing":[65],"thickness":[67],"tested":[69],"versus":[70],"commercial":[72],"tablet.":[73],"study,":[76],"based":[79],"balanced":[82],"incomplete":[83],"block":[84],"design,":[85],"involved":[86],"six":[87],"volunteers":[88],"in":[89,96,127,143],"sequences.":[91],"drug":[93],"quantified":[95],"plasma":[97],"by":[98,111],"HPLC":[100],"method.":[101],"Computation":[102],"and":[103],"statistical":[104],"analysis":[105],"pharmacokinetic":[107],"parameters":[108],"means":[112],"SIPHARR":[114],"package":[115],"(Simed,":[116],"F).":[117],"results":[119,146],"show":[120],"approach":[123],"coating,":[126],"modify":[130],"rate":[133],"from":[134],"minimatrices,":[135],"is":[136],"feasible,":[137],"but":[138],"it":[139],"must":[140],"be":[141],"improved;":[142],"particular":[144],"point":[147],"necessity":[150],"reducing":[152],"susceptibility":[155],"pH":[157],"changes.":[158]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}