{"id":"https://openalex.org/W2345980210","doi":null,"title":"Reactivation of the p53 pathway by MDM2 inhibitor Nutlin-3: Application in photochemical internalisation (PCI)","display_name":"Reactivation of the p53 pathway by MDM2 inhibitor Nutlin-3: Application in photochemical internalisation (PCI)","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2345980210","mag":"2345980210"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/36146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/36146","pdf_url":"http://hdl.handle.net/10852/36146","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/36146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033715791","display_name":"Camilla Lavoll","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Camilla Lavoll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5033715791"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nutlin-3","display_name":"Nutlin-3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mdm2-amplification","display_name":"MDM2 amplification","score":0.7699999809265137},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.8149999976158142},{"id":"https://openalex.org/keywords/saporin","display_name":"saporin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.859000027179718},{"id":"https://openalex.org/keywords/g1-s-checkpoint","display_name":"G1/S checkpoint","score":0.8619999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9570000171661377},{"id":"https://openalex.org/keywords/p53-mdm2-interaction","display_name":"p53-MDM2 interaction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.775240421295166},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5572420954704285},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.5521433353424072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47214391827583313},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3486921489238739},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26102215051651},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15055552124977112},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.13325288891792297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12384507060050964},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/36146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/36146","pdf_url":"http://hdl.handle.net/10852/36146","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2345980210","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/handle/10852/36146/Masteroppgave-Camilla-Lavoll2.pdf?sequence=5","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/36146","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/36146","pdf_url":"http://hdl.handle.net/10852/36146","source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2345980210.pdf","grobid_xml":"https://content.openalex.org/works/W2345980210.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W32978912","https://openalex.org/W45511541","https://openalex.org/W78239319","https://openalex.org/W118828521","https://openalex.org/W174322373","https://openalex.org/W1596376363","https://openalex.org/W1596848781","https://openalex.org/W1600706591","https://openalex.org/W1767730307","https://openalex.org/W1884403785","https://openalex.org/W1897342331","https://openalex.org/W1954387510","https://openalex.org/W1963542258","https://openalex.org/W1964170886","https://openalex.org/W1966163762","https://openalex.org/W1974404124","https://openalex.org/W1978518304","https://openalex.org/W1982670681","https://openalex.org/W1986011493","https://openalex.org/W1987788885","https://openalex.org/W1988125845","https://openalex.org/W1991494214","https://openalex.org/W1992180725","https://openalex.org/W1993263392","https://openalex.org/W1993641358","https://openalex.org/W1994852323","https://openalex.org/W1998963151","https://openalex.org/W2001533493","https://openalex.org/W2008887283","https://openalex.org/W2011892634","https://openalex.org/W2027072436","https://openalex.org/W2034824476","https://openalex.org/W2036937264","https://openalex.org/W2041685462","https://openalex.org/W2043977277","https://openalex.org/W2053155947","https://openalex.org/W2055011486","https://openalex.org/W2058402966","https://openalex.org/W2059817880","https://openalex.org/W2062273647","https://openalex.org/W2074778020","https://openalex.org/W2076147908","https://openalex.org/W2080533553","https://openalex.org/W2092675732","https://openalex.org/W2097933346","https://openalex.org/W2098595271","https://openalex.org/W2101245843","https://openalex.org/W2103616303","https://openalex.org/W2105155498","https://openalex.org/W2105807089","https://openalex.org/W2108932391","https://openalex.org/W2113370608","https://openalex.org/W2114205900","https://openalex.org/W2120132028","https://openalex.org/W2122917500","https://openalex.org/W2124047145","https://openalex.org/W2126708001","https://openalex.org/W2132834292","https://openalex.org/W2133959309","https://openalex.org/W2135658143","https://openalex.org/W2140723802","https://openalex.org/W2145282879","https://openalex.org/W2151734986","https://openalex.org/W2153641948","https://openalex.org/W2153680912","https://openalex.org/W2155786178","https://openalex.org/W2161379087","https://openalex.org/W2161513935","https://openalex.org/W2162262059","https://openalex.org/W2165517578","https://openalex.org/W2170008898","https://openalex.org/W2341769195","https://openalex.org/W2406728090","https://openalex.org/W2407860852","https://openalex.org/W4237139417"],"related_works":["https://openalex.org/W2062942844","https://openalex.org/W65729443","https://openalex.org/W2153641948","https://openalex.org/W2140723802","https://openalex.org/W2053065962","https://openalex.org/W2052516738","https://openalex.org/W2056887819","https://openalex.org/W2767273060","https://openalex.org/W2145273779","https://openalex.org/W4319745919"],"abstract_inverted_index":{"With":[0],"approximately":[1],"50%":[2],"of":[3,17,35,41,87,100,113,133,137,145,154,162,174,199,202,211,253],"tumours":[4,27,74],"bearing":[5],"mutations":[6],"in":[7,23,73,103,159,176,185,207,226,230,270],"the":[8,11,18,39,42,58,85,91,98,114,118,121,143,148,165,186,197,217,227,241,254],"TP53":[9],"gene,":[10],"tumour":[12,266],"suppressor":[13],"p53":[14,43,47,72,149,163,166,234],"is":[15,66,80,95],"one":[16],"most":[19],"frequently":[20],"altered":[21],"proteins":[22],"human":[24],"cancer.":[25],"In":[26,117],"retaining":[28,273],"wild-type":[29,274],"p53,":[30],"other":[31],"aberrations":[32],"including":[33],"overexpression":[34],"MDM2":[36,45],"may":[37,259],"impair":[38],"function":[40],"pathway.":[44,150],"regulates":[46],"by":[48,109],"inhibiting":[49],"p53-mediated":[50],"transcriptional":[51],"activity":[52],"and":[53,135,156,164,171,204,209],"promoting":[54],"its":[55],"degradation.":[56],"Inhibiting":[57],"MDM2-p53":[59],"interaction":[60,256],"with":[61,130,152,178,257],"small":[62],"molecule":[63],"antagonist":[64],"Nutlin-3":[65,134,146,157,179,212,225,258],"an":[67],"attractive":[68],"approach":[69],"to":[70,141,236,268],"reactivate":[71],"overexpressing":[75],"MDM2.":[76],"Photochemical":[77],"internalisation":[78],"(PCI)":[79],"a":[81,131,193,261],"novel":[82],"technology":[83,94],"for":[84,264],"release":[86,112],"therapeutic":[88],"macromolecules":[89],"into":[90],"cytosol.":[92],"The":[93,247],"based":[96],"on":[97,147,196,243],"use":[99],"photosensitizers":[101],"located":[102],"endocytic":[104],"vesicles":[105],"that":[106,224,251],"upon":[107],"activation":[108],"light":[110],"induces":[111],"endocytosed":[115],"macromolecules.":[116],"current":[119,248],"study,":[120],"p53Wt":[122],"MDM2Ampl":[123,271],"osteosarcoma":[124],"cell":[125,182,214,237],"line":[126],"SJSA-1":[127],"was":[128],"treated":[129],"combination":[132,177],"PCI":[136,153,173,201,269],"bleomycin":[138,155,175,203],"or":[139],"saporin":[140,205],"study":[142,232,249],"impact":[144,195],"Treatment":[151],"resulted":[158],"increased":[160],"expression":[161],"target":[167],"genes":[168],"MDM2,":[169],"p21":[170],"Bax.":[172],"also":[180],"induced":[181],"cycle":[183,238],"arrest":[184],"G1/S":[187],"checkpoint,":[188],"but":[189,216],"did":[190],"not":[191],"have":[192],"substantial":[194],"induction":[198],"apoptosis.":[200],"both":[206],"presence":[208],"absence":[210],"inhibited":[213],"growth,":[215],"differences":[218],"were":[219],"negligible.":[220],"These":[221],"results":[222],"indicate":[223],"concentration":[228],"given":[229],"this":[231],"activates":[233],"leading":[235],"arrest,":[239],"while":[240],"effect":[242],"apoptosis":[244],"remain":[245],"ambiguous.":[246],"suggests":[250],"inhibition":[252],"p53-MDM2":[255],"be":[260],"promising":[262],"strategy":[263],"improving":[265],"response":[267],"malignancies":[272],"p53.":[275]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}