{"id":"https://openalex.org/W23459527","doi":null,"title":"Fenofibrate improves microcirculation in patients with hyperlipidemia.","display_name":"Fenofibrate improves microcirculation in patients with hyperlipidemia.","publication_year":1998,"publication_date":"1998-02-21","ids":{"openalex":"https://openalex.org/W23459527","mag":"23459527","pmid":"https://pubmed.ncbi.nlm.nih.gov/9512968"},"language":"en","primary_location":{"id":"pmid:9512968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9512968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113171537","display_name":"T Haak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Haak","raw_affiliation_strings":["Medical Department, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. DSZ-Haak@em.uni-frankfurt.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany. DSZ-Haak@em.uni-frankfurt.de","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030703447","display_name":"Eva Haak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Haak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110017787","display_name":"Klaus Kusterer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kusterer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Weber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008147080","display_name":"M. Kohleisen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kohleisen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113674830","display_name":"K.-H. Usadel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K H Usadel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5012,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.83408142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"3","issue":"1-2","first_page":"50","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.03750000149011612,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fenofibrate","display_name":"fenofibrate","score":1.0},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.906000018119812},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nailfold-capillaroscopy","display_name":"nailfold capillaroscopy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.8669999837875366},{"id":"https://openalex.org/keywords/plasma-viscosity","display_name":"plasma viscosity","score":0.8899999856948853},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apolipoprotein-a","display_name":"apolipoprotein(a)","score":0.8450000286102295},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9750000238418579},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6499999761581421},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.9553056955337524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7675095200538635},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.7334775924682617},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.6572161912918091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6359449625015259},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.532470703125},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.528810977935791},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.511239767074585},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4904744327068329},{"id":"https://openalex.org/C3019128504","wikidata":"https://www.wikidata.org/wiki/Q948806","display_name":"Reactive hyperemia","level":3,"score":0.47512227296829224},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.4680122137069702},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4245806634426117},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.41777780652046204},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4133864939212799},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33965328335762024},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.23702824115753174},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.055832087993621826}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000960","descriptor_name":"Hypolipidemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011345","descriptor_name":"Fenofibrate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9512968","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9512968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Journal Article"},{"id":"mag:23459527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9512968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W94145098"],"related_works":["https://openalex.org/W2377291239","https://openalex.org/W2056319820","https://openalex.org/W2380928012","https://openalex.org/W2349368430","https://openalex.org/W1982699064","https://openalex.org/W2390088910","https://openalex.org/W1986416204","https://openalex.org/W7095374469","https://openalex.org/W2139315494","https://openalex.org/W2409522833"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,71,96,114,132,199],"investigate":[3],"the":[4,24,69,82,166,174,186,201,207],"effect":[5,152,181],"of":[6,26,65,81,153,162,185,206],"fenofibrate":[7,36,142,154,196],"on":[8,121,182],"microcirculation,":[9],"16":[10,97],"patients":[11,147],"(5":[12],"female,":[13],"11":[14],"male,":[15],"age":[16],"58":[17],"+/-":[18,94,98],"8":[19],"years)":[20],"were":[21,106],"studied":[22],"with":[23,33,117,148],"aid":[25],"nailfold":[27],"capillaroscopy":[28],"before":[29],"and":[30,51,53,56,131,135],"after":[31],"treatment":[32,143],"200":[34,88],"mg":[35],"per":[37],"day":[38],"over":[39],"six":[40],"weeks.":[41],"Fenofibrate":[42],"resulted":[43],"in":[44,48,59,112,146,168],"a":[45,63,118],"significant":[46],"decrease":[47,167],"triglycerides,":[49],"total":[50,129],"LDL-cholesterol":[52],"apolipoprotein":[54,60],"B":[55],"an":[57,66,179],"increase":[58],"A.":[61],"As":[62],"parameter":[64],"improved":[67],"microcirculation":[68,145],"time":[70],"peak":[72],"capillary":[73],"blood":[74,133],"cell":[75],"velocity":[76],"during":[77],"postreactive":[78],"hyperemia":[79],"(occlusion":[80],"lower":[83],"arm":[84],"for":[85],"2":[86],"minutes,":[87],"mmHg)":[89],"decreased":[90,108],"markedly":[91],"from":[92,157,190],"45":[93],"5":[95],"3":[99],"s,":[100],"p":[101],"<":[102,110],"0.0001).":[103],"Fibrinogen":[104],"levels":[105,170],"significantly":[107],"(p":[109],"0.04)":[111],"contrast":[113],"other":[115,175],"parameters":[116],"possible":[119],"impact":[120],"microvascular":[122],"perfusion":[123],"(hemoglobin,":[124],"hematocrit,":[125],"mean":[126],"platelet":[127],"volume,":[128],"protein)":[130],"pressure":[134],"heart":[136],"rate.":[137],"These":[138],"findings":[139],"suggest":[140],"that":[141],"improves":[144],"hyperlipidemia.":[149],"This":[150],"beneficial":[151],"may":[155],"arise":[156],"two":[158],"leading":[159],"mechanisms.":[160],"One":[161],"these":[163],"might":[164,177],"be":[165,178],"fibrinogen":[169],"reducing":[171],"plasma":[172,194],"viscosity,":[173],"mechanism":[176],"indirect":[180],"functional":[183],"abnormalities":[184],"vascular":[187],"endothelium":[188,208],"arising":[189],"hyperlipdidemia.":[191],"By":[192],"lowering":[193],"lipids":[195],"is":[197],"likely":[198],"restore":[200],"impaired":[202],"formation":[203],"or":[204],"efficacy":[205],"derived":[209],"relaxing":[210],"factor":[211],"(nitric":[212],"oxide,":[213],"NO).":[214]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}