{"id":"https://openalex.org/W2345859986","doi":null,"title":"Antivirulence activities of Bioactive Peptides produced by Lactobacillus helveticus and Lactobacillus acidophilus against Salmonella enterica serovar Typhimurium","display_name":"Antivirulence activities of Bioactive Peptides produced by Lactobacillus helveticus and Lactobacillus acidophilus against Salmonella enterica serovar Typhimurium","publication_year":2014,"publication_date":"2014-09-19","ids":{"openalex":"https://openalex.org/W2345859986","mag":"2345859986"},"language":"en","primary_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8476","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8476","pdf_url":"http://hdl.handle.net/10214/8476","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10214/8476","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103812908","display_name":"Sapana Sharma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sapana Sharma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103812908"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-virulence-activity","display_name":"anti-virulence activity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bioactive-peptides","display_name":"bioactive peptides","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lactobacillus-helveticus","display_name":"Lactobacillus helveticus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactobacillus-acidophilus","display_name":"Lactobacillus acidophilus","score":1.0},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.9850000143051147},{"id":"https://openalex.org/keywords/virulence-genes","display_name":"virulence genes","score":0.5649999976158142},{"id":"https://openalex.org/keywords/sipb","display_name":"SipB","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hila","display_name":"hilA","score":0.9739999771118164},{"id":"https://openalex.org/keywords/inva-gene","display_name":"invA gene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/fermentation-conditions","display_name":"fermentation conditions","score":0.6240000128746033},{"id":"https://openalex.org/keywords/anaerobic-fermentation","display_name":"anaerobic fermentation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/skim-milk-fermentation","display_name":"skim milk fermentation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.48500001430511475},{"id":"https://openalex.org/keywords/enteric-pathogens","display_name":"enteric pathogens","score":0.6880000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3409999907016754},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2776030290","wikidata":"https://www.wikidata.org/wiki/Q142378","display_name":"Lactobacillus helveticus","level":4,"score":0.9242956638336182},{"id":"https://openalex.org/C2779607309","wikidata":"https://www.wikidata.org/wiki/Q2264864","display_name":"Salmonella enterica","level":4,"score":0.8753331303596497},{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.7702550888061523},{"id":"https://openalex.org/C2777221637","wikidata":"https://www.wikidata.org/wiki/Q132644","display_name":"Lactobacillus acidophilus","level":4,"score":0.7160415649414062},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6407956480979919},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.6264174580574036},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.49348151683807373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43151095509529114},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3692593574523926},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.22693756222724915},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22160163521766663},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0889330804347992},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8476","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8476","pdf_url":"http://hdl.handle.net/10214/8476","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2345859986","doi":null,"is_oa":false,"landing_page_url":"https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8476","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/8476","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/8476","pdf_url":"http://hdl.handle.net/10214/8476","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2345859986.pdf","grobid_xml":"https://content.openalex.org/works/W2345859986.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W5581280","https://openalex.org/W55574097","https://openalex.org/W321478765","https://openalex.org/W605682515","https://openalex.org/W611272448","https://openalex.org/W1158323695","https://openalex.org/W1485411672","https://openalex.org/W1487990560","https://openalex.org/W1506856429","https://openalex.org/W1521734634","https://openalex.org/W1532426033","https://openalex.org/W1550225293","https://openalex.org/W1561489271","https://openalex.org/W1573276067","https://openalex.org/W1592363623","https://openalex.org/W1595581896","https://openalex.org/W1605971135","https://openalex.org/W1649341603","https://openalex.org/W1698486782","https://openalex.org/W1700821190","https://openalex.org/W1804759123","https://openalex.org/W1952460190","https://openalex.org/W1965657989","https://openalex.org/W1968370518","https://openalex.org/W1970334112","https://openalex.org/W1970748157","https://openalex.org/W1973711487","https://openalex.org/W1975913397","https://openalex.org/W1979963523","https://openalex.org/W1980070534","https://openalex.org/W1984520240","https://openalex.org/W1990122501","https://openalex.org/W1993849836","https://openalex.org/W1994606289","https://openalex.org/W1994633231","https://openalex.org/W1994954454","https://openalex.org/W1995475849","https://openalex.org/W1995760942","https://openalex.org/W1997062053","https://openalex.org/W1999372506","https://openalex.org/W2001257468","https://openalex.org/W2001301879","https://openalex.org/W2001526641","https://openalex.org/W2002212320","https://openalex.org/W2002945113","https://openalex.org/W2006086331","https://openalex.org/W2006968989","https://openalex.org/W2008450208","https://openalex.org/W2013164318","https://openalex.org/W2013936027","https://openalex.org/W2022193058","https://openalex.org/W2023822923","https://openalex.org/W2027542963","https://openalex.org/W2028148543","https://openalex.org/W2028989327","https://openalex.org/W2030855312","https://openalex.org/W2033307963","https://openalex.org/W2033604879","https://openalex.org/W2034915619","https://openalex.org/W2035758756","https://openalex.org/W2038065826","https://openalex.org/W2040356035","https://openalex.org/W2042478438","https://openalex.org/W2043772594","https://openalex.org/W2047542783","https://openalex.org/W2050634031","https://openalex.org/W2050819949","https://openalex.org/W2051526455","https://openalex.org/W2052224919","https://openalex.org/W2054332307","https://openalex.org/W2054367568","https://openalex.org/W2056010853","https://openalex.org/W2056548716","https://openalex.org/W2057536036","https://openalex.org/W2062565002","https://openalex.org/W2064159768","https://openalex.org/W2064683530","https://openalex.org/W2076947568","https://openalex.org/W2081044684","https://openalex.org/W2083197722","https://openalex.org/W2083671868","https://openalex.org/W2086045209","https://openalex.org/W2086653080","https://openalex.org/W2087797651","https://openalex.org/W2088732289","https://openalex.org/W2090256785","https://openalex.org/W2093343169","https://openalex.org/W2093974041","https://openalex.org/W2094009676","https://openalex.org/W2094306515","https://openalex.org/W2095017924","https://openalex.org/W2095782520","https://openalex.org/W2096715597","https://openalex.org/W2097221730","https://openalex.org/W2097697877","https://openalex.org/W2098593307","https://openalex.org/W2101997581","https://openalex.org/W2105616599","https://openalex.org/W2107277218","https://openalex.org/W2108244474","https://openalex.org/W2109554857","https://openalex.org/W2109689528","https://openalex.org/W2114760499","https://openalex.org/W2115496478","https://openalex.org/W2118266802","https://openalex.org/W2121396317","https://openalex.org/W2123406771","https://openalex.org/W2124251044","https://openalex.org/W2125114744","https://openalex.org/W2127697422","https://openalex.org/W2128591134","https://openalex.org/W2132796888","https://openalex.org/W2133603290","https://openalex.org/W2138347066","https://openalex.org/W2139278911","https://openalex.org/W2143398242","https://openalex.org/W2144878722","https://openalex.org/W2147303996","https://openalex.org/W2148719079","https://openalex.org/W2150705960","https://openalex.org/W2150769218","https://openalex.org/W2151026417","https://openalex.org/W2157990011","https://openalex.org/W2162487356","https://openalex.org/W2164633657","https://openalex.org/W2164863538","https://openalex.org/W2167730443","https://openalex.org/W2167917016","https://openalex.org/W2169398533","https://openalex.org/W2169650544","https://openalex.org/W2170855346","https://openalex.org/W2171865415","https://openalex.org/W2171980652","https://openalex.org/W2172284440","https://openalex.org/W2285046969","https://openalex.org/W2337111243","https://openalex.org/W2340466118","https://openalex.org/W2436098338","https://openalex.org/W2478790044","https://openalex.org/W2916906873","https://openalex.org/W3108142925"],"related_works":["https://openalex.org/W2541929830","https://openalex.org/W2593353862","https://openalex.org/W4226025234","https://openalex.org/W2461916359","https://openalex.org/W2971772623","https://openalex.org/W2273416388","https://openalex.org/W2125236230","https://openalex.org/W2025069365","https://openalex.org/W2141162153","https://openalex.org/W2022518106"],"abstract_inverted_index":{"During":[0],"fermentation,":[1],"Lactobacillus":[2,5,48,51,77,86,93,271,274,295],"acidophilus":[3,52,94,275],"and":[4,29,50,60,92,157,168,192,200,209,226,273,281],"helveticus":[6,49,87,272],"release":[7],"many":[8],"small":[9],"peptides":[10,46,75,161,268,291],"as":[11,108],"secondary":[12],"metabolites.":[13],"Previous":[14],"studies":[15],"have":[16],"showed":[17,195,230],"the":[18,35,41,44,54,63,69,73,127,130,143,147,163,175,235,241,266,311,317],"protective":[19],"effects":[20,42,64,125,145,299],"of":[21,34,43,57,65,72,126,133,146,187,224,233,240,313,316],"these":[22],"biomolecules":[23],"against":[24,278,300],"enteric":[25],"pathogens":[26],"in":[27,30,115,162,181,198,205,288],"vitro":[28],"vivo.":[31],"The":[32,124,166,213,238,303],"purpose":[33],"present":[36],"study":[37],"is":[38,106],"to":[39,61,111,309],"observe":[40,62],"bioactive":[45,74,267],"from":[47,76,85,270,293],"on":[53,68,129],"virulence":[55,242],"factors":[56],"Salmonella":[58,116,134,179,285,301],"Typhimurium":[59,286],"fermentation":[66,153],"conditions":[67,154],"antivirulence":[70,144,298,314],"activities":[71],"acidophilus.":[78],"Cell-free":[79],"spent":[80],"media":[81],"(CFSMs)":[82],"were":[83,135,155],"prepared":[84],"(LH-2)":[88],"fermented":[89,96],"skim":[90],"milk":[91],"(La-5)":[95],"whey":[97],"protein":[98],"based":[99],"media.":[100],"Lactate":[101],"dehydrogenase":[102],"(LDH)":[103],"production,":[104],"which":[105],"used":[107],"an":[109],"indicator":[110],"cytotoxicity,":[112],"was":[113,256],"assayed":[114],"infected":[117],"RAW":[118,182],"264.7":[119,183],"cells":[120],"co-incubated":[121],"with":[122,159,221,246],"CFSMs.":[123,165],"CFSMs":[128,149,170,194],"gene":[131,188],"expression":[132],"analyzed":[136],"using":[137],"a":[138],"two-step":[139],"RT-qPCR":[140],"assay.":[141],"Additionally,":[142],"La-5":[148,164,169,193,214],"produced":[150,216],"under":[151,217],"different":[152],"compared":[156],"correlated":[158,245],"specific":[160,260],"LH-2":[167,191],"significantly":[171],"decreased":[172],"(p<":[173],"0.05)":[174],"cytotoxicity":[176],"caused":[177,283],"by":[178,284],"infection":[180,287],"cells.":[184],"In":[185],"terms":[186],"expression,":[189],"both":[190,294],"two-fold":[196],"down-regulation":[197,204,232,239],"sipB":[199],"more":[201],"than":[202],"six-fold":[203],"hilA,":[206],"ssrB,":[207],"sopD":[208],"invA":[210],"genes":[211,236,243],"expression.":[212],"CFSM":[215],"strict":[218],"anaerobic":[219],"condition":[220],"medium":[222],"rate":[223],"agitation":[225],"fresh":[227],"culture":[228],"inoculation":[229],"highest":[231],"all":[234],"tested.":[237],"when":[244],"reverse":[247],"phase-":[248],"HPLC":[249],"profiles,":[250],"significant":[251],"correlation":[252],"(p<0.01":[253],"or":[254],"p<0.05)":[255],"found":[257],"for":[258],"few":[259],"peaks.":[261],"These":[262],"results":[263],"suggest":[264],"that":[265],"obtained":[269,292],"can":[276,306],"protect":[277],"cell":[279],"damage":[280],"apoptosis":[282],"vitro.":[289],"Bioactive":[290],"species":[296],"exhibited":[297],"Typhimurium.":[302],"production":[304],"method":[305],"be":[307],"optimized":[308],"increase":[310],"efficacy":[312],"effect":[315],"peptides.":[318]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}