{"id":"https://openalex.org/W2345841092","doi":"https://doi.org/10.1016/j.celrep.2016.04.036","title":"Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage","display_name":"Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2345841092","doi":"https://doi.org/10.1016/j.celrep.2016.04.036","mag":"2345841092","pmid":"https://pubmed.ncbi.nlm.nih.gov/27160911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4893157"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2016.04.036","doi":"https://doi.org/10.1016/j.celrep.2016.04.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2016.04.036","pdf_url":"http://www.cell.com/article/S2211124716304636/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124716304636/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037014015","display_name":"Cosetta Bertoli","orcid":"https://orcid.org/0000-0001-5684-4630","observed_orcids":["https://orcid.org/0000-0001-5684-4630"]},"institutions":[{"id":"https://openalex.org/I4210093127","display_name":"MRC Laboratory for Molecular Cell Biology","ror":"https://ror.org/00fv61j67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210093127","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cosetta Bertoli","raw_affiliation_strings":["MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019720646","display_name":"Anna E. Herlihy","orcid":"https://orcid.org/0000-0002-0393-7531","observed_orcids":["https://orcid.org/0000-0002-0393-7531"]},"institutions":[{"id":"https://openalex.org/I4210093127","display_name":"MRC Laboratory for Molecular Cell Biology","ror":"https://ror.org/00fv61j67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210093127","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna E. Herlihy","raw_affiliation_strings":["MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046451491","display_name":"Betheney R. Pennycook","orcid":"https://orcid.org/0000-0001-5721-6994","observed_orcids":["https://orcid.org/0000-0001-5721-6994"]},"institutions":[{"id":"https://openalex.org/I4210093127","display_name":"MRC Laboratory for Molecular Cell Biology","ror":"https://ror.org/00fv61j67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210093127","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Betheney R. Pennycook","raw_affiliation_strings":["MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036989588","display_name":"J\u00e1nos Kriston-Vizi","orcid":"https://orcid.org/0000-0002-0149-145X","observed_orcids":["https://orcid.org/0000-0002-0149-145X"]},"institutions":[{"id":"https://openalex.org/I4210093127","display_name":"MRC Laboratory for Molecular Cell Biology","ror":"https://ror.org/00fv61j67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210093127","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Janos Kriston-Vizi","raw_affiliation_strings":["MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK; Bioinformatics Image Core (BIONIC), University College London, London WC1E 6BT, UK","Bioinformatics Image Core (BIONIC), University College London, London WC1E 6BT, UK","MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK; Bioinformatics Image Core (BIONIC), University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Bioinformatics Image Core (BIONIC), University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006707488","display_name":"Robertus A.M. de Bruin","orcid":"https://orcid.org/0000-0001-9957-1409","observed_orcids":["https://orcid.org/0000-0001-9957-1409"]},"institutions":[{"id":"https://openalex.org/I4210093127","display_name":"MRC Laboratory for Molecular Cell Biology","ror":"https://ror.org/00fv61j67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210087105","https://openalex.org/I4210093127","https://openalex.org/I45129253","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Robertus A.M. de Bruin","raw_affiliation_strings":["MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK; The UCL Cancer Institute, University College London, London WC1E 6BT, UK. Electronic address: r.debruin@ucl.ac.uk","MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK","The UCL Cancer Institute, University College London, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK; The UCL Cancer Institute, University College London, London WC1E 6BT, UK. Electronic address: r.debruin@ucl.ac.uk","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]},{"raw_affiliation_string":"MRC Laboratory for Molecular Cell Biology , University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"]},{"raw_affiliation_string":"The UCL Cancer Institute, University College London, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006707488"],"corresponding_institution_ids":["https://openalex.org/I4210093127","https://openalex.org/I45129253"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":4433,"currency":"EUR","value_usd":4780},"fwci":3.0727,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.92427213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"7","first_page":"1412","last_page":"1422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replication-stress","display_name":"replication stress","score":0.8389999866485596},{"id":"https://openalex.org/keywords/replication-fork-stalling","display_name":"replication fork stalling","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7429999709129333},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.777999997138977},{"id":"https://openalex.org/keywords/oncogene-induced-replication-stress","display_name":"oncogene-induced replication stress","score":0.9559999704360962},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8600000143051147},{"id":"https://openalex.org/keywords/intra-s-phase-checkpoint","display_name":"S-phase checkpoint","score":0.4819999933242798},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5969245433807373},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.578934371471405},{"id":"https://openalex.org/C83258922","wikidata":"https://www.wikidata.org/wiki/Q24771933","display_name":"E2F","level":4,"score":0.5237167477607727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5235726237297058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4883215129375458},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4764288365840912},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.44995832443237305},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.44130924344062805},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3495548665523529},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3292200565338135},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23965713381767273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14807796478271484},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050684","descriptor_name":"E2F Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.celrep.2016.04.036","doi":"https://doi.org/10.1016/j.celrep.2016.04.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2016.04.036","pdf_url":"http://www.cell.com/article/S2211124716304636/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3870414","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4893157","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:27160911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27160911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4893157","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4893157/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4ab6b935d351488b87d5dd3eafccf349","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4ab6b935d351488b87d5dd3eafccf349","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 15, Iss 7, Pp 1412-1422 (2016)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1494034","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1494034/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports , 15 (7) pp. 1412-1422. (2016)","raw_type":"Article"},{"id":"mag:2740085071","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/cell-reports/pdf/S2211-1247(16)30463-6.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2016.04.036","doi":"https://doi.org/10.1016/j.celrep.2016.04.036","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2016.04.036","pdf_url":"http://www.cell.com/article/S2211124716304636/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5917610388","display_name":null,"funder_award_id":"20147","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8751681178","display_name":"A Translational Research Resource Centre and Image-Based Screening Platform for MRC-LMCB, UCL.","funder_award_id":"MC_EX_G0800785","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332495","display_name":"U.S. Bureau of Land Management","ror":"https://ror.org/03v0pmy70"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2345841092.pdf"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1855851918","https://openalex.org/W1967630574","https://openalex.org/W1969127943","https://openalex.org/W1970471893","https://openalex.org/W1970578083","https://openalex.org/W1984373702","https://openalex.org/W1986121915","https://openalex.org/W1990623204","https://openalex.org/W1991199800","https://openalex.org/W1995479856","https://openalex.org/W2007889926","https://openalex.org/W2010869413","https://openalex.org/W2043745733","https://openalex.org/W2055604308","https://openalex.org/W2057625439","https://openalex.org/W2062739292","https://openalex.org/W2063979868","https://openalex.org/W2077436902","https://openalex.org/W2085989811","https://openalex.org/W2094965826","https://openalex.org/W2117273743","https://openalex.org/W2128252882","https://openalex.org/W2135469496","https://openalex.org/W2145200068","https://openalex.org/W2161041571","https://openalex.org/W2171439401","https://openalex.org/W7074134823"],"related_works":["https://openalex.org/W2707646325","https://openalex.org/W2740085071","https://openalex.org/W3133052187","https://openalex.org/W2911234930","https://openalex.org/W2085989811","https://openalex.org/W2591801412","https://openalex.org/W1984528393","https://openalex.org/W1976853883","https://openalex.org/W3108117377","https://openalex.org/W2111346575"],"abstract_inverted_index":{"Recent":[0],"work":[1],"established":[2],"DNA":[3,45,116],"replication":[4,33,96,106,128,146],"stress":[5,34,129],"as":[6],"a":[7,14,50,121],"crucial":[8,77],"driver":[9],"of":[10,20,39,61,94,115,132,145],"genomic":[11],"instability":[12],"and":[13,73,84],"key":[15,40],"event":[16],"at":[17],"the":[18,29,37,59,92],"onset":[19],"cancer.":[21],"Post-translational":[22],"modifications":[23],"play":[24],"an":[25],"important":[26],"role":[27,53],"in":[28,57,91,123],"cellular":[30],"response":[31],"to":[32,42,104,112,137,140],"by":[35],"regulating":[36],"activity":[38,101,109,139],"components":[41],"prevent":[43],"replication-stress-induced":[44,62],"damage.":[46,117],"Here,":[47],"we":[48,87],"establish":[49],"far":[51],"greater":[52],"for":[54,75],"transcriptional":[55],"control":[56],"determining":[58],"outcome":[60],"events":[63],"than":[64],"previously":[65],"suspected.":[66],"Sustained":[67],"E2F-dependent":[68,133],"transcription":[69,134],"is":[70,102,110],"both":[71],"required":[72,111],"sufficient":[74],"many":[76],"checkpoint":[78],"functions,":[79],"including":[80],"fork":[81],"stalling,":[82],"stabilization,":[83],"resolution.":[85],"Importantly,":[86],"also":[88],"find":[89],"that,":[90],"context":[93],"oncogene-induced":[95,127],"stress,":[97,107],"where":[98],"increased":[99],"E2F":[100,108,138],"thought":[103],"cause":[105],"limit":[113],"levels":[114,144],"These":[118],"data":[119],"suggest":[120],"model":[122],"which":[124],"cells":[125],"experiencing":[126],"through":[130],"deregulation":[131],"become":[135],"addicted":[136],"cope":[141],"with":[142],"high":[143],"stress.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
