{"id":"https://openalex.org/W2345765618","doi":null,"title":"Protein Pathway Activation Mapping for Multi-Omic Based Precision Medicine","display_name":"Protein Pathway Activation Mapping for Multi-Omic Based Precision Medicine","publication_year":2016,"publication_date":"2016-04-04","ids":{"openalex":"https://openalex.org/W2345765618","mag":"2345765618"},"language":"en","primary_location":{"id":"mag:2345765618","doi":null,"is_oa":false,"landing_page_url":"https://www.gotoper.com/publications/ajho/2016/2016Mar/Protein-Pathway-Activation-Mapping-for-Multi-Omic-Based-Precision-Medicine","pdf_url":null,"source":{"id":"https://openalex.org/S4306501600","display_name":"American Journal of Hematology / Oncology\u00ae","issn_l":"1939-6163","issn":["1939-6163"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Hematology / Oncology\u00ae","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073337554","display_name":"Mariaelena Pierobon","orcid":"https://orcid.org/0000-0003-2084-1029","observed_orcids":["https://orcid.org/0000-0003-2084-1029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariaelena Pierobon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2084-1029","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020504047","display_name":"Leena Gandhi","orcid":"https://orcid.org/0000-0002-2398-9179","observed_orcids":["https://orcid.org/0000-0002-2398-9179"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leena Gandhi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2398-9179","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032987754","display_name":"Massimo Cristofanilli","orcid":"https://orcid.org/0000-0002-4194-7175","observed_orcids":["https://orcid.org/0000-0002-4194-7175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Cristofanilli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4194-7175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083321","display_name":"Debu Tripathy","orcid":"https://orcid.org/0000-0002-5711-2404","observed_orcids":["https://orcid.org/0000-0002-5711-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debu Tripathy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023762376","display_name":"Emanuel F. Petricoin","orcid":"https://orcid.org/0000-0001-9146-5572","observed_orcids":["https://orcid.org/0000-0001-9146-5572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emanuel F. Petricoin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9146-5572","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2561,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.56265244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7813000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.1956000030040741,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.7870000004768372},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-molecular-heterogeneity","display_name":"tumor molecular heterogeneity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/oncogenic-drivers","display_name":"oncogenic drivers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5400000214576721},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.718999981880188},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9309999942779541},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.4569999873638153},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.6990000009536743},{"id":"https://openalex.org/keywords/treatment-response-variability","display_name":"treatment response variability","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.6333958506584167},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.6274604201316833},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6204610466957092},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5084008574485779},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5068133473396301},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4635780155658722},{"id":"https://openalex.org/C74092355","wikidata":"https://www.wikidata.org/wiki/Q1056943","display_name":"Molecular pathology","level":3,"score":0.45688965916633606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4344833493232727},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4218290448188782},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41988301277160645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4178369641304016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40069282054901123},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37090206146240234},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3590947985649109},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2744297981262207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22237011790275574},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1566809117794037},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15663683414459229}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2345765618","doi":null,"is_oa":false,"landing_page_url":"https://www.gotoper.com/publications/ajho/2016/2016Mar/Protein-Pathway-Activation-Mapping-for-Multi-Omic-Based-Precision-Medicine","pdf_url":null,"source":{"id":"https://openalex.org/S4306501600","display_name":"American Journal of Hematology / Oncology\u00ae","issn_l":"1939-6163","issn":["1939-6163"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"American Journal of Hematology / Oncology\u00ae","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W94805890","https://openalex.org/W964049080","https://openalex.org/W1484764033","https://openalex.org/W1846586690","https://openalex.org/W1975332859","https://openalex.org/W1995219023","https://openalex.org/W2020515057","https://openalex.org/W2022495797","https://openalex.org/W2028701603","https://openalex.org/W2041399083","https://openalex.org/W2041993682","https://openalex.org/W2058659214","https://openalex.org/W2059200168","https://openalex.org/W2095659509","https://openalex.org/W2103906171","https://openalex.org/W2113762115","https://openalex.org/W2118912064","https://openalex.org/W2139126824","https://openalex.org/W2143618467","https://openalex.org/W2157771579","https://openalex.org/W2159715390","https://openalex.org/W2165207436","https://openalex.org/W2483561340"],"related_works":["https://openalex.org/W2767530344","https://openalex.org/W3014050071","https://openalex.org/W7133629021","https://openalex.org/W7159738247","https://openalex.org/W2110999983","https://openalex.org/W2965072406","https://openalex.org/W4406231709","https://openalex.org/W3179931814","https://openalex.org/W7220865693","https://openalex.org/W3194540628"],"abstract_inverted_index":{"Introduction":[0],"Molecular":[1],"studies":[2],"mapping":[3],"malignant":[4,178],"lesions":[5,51],"of":[6,37,41,133,168,171,196,206,222,234,252,266,312,330],"similar":[7,54],"anatomical":[8],"origin":[9],"have":[10,53,72,257],"led":[11],"to":[12,123,130,212,245,304,325],"the":[13,19,27,38,58,97,111,120,150,169,223,231,235,250,264,274,285,294,305,310,326],"understanding":[14],"that":[15,52,74,256],"tumors":[16,75,128],"originating":[17,76],"from":[18,77],"same":[20,59,286,295,306],"organ":[21,290],"can":[22,269],"be":[23,117,318],"extremely":[24],"heterogeneous":[25],"at":[26],"molecular":[28,32,62,83,141,160,204],"level.":[29],"This":[30,114],"underpinning":[31],"heterogeneity":[33],"is":[34,100,162,210],"considered":[35],"one":[36],"underlying":[39],"causes":[40],"high":[42],"discrepancy":[43],"in":[44,119,148,214,230,315],"treatment":[45],"success":[46],"rates":[47,303],"across":[48],"patients":[49,104,134,156,324],"with":[50,105,136,157,292],"histopathologic":[55],"characteristics.":[56],"At":[57],"time,":[60],"broad-scale":[61],"profiling":[63,161],"efforts":[64],"such":[65,89,144],"as":[66,90,187],"The":[67],"Cancer":[68],"Genome":[69],"Atlas":[70],"(TCGA)":[71],"revealed":[73],"different":[78,289],"organs":[79],"also":[80],"share":[81],"common":[82],"alterations.":[84],"For":[85],"these":[86,140,267],"reasons,":[87],"drugs":[88],"trastuzumab":[91],"(Herceptin),":[92],"a":[93,131,145,164,194],"monoclonal":[94],"antibody":[95],"targeting":[96],"HER2":[98,112,125,137],"protein,":[99],"FDA-approved":[101],"for":[102,155,174,190,261,273,322],"treating":[103,275],"breast":[106],"or":[107,243],"gastric":[108],"cancer":[109],"overexpressing":[110,126],"protein.":[113],"approval":[115],"may":[116,317],"broadened":[118],"near":[121],"future":[122],"other":[124],"solid":[127],"and":[129,176,180,199,225],"subpopulation":[132],"presenting":[135],"mutations.":[138],"Because":[139],"characteristics":[142],"play":[143],"central":[146],"role":[147],"determining":[149],"most":[151,327],"appropriate":[152,328],"therapeutic":[153],"approach":[154],"cancer,":[158],"upfront":[159],"becoming":[163],"de":[165],"facto":[166],"part":[167],"standard":[170],"care":[172],"work-up":[173],"classifying":[175],"describing":[177],"lesions,":[179],"true":[181],"oncogenic":[182],"drivers":[183,221],"are":[184,202,220,238,281],"being":[185],"used":[186],"key":[188],"targets":[189],"effective":[191],"therapy.":[192],"Although":[193],"number":[195],"DNA":[197],"mutations":[198],"chromosomal":[200],"amplifications/translocations":[201],"recognized":[203],"\u2018drivers\u2019":[205],"many":[207],"cancers,":[208],"it":[209],"impossible":[211],"distinguish":[213],"any":[215,240],"given":[216],"tumor":[217,247],"which":[218,226],"alterations":[219],"disease":[224],"adjustments":[227],"were":[228],"necessary":[229,242],"early":[232],"stage":[233],"malignancy,":[236],"but":[237],"not":[239],"more":[241],"sufficient":[244,321],"sustain":[246],"progression.":[248],"Despite":[249],"development":[251],"high-throughput":[253],"genomic":[254,279,297,313],"technologies":[255],"opened":[258],"new":[259],"opportunities":[260],"precision":[262],"medicine,":[263],"results":[265],"analyses":[268],"generate":[270],"unclear":[271],"data":[272],"physician":[276],"because":[277],"multiple":[278],"abnormalities":[280],"often":[282,299],"identified":[283],"within":[284],"lesion.":[287],"Moreover,":[288],"sites,":[291],"ostensibly":[293],"driving":[296],"event,":[298],"show":[300],"diverse":[301],"response":[302],"targeted":[307],"compound.":[308],"Therefore,":[309],"identification":[311],"changes":[314],"isolation":[316],"only":[319],"partially":[320],"stratifying":[323],"line":[329],"treatment.":[331],"Abstract":[332]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
