{"id":"https://openalex.org/W2345761702","doi":"https://doi.org/10.1182/blood.v122.21.318.318","title":"Imaging Flow Cytometry and Microfluidic Flow Assays Demonstrate Heterocellular Aggregation Of Immature Sickle Erythrocytes To Neutrophils Via Mac-1/VLA-4 Interactions","display_name":"Imaging Flow Cytometry and Microfluidic Flow Assays Demonstrate Heterocellular Aggregation Of Immature Sickle Erythrocytes To Neutrophils Via Mac-1/VLA-4 Interactions","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2345761702","doi":"https://doi.org/10.1182/blood.v122.21.318.318","mag":"2345761702"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.318.318","doi":"https://doi.org/10.1182/blood.v122.21.318.318","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.318.318","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051661479","display_name":"Venina Marcela Dominical","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Venina Marcela Dominical","raw_affiliation_strings":["Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077898822","display_name":"Leigh Samsel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leigh Samsel","raw_affiliation_strings":["Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031607862","display_name":"Daiana Morelli Vital","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daiana Morelli Vital","raw_affiliation_strings":["Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105421158","display_name":"James S. Nichols","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James S Nichols","raw_affiliation_strings":["Sickle Cell Vascular Disease Section, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sickle Cell Vascular Disease Section, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059146573","display_name":"Vanessa T. Garrido","orcid":"https://orcid.org/0000-0002-5014-1608","observed_orcids":["https://orcid.org/0000-0002-5014-1608"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Vanessa Tonin Garrido","raw_affiliation_strings":["Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109135656","display_name":"Sara T. Olalla Saad","orcid":"https://orcid.org/0000-0003-0809-8068","observed_orcids":["https://orcid.org/0000-0003-0809-8068"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sara T O Saad","raw_affiliation_strings":["Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067713063","display_name":"Fernando Ferreira Costa","orcid":"https://orcid.org/0000-0002-4632-572X","observed_orcids":["https://orcid.org/0000-0002-4632-572X","https://orcid.org/0009-0002-1844-2870"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Ferreira Costa","raw_affiliation_strings":["Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102771781","display_name":"John Philip McCoy","orcid":"https://orcid.org/0000-0002-8118-5275","observed_orcids":["https://orcid.org/0000-0002-8118-5275"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Philip McCoy","raw_affiliation_strings":["Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067515209","display_name":"Nicola Conran","orcid":"https://orcid.org/0000-0001-5726-7919","observed_orcids":["https://orcid.org/0000-0001-5726-7919"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nicola Conran","raw_affiliation_strings":["Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology and Hemotherapy Center, University of Campinas - UNICAMP, INCT do Sangue, Campinas, Brazil,","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066832003","display_name":"Gregory James Kato","orcid":"https://orcid.org/0000-0003-4465-3217","observed_orcids":["https://orcid.org/0000-0003-4465-3217"]},"institutions":[{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory J. Kato","raw_affiliation_strings":["Sickle Cell Vascular Disease Section, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sickle Cell Vascular Disease Section, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210106489"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031607862","https://openalex.org/A5051661479","https://openalex.org/A5059146573","https://openalex.org/A5077898822","https://openalex.org/A5105421158"],"corresponding_institution_ids":["https://openalex.org/I181391015","https://openalex.org/I4210106489"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.21642677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"122","issue":"21","first_page":"318","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vessel-occlusion","display_name":"vascular occlusion","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.875},{"id":"https://openalex.org/keywords/reticulocytes","display_name":"reticulocytes","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.7919999957084656},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6222508549690247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5398492217063904},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.5375200510025024},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5118119120597839},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.44554463028907776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37129223346710205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36847826838493347},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36311960220336914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3570883274078369},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.32789039611816406},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2602313160896301},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2571067810058594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1278056502342224}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.318.318","doi":"https://doi.org/10.1182/blood.v122.21.318.318","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.318.318","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2115068232","https://openalex.org/W2749636898","https://openalex.org/W2739026297","https://openalex.org/W2885266878","https://openalex.org/W2558441084","https://openalex.org/W1491497891","https://openalex.org/W2596847622","https://openalex.org/W2067804534","https://openalex.org/W1595400055","https://openalex.org/W2161747330"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Vaso-occlusion":[2],"(VO)":[3],"is":[4,523],"a":[5,165,323,367,526],"major":[6],"acute":[7],"complication":[8],"of":[9,21,31,108,203,230,257,284,294,326,373,409,424,426,454,475,477,484,540,559],"sickle":[10,63],"cell":[11,40,64,127],"disease":[12],"(SCD).":[13],"Sickle":[14],"mouse":[15],"models":[16],"indicate":[17],"that":[18,536],"the":[19,24,29,134,282,291,295,342,422,482,538],"recruitment":[20],"leukocytes":[22],"to":[23,42,79,197,221,235,252,265,341,370,378,387,396,400,432,442,469,507,561],"endothelium":[25],"may":[26,547],"participate":[27],"in":[28,48,54,62,96,194,276,337,481,528,553],"initiation/propagation":[30],"VO,":[32],"consequently":[33],"interacting":[34],"with":[35,57,75,112,159,174,206,261,281,375,391,428,495,517,525],"circulating":[36],"erythrocytes":[37],"and":[38,68,93,101,110,148,156,300,309,316,322,404,445],"other":[39],"types":[41],"impair":[43],"blood":[44,59,85,126],"flow.":[45],"We":[46],"investigated,":[47],"vitro,":[49],"whether":[50,69],"neutrophils":[51,476],"(Neut)":[52],"circulate":[53,480],"heterocellular":[55],"aggregates":[56,128,258],"red":[58],"cells":[60,180,510],"(RBC)":[61],"anemia":[65],"(SCA)":[66,100],"patients,":[67,311],"Neut":[70,204,250,376,393,430,501],"from":[71,88,402,447,502],"SCA":[72,94,277,308,338,383,439,478,503,518],"individuals":[73,91,199,406],"interact":[74,388,514],"RBC":[76,160,237,374,384,401,410,427,444,446],"once":[77],"tethered":[78],"vessel":[80,379],"wall":[81,380],"components.":[82],"Methods":[83],"Peripheral":[84],"was":[86,435],"obtained":[87],"healthy":[89],"control":[90],"(CON)":[92],"patients":[95,278,448,479],"steady":[97],"state,":[98],"off":[99],"on":[102,314,319,329,449],"hydroxyurea":[103],"(SCAHU;":[104],"15-30mg/kg/day).":[105],"After":[106],"Ficoll-sedimentation":[107],"granulocytes":[109],"incubation":[111],"antibodies":[113,321],"against":[114],"RBC/Neut":[115],"surface":[116,292],"proteins":[117],"(RBC:":[118],"CD235a,":[119],"CD71;":[120],"Neut:":[121],"CD66b,":[122],"CD11a,":[123],"CD11b),":[124],"neutrophil-red":[125],"(Neut-RBC":[129],"agg)":[130],"were":[131,144,161,191,227,259,302,385,493],"evaluated":[132],"using":[133,164],"Amnis\u00ae":[135],"ImageStreamX":[136],"MKII":[137],"imaging":[138],"flow":[139],"cytometer.":[140],"CD66b+":[141],"events":[142],"(6000)":[143],"acquired":[145],"at":[146],"40X":[147],"data":[149],"analyzed":[150],"by":[151,543],"IDEAS":[152],"6.0.":[153],"Neutrophil":[154],"adhesion":[155],"heterotypic":[157,530],"interactions":[158,372,425,546],"also":[162],"monitored":[163],"Cellix":[166],"VenafluxTM":[167],"microfluidics":[168],"platform,":[169],"employing":[170],"800-\u03bcm-channel":[171],"biochips":[172],"lined":[173],"activated":[175,397,508],"human":[176],"umbilical":[177],"vein":[178],"endothelial":[179,509,512],"(HUVECs),":[181],"or":[182,267,269,511,533],"E-selectin":[183,434],"(4\u00b5g/mL).":[184],"Results":[185],"Circulating":[186],"Neut-RBC":[187,225,285,334,497,541],"agg":[188,226,286,335,498,542],"(CD66+CD235a+":[189],"events)":[190],"significantly":[192,304,332,389,436],"increased":[193],"SCA,":[195,208,219,241,456,467],"compared":[196,340,399,441],"CON":[198,405,443],"(Mean":[200,239,348,407,451],"\u00b1SEM":[201,408,452],"%":[202],"aggregated":[205,251],"RBC;":[207,519],"10.9":[209],"\u00b11.6%;":[210,243],"SCAHU,":[211,244,462],"11.5":[212],"\u00b12.6%;":[213],"CON,":[214,247,307,459],"5.4":[215],"\u00b11.7%;":[216,352],"n\u22657;":[217,254],"p<0.05,":[218],"comp.":[220,468],"CON)":[222],"(See":[223],"Figure).":[224],"composed":[228],"mainly":[229],"CD235+CD71+":[231],"reticulocytes,":[232],"as":[233],"opposed":[234],"mature":[236,330],"(CD235+CD71-)":[238],"\u00b1SEM;":[240,349],"6.9":[242],"7.2":[245],"\u00b11.9%;":[246],"1.8":[248],"\u00b11.3%":[249],"reticulocytes;":[253,489],"p<0.01).":[255],"Sizes":[256],"variable,":[260],"each":[262],"neutrophil":[263,296],"binding":[264],"1":[266],"2":[268],"more":[270,390,515],"RBCs.":[271],"Fetal":[272],"hemoglobin":[273],"(HbF)":[274],"levels":[275,492],"inversely":[279],"correlated":[280],"percentage":[283],"(rS=-0.55;":[287],"p<0.05;":[288,360,364],"n=17).":[289],"While":[290],"expressions":[293],"\u03b22":[297],"integrins,":[298],"LFA-1":[299],"Mac-1,":[301],"not":[303],"different":[305],"between":[306],"SCAHU":[310,403],"Mac-1":[312],"(expressed":[313,318,328],"Neut),":[315],"VLA-4":[317],"reticulocytes)-blocking":[320],"peptide":[324],"inhibitor":[325],"ICAM-4":[327],"RBC),":[331],"decreased":[333,496],"found":[336,386],"samples,":[339],"respective":[343],"isotype":[344],"negative":[345],"controls":[346],"(INC)":[347],"INC,":[350],"7.75":[351],"anti-Mac-1,":[353],"4.9":[354],"\u00b11.5%,":[355,359,363],"p<0.01;":[356],"anti-VLA-4,":[357],"5.67":[358],"anti-ICAM-4,":[361],"5.63":[362],"n\u226513).":[365],"Using":[366],"microfluidic":[368],"platform":[369],"monitor":[371],"adhered":[377,395,506],"components,":[381],"perfused":[382],"autologous":[392,429],"previously":[394],"HUVECs,":[398],"adhered/Neut:":[411],"2.5":[412],"\u00b10.5;":[413],"1.0":[414,416],"\u00b10.3;":[415],"\u00b10.3,":[417],"respectively;":[418],"n\u226509;":[419],"p=0.01).":[420],"Furthermore,":[421,500],"duration":[423,453],"pre-adhered":[431],"recombinant":[433],"higher":[437,490],"for":[438,550],"RBC,":[440],"HU":[450,521],"interactions:":[455],"1.57":[457],"\u00b10.10s;":[458],"1.17":[460],"\u00b10.04s;":[461,464],"1.19":[463],"n\u226505;":[465],"p<0.01":[466],"CON).":[470],"Conclusion":[471],"A":[472],"significant":[473],"proportion":[474],"form":[483],"neut-RBC":[485],"agg,":[486],"particularly":[487],"involving":[488],"HbF":[491],"associated":[494,524],"formation.":[499],"individuals,":[504],"when":[505],"ligands,":[513],"readily":[516],"additionally,":[520],"therapy":[522],"reduction":[527],"these":[529],"interactions.":[531],"Antibodies":[532],"pharmacological":[534],"approaches":[535],"reduce":[537],"formation":[539],"targeting":[544],"Mac-1/VLA-4":[545],"hold":[548],"potential":[549],"clinical":[551],"benefits":[552],"SCD.":[554],"Disclosures:":[555],"No":[556],"relevant":[557],"conflicts":[558],"interest":[560],"declare.":[562]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}