{"id":"https://openalex.org/W2345694792","doi":"https://doi.org/10.2147/dddt.s105021","title":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study","display_name":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W2345694792","doi":"https://doi.org/10.2147/dddt.s105021","mag":"2345694792","pmid":"https://pubmed.ncbi.nlm.nih.gov/27274195"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s105021","doi":"https://doi.org/10.2147/dddt.s105021","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s105021","pdf_url":"https://www.dovepress.com/getfile.php?fileID=30277","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=30277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058103759","display_name":"Lei Sheng","orcid":"https://orcid.org/0000-0002-5784-076X","observed_orcids":["https://orcid.org/0000-0002-5784-076X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Sheng","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113657077","display_name":"Hongrong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongrong Xu","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084041983","display_name":"Weili Chen","orcid":"https://orcid.org/0000-0003-1998-5965","observed_orcids":["https://orcid.org/0000-0003-1998-5965","https://orcid.org/0009-0006-5839-6580"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weili Chen","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102001611","display_name":"Fei Yuan","orcid":"https://orcid.org/0000-0002-6355-636X","observed_orcids":["https://orcid.org/0000-0002-6355-636X"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Yuan","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080943944","display_name":"Mengjie Yang","orcid":"https://orcid.org/0000-0001-7683-1888","observed_orcids":["https://orcid.org/0000-0001-7683-1888","https://orcid.org/0009-0007-4974-1693","https://orcid.org/0000-0003-0317-4412"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjie Yang","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Li","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101995287","display_name":"Xuening Li","orcid":"https://orcid.org/0000-0003-3899-5245","observed_orcids":["https://orcid.org/0000-0003-3899-5245"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-ning Li","raw_affiliation_strings":["Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Clinical Pharmacology, ZhongShan Hospital, Fudan University, Shanghai, People\u2019s Republic of China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139169","display_name":"Hua Medicine (China)","ror":"https://ror.org/03xpnp312","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210139169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"John Choi","raw_affiliation_strings":["Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210139169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001386082","display_name":"Guiyu Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139169","display_name":"Hua Medicine (China)","ror":"https://ror.org/03xpnp312","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210139169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiyu Zhao","raw_affiliation_strings":["Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210139169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112371964","display_name":"Tian\u2010Xin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139169","display_name":"Hua Medicine (China)","ror":"https://ror.org/03xpnp312","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210139169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianxin Hu Hu","raw_affiliation_strings":["Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210139169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049506877","display_name":"Yongguo Li","orcid":"https://orcid.org/0000-0003-2157-3492","observed_orcids":["https://orcid.org/0000-0003-2157-3492"]},"institutions":[{"id":"https://openalex.org/I4210139169","display_name":"Hua Medicine (China)","ror":"https://ror.org/03xpnp312","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210139169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongguo Li","raw_affiliation_strings":["Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210139169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458997","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0003-1800-5339","observed_orcids":["https://orcid.org/0000-0003-1800-5339"]},"institutions":[{"id":"https://openalex.org/I4210139169","display_name":"Hua Medicine (China)","ror":"https://ror.org/03xpnp312","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210139169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210139169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100379264","display_name":"Li Chen","orcid":"https://orcid.org/0000-0002-6192-3752","observed_orcids":["https://orcid.org/0000-0002-6192-3752","https://orcid.org/0000-0003-2243-3336"]},"institutions":[{"id":"https://openalex.org/I4210139169","display_name":"Hua Medicine (China)","ror":"https://ror.org/03xpnp312","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210139169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Chen","raw_affiliation_strings":["Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research & Development, Hua Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I4210139169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.0222,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86805026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":null,"first_page":"1619","last_page":"1619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucokinase-activators","display_name":"glucokinase activators","score":0.9789999723434448},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucose-lowering-effect","display_name":"glucose-lowering effect","score":0.7870000004768372},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.7680000066757202},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.8489999771118164},{"id":"https://openalex.org/keywords/apparent-clearance","display_name":"apparent clearance","score":0.515999972820282},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5170000195503235},{"id":"https://openalex.org/keywords/first-in-human","display_name":"first-in-human","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.785019040107727},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7840583324432373},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7622225880622864},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7194762229919434},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6813177466392517},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6404006481170654},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.613162100315094},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.6131042242050171},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.500370979309082},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45779094099998474},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4451074004173279},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33947789669036865},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.28797388076782227},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0512942373752594},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005941","descriptor_name":"Glucokinase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017850","descriptor_name":"Economics, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017850","descriptor_name":"Economics, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017850","descriptor_name":"Economics, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/dddt.s105021","doi":"https://doi.org/10.2147/dddt.s105021","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s105021","pdf_url":"https://www.dovepress.com/getfile.php?fileID=30277","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmid:27274195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27274195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3862288","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4869670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4869670","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4869670","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e563300bb59f4f0f8f238fe11cb36d5e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e563300bb59f4f0f8f238fe11cb36d5e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol 2016, Iss Issue 1, Pp 1619-1626 (2016)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/26834","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-novel-glu-peer-reviewed-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s105021","doi":"https://doi.org/10.2147/dddt.s105021","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s105021","pdf_url":"https://www.dovepress.com/getfile.php?fileID=30277","source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320327516","display_name":"Program of Shanghai Subject Chief Scientist","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2345694792.pdf","grobid_xml":"https://content.openalex.org/works/W2345694792.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1586381786","https://openalex.org/W1971654760","https://openalex.org/W1982600501","https://openalex.org/W1984089538","https://openalex.org/W1987802058","https://openalex.org/W1990731286","https://openalex.org/W1992428632","https://openalex.org/W2006868143","https://openalex.org/W2013481385","https://openalex.org/W2049033217","https://openalex.org/W2066377005","https://openalex.org/W2081276121","https://openalex.org/W2087927715","https://openalex.org/W2096318148","https://openalex.org/W2132613598","https://openalex.org/W2133560510","https://openalex.org/W2149353738","https://openalex.org/W2153041556","https://openalex.org/W2161542744","https://openalex.org/W2164306929","https://openalex.org/W2330057838"],"related_works":["https://openalex.org/W4311628015","https://openalex.org/W3191427281","https://openalex.org/W2087016115","https://openalex.org/W2305775430","https://openalex.org/W2783315223","https://openalex.org/W1490050402","https://openalex.org/W1990197915","https://openalex.org/W4367054960","https://openalex.org/W2327615024","https://openalex.org/W1647379185"],"abstract_inverted_index":{"BACKGROUND:":[0],"HMS5552,":[1],"a":[2,94],"novel":[3],"fourth-generation":[4],"glucokinase":[5],"(GK)":[6],"activator,":[7],"has":[8],"demonstrated":[9,174],"promising":[10],"effects":[11,253],"on":[12],"glycemic":[13],"control":[14],"in":[15,109,169,178,222,244,260,270],"preclinical":[16],"models":[17],"of":[18,39,53,75,180,239,257],"type":[19],"2":[20],"diabetes.":[21],"This":[22,230],"single":[23,232],"ascending":[24,233],"dose":[25,234],"study":[26,235],"was":[27,167,273],"conducted":[28],"to":[29,115,148,157,267],"investigate":[30],"the":[31,72,112,116,215,255],"safety,":[32,99],"tolerability,":[33],"pharmacokinetics":[34],"(PK),":[35],"and":[36,61,77,85,92,101,121,133,138,151,187,212,224,246,275],"pharmacodynamics":[37],"(PD)":[38],"HMS5552":[40,76,82,105,172,211,240,263],"during":[41,90],"its":[42],"first-in-human":[43,231],"exposure.":[44],"METHODS:":[45],"Sixty":[46],"healthy":[47,261,271],"subjects":[48,65,70,208,272],"were":[49,66,87,135,204,220],"enrolled.":[50],"In":[51],"each":[52],"six":[54],"dose-cohorts":[55],"(5,":[56],"10,":[57],"15,":[58],"25,":[59],"35,":[60],"50":[62,268],"mg),":[63],"ten":[64],"randomized":[67],"with":[68,210,214,241],"eight":[69],"receiving":[71,79],"same":[73],"cohort-dose":[74],"two":[78],"placebo.":[80],"Plasma":[81],"exposure,":[83],"glucose,":[84],"insulin":[86],"measured":[88],"repeatedly":[89],"fasting":[91],"after":[93],"standardized":[95],"meal.":[96],"Assessment":[97],"included":[98],"PK,":[100],"PD":[102,176],"endpoints.":[103],"RESULTS:":[104],"showed":[106],"dose-proportional":[107,242],"increases":[108,243],"area":[110,190],"under":[111,191],"curve":[113,193],"0":[114],"last":[117],"quantifiable":[118],"concentration":[119,124],"(AUC0-t)":[120],"maximum":[122,181],"plasma":[123],"(Cmax).":[125],"Slopes":[126],"estimated":[127],"by":[128,206],"linear":[129],"regression":[130],"for":[131],"AUC0-t":[132,245],"Cmax":[134],"~1.0":[136],"(0.932":[137],"0.933,":[139],"respectively).":[140],"Geometric":[141],"mean":[142,188],"elimination":[143],"half-life":[144],"ranged":[145,154],"from":[146,155,184,197],"4.48":[147],"7.51":[149],"hours":[150,195],"apparent":[152],"clearance":[153],"11.5":[156],"13.1":[158],"L/h":[159],"across":[160],"all":[161],"doses.":[162],"No":[163],"significant":[164],"sex":[165],"effect":[166,192],"observed":[168],"PK":[170,238],"parameters.":[171],"also":[173],"dose-related":[175,251],"responses":[177],"terms":[179],"glucose":[182,189],"change":[183,196],"baseline":[185,198],"(%)":[186,199],"0-4":[194],"(P<0.001).":[200],"Fifteen":[201],"adverse":[202,218],"events":[203,219],"reported":[205],"nine":[207],"(ten":[209],"five":[213],"placebo).":[216],"All":[217],"mild":[221],"intensity":[223],"resolved":[225],"without":[226],"any":[227],"treatment.":[228],"CONCLUSION:":[229],"provided":[236],"predicted":[237],"Cmax,":[247],"as":[248,250],"well":[249],"glucose-lowering":[252],"over":[254],"range":[256],"5-50":[258],"mg":[259,269],"subjects.":[262],"at":[264],"doses":[265],"up":[266],"safe":[274],"well-tolerated.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}