{"id":"https://openalex.org/W2345533772","doi":"https://doi.org/10.1242/dev.124.14.2789","title":"Infection of the germ line by retroviral particles produced in the follicle cells: a possible mechanism for the mobilization of the gypsy retroelement of Drosophila","display_name":"Infection of the germ line by retroviral particles produced in the follicle cells: a possible mechanism for the mobilization of the gypsy retroelement of Drosophila","publication_year":1997,"publication_date":"1997-07-15","ids":{"openalex":"https://openalex.org/W2345533772","doi":"https://doi.org/10.1242/dev.124.14.2789","mag":"2345533772","pmid":"https://pubmed.ncbi.nlm.nih.gov/9226450"},"language":"en","primary_location":{"id":"doi:10.1242/dev.124.14.2789","doi":"https://doi.org/10.1242/dev.124.14.2789","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.124.14.2789","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106584112","display_name":"Sun U. Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sun U. Song","raw_affiliation_strings":["The Johns Hopkins University, Baltimore, MD 21218, USA 1 Department of Biology ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University, Baltimore, MD 21218, USA 1 Department of Biology ,","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111185330","display_name":"Manucios Marios Kurkulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Kurkulos","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 Department of Molecular Biology and Genetics ,","The Johns Hopkins University, Baltimore, MD 21218, USA 1 Department of Biology ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 Department of Molecular Biology and Genetics ,","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Johns Hopkins University, Baltimore, MD 21218, USA 1 Department of Biology ,","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075536007","display_name":"Jef D. Boeke","orcid":"https://orcid.org/0000-0001-5322-4946","observed_orcids":["https://orcid.org/0000-0001-5322-4946"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jef D. Boeke","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 Department of Molecular Biology and Genetics ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA 2 Department of Molecular Biology and Genetics ,","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082436986","display_name":"Victor G. Corces","orcid":"https://orcid.org/0000-0001-5140-4337","observed_orcids":["https://orcid.org/0000-0001-5140-4337"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor G. Corces","raw_affiliation_strings":["The Johns Hopkins University, Baltimore, MD 21218, USA 1 Department of Biology ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Johns Hopkins University, Baltimore, MD 21218, USA 1 Department of Biology ,","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":1.281,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.79003941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"124","issue":"14","first_page":"2789","last_page":"2798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retrotransposition","display_name":"retrotransposition","score":0.6000000238418579},{"id":"https://openalex.org/keywords/follicle-cells","display_name":"follicle cells","score":0.8899999856948853},{"id":"https://openalex.org/keywords/retroviral-particles","display_name":"retroviral particles","score":0.718999981880188},{"id":"https://openalex.org/keywords/retroviral-envelope-protein","display_name":"retroviral envelope protein","score":0.6349999904632568},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"reverse transcriptase","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oogenesis","display_name":"oogenesis","score":0.640999972820282},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7149999737739563},{"id":"https://openalex.org/keywords/germplasm","display_name":"germplasm","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9562131762504578},{"id":"https://openalex.org/C156708679","wikidata":"https://www.wikidata.org/wiki/Q242412","display_name":"Mobilization","level":2,"score":0.6296783089637756},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5909205079078674},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.5525156259536743},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5492817759513855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5278351902961731},{"id":"https://openalex.org/C2780258238","wikidata":"https://www.wikidata.org/wiki/Q2520842","display_name":"Germ","level":2,"score":0.4975791275501251},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4591085910797119},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.4554547667503357},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38781869411468506},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.38188478350639343},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2352330982685089},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08460178971290588},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009866","descriptor_name":"Oogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012191","descriptor_name":"Retroviridae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015684","descriptor_name":"Gene Products, pol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018626","descriptor_name":"Retroelements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.124.14.2789","doi":"https://doi.org/10.1242/dev.124.14.2789","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.124.14.2789","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:9226450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9226450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5584530978","display_name":"Program on Molecular and Cellular Mechanisms of Tumorigenesis","funder_award_id":"P01CA016519","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1019447032","https://openalex.org/W1426240221","https://openalex.org/W1541869159","https://openalex.org/W1594700207","https://openalex.org/W1767750055","https://openalex.org/W1799965348","https://openalex.org/W1856683646","https://openalex.org/W1933609030","https://openalex.org/W1986069669","https://openalex.org/W1990334833","https://openalex.org/W2036772297","https://openalex.org/W2053880432","https://openalex.org/W2058524246","https://openalex.org/W2078938551","https://openalex.org/W2085747761","https://openalex.org/W2104267721","https://openalex.org/W2117053331","https://openalex.org/W2162906125","https://openalex.org/W2254401250","https://openalex.org/W2324033262","https://openalex.org/W2334397963","https://openalex.org/W2417974184","https://openalex.org/W2896633937"],"related_works":["https://openalex.org/W2173570428","https://openalex.org/W2052917423","https://openalex.org/W1426240221","https://openalex.org/W2053880432","https://openalex.org/W639816671","https://openalex.org/W2152172179","https://openalex.org/W2115278178","https://openalex.org/W2064717466","https://openalex.org/W1745598808","https://openalex.org/W2162906125"],"abstract_inverted_index":{"The":[0,90,112],"gypsy":[1,39,63,184,191,208],"retroelement":[2],"of":[3,13,16,29,37,44,52,78,87,126,135,146,183,190,214],"Drosophila":[4],"moves":[5],"at":[6,106,123,166],"high":[7,27],"frequency":[8],"in":[9,21,41,75,83,95,109,118,131,161,194],"the":[10,14,22,42,50,62,76,84,110,119,132,136,143,147,162,188,195,204,211,215],"germ":[11,212],"line":[12,213],"progeny":[15],"females":[17,80],"carrying":[18],"a":[19,177],"mutation":[20],"flamenco":[23],"(flam)":[24],"gene.":[25],"This":[26],"rate":[28],"de":[30],"novo":[31],"insertion":[32,209],"correlates":[33],"with":[34],"elevated":[35],"accumulation":[36],"full-length":[38],"RNA":[40],"ovaries":[43,77],"these":[45,71],"females,":[46],"as":[47,49],"well":[48],"presence":[51],"an":[53],"env-specific":[54],"RNA.":[55],"We":[56,175],"have":[57],"prepared":[58],"monoclonal":[59],"antibodies":[60],"against":[61],"Pol":[64,91],"and":[65,68,81,98,202],"Env":[66,113],"products":[67],"found":[69],"that":[70,186],"proteins":[72,92,114],"are":[73,93,115],"expressed":[74,94,116],"flam":[79],"processed":[82],"manner":[85],"characteristic":[86],"vertebrate":[88],"retroviruses.":[89],"both":[96],"follicle":[97,120,196],"nurse":[99],"cells,":[100,197],"but":[101],"they":[102,129,151,200],"do":[103],"not":[104],"accumulate":[105,130],"detectable":[107],"levels":[108],"oocyte.":[111],"exclusively":[117],"cells":[121],"starting":[122,165],"stage":[124,167],"9":[125],"oogenesis,":[127],"where":[128,150,199],"secretory":[133],"apparatus":[134],"endoplasmic":[137],"reticulum.":[138],"They":[139],"then":[140],"migrate":[141],"to":[142,179],"inner":[144],"side":[145],"cytoplasmic":[148],"membrane":[149],"assemble":[152],"into":[153,210],"viral":[154,192],"particles.":[155],"These":[156],"particles":[157,193],"can":[158],"be":[159],"observed":[160],"perivitelline":[163],"space":[164],"10":[168],"by":[169],"immunoelectron":[170],"microscopy":[171],"using":[172],"anti-Env":[173],"antibodies.":[174],"propose":[176],"model":[178],"explain":[180],"flamenco-mediated":[181],"induction":[182],"mobilization":[185],"involves":[187],"synthesis":[189],"from":[198],"leave":[201],"infect":[203],"oocyte,":[205],"thus":[206],"explaining":[207],"subsequent":[216],"generation.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}