{"id":"https://openalex.org/W2344927296","doi":"https://doi.org/10.1002/lsm.22512","title":"Low\u2010level laser therapy as a treatment for androgenetic alopecia","display_name":"Low\u2010level laser therapy as a treatment for androgenetic alopecia","publication_year":2016,"publication_date":"2016-04-25","ids":{"openalex":"https://openalex.org/W2344927296","doi":"https://doi.org/10.1002/lsm.22512","mag":"2344927296","pmid":"https://pubmed.ncbi.nlm.nih.gov/27114071"},"language":"en","primary_location":{"id":"doi:10.1002/lsm.22512","doi":"https://doi.org/10.1002/lsm.22512","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lsm.22512","pdf_url":null,"source":{"id":"https://openalex.org/S155721155","display_name":"Lasers in Surgery and Medicine","issn_l":"0196-8092","issn":["0196-8092","1096-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Surgery and Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078506978","display_name":"Ladan Afifi","orcid":"https://orcid.org/0000-0002-8413-3067","observed_orcids":["https://orcid.org/0000-0002-8413-3067"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ladan Afifi","raw_affiliation_strings":["Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003808750","display_name":"Eric Laurent Maranda","orcid":"https://orcid.org/0000-0002-4873-8229","observed_orcids":["https://orcid.org/0000-0002-4873-8229"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Maranda","raw_affiliation_strings":["Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075697829","display_name":"Mina Zarei","orcid":"https://orcid.org/0000-0003-4683-4097","observed_orcids":["https://orcid.org/0000-0003-4683-4097","https://orcid.org/0009-0002-3735-9458"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mina Zarei","raw_affiliation_strings":["Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076813622","display_name":"Gina M. DelCanto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gina M. Delcanto","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida","Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060936846","display_name":"Leyre Ainara Falto-Aizpurua","orcid":"https://orcid.org/0000-0002-5553-4507","observed_orcids":["https://orcid.org/0000-0002-5553-4507"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leyre Falto\u2010Aizpurua","raw_affiliation_strings":["Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031274762","display_name":"Wouter P. Kluijfhout","orcid":"https://orcid.org/0000-0001-9269-1539","observed_orcids":["https://orcid.org/0000-0001-9269-1539"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wouter P. Kluijfhout","raw_affiliation_strings":["Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068009659","display_name":"Joaquin Juan Jimenez","orcid":"https://orcid.org/0000-0002-1544-5892","observed_orcids":["https://orcid.org/0000-0002-1544-5892"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joaquin J. Jimenez","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida","Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078506978"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":1.5915,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.85775862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"49","issue":"1","first_page":"27","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-level-laser-therapy","display_name":"low-level laser therapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/androgenetic-alopecia","display_name":"androgenetic alopecia","score":0.9670000076293945},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hair-regrowth","display_name":"hair regrowth","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hair-density","display_name":"hair density","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hair-thickness","display_name":"hair thickness","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tensile-strength","display_name":"tensile strength","score":0.7979999780654907},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2993195213","wikidata":"https://www.wikidata.org/wiki/Q851186","display_name":"Laser therapy","level":3,"score":0.7001389265060425},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5919989943504333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5870667099952698},{"id":"https://openalex.org/C2778023920","wikidata":"https://www.wikidata.org/wiki/Q1872556","display_name":"Low level laser therapy","level":4,"score":0.5015091896057129},{"id":"https://openalex.org/C3019557043","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser treatment","level":3,"score":0.4390900433063507},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.3127484917640686},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10965660214424133},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08241304755210876}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D004954","descriptor_name":"Esthetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D028022","descriptor_name":"Low-Level Light Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/lsm.22512","doi":"https://doi.org/10.1002/lsm.22512","is_oa":false,"landing_page_url":"https://doi.org/10.1002/lsm.22512","pdf_url":null,"source":{"id":"https://openalex.org/S155721155","display_name":"Lasers in Surgery and Medicine","issn_l":"0196-8092","issn":["0196-8092","1096-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Surgery and Medicine","raw_type":"journal-article"},{"id":"pmid:27114071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27114071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in surgery and medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1528591181","https://openalex.org/W1900569162","https://openalex.org/W1966763936","https://openalex.org/W1970913044","https://openalex.org/W1976818663","https://openalex.org/W1986744290","https://openalex.org/W1987981882","https://openalex.org/W2007372522","https://openalex.org/W2015278347","https://openalex.org/W2019630276","https://openalex.org/W2024218120","https://openalex.org/W2031324836","https://openalex.org/W2036397448","https://openalex.org/W2068637164","https://openalex.org/W2073230702","https://openalex.org/W2074592881","https://openalex.org/W2080383640","https://openalex.org/W2086337257","https://openalex.org/W2091233844","https://openalex.org/W2095520199","https://openalex.org/W2107434674","https://openalex.org/W2110166282","https://openalex.org/W2113820444","https://openalex.org/W2127751287","https://openalex.org/W2132672239","https://openalex.org/W2134718981","https://openalex.org/W2135118056","https://openalex.org/W2150083629","https://openalex.org/W2152867766","https://openalex.org/W2156757464","https://openalex.org/W2158621372","https://openalex.org/W2166093573","https://openalex.org/W2168336358","https://openalex.org/W2169145189","https://openalex.org/W2169457248","https://openalex.org/W2310157986","https://openalex.org/W2316100429","https://openalex.org/W2318163251","https://openalex.org/W2481037244","https://openalex.org/W2503941707","https://openalex.org/W2942719587","https://openalex.org/W4231555499","https://openalex.org/W4253661234"],"related_works":["https://openalex.org/W4361277960","https://openalex.org/W2779466615","https://openalex.org/W2913209689","https://openalex.org/W4213028187","https://openalex.org/W2810049987","https://openalex.org/W2168336358","https://openalex.org/W4366503656","https://openalex.org/W3011619691","https://openalex.org/W7118954803","https://openalex.org/W2776196313"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Androgenetic":[3],"alopecia":[4],"(AGA)":[5],"affects":[6],"50%":[7,14],"of":[8,15,23,122,133,137,145,175,200],"males":[9,139,158],"by":[10,17,101],"age":[11,18],"50":[12],"and":[13,37,67,85,93,104,109,118,140,159,167,185,214,239],"females":[16,160],"80.":[19],"Recently,":[20],"the":[21,49,194],"use":[22,250],"low-level":[24],"laser":[25],"therapy":[26,60,230,252],"(LLLT)":[27],"has":[28],"been":[29],"proposed":[30],"as":[31,191,193,242],"a":[32,131,234],"treatment":[33],"for":[34,61,106,120,237,246],"hair":[35,40,149,165,211],"loss":[36],"to":[38,47,53,78,232,249],"stimulate":[39],"regrowth":[41],"in":[42,156,172,182,203,210],"AGA.":[43],"This":[44],"paper":[45],"aims":[46],"review":[48,75,205],"existing":[50],"research":[51],"studies":[52,126,147,201],"determine":[54],"whether":[55],"LLLT":[56,162,218,229],"is":[57],"an":[58,207,243],"effective":[59,244],"AGA":[62,238],"based":[63,114],"on":[64,81,115],"objective":[65,195],"measurements":[66],"patient":[68,215],"satisfaction.":[69],"STUDY":[70],"DESIGN:":[71],"A":[72],"systematic":[73],"literature":[74],"was":[76,180,186],"done":[77],"identify":[79],"articles":[80],"Medline,":[82],"Google":[83],"Scholar,":[84],"Embase":[86],"that":[87],"were":[88,99,112,127],"published":[89],"between":[90],"January":[91],"1960":[92],"November":[94],"2015.":[95],"All":[96],"search":[97],"hits":[98],"screened":[100],"two":[102,173],"reviewers":[103],"examined":[105],"relevant":[107],"abstracts":[108],"titles.":[110],"Articles":[111],"divided":[113],"study":[116],"design":[117],"assessed":[119],"risk":[121],"bias.":[123],"RESULTS:":[124],"Eleven":[125],"evaluated,":[128],"which":[129],"investigated":[130,181],"total":[132],"680":[134],"patients,":[135],"consisting":[136],"444":[138],"236":[141],"females.":[142],"Nine":[143],"out":[144,174],"11":[146],"assessing":[148],"count/hair":[150],"density":[151],"found":[152,206],"statistically":[153],"significant":[154],"improvements":[155],"both":[157],"following":[161,217],"treatment.":[163],"Additionally,":[164],"thickness":[166],"tensile":[168],"strength":[169],"significantly":[170],"improved":[171],"four":[176],"studies.":[177],"Patient":[178],"satisfaction":[179,216],"five":[183],"studies,":[184],"overall":[187,208],"positive,":[188],"though":[189],"not":[190],"profound":[192],"outcomes.":[196],"CONCLUSION:":[197],"The":[198],"majority":[199],"covered":[202],"this":[204],"improvement":[209],"regrowth,":[212],"thickness,":[213],"therapy.":[219],"Although":[220],"we":[221],"should":[222],"be":[223,233],"cautious":[224],"when":[225],"interpreting":[226],"these":[227],"findings,":[228],"seems":[231],"promising":[235],"monotherapy":[236],"may":[240],"serve":[241],"alternative":[245],"individuals":[247],"unwilling":[248],"medical":[251],"or":[253],"undergo":[254],"surgical":[255],"options.":[256],"Lasers":[257],"Surg.":[258],"Med.":[259],"49:27-39,":[260],"2017.":[261],"\u00a9":[262],"2016":[263],"Wiley":[264],"Periodicals,":[265],"Inc.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}