{"id":"https://openalex.org/W2344922969","doi":null,"title":"Phage selection and characterization of bicyclic peptide binders of Carbonic Anhydrase IX","display_name":"Phage selection and characterization of bicyclic peptide binders of Carbonic Anhydrase IX","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W2344922969","mag":"2344922969"},"language":"en","primary_location":{"id":"mag:2344922969","doi":null,"is_oa":false,"landing_page_url":"http://tesi.cab.unipd.it/41357/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bruce T. Volpe","orcid":"https://orcid.org/0000-0002-1098-1848","observed_orcids":["https://orcid.org/0000-0002-1098-1848"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bruce T. Volpe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1098-1848","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18910222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bicyclic-peptides","display_name":"bicyclic peptides","score":0.8500000238418579},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.9039999842643738},{"id":"https://openalex.org/keywords/peptide-ligands","display_name":"peptide ligands","score":0.7639999985694885},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tumor-overexpression","display_name":"tumor overexpression","score":0.6000000238418579},{"id":"https://openalex.org/keywords/fluorescence-polarization-binding-assay","display_name":"fluorescence polarization binding assay","score":0.7139999866485596},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.4880000054836273},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.5960000157356262},{"id":"https://openalex.org/keywords/therapeutics-development","display_name":"therapeutics development","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.6914879679679871},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.679559051990509},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.678095281124115},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.6256511807441711},{"id":"https://openalex.org/C24961977","wikidata":"https://www.wikidata.org/wiki/Q225972","display_name":"Bicyclic molecule","level":2,"score":0.5529749393463135},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5487356185913086},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5343678593635559},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.45748865604400635},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.45482495427131653},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45425087213516235},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.3768560290336609},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37021875381469727},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33993977308273315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2848399579524994},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2771872282028198},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2375403642654419},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08657437562942505},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2344922969","doi":null,"is_oa":false,"landing_page_url":"http://tesi.cab.unipd.it/41357/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071135907","https://openalex.org/W2576620943","https://openalex.org/W2767331649","https://openalex.org/W2059937984","https://openalex.org/W7098101336","https://openalex.org/W2015049615","https://openalex.org/W2895074301","https://openalex.org/W1852494546","https://openalex.org/W2403140238","https://openalex.org/W1764030784"],"abstract_inverted_index":{"Bicyclic":[0],"peptides,":[1],"generated":[2],"with":[3,53,67],"a":[4,12,38,54],"combinatorial":[5],"approach":[6],"based":[7],"on":[8],"Phage":[9],"Display,":[10],"are":[11],"suitable":[13],"molecular":[14],"format":[15],"for":[16],"the":[17,25],"development":[18],"of":[19,27,34],"therapeutics.":[20],"This":[21],"work":[22],"aimed":[23],"at":[24],"generation":[26],"bibyclic":[28],"peptides":[29,46],"ligends":[30],"(":[31,70],"or":[32],"inhibitors)":[33],"Carbonic":[35],"Anhydrase":[36],"IX,":[37],"transmembrane":[39],"overexpressed":[40],"in":[41],"many":[42],"tumor":[43],"types.":[44],"Selected":[45],"were":[47],"chemically":[48],"synthetized,":[49],"cyclized":[50],"and":[51,73],"labeled":[52],"Fluorophore.":[55],"Fluorescence":[56],"Polarization":[57],"assay":[58],"showed":[59],"that":[60],"one":[61],"peptide":[62],"was":[63],"binding":[64],"CA":[65],"IX":[66],"high":[68],"affinity":[69],"kd":[71],"203.3nM)":[72],"good":[74],"specificity":[75]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}