{"id":"https://openalex.org/W2344909497","doi":null,"title":"Defining stress-induced systemic sterile inflammatory responses: Network, signals, and pathways","display_name":"Defining stress-induced systemic sterile inflammatory responses: Network, signals, and pathways","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2344909497","mag":"2344909497"},"language":"en","primary_location":{"id":"pmh:oai:cuscholar:5712m6656","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","pdf_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040373664","display_name":"Thomas Maslanik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Thomas Maslanik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040373664"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-proteins","display_name":"inflammatory proteins","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cytokine-network","display_name":"cytokine network","score":0.6179999709129333},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.8989999890327454},{"id":"https://openalex.org/keywords/microbe-associated-molecular-patterns","display_name":"microbe-associated molecular patterns","score":0.8989999890327454},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.8740000128746033},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.8240000009536743},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.546999990940094},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.48848092555999756},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3410625755786896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.338998019695282},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:cuscholar:5712m6656","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","pdf_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:oai:scholar.colorado.edu:iphy_gradetds-1016","doi":null,"is_oa":false,"landing_page_url":"https://scholar.colorado.edu/iphy_gradetds/16","pdf_url":null,"source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Integrative Physiology Graduate Theses &amp; Dissertations","raw_type":"text"},{"id":"mag:2344909497","doi":null,"is_oa":false,"landing_page_url":"http://scholar.colorado.edu/cgi/viewcontent.cgi?article=1016&context=iphy_gradetds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:cuscholar:5712m6656","doi":null,"is_oa":true,"landing_page_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","pdf_url":"https://scholar.colorado.edu/concern/graduate_thesis_or_dissertations/5712m6656","source":{"id":"https://openalex.org/S4306401957","display_name":"CU Scholar (University of Colorado Boulder)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188538660","host_organization_name":"University of Colorado Boulder","host_organization_lineage":["https://openalex.org/I188538660"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2344909497.pdf","grobid_xml":"https://content.openalex.org/works/W2344909497.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W27590684","https://openalex.org/W102870182","https://openalex.org/W190744314","https://openalex.org/W1536660914","https://openalex.org/W1560867514","https://openalex.org/W1578606146","https://openalex.org/W1582754633","https://openalex.org/W1594627772","https://openalex.org/W1906256166","https://openalex.org/W1931315964","https://openalex.org/W1964518559","https://openalex.org/W1966672895","https://openalex.org/W1967669195","https://openalex.org/W1969368124","https://openalex.org/W1975437647","https://openalex.org/W1978239142","https://openalex.org/W1979055337","https://openalex.org/W1979991507","https://openalex.org/W1981187079","https://openalex.org/W1981724309","https://openalex.org/W1983419107","https://openalex.org/W1986883807","https://openalex.org/W1988925586","https://openalex.org/W1989249407","https://openalex.org/W1989889539","https://openalex.org/W1990071637","https://openalex.org/W1990249993","https://openalex.org/W1991832915","https://openalex.org/W1992463789","https://openalex.org/W1992789370","https://openalex.org/W1995736605","https://openalex.org/W1997332169","https://openalex.org/W2001524048","https://openalex.org/W2001821405","https://openalex.org/W2006143607","https://openalex.org/W2007195303","https://openalex.org/W2009435405","https://openalex.org/W2012443484","https://openalex.org/W2014574137","https://openalex.org/W2019573101","https://openalex.org/W2023634223","https://openalex.org/W2025063186","https://openalex.org/W2026544037","https://openalex.org/W2028017703","https://openalex.org/W2028046989","https://openalex.org/W2029739208","https://openalex.org/W2029842191","https://openalex.org/W2030282697","https://openalex.org/W2034052955","https://openalex.org/W2034157973","https://openalex.org/W2034946303","https://openalex.org/W2038270610","https://openalex.org/W2040951062","https://openalex.org/W2041511592","https://openalex.org/W2047570180","https://openalex.org/W2048032544","https://openalex.org/W2048489884","https://openalex.org/W2055132644","https://openalex.org/W2056312910","https://openalex.org/W2057396462","https://openalex.org/W2058270614","https://openalex.org/W2061809825","https://openalex.org/W2062140760","https://openalex.org/W2062294413","https://openalex.org/W2062346797","https://openalex.org/W2064339254","https://openalex.org/W2064955349","https://openalex.org/W2066176460","https://openalex.org/W2069007145","https://openalex.org/W2069360787","https://openalex.org/W2072970694","https://openalex.org/W2079813815","https://openalex.org/W2079927878","https://openalex.org/W2080283023","https://openalex.org/W2081823959","https://openalex.org/W2082347869","https://openalex.org/W2084462944","https://openalex.org/W2085765746","https://openalex.org/W2086939291","https://openalex.org/W2090827455","https://openalex.org/W2092157690","https://openalex.org/W2092939498","https://openalex.org/W2092946161","https://openalex.org/W2093539486","https://openalex.org/W2094422818","https://openalex.org/W2097002762","https://openalex.org/W2101875009","https://openalex.org/W2102943702","https://openalex.org/W2105482626","https://openalex.org/W2105556644","https://openalex.org/W2105702970","https://openalex.org/W2107155323","https://openalex.org/W2107277218","https://openalex.org/W2107677337","https://openalex.org/W2108486364","https://openalex.org/W2110505933","https://openalex.org/W2113822705","https://openalex.org/W2113940450","https://openalex.org/W2114144373","https://openalex.org/W2114570899","https://openalex.org/W2118403357","https://openalex.org/W2120524170","https://openalex.org/W2121141076","https://openalex.org/W2121195298","https://openalex.org/W2122018794","https://openalex.org/W2122309805","https://openalex.org/W2123105350","https://openalex.org/W2124351063","https://openalex.org/W2124380083","https://openalex.org/W2127538271","https://openalex.org/W2128203138","https://openalex.org/W2128464705","https://openalex.org/W2130989367","https://openalex.org/W2131876626","https://openalex.org/W2132720092","https://openalex.org/W2134007048","https://openalex.org/W2135124644","https://openalex.org/W2136153888","https://openalex.org/W2136552678","https://openalex.org/W2139240706","https://openalex.org/W2140277419","https://openalex.org/W2141465922","https://openalex.org/W2142204002","https://openalex.org/W2143862999","https://openalex.org/W2144415706","https://openalex.org/W2144467901","https://openalex.org/W2145509588","https://openalex.org/W2145619229","https://openalex.org/W2147546596","https://openalex.org/W2149415083","https://openalex.org/W2150464490","https://openalex.org/W2155066423","https://openalex.org/W2161102071","https://openalex.org/W2162088497","https://openalex.org/W2162748874","https://openalex.org/W2163144555","https://openalex.org/W2163683111","https://openalex.org/W2164484600","https://openalex.org/W2165218249","https://openalex.org/W2169282830","https://openalex.org/W2169664580","https://openalex.org/W2170925079","https://openalex.org/W2178789259","https://openalex.org/W2184524138","https://openalex.org/W2220418709","https://openalex.org/W2239977054","https://openalex.org/W2267259862","https://openalex.org/W2288478936","https://openalex.org/W2323852841","https://openalex.org/W2346103662","https://openalex.org/W2415287987","https://openalex.org/W2497028637"],"related_works":["https://openalex.org/W2081823959","https://openalex.org/W2066906062","https://openalex.org/W2315833489","https://openalex.org/W3048598634","https://openalex.org/W2363613772","https://openalex.org/W4213025533","https://openalex.org/W2146974874","https://openalex.org/W2022398923","https://openalex.org/W6980506465","https://openalex.org/W2009913004"],"abstract_inverted_index":{"Systemic":[0],"sterile":[1,168],"inflammatory":[2,20,84,113,169],"responses":[3],"(SSIRs)":[4],"are":[5,23,49,102,171],"characterized":[6],"by":[7,26,125,173,203],"an":[8],"increase":[9],"in":[10,36,75,87,119,161],"concentrations":[11],"of":[12,58,78,98,109,177,183,186],"blood":[13],"and":[14,18,33,42,61,83,115,131,137,148,158,179,189],"tissue":[15],"cytokines,":[16,111,187],"chemokines":[17],"other":[19,190],"proteins.":[21,192],"SSIRs":[22,48,88],"commonly":[24],"evoked":[25],"trauma":[27],"or":[28],"exposure":[29],"to":[30,46,71,142,145,216],"severe":[31],"stressors":[32],"may":[34,140,207],"result":[35],"negative":[37],"consequences":[38],"including":[39,129],"multi-organ":[40],"failure":[41],"death.":[43],"Current":[44],"attempts":[45],"treat":[47],"often":[50],"ineffective,":[51],"reflecting":[52],"the":[53,59,79,103,107,126,156,181,210,219],"need":[54],"for":[55,226],"additional":[56],"characterization":[57],"signals":[60],"pathways":[62,82],"that":[63,92,139,166,197],"drive":[64],"these":[65],"processes.":[66],"Specifically,":[67],"it":[68],"is":[69,214,221],"important":[70],"explore":[72],"recent":[73],"advances":[74],"our":[76],"understanding":[77],"underlying":[80],"signaling":[81,143,154],"proteins":[85,114],"involved":[86,118],"such":[89],"as":[90],"those":[91],"follow":[93],"stressor":[94],"exposure.":[95],"The":[96],"goals":[97],"this":[99,198],"dissertation,":[100],"therefore,":[101],"following:":[104],"(1)":[105],"characterize":[106],"network":[108],"diverse":[110,205],"chemokines,":[112,188],"their":[116],"receptors":[117],"SSIRs;":[120,147],"(2)":[121],"discuss":[122],"factors":[123],"impacted":[124],"stress":[127],"response":[128],"danger-":[130],"microbe":[132],"associated":[133],"molecular":[134],"patterns":[135],"(DAMPs":[136],"MAMPs)":[138],"contribute":[141],"processes":[144,170],"stimulate":[146],"(3)":[149],"highlight":[150],"a":[151,174,184,222],"recently":[152],"discovered":[153],"complex,":[155],"inflammasome,":[157],"its":[159],"role":[160],"stress-induced":[162],"SSIRs.":[163,227],"We":[164],"propose":[165],"systemic":[167],"initiated":[172,202],"wide":[175],"variety":[176],"molecules":[178],"involve":[180],"release":[182],"plethora":[185],"immunomodulatory":[191],"Importantly,":[193],"we":[194],"present":[195],"evidence":[196],"cytokine":[199],"storm,":[200],"although":[201],"many":[204],"signals,":[206],"converge":[208],"on":[209],"inflammasome.":[211],"Additional":[212],"research":[213],"necessary":[215],"determine":[217],"whether":[218],"inflammasome":[220],"suitable":[223],"pharmacological":[224],"target":[225]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
