{"id":"https://openalex.org/W2344739684","doi":"https://doi.org/10.1093/carcin/bgw054","title":"Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation ofApc","display_name":"Obesity promotes PhIP-induced small intestinal carcinogenesis in hCYP1A-db/db mice: involvement of mutations and DNA hypermethylation ofApc","publication_year":2016,"publication_date":"2016-05-02","ids":{"openalex":"https://openalex.org/W2344739684","doi":"https://doi.org/10.1093/carcin/bgw054","mag":"2344739684","pmid":"https://pubmed.ncbi.nlm.nih.gov/27207656","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936388"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/bgw054","doi":"https://doi.org/10.1093/carcin/bgw054","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/bgw054","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936388","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100370968","display_name":"Hong Wang","orcid":"https://orcid.org/0000-0003-0212-5379","observed_orcids":["https://orcid.org/0000-0003-0212-5379"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101683663","display_name":"Anna Liu","orcid":"https://orcid.org/0000-0001-6333-1665","observed_orcids":["https://orcid.org/0000-0001-6333-1665"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Liu","raw_affiliation_strings":["Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040054882","display_name":"Ying-Yi Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingyi Kuo","raw_affiliation_strings":["Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057147247","display_name":"Eric Chi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Chi","raw_affiliation_strings":["Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069061068","display_name":"Xu Yang","orcid":"https://orcid.org/0000-0003-1326-9861","observed_orcids":["https://orcid.org/0000-0003-1326-9861"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Yang","raw_affiliation_strings":["Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046441324","display_name":"Lanjing Zhang","orcid":"https://orcid.org/0000-0001-5436-887X","observed_orcids":["https://orcid.org/0000-0001-5436-887X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210094960","display_name":"University Medical Center of Princeton","ror":"https://ror.org/00mbhee72","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210094960"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lanjing Zhang","raw_affiliation_strings":["Department of Pathology, Robert Wood Johnson Medical School and Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA","Department of Pathology, University Medical Center of Princeton, Plainsboro, NJ 08536, USA and","Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Robert Wood Johnson Medical School and Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]},{"raw_affiliation_string":"Department of Pathology, University Medical Center of Princeton, Plainsboro, NJ 08536, USA and","institution_ids":["https://openalex.org/I20089843","https://openalex.org/I4210094960"]},{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086188593","display_name":"Chung Shu Yang","orcid":"https://orcid.org/0000-0001-6713-4837","observed_orcids":["https://orcid.org/0000-0001-6713-4837"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung S. Yang","raw_affiliation_strings":["Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100370968"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":0.5196,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.6878254,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"37","issue":"7","first_page":"723","last_page":"730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phip","display_name":"PhIP","score":0.9670000076293945},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.828000009059906},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.8769999742507935},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6901952028274536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5313758254051208},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5302600264549255},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5085088014602661},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.49656611680984497},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.4932829737663269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43144336342811584},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4233867824077606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4178527295589447},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3310397267341614},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2737846374511719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10622239112854004},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09016704559326172},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08873078227043152}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/carcin/bgw054","doi":"https://doi.org/10.1093/carcin/bgw054","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/bgw054","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4936388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Text"},{"id":"pmid:27207656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27207656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:carcin:37/7/723","doi":null,"is_oa":false,"landing_page_url":"http://carcin.oxfordjournals.org/cgi/content/short/37/7/723","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4936388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4936388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4727286232","display_name":"Prevention of Colon Cancer by Epigallocatechin Gallate and Atorvastatin","funder_award_id":"R01CA120915","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1522687886","https://openalex.org/W1522996100","https://openalex.org/W1935309186","https://openalex.org/W1973611057","https://openalex.org/W1975390269","https://openalex.org/W1976844911","https://openalex.org/W1990655930","https://openalex.org/W2003355286","https://openalex.org/W2004316615","https://openalex.org/W2005338000","https://openalex.org/W2007461756","https://openalex.org/W2008029061","https://openalex.org/W2018755172","https://openalex.org/W2027835379","https://openalex.org/W2033801553","https://openalex.org/W2037487766","https://openalex.org/W2039976313","https://openalex.org/W2042655206","https://openalex.org/W2045304379","https://openalex.org/W2054141897","https://openalex.org/W2056499167","https://openalex.org/W2062487838","https://openalex.org/W2063579638","https://openalex.org/W2070818486","https://openalex.org/W2074678122","https://openalex.org/W2081457097","https://openalex.org/W2089214430","https://openalex.org/W2092509345","https://openalex.org/W2094882027","https://openalex.org/W2095012266","https://openalex.org/W2116891307","https://openalex.org/W2118224153","https://openalex.org/W2123815655","https://openalex.org/W2124191889","https://openalex.org/W2124408205","https://openalex.org/W2125052212","https://openalex.org/W2131474316","https://openalex.org/W2137846548","https://openalex.org/W2141662760","https://openalex.org/W2143929290","https://openalex.org/W2145562168","https://openalex.org/W2147242432","https://openalex.org/W2149469183","https://openalex.org/W2150625137","https://openalex.org/W2153383900","https://openalex.org/W2155052327","https://openalex.org/W2155380042","https://openalex.org/W2163710303","https://openalex.org/W2170552969","https://openalex.org/W2259938310","https://openalex.org/W2466395405"],"related_works":["https://openalex.org/W2254542470","https://openalex.org/W2134015444","https://openalex.org/W2037487766","https://openalex.org/W1976053804","https://openalex.org/W2155380042","https://openalex.org/W808656619","https://openalex.org/W2313142753","https://openalex.org/W2052709075","https://openalex.org/W2085872938","https://openalex.org/W2033842838"],"abstract_inverted_index":{"Obesity":[0,41],"is":[1,208,224],"associated":[2],"with":[3,38,49,226],"an":[4],"increased":[5,233],"risk":[6],"of":[7,13,72,79,116,127,167,170,192,229,235],"cancer.":[8],"To":[9],"study":[10],"the":[11,54,70,77,103,190,193,227,232],"promotion":[12],"dietary":[14],"carcinogen-induced":[15],"gastrointestinal":[16,100],"cancer":[17,238],"by":[18,47,61,210,218],"obesity,":[19],"we":[20,111,146,172],"employed":[21],"2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine":[22],"(PhIP)":[23],"to":[24,52],"induce":[25],"intestinal":[26,74,133,152,203,237],"tumorigenesis":[27],"in":[28,32,44,82,88,96,102,131,137,154,163,176,181,205,239,241],"CYP1A-humanized":[29],"(hCYP1A)":[30],"mice,":[31,85],"which":[33,186],"mouse":[34],"Cyp1a1/1a2":[35],"was":[36,42],"replaced":[37],"human":[39],"CYP1A1/1A2":[40],"introduced":[43],"hCYP1A":[45,63,84,90],"mice":[46,51,59,64,156,207],"breeding":[48],"Lepr(db/+)":[50],"establish":[53],"genetically":[55],"induced":[56,69],"obese":[57,83,106,155],"hCYP1A-Lepr(db/db)":[58],"or":[60,105],"feeding":[62],"a":[65,159,177],"high-fat":[66],"diet.":[67],"PhIP":[68],"formation":[71],"small":[73,132,151,202,236],"tumors":[75,93,153],"at":[76],"ages":[78],"weeks":[80],"28-40":[81],"but":[86,135],"not":[87,136],"lean":[89,104],"mice.":[91,107],"No":[92],"were":[94],"found":[95,112,147,173],"colon":[97],"and":[98,120,143,212,216,231],"other":[99],"organs":[101],"Using":[108],"immunohistochemistry":[109],"(IHC),":[110],"strong":[113],"positive":[114],"staining":[115],"NF-\u03baB":[117],"p65,":[118],"pSTAT3":[119],"COX2":[121],"as":[122,124],"well":[123],"elevated":[125],"levels":[126],"nuclear":[128],"\u03b2-catenin":[129],"(Ctnnb1)":[130],"tumors,":[134],"normal":[138],"tissues.":[139],"By":[140,165],"sequencing":[141],"Apc":[142,164,195,214],"Ctnnb1":[144],"genes,":[145],"that":[148,200],"most":[149,187],"PhIP-induced":[150,201],"carried":[157],"only":[158],"single":[160],"heterozygous":[161],"mutation":[162,215],"bisulfite-sequencing":[166],"CpG":[168,178],"islands":[169],"Apc,":[171],"DNA":[174,219],"hypermethylation":[175],"cluster":[179],"located":[180],"its":[182],"transcription":[183],"initiation":[184],"site,":[185],"likely":[188],"caused":[189],"inactivation":[191,217],"wild-type":[194],"allele.":[196],"Our":[197],"findings":[198],"demonstrate":[199],"carcinogenesis":[204],"hCYP1A-db/db":[206],"promoted":[209],"obesity":[211,230],"involves":[213],"hypermethylation.":[220],"This":[221],"experimental":[222],"result":[223],"consistent":[225],"association":[228],"incidence":[234],"humans":[240],"recent":[242],"decades.":[243]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}