{"id":"https://openalex.org/W2344712410","doi":"https://doi.org/10.1084/jem.20150537","title":"Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells","display_name":"Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells","publication_year":2016,"publication_date":"2016-04-25","ids":{"openalex":"https://openalex.org/W2344712410","doi":"https://doi.org/10.1084/jem.20150537","mag":"2344712410","pmid":"https://pubmed.ncbi.nlm.nih.gov/27114609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4854724"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20150537","doi":"https://doi.org/10.1084/jem.20150537","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.20150537","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4854724","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033378036","display_name":"Andrew Getahun","orcid":"https://orcid.org/0000-0002-5663-6812","observed_orcids":["https://orcid.org/0000-0002-5663-6812"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Getahun","raw_affiliation_strings":["Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001323222","display_name":"Nicole A. Beavers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole A. Beavers","raw_affiliation_strings":["Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050639318","display_name":"Sandy R. Larson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandy R. Larson","raw_affiliation_strings":["Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080114183","display_name":"Mark Jay Shlomchik","orcid":"https://orcid.org/0000-0002-2152-0959","observed_orcids":["https://orcid.org/0000-0002-2152-0959"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Shlomchik","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 3","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063233755","display_name":"John C. Cambier","orcid":"https://orcid.org/0000-0002-7803-242X","observed_orcids":["https://orcid.org/0000-0002-7803-242X"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John C. Cambier","raw_affiliation_strings":["Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Research, National Jewish Health, Denver, CO 80206 2","institution_ids":["https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045 1","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063233755"],"corresponding_institution_ids":["https://openalex.org/I3019586173","https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":9.0879,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.98255706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"213","issue":"5","first_page":"751","last_page":"769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9326000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-anergy","display_name":"B cell anergy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ship1","display_name":"SHIP1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inhibitory-signaling","display_name":"inhibitory signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/autoreactive-b-cells","display_name":"autoreactive B cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.4699999988079071},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9890000224113464},{"id":"https://openalex.org/keywords/plasma-cell-differentiation","display_name":"plasma cell differentiation","score":0.5350000262260437},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.8206157684326172},{"id":"https://openalex.org/C2779062720","wikidata":"https://www.wikidata.org/wiki/Q529298","display_name":"Clonal anergy","level":5,"score":0.6514553427696228},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.556125819683075},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5495936274528503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5417360663414001},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.510908305644989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.488278865814209},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.4253709614276886},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4141887426376343},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.4126230776309967},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.392681360244751},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3378138244152069},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3285673260688782},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.23589563369750977},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2326321005821228},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.18741631507873535},{"id":"https://openalex.org/C3017602531","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Lymphocyte activation","level":4,"score":0.16102740168571472},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10796216130256653}],"mesh":[{"descriptor_ui":"D000072183","descriptor_name":"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072183","descriptor_name":"Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017635","descriptor_name":"Clonal Anergy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.20150537","doi":"https://doi.org/10.1084/jem.20150537","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.20150537","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4854724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4854724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:27114609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27114609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4854724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4854724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2030838714","display_name":"B Cells and Type 1 Diabetes","funder_award_id":"R01DK096492","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2900422150","display_name":"Antigen Recognition by Lymphocytes","funder_award_id":"P01AI022295","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G401167513","display_name":"Infectious Agents and B Cell Anergy","funder_award_id":"R01AI077597","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4319397491","display_name":"Signaling and Selection in Germinal Center B Cells","funder_award_id":"R01AI105018","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5110829191","display_name":"Autoimmunity risk alleles compromising B cell anergy","funder_award_id":"R01AI124487","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000033243","display_name":null,"funder_award_id":"PO1 AI22295","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W136542906","https://openalex.org/W793436564","https://openalex.org/W1524173996","https://openalex.org/W1530637230","https://openalex.org/W1586126658","https://openalex.org/W1587113887","https://openalex.org/W1635630008","https://openalex.org/W1673038424","https://openalex.org/W1686167184","https://openalex.org/W1813717128","https://openalex.org/W1885397918","https://openalex.org/W1905977298","https://openalex.org/W1927916230","https://openalex.org/W1966949480","https://openalex.org/W1969140398","https://openalex.org/W1973640108","https://openalex.org/W1975673932","https://openalex.org/W1976046500","https://openalex.org/W1981352846","https://openalex.org/W1986925279","https://openalex.org/W1987318925","https://openalex.org/W1991988533","https://openalex.org/W1995025510","https://openalex.org/W1999317776","https://openalex.org/W2003955248","https://openalex.org/W2004756723","https://openalex.org/W2007886976","https://openalex.org/W2007929292","https://openalex.org/W2011444435","https://openalex.org/W2014523162","https://openalex.org/W2015867761","https://openalex.org/W2016208323","https://openalex.org/W2022012352","https://openalex.org/W2022192437","https://openalex.org/W2030884423","https://openalex.org/W2035915920","https://openalex.org/W2050537908","https://openalex.org/W2063825367","https://openalex.org/W2064431167","https://openalex.org/W2067427665","https://openalex.org/W2075130635","https://openalex.org/W2076198413","https://openalex.org/W2078906337","https://openalex.org/W2079270029","https://openalex.org/W2081416658","https://openalex.org/W2085736652","https://openalex.org/W2087019780","https://openalex.org/W2087976968","https://openalex.org/W2088551118","https://openalex.org/W2091850111","https://openalex.org/W2091986547","https://openalex.org/W2093262780","https://openalex.org/W2094758239","https://openalex.org/W2095547255","https://openalex.org/W2098497060","https://openalex.org/W2109627278","https://openalex.org/W2110948560","https://openalex.org/W2117309266","https://openalex.org/W2118994799","https://openalex.org/W2120096027","https://openalex.org/W2126743117","https://openalex.org/W2129349499","https://openalex.org/W2134544592","https://openalex.org/W2135169909","https://openalex.org/W2136408524","https://openalex.org/W2141111992","https://openalex.org/W2142676020","https://openalex.org/W2147191040","https://openalex.org/W2149100729","https://openalex.org/W2151005858","https://openalex.org/W2160692283","https://openalex.org/W2162154761","https://openalex.org/W2166307427","https://openalex.org/W2171833659","https://openalex.org/W2172208544","https://openalex.org/W4313333705"],"related_works":["https://openalex.org/W2011444435","https://openalex.org/W793436564","https://openalex.org/W2805720509","https://openalex.org/W2803735519","https://openalex.org/W7134184065","https://openalex.org/W2340566270","https://openalex.org/W1991988533","https://openalex.org/W2071959150","https://openalex.org/W1851200632","https://openalex.org/W2971345851"],"abstract_inverted_index":{"Many":[0],"autoreactive":[1],"B":[2,38,115],"cells":[3,39,97,116],"persist":[4],"in":[5,8,100,109,114],"the":[6,52,61,66,110],"periphery":[7],"a":[9],"state":[10],"of":[11,36,44,55,77,81,83,94],"unresponsiveness":[12,16],"called":[13],"anergy.":[14,74],"This":[15],"is":[17],"rapidly":[18],"reversible,":[19],"requiring":[20],"continuous":[21,53],"BCR":[22],"interaction":[23],"with":[24,40,106],"self-antigen":[25],"and":[26,65,92],"resultant":[27],"regulatory":[28],"signaling":[29,58],"for":[30],"its":[31],"maintenance.":[32],"Using":[33],"adoptive":[34],"transfer":[35],"anergic":[37],"subsequent":[41],"acute":[42],"induction":[43],"gene":[45],"deletion":[46],"or":[47],"expression,":[48],"we":[49],"demonstrate":[50],"that":[51,98],"activities":[54],"independent":[56],"inhibitory":[57],"pathways":[59,85],"involving":[60],"tyrosine":[62],"phosphatase":[63,68],"SHP-1":[64],"inositol":[67],"SHIP-1":[69],"are":[70,104],"required":[71],"to":[72,87],"maintain":[73],"Acute":[75],"breach":[76],"anergy":[78],"by":[79],"compromise":[80],"either":[82],"these":[84],"leads":[86],"rapid":[88],"cell":[89],"activation,":[90],"proliferation,":[91],"generation":[93],"short-lived":[95],"plasma":[96],"reside":[99],"extrafollicular":[101],"foci.":[102],"Results":[103],"consistent":[105],"predicted/observed":[107],"reduction":[108],"Lyn-SHIP-1-PTEN-SHP-1":[111],"axis":[112],"function":[113],"from":[117],"systemic":[118],"lupus":[119],"erythematosus":[120],"patients.":[121]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}