{"id":"https://openalex.org/W2344665283","doi":null,"title":"A flaw in the detection of antigenic sites","display_name":"A flaw in the detection of antigenic sites","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2344665283","mag":"2344665283"},"language":"en","primary_location":{"id":"mag:2344665283","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/imto/pdf/0167-5699(93)90240-L.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025477288","display_name":"Francesca Santini","orcid":"https://orcid.org/0000-0001-5346-5766","observed_orcids":["https://orcid.org/0000-0001-5346-5766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Santini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5346-5766","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039320260","display_name":"Michael A. Beaven","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Beaven","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17338548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6074000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3456999957561493,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.7990000247955322},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.75},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.796999990940094},{"id":"https://openalex.org/keywords/herbimycin-a","display_name":"herbimycin A","score":0.8560000061988831},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/phospholipid-hydrolysis","display_name":"phospholipid hydrolysis","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.7848316431045532},{"id":"https://openalex.org/C2778988552","wikidata":"https://www.wikidata.org/wiki/Q419401","display_name":"Carbachol","level":3,"score":0.7166558504104614},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7119200825691223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5574630498886108},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5421726107597351},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5140382051467896},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.48771557211875916},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4806636571884155},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.47104573249816895},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4412652552127838},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.421636700630188},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.41145145893096924},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34714558720588684},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33183956146240234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31268513202667236},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3098737299442291},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18202704191207886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.13137146830558777},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2344665283","doi":null,"is_oa":false,"landing_page_url":"https://www.cell.com/imto/pdf/0167-5699(93)90240-L.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2100092765"],"related_works":["https://openalex.org/W1990345081","https://openalex.org/W2245208343","https://openalex.org/W1765634896","https://openalex.org/W7097355762","https://openalex.org/W2417967651","https://openalex.org/W2410937760","https://openalex.org/W1974038614","https://openalex.org/W6996726754","https://openalex.org/W1928783644","https://openalex.org/W2037010431"],"abstract_inverted_index":{"had":[0],"been":[1],"transfected":[2],"with":[3,15,50,152],"the":[4,7,35,64,67,73,90,111,132],"gene":[5],"for":[6,55,146],"G":[8,125],"protein-coupled":[9],"muscarinic":[10],"ml":[11],"receptor":[12],"and":[13,42,80,140],"stimulated":[14],"carbachol":[16],"which,":[17],"unlike":[18],"antigen,":[19],"does":[20],"not":[21],"induce":[22],"tyrosine":[23],"phosphorylation":[24],"of":[25,37,70,85,128,137,149],"phospholipase":[26],"Cfl":[27],"s.":[28],"A":[29],"large":[30],"difference":[31],"was":[32,76,95],"observed":[33],"in":[34,40,63,87,93,105,109,116],"amounts":[36],"[3H]inositol":[38],"phosphates":[39],"untreated":[41],"herbimycin":[43,117],"A-treated":[44,118],"cells":[45,57,119],"(>90%":[46],"decrease)":[47],"after":[48],"stimulation":[49],"1":[51],"mM":[52],"carbachol.":[53],"Values":[54],"unstimulated":[56,88],"were":[58],"almost":[59],"identical":[60],"to":[61],"those":[62],"Table.":[65],"When":[66],"reduced":[68],"incorpotation":[69],"radiolabel":[71],"i,lto":[72],"phospholipid":[74,114,139],"pool":[75],"taken":[77],"into":[78],"account":[79],"values":[81],"expressed":[82],"as":[83,101],"percent":[84],"[3Hlphospholipids":[86],"cells,":[89],"apparent":[91],"decrease":[92],"response":[94],"much":[96],"less":[97],"(about":[98],"50%).":[99],"Finally,":[100],"will":[102],"be":[103],"described":[104],"detail":[106],"elsewhere":[107],"(manuscript":[108],"preparation),":[110],"residual":[112],"antigeninduced":[113],"hydrolysis":[115],"(Table)":[120],"represented":[121],"a":[122],"partially":[123],"masked":[124],"protein-dependent":[126],"component":[127],"hydrolysis.":[129],"We":[130],"reemphasize":[131],"point":[133],"that":[134],"complete":[135],"accounting":[136],"inositol":[138,141],"phosphate":[142],"pools":[143],"is":[144],"essential":[145],"correct":[147],"interpretation":[148],"all":[150],"studies":[151],"myo-[":[153],"3H]inositol.":[154]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
