{"id":"https://openalex.org/W2344533005","doi":"https://doi.org/10.1093/emph/eow014","title":"Mouse Models of Human Disease: An Evolutionary Perspective","display_name":"Mouse Models of Human Disease: An Evolutionary Perspective","publication_year":2016,"publication_date":"2016-04-27","ids":{"openalex":"https://openalex.org/W2344533005","doi":"https://doi.org/10.1093/emph/eow014","mag":"2344533005","pmid":"https://pubmed.ncbi.nlm.nih.gov/27121451","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4875775"},"language":"en","primary_location":{"id":"doi:10.1093/emph/eow014","doi":"https://doi.org/10.1093/emph/eow014","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emph/eow014","pdf_url":"https://academic.oup.com/emph/article-pdf/2016/1/170/9497614/eow014.pdf","source":{"id":"https://openalex.org/S4210240792","display_name":"Evolution Medicine and Public Health","issn_l":"2050-6201","issn":["2050-6201"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution, Medicine, and Public Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/emph/article-pdf/2016/1/170/9497614/eow014.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053382593","display_name":"Robert L. Perlman","orcid":"https://orcid.org/0000-0003-2150-4753","observed_orcids":["https://orcid.org/0000-0003-2150-4753"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert L. Perlman","raw_affiliation_strings":["Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave, MC 5058, Chicago, IL 60637, USA r-perlman@uchicago.edu","Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave, MC 5058, Chicago, IL 60637, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave, MC 5058, Chicago, IL 60637, USA r-perlman@uchicago.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave, MC 5058, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053382593"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":3629,"currency":"USD","value_usd":3629},"apc_paid":{"value":3629,"currency":"USD","value_usd":3629},"fwci":71.8143,"has_fulltext":true,"cited_by_count":709,"citation_normalized_percentile":{"value":0.99952415,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"2016","issue":"1","first_page":"eow014","last_page":"eow014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.5160999894142151,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy of Biology and Scientific Explanation","score":0.25220000743865967,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-models-of-human-disease","display_name":"mouse models of human disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/human-mouse-comparison","display_name":"human-mouse comparison","score":0.47999998927116394},{"id":"https://openalex.org/keywords/evolutionary-medicine","display_name":"evolutionary medicine","score":0.49900001287460327},{"id":"https://openalex.org/keywords/gene-disease-networks","display_name":"gene-disease networks","score":0.7620000243186951},{"id":"https://openalex.org/keywords/translational-research-limitations","display_name":"translational research limitations","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7726629972457886},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6487224102020264},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.5803920030593872},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5663220882415771},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5536636710166931},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5424145460128784},{"id":"https://openalex.org/C2778914748","wikidata":"https://www.wikidata.org/wiki/Q10850","display_name":"Rodent","level":2,"score":0.526079535484314},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.5244060754776001},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.45818156003952026},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.44949930906295776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3895755708217621},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38723111152648926},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33660125732421875},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.17141076922416687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08004352450370789},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1093/emph/eow014","doi":"https://doi.org/10.1093/emph/eow014","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emph/eow014","pdf_url":"https://academic.oup.com/emph/article-pdf/2016/1/170/9497614/eow014.pdf","source":{"id":"https://openalex.org/S4210240792","display_name":"Evolution Medicine and Public Health","issn_l":"2050-6201","issn":["2050-6201"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution, Medicine, and Public Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4875775","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4875775","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evol Med Public Health","raw_type":"Text"},{"id":"pmid:27121451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27121451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution, medicine, and public health","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:emph:2016/1/170","doi":null,"is_oa":false,"landing_page_url":"http://emph.oxfordjournals.org/cgi/content/short/2016/1/170","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/emph/eow014","doi":"https://doi.org/10.1093/emph/eow014","is_oa":true,"landing_page_url":"https://doi.org/10.1093/emph/eow014","pdf_url":"https://academic.oup.com/emph/article-pdf/2016/1/170/9497614/eow014.pdf","source":{"id":"https://openalex.org/S4210240792","display_name":"Evolution Medicine and Public Health","issn_l":"2050-6201","issn":["2050-6201"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-2","ki-jl-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evolution, Medicine, and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2344533005.pdf","grobid_xml":"https://content.openalex.org/works/W2344533005.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W32833316","https://openalex.org/W188558181","https://openalex.org/W595866631","https://openalex.org/W1562852527","https://openalex.org/W1564788759","https://openalex.org/W1566888664","https://openalex.org/W1576989171","https://openalex.org/W1971092719","https://openalex.org/W1976153089","https://openalex.org/W1976209715","https://openalex.org/W1976274498","https://openalex.org/W1977281013","https://openalex.org/W1991968204","https://openalex.org/W1995234326","https://openalex.org/W1998414833","https://openalex.org/W2012101993","https://openalex.org/W2021073704","https://openalex.org/W2033085346","https://openalex.org/W2053277232","https://openalex.org/W2055755973","https://openalex.org/W2058647415","https://openalex.org/W2070831760","https://openalex.org/W2073940054","https://openalex.org/W2080843536","https://openalex.org/W2083045667","https://openalex.org/W2088229792","https://openalex.org/W2096114109","https://openalex.org/W2096565553","https://openalex.org/W2104209550","https://openalex.org/W2104244948","https://openalex.org/W2105179930","https://openalex.org/W2108752700","https://openalex.org/W2109963121","https://openalex.org/W2120666441","https://openalex.org/W2127364791","https://openalex.org/W2127787997","https://openalex.org/W2137516955","https://openalex.org/W2137585654","https://openalex.org/W2138111534","https://openalex.org/W2147296371","https://openalex.org/W2148103005","https://openalex.org/W2149075785","https://openalex.org/W2151464048","https://openalex.org/W2249140533","https://openalex.org/W2314347989","https://openalex.org/W2327883350","https://openalex.org/W2329825225","https://openalex.org/W2502732896","https://openalex.org/W2588914676","https://openalex.org/W2751618905","https://openalex.org/W4239578492"],"related_works":["https://openalex.org/W7098959980","https://openalex.org/W797998171","https://openalex.org/W2796670445","https://openalex.org/W2969179639","https://openalex.org/W1523074674","https://openalex.org/W2915941065","https://openalex.org/W995795275","https://openalex.org/W4212998408","https://openalex.org/W2735657139","https://openalex.org/W1995363983"],"abstract_inverted_index":{"The":[0,125],"use":[1,126],"of":[2,74,97,106,127,136],"mice":[3,23,128,146],"as":[4,104,140,142],"model":[5],"organisms":[6],"to":[7,32,50,94,115,119,133],"study":[8],"human":[9,107],"biology":[10],"is":[11],"predicated":[12],"on":[13],"the":[14,20,72,75,83,88,111,122,137,143],"genetic":[15],"and":[16,24,29,35,77,80,147],"physiological":[17],"similarities":[18,144],"between":[19,121,145],"species.":[21,99,124],"Nonetheless,":[22],"humans":[25],"have":[26,42,68],"evolved":[27,138],"in":[28,53,129],"become":[30,43],"adapted":[31],"different":[33,45,98],"environments":[34],"so,":[36],"despite":[37],"their":[38],"phylogenetic":[39],"relatedness,":[40],"they":[41],"very":[44],"organisms.":[46],"Mice":[47,60,100],"often":[48],"respond":[49],"experimental":[51],"interventions":[52],"ways":[54],"that":[55,67],"differ":[56,120],"strikingly":[57],"from":[58],"humans.":[59,148],"are":[61,101,117],"invaluable":[62],"for":[63,81],"studying":[64],"biological":[65],"processes":[66],"been":[69],"conserved":[70,89],"during":[71],"evolution":[73],"rodent":[76],"primate":[78],"lineages":[79],"investigating":[82],"developmental":[84],"mechanisms":[85],"by":[86],"which":[87],"mammalian":[90],"genome":[91],"gives":[92],"rise":[93],"a":[95],"variety":[96],"less":[102],"reliable":[103],"models":[105],"disease,":[108],"however,":[109],"because":[110],"networks":[112],"linking":[113],"genes":[114],"disease":[116],"likely":[118],"two":[123],"biomedical":[130],"research":[131],"needs":[132],"take":[134],"account":[135],"differences":[139],"well":[141]},"counts_by_year":[{"year":2026,"cited_by_count":47},{"year":2025,"cited_by_count":71},{"year":2024,"cited_by_count":101},{"year":2023,"cited_by_count":69},{"year":2022,"cited_by_count":75},{"year":2021,"cited_by_count":93},{"year":2020,"cited_by_count":101},{"year":2019,"cited_by_count":93},{"year":2018,"cited_by_count":44},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}