{"id":"https://openalex.org/W2344335337","doi":"https://doi.org/10.1186/s12951-016-0187-8","title":"Contribution of actin filaments and microtubules to cell elongation and alignment depends on the grating depth of microgratings","display_name":"Contribution of actin filaments and microtubules to cell elongation and alignment depends on the grating depth of microgratings","publication_year":2016,"publication_date":"2016-04-29","ids":{"openalex":"https://openalex.org/W2344335337","doi":"https://doi.org/10.1186/s12951-016-0187-8","mag":"2344335337","pmid":"https://pubmed.ncbi.nlm.nih.gov/27129379","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4850729"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-016-0187-8","doi":"https://doi.org/10.1186/s12951-016-0187-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-016-0187-8","pdf_url":"https://jnanobiotechnology.biomedcentral.com/track/pdf/10.1186/s12951-016-0187-8","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jnanobiotechnology.biomedcentral.com/track/pdf/10.1186/s12951-016-0187-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kyunghee Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210164985","display_name":"National NanoFab Center","ror":"https://ror.org/05k1va520","country_code":"KR","type":"facility","lineage":["https://openalex.org/I157485424","https://openalex.org/I4210164985"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["KR","SG"],"is_corresponding":false,"raw_author_name":"Kyunghee Lee","raw_affiliation_strings":["Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea","Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea","institution_ids":["https://openalex.org/I4210164985"]},{"raw_affiliation_string":"Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078698706","display_name":"Ee Hyun Kim","orcid":"https://orcid.org/0009-0001-5013-9313","observed_orcids":["https://orcid.org/0009-0001-5013-9313"]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["KR","SG"],"is_corresponding":false,"raw_author_name":"Ee Hyun Kim","raw_affiliation_strings":["Department of Chemistry and Nano Sciences (BK21 plus), Ewha Womans University, Seoul, 120-750, South Korea","Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Nano Sciences (BK21 plus), Ewha Womans University, Seoul, 120-750, South Korea","institution_ids":["https://openalex.org/I138925566"]},{"raw_affiliation_string":"Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007895498","display_name":"Naeun Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138925566","display_name":"Ewha Womans University","ror":"https://ror.org/053fp5c05","country_code":"KR","type":"education","lineage":["https://openalex.org/I138925566"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Naeun Oh","raw_affiliation_strings":["Department of Chemistry and Nano Sciences (BK21 plus), Ewha Womans University, Seoul, 120-750, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Nano Sciences (BK21 plus), Ewha Womans University, Seoul, 120-750, South Korea","institution_ids":["https://openalex.org/I138925566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632420","display_name":"Nguy\u1ec5n Anh Tu\u1ea5n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nguyen Anh Tuan","raw_affiliation_strings":["Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065602083","display_name":"Nam Ho Bae","orcid":"https://orcid.org/0000-0003-2561-7739","observed_orcids":["https://orcid.org/0000-0003-2561-7739"]},"institutions":[{"id":"https://openalex.org/I4210164985","display_name":"National NanoFab Center","ror":"https://ror.org/05k1va520","country_code":"KR","type":"facility","lineage":["https://openalex.org/I157485424","https://openalex.org/I4210164985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nam Ho Bae","raw_affiliation_strings":["Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea","institution_ids":["https://openalex.org/I4210164985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043271168","display_name":"Seok Jae Lee","orcid":"https://orcid.org/0000-0003-1523-0012","observed_orcids":["https://orcid.org/0000-0003-1523-0012"]},"institutions":[{"id":"https://openalex.org/I4210164985","display_name":"National NanoFab Center","ror":"https://ror.org/05k1va520","country_code":"KR","type":"facility","lineage":["https://openalex.org/I157485424","https://openalex.org/I4210164985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok Jae Lee","raw_affiliation_strings":["Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea","institution_ids":["https://openalex.org/I4210164985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070184221","display_name":"Kyoung G. Lee","orcid":"https://orcid.org/0000-0003-2691-0910","observed_orcids":["https://orcid.org/0000-0003-2691-0910"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210164985","display_name":"National NanoFab Center","ror":"https://ror.org/05k1va520","country_code":"KR","type":"facility","lineage":["https://openalex.org/I157485424","https://openalex.org/I4210164985"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["KR","SG"],"is_corresponding":false,"raw_author_name":"Kyoung G. Lee","raw_affiliation_strings":["Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea","Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nano Bio Research, National Nanofab Center (NNFC), Daejeon, 305-806, South Korea","institution_ids":["https://openalex.org/I4210164985"]},{"raw_affiliation_string":"Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029607367","display_name":"Chi\u2010Yong Eom","orcid":"https://orcid.org/0000-0003-4578-9298","observed_orcids":["https://orcid.org/0000-0003-4578-9298"]},"institutions":[{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chi-Yong Eom","raw_affiliation_strings":["Seoul Center, Korea Basic Science Institute, Seoul, 136-713, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul Center, Korea Basic Science Institute, Seoul, 136-713, South Korea","institution_ids":["https://openalex.org/I4210139925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080324706","display_name":"Evelyn K. F. Yim","orcid":"https://orcid.org/0000-0001-9812-1801","observed_orcids":["https://orcid.org/0000-0001-9812-1801"]},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["CA","SG"],"is_corresponding":false,"raw_author_name":"Evelyn K. Yim","raw_affiliation_strings":["Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada","Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Mechanobiology Institute (MBI), National University of Singapore, Singapore, 117411, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087157024","display_name":"Sungsu Park","orcid":"https://orcid.org/0000-0003-3062-1302","observed_orcids":["https://orcid.org/0000-0003-3062-1302","https://orcid.org/0009-0007-8547-3761"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sungsu Park","raw_affiliation_strings":["School of Mechanical Engineering, Sungkyunkwan University, Suwon, 440-746, South Korea. nanopark@skku.edu","School of Mechanical Engineering, Sungkyunkwan University, Suwon, 440-746, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechanical Engineering, Sungkyunkwan University, Suwon, 440-746, South Korea. nanopark@skku.edu","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"School of Mechanical Engineering, Sungkyunkwan University, Suwon, 440-746, South Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5087157024"],"corresponding_institution_ids":["https://openalex.org/I848706"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":2.3429,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.8719667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.859000027179718},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":1.0},{"id":"https://openalex.org/keywords/cell-elongation","display_name":"cell elongation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cell-alignment","display_name":"cell alignment","score":0.996999979019165},{"id":"https://openalex.org/keywords/grating-depth","display_name":"grating depth","score":0.9110000133514404},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.6800000071525574},{"id":"https://openalex.org/keywords/rpe-1-cells","display_name":"RPE1 cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/surface-patterning","display_name":"surface patterning","score":0.6290000081062317},{"id":"https://openalex.org/keywords/actin-polymerization-inhibition","display_name":"actin polymerization inhibition","score":0.8209999799728394},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cell-aspect-ratio","display_name":"cell aspect ratio","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.8767683506011963},{"id":"https://openalex.org/C14228908","wikidata":"https://www.wikidata.org/wiki/Q2920483","display_name":"Protein filament","level":2,"score":0.7412458062171936},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6405341625213623},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.62041836977005},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5512871146202087},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5323299169540405},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44769397377967834},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43066078424453735},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33814820647239685},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3262607455253601},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2698213458061218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2265559434890747},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12808829545974731},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07080644369125366},{"id":"https://openalex.org/C112950240","wikidata":"https://www.wikidata.org/wiki/Q76005","display_name":"Ultimate tensile strength","level":2,"score":0.06349092721939087},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.059475094079971313}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015638","descriptor_name":"Cytochalasin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055213","descriptor_name":"Retinal Pigment Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12951-016-0187-8","doi":"https://doi.org/10.1186/s12951-016-0187-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-016-0187-8","pdf_url":"https://jnanobiotechnology.biomedcentral.com/track/pdf/10.1186/s12951-016-0187-8","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},{"id":"pmid:27129379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27129379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4850729","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4850729/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nanobiotechnology","raw_type":"Text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/174258","doi":null,"is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/174258","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20200831","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12951-016-0187-8","doi":"https://doi.org/10.1186/s12951-016-0187-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-016-0187-8","pdf_url":"https://jnanobiotechnology.biomedcentral.com/track/pdf/10.1186/s12951-016-0187-8","source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1252976735","display_name":null,"funder_award_id":"2012M3A2A1051681","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2709878167","display_name":null,"funder_award_id":"2012M3A2A1051681","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320324605","display_name":"Mechanobiology Institute, Singapore","ror":"https://ror.org/01tgyzw49"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2344335337.pdf","grobid_xml":"https://content.openalex.org/works/W2344335337.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1855561741","https://openalex.org/W1964413664","https://openalex.org/W1972081276","https://openalex.org/W1973957801","https://openalex.org/W1994186189","https://openalex.org/W1995051428","https://openalex.org/W2002475826","https://openalex.org/W2023413608","https://openalex.org/W2024121819","https://openalex.org/W2025587555","https://openalex.org/W2025625458","https://openalex.org/W2030041577","https://openalex.org/W2032884095","https://openalex.org/W2038252444","https://openalex.org/W2056661372","https://openalex.org/W2074307550","https://openalex.org/W2075755310","https://openalex.org/W2076724837","https://openalex.org/W2080392390","https://openalex.org/W2084162464","https://openalex.org/W2112129259","https://openalex.org/W2119952613","https://openalex.org/W2133769499","https://openalex.org/W2153056550","https://openalex.org/W2185006302","https://openalex.org/W2187748291","https://openalex.org/W2468930230"],"related_works":["https://openalex.org/W6977500860","https://openalex.org/W7100891249","https://openalex.org/W1987075295","https://openalex.org/W2080392390","https://openalex.org/W1948887717","https://openalex.org/W1996593112","https://openalex.org/W2886897413","https://openalex.org/W2023413608","https://openalex.org/W2081656933","https://openalex.org/W2089446445"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"has":[2],"been":[3],"reported":[4],"that":[5,180],"both":[6,135],"chemical":[7,43],"and":[8,19,29,44,50,56,73,132,138,160,186,191],"physical":[9,45],"surface":[10,92,114],"patterns":[11,46],"influence":[12],"cellular":[13],"behaviors,":[14],"such":[15],"as":[16],"cell":[17,48,101,158],"alignment":[18,51,133,161,192],"elongation.":[20],"However,":[21],"it":[22],"still":[23],"remains":[24],"unclear":[25],"how":[26],"actin":[27,54,152,184],"filament":[28,55],"microtubules":[30],"(MTs)":[31],"differentially":[32],"respond":[33],"to":[34,188],"these":[35,204],"patterns.":[36],"RESULTS:":[37],"We":[38],"examined":[39],"the":[40,91,100,113,121,125,128,181,189,200],"effects":[41],"of":[42,58,127,151,183,193,203],"on":[47,66,112,120,124,134,162,196,199],"elongation":[49,119,131,159,190],"by":[52,149,173],"observing":[53],"MTs":[57,187],"retinal":[59],"pigment":[60],"epithelium-1(RPE-1)":[61],"cells,":[62],"which":[63],"were":[64,104,146,170],"cultured":[65],"either":[67,94,148],"fibronectin":[68],"(FN)-line":[69],"pattern":[70,96,137],"(line":[71],"width":[72],"spacing:":[74],"1":[75,79,88,139,163,167],"\u03bcm)":[76],"or":[77,87,97,154],"FN-coated":[78],"\u03bcm":[80,140,144,164,168],"gratings":[81,122,141,165],"with":[82,93,115,142,166],"two":[83,107],"different":[84],"depths":[85],"(0.35":[86],"\u03bcm).":[89],"On":[90],"FN-line":[95,136],"micrograting":[98],"structure,":[99],"aspect":[102],"ratios":[103],"at":[105],"least":[106],"times":[108],"higher":[109],"than":[110],"those":[111],"no":[116],"pattern.":[117],"Cell":[118,130],"depended":[123],"depth":[126,145,169,202],"gratings.":[129,205],"0.35":[143],"perturbed":[147,171],"inhibition":[150],"polymerization":[153],"MT":[155,174],"depletion,":[156],"while":[157],"only":[172],"depletion.":[175],"CONCLUSIONS:":[176],"Our":[177],"results":[178],"suggest":[179],"contribution":[182],"filaments":[185],"epithelial":[194],"cells":[195],"microgratings":[197],"depends":[198],"groove":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}