{"id":"https://openalex.org/W2344089340","doi":"https://doi.org/10.1016/j.abb.2016.04.014","title":"A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer","display_name":"A comprehensive review of the role of zinc in normal prostate function and metabolism; and its implications in prostate cancer","publication_year":2016,"publication_date":"2016-04-30","ids":{"openalex":"https://openalex.org/W2344089340","doi":"https://doi.org/10.1016/j.abb.2016.04.014","mag":"2344089340","pmid":"https://pubmed.ncbi.nlm.nih.gov/27132038","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5083243"},"language":"en","primary_location":{"id":"doi:10.1016/j.abb.2016.04.014","doi":"https://doi.org/10.1016/j.abb.2016.04.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.abb.2016.04.014","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5083243","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110882079","display_name":"Leslie C. Costello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie C. Costello","raw_affiliation_strings":["Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA; The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA. Electronic address: lcostello@umaryland.edu","Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA","The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA; The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA. Electronic address: lcostello@umaryland.edu","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000223607","display_name":"RENTY B. FRANKLIN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renty B. Franklin","raw_affiliation_strings":["Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA; The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA","Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA","The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA; The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]},{"raw_affiliation_string":"Department of Oncology and Diagnostic Sciences, Dental School/University of Maryland, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA","institution_ids":["https://openalex.org/I4390039317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110882079"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":2.1002,"has_fulltext":false,"cited_by_count":244,"citation_normalized_percentile":{"value":0.88791423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"611","issue":null,"first_page":"100","last_page":"112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9810000061988831},{"id":"https://openalex.org/keywords/prostate","display_name":"prostate","score":0.6919999718666077},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/citrate-metabolism","display_name":"citrate metabolism","score":0.628000020980835},{"id":"https://openalex.org/keywords/terminal-oxidation","display_name":"terminal oxidation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/zinc-accumulation","display_name":"zinc accumulation","score":0.546999990940094},{"id":"https://openalex.org/keywords/acinar-cells","display_name":"acinar cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/zip1","display_name":"ZIP1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/zinc-transporters","display_name":"zinc transporters","score":0.6340000033378601},{"id":"https://openalex.org/keywords/clioquinol","display_name":"clioquinol","score":0.8370000123977661},{"id":"https://openalex.org/keywords/zinc-ionophore","display_name":"zinc ionophore","score":0.9729999899864197},{"id":"https://openalex.org/keywords/zinc-therapy","display_name":"zinc therapy","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8426409959793091},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7626829147338867},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.6572744250297546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5710754990577698},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5315656065940857},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47586530447006226},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45558130741119385},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44060465693473816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42640185356140137},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4213883578777313},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33157992362976074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3130636215209961},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000154","descriptor_name":"Aconitate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002951","descriptor_name":"Citrates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.abb.2016.04.014","doi":"https://doi.org/10.1016/j.abb.2016.04.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.abb.2016.04.014","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:27132038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27132038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4620617","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5083243","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5083243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5083243","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Arch Biochem Biophys","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4620617","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5083243","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2981266267","display_name":"Concept of bone \"citration\": an essential function of differentiated osteoblasts","funder_award_id":"R21AR064808","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3945011262","display_name":"Prolactin receptor signaling of prolactin metabolic effects in the prostate","funder_award_id":"R01DK076763","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3945199653","display_name":null,"funder_award_id":"DK076783","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5848323462","display_name":"Zinc Transport Relationships in Prostate Cancer Cells","funder_award_id":"R01CA079903","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6843183286","display_name":"HORMONAL REGULATION OF PROSTATE CITRATE PRODUCTION","funder_award_id":"R01DK042839","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W136635533","https://openalex.org/W205075771","https://openalex.org/W1199385631","https://openalex.org/W1491350259","https://openalex.org/W1963883162","https://openalex.org/W1967714958","https://openalex.org/W1979377912","https://openalex.org/W1985057934","https://openalex.org/W1986171863","https://openalex.org/W1987963598","https://openalex.org/W1989600065","https://openalex.org/W1992296450","https://openalex.org/W1992678832","https://openalex.org/W1993236276","https://openalex.org/W1996457684","https://openalex.org/W1997472806","https://openalex.org/W1999985306","https://openalex.org/W2004554848","https://openalex.org/W2005762905","https://openalex.org/W2007579725","https://openalex.org/W2009441540","https://openalex.org/W2016819606","https://openalex.org/W2017292681","https://openalex.org/W2018362863","https://openalex.org/W2020047220","https://openalex.org/W2025969021","https://openalex.org/W2026983616","https://openalex.org/W2035417906","https://openalex.org/W2035594105","https://openalex.org/W2036516190","https://openalex.org/W2037360899","https://openalex.org/W2044909936","https://openalex.org/W2047845409","https://openalex.org/W2049428603","https://openalex.org/W2054569628","https://openalex.org/W2057726768","https://openalex.org/W2058718966","https://openalex.org/W2060791774","https://openalex.org/W2062475888","https://openalex.org/W2069613122","https://openalex.org/W2073039237","https://openalex.org/W2073495377","https://openalex.org/W2075211846","https://openalex.org/W2075619210","https://openalex.org/W2076880479","https://openalex.org/W2078874397","https://openalex.org/W2079722596","https://openalex.org/W2080645415","https://openalex.org/W2088942127","https://openalex.org/W2092473371","https://openalex.org/W2095485607","https://openalex.org/W2099018448","https://openalex.org/W2102350033","https://openalex.org/W2110652761","https://openalex.org/W2112066669","https://openalex.org/W2116150569","https://openalex.org/W2129559645","https://openalex.org/W2133324295","https://openalex.org/W2134102934","https://openalex.org/W2140025679","https://openalex.org/W2150144448","https://openalex.org/W2155019993","https://openalex.org/W2157518260","https://openalex.org/W2163578998","https://openalex.org/W2163580244","https://openalex.org/W2170552969","https://openalex.org/W2279232157","https://openalex.org/W2321357528","https://openalex.org/W2403499346","https://openalex.org/W2414212594","https://openalex.org/W2417338795","https://openalex.org/W6627886938","https://openalex.org/W6695326082"],"related_works":["https://openalex.org/W1988590690","https://openalex.org/W2073039237","https://openalex.org/W2112066669","https://openalex.org/W1998648476","https://openalex.org/W4245247764","https://openalex.org/W2025969021","https://openalex.org/W2386723923","https://openalex.org/W44709106","https://openalex.org/W2321357528","https://openalex.org/W1984153633"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}