{"id":"https://openalex.org/W2343974428","doi":null,"title":"Development of a Vero cell-derived influenza whole virus vaccine.","display_name":"Development of a Vero cell-derived influenza whole virus vaccine.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2343974428","mag":"2343974428","pmid":"https://pubmed.ncbi.nlm.nih.gov/10494963"},"language":"en","primary_location":{"id":"pmid:10494963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10494963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developments in biological standardization","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013621761","display_name":"Otfried Kistner","orcid":"https://orcid.org/0000-0003-0828-9550","observed_orcids":["https://orcid.org/0000-0003-0828-9550"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Kistner","raw_affiliation_strings":["Biomedical Research Center, Immuno AG, Orth/Donau, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, Immuno AG, Orth/Donau, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047355120","display_name":"Barrett Pn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P N Barrett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028900692","display_name":"Wolfgang Mundt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Mundt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047830712","display_name":"Manfred Reiter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Reiter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080017812","display_name":"Susanne Schober-Bendixen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Schober-Bendixen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112231155","display_name":"Gerald Eder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Eder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051100583","display_name":"F Dorner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Dorner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1343,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.75330101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"98","issue":null,"first_page":"101","last_page":"10; discussion 111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.921999990940094},{"id":"https://openalex.org/keywords/vero-cell-culture","display_name":"Vero cell culture","score":0.7620000243186951},{"id":"https://openalex.org/keywords/whole-virus-vaccine","display_name":"whole-virus vaccine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cell-culture-vaccine-production","display_name":"cell culture vaccine production","score":0.7239999771118164},{"id":"https://openalex.org/keywords/serum-free-culture","display_name":"serum-free culture","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vaccine-purification","display_name":"vaccine purification","score":0.6259999871253967},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C129470801","wikidata":"https://www.wikidata.org/wiki/Q5370234","display_name":"Embryonated","level":3,"score":0.9367514848709106},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8432658910751343},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.8426104784011841},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6790070533752441},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.6221827268600464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6088350415229797},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5633425116539001},{"id":"https://openalex.org/C2781416681","wikidata":"https://www.wikidata.org/wiki/Q287246","display_name":"Orthomyxoviridae","level":4,"score":0.511074423789978},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4423278272151947},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42755964398384094},{"id":"https://openalex.org/C73401843","wikidata":"https://www.wikidata.org/wiki/Q845523","display_name":"Industrial fermentation","level":3,"score":0.4102305769920349},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.3558511734008789},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.10424432158470154},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002679","descriptor_name":"Pan troglodytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014776","descriptor_name":"Virus Cultivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10494963","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10494963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developments in biological standardization","raw_type":"Journal Article"},{"id":"mag:2343974428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10494963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019850722","https://openalex.org/W2254113059","https://openalex.org/W2401128702","https://openalex.org/W1978197000","https://openalex.org/W2144256020","https://openalex.org/W2016293059","https://openalex.org/W2028232308","https://openalex.org/W2128992161","https://openalex.org/W2523532621","https://openalex.org/W29230149"],"abstract_inverted_index":{"Influenza":[0],"vaccine":[1,79],"production":[2,48,80],"is":[3,16],"dependent":[4],"on":[5],"the":[6,32],"availability":[7],"of":[8,28,34,49,52],"embryonated":[9],"hen":[10],"eggs":[11],"for":[12],"virus":[13,29,98],"growth.":[14],"This":[15,72,100],"an":[17,40],"extremely":[18],"cumbersome":[19],"system":[20,44,73],"with":[21,24,81],"many":[22,66],"disadvantages":[23],"respect":[25],"to":[26,64,69,77,103],"selection":[27],"variants":[30],"and":[31],"presence":[33],"adventitious":[35],"viruses.":[36],"We":[37],"have":[38],"developed":[39,90],"alternative":[41],"cell":[42,57],"culture":[43,63],"which":[45,91],"allows":[46],"rapid":[47],"large":[50],"volumes":[51],"vaccine.":[53,99],"The":[54],"WHO-approved":[55],"Vero":[56],"line":[58],"was":[59,89,101],"used":[60],"in":[61,93],"serum-free":[62],"grow":[65],"influenza":[67],"strains":[68],"high":[70,95],"titre.":[71],"could":[74],"be":[75,104],"scaled-up":[76],"allow":[78],"a":[82,94,110],"1200":[83],"litre":[84],"fermenter.":[85],"A":[86],"purification":[87],"scheme":[88],"resulted":[92],"purity":[96],"whole":[97],"demonstrated":[102],"at":[105],"least":[106],"as":[107,109],"immunogenic":[108],"conventional":[111],"egg-derived":[112],"preparation.":[113]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}