{"id":"https://openalex.org/W2343649864","doi":"https://doi.org/10.1152/jappl.1991.70.4.1524","title":"Changes in plasma adenosine during simulated birth of fetal sheep","display_name":"Changes in plasma adenosine during simulated birth of fetal sheep","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W2343649864","doi":"https://doi.org/10.1152/jappl.1991.70.4.1524","mag":"2343649864","pmid":"https://pubmed.ncbi.nlm.nih.gov/2055831"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1991.70.4.1524","doi":"https://doi.org/10.1152/jappl.1991.70.4.1524","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1991.70.4.1524","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000247435","display_name":"Rintaro Sawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Sawa","raw_affiliation_strings":["Division of Perinatal Biology, School of Medicine, Loma Linda University, California 92350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Biology, School of Medicine, Loma Linda University, California 92350","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081225839","display_name":"Hidesaku Asakura","orcid":"https://orcid.org/0000-0003-1834-1690","observed_orcids":["https://orcid.org/0000-0003-1834-1690"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Asakura","raw_affiliation_strings":["Division of Perinatal Biology, School of Medicine, Loma Linda University, California 92350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Biology, School of Medicine, Loma Linda University, California 92350","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085647163","display_name":"Gordon G. Power","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. G. Power","raw_affiliation_strings":["Division of Perinatal Biology, School of Medicine, Loma Linda University, California 92350"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Perinatal Biology, School of Medicine, Loma Linda University, California 92350","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":null,"apc_paid":null,"fwci":2.0068,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.87585943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"70","issue":"4","first_page":"1524","last_page":"1528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.5260000228881836},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/umbilical-cord-occlusion","display_name":"umbilical cord occlusion","score":0.8090000152587891},{"id":"https://openalex.org/keywords/fetal-hypothermia","display_name":"fetal hypothermia","score":0.7210000157356262},{"id":"https://openalex.org/keywords/oxygenation","display_name":"oxygenation","score":0.40400001406669617},{"id":"https://openalex.org/keywords/plasma-glycerol","display_name":"plasma glycerol","score":0.800000011920929},{"id":"https://openalex.org/keywords/fetal-oxygen-consumption","display_name":"fetal oxygen consumption","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.7609999775886536},{"id":"https://openalex.org/keywords/births","display_name":"births","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.8145742416381836},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.6654869914054871},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.664577066898346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.656190037727356},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6426874399185181},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5234783887863159},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.44874733686447144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35029613971710205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3249642848968506},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.306303471326828},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.12045025825500488},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11435025930404663},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007743","descriptor_name":"Labor, Obstetric","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/jappl.1991.70.4.1524","doi":"https://doi.org/10.1152/jappl.1991.70.4.1524","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1991.70.4.1524","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:2055831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2055831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"mag:3143372061","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000088917","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1563650372","display_name":"FETAL HEAT PRODUCTION AND TEMPERATURE REGULATION","funder_award_id":"R01HD016827","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1967332310","https://openalex.org/W2281177987","https://openalex.org/W2008557980","https://openalex.org/W4252436368","https://openalex.org/W4254647075","https://openalex.org/W2404836645","https://openalex.org/W1984924704","https://openalex.org/W2007277506","https://openalex.org/W2223002164","https://openalex.org/W1228892291"],"abstract_inverted_index":{"Adenosine":[0],"is":[1],"known":[2],"to":[3,15,36,145,149,154,216,260],"inhibit":[4],"nonshivering":[5],"thermogenesis":[6,35,134,249,259],"in":[7,22,27,53,219,229],"adult":[8],"brown":[9],"fat.":[10],"These":[11,237],"experiments":[12],"were":[13,141,165],"undertaken":[14],"test":[16,39],"whether":[17],"fetal":[18,44,55,69,105,111,119,139,230,246],"adenosine,":[19],"normally":[20],"present":[21],"high":[23,245],"concentrations,":[24],"suppresses":[25],"lipolysis":[26],"utero":[28],"and":[29,162,177,194,226],"then":[30,92,253],"falls":[31],"after":[32,255],"birth,":[33],"permitting":[34],"begin.":[37],"To":[38],"this":[40],"hypothesis,":[41],"we":[42],"measured":[43],"plasma":[45,220],"adenosine":[46],"concentration":[47],"[ADO]":[48,70,80,120,158,174,205,247],"using":[49],"high-performance":[50],"liquid":[51],"chromatography":[52],"11":[54],"sheep":[56],"at":[57],"135-140":[58],"days":[59],"gestation":[60],"during":[61],"simulated":[62],"birth.":[63],"During":[64],"an":[65],"initial":[66,188],"control":[67,189],"period,":[68],"averaged":[71,121,181],"1.9":[72],"+/-":[73,82,123,183],"0.3":[74],"microM,":[75,84,125,185],"about":[76,103],"four":[77],"times":[78],"maternal":[79],"(0.4":[81],"0.1":[83],"P":[85],"less":[86,130,191,201,223,234],"than":[87,131,151,192,202,224,235],"0.001).":[88,203,236],"The":[89],"fetus":[90],"was":[91,171],"cooled":[93],"by":[94,214],"circulating":[95],"cold":[96],"water":[97],"through":[98],"a":[99,126,227],"plastic":[100],"coil":[101],"encircled":[102],"the":[104,138,168,197,242],"torso.":[106],"One":[107],"hour":[108],"later,":[109],"when":[110],"core":[112],"temperature":[113],"had":[114],"decreased":[115,159,175],"2.3":[116],"degrees":[117],"C,":[118],"2.8":[122],"0.5":[124],"50%":[127],"increase":[128],"(P":[129,190,200,222,233],"0.05),":[132],"while":[133],"remained":[135],"inactive.":[136],"Next":[137],"lungs":[140],"ventilated":[142],"with":[143,241],"O2":[144,231],"raise":[146],"arterial":[147],"Po2":[148],"greater":[150],"or":[152],"equal":[153],"150":[155],"Torr.":[156],"Fetal":[157,173],"only":[160],"slightly,":[161],"thermogenic":[163,208],"responses":[164,209],"modest.":[166],"Finally,":[167],"umbilical":[169],"cord":[170,256],"occluded.":[172],"rapidly":[176],"60":[178],"min":[179],"later":[180],"1.1":[182],"0.2":[184],"40%":[186],"below":[187,196],"0.05)":[193],"57%":[195],"previous":[198],"period":[199],"As":[204],"fell,":[206],"strong":[207],"became":[210],"apparent,":[211],"as":[212],"indicated":[213],"seven-":[215],"eightfold":[217],"increases":[218],"glycerol":[221],"0.001)":[225],"doubling":[228],"consumption":[232],"results":[238],"are":[239],"consistent":[240],"hypothesis":[243],"that":[244],"inhibits":[248],"before":[250],"birth":[251],"but":[252],"decreases":[254],"occlusion,":[257],"allowing":[258],"begin.(ABSTRACT":[261],"TRUNCATED":[262],"AT":[263],"250":[264],"WORDS)":[265]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}