{"id":"https://openalex.org/W2343580940","doi":"https://doi.org/10.1002/jbt.21815","title":"Acute Administration of Diazepam Provokes Redox Homeostasis Imbalance in the Rat Brain: Prevention by Simvastatin","display_name":"Acute Administration of Diazepam Provokes Redox Homeostasis Imbalance in the Rat Brain: Prevention by Simvastatin","publication_year":2016,"publication_date":"2016-04-25","ids":{"openalex":"https://openalex.org/W2343580940","doi":"https://doi.org/10.1002/jbt.21815","mag":"2343580940","pmid":"https://pubmed.ncbi.nlm.nih.gov/27111380"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.21815","doi":"https://doi.org/10.1002/jbt.21815","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.21815","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025511353","display_name":"Guilherme Andr\u00e9 Eger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Andr\u00e9 Eger","raw_affiliation_strings":["Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049874523","display_name":"Vin\u00edcius Vialle Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vin\u00edcius Vialle Ferreira","raw_affiliation_strings":["Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080472613","display_name":"Camila Ribeiro Batista","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Ribeiro Batista","raw_affiliation_strings":["Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051941019","display_name":"HENRIQUE LUIS P. BONDE","orcid":"https://orcid.org/0000-0002-3977-6717","observed_orcids":["https://orcid.org/0000-0002-3977-6717"]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Henrique LuisPetrek Bonde","raw_affiliation_strings":["Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga, 140 Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002909253","display_name":"Daniela Delwing de Lima","orcid":"https://orcid.org/0000-0001-5335-5102","observed_orcids":["https://orcid.org/0000-0001-5335-5102","https://orcid.org/0000-0003-4459-1562"]},"institutions":[{"id":"https://openalex.org/I4210100389","display_name":"Universidade da Regi\u00e3o de Joinville","ror":"https://ror.org/00je1p681","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210100389"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniela Delwing de Lima","raw_affiliation_strings":["Department of Medicine, University of Joinville Region; Campus Universit\u00e1rio; Bairro Bom Retiro Joinville SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Joinville Region; Campus Universit\u00e1rio; Bairro Bom Retiro Joinville SC Brazil","institution_ids":["https://openalex.org/I4210100389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038597736","display_name":"Andr\u00e9 Felipe Rodrigues","orcid":"https://orcid.org/0000-0002-7219-6896","observed_orcids":["https://orcid.org/0000-0002-7219-6896"]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Felipe Rodrigues","raw_affiliation_strings":["Department of Natural Sciences; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Natural Sciences; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113445994","display_name":"Jos\u00e9 Geraldo Pereira da Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Geraldo Pereira da Cruz","raw_affiliation_strings":["Department of Natural Sciences; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Natural Sciences; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038359564","display_name":"D\u00e9bora Delwing Dal Magro","orcid":"https://orcid.org/0000-0003-4459-1562","observed_orcids":["https://orcid.org/0000-0003-4459-1562"]},"institutions":[{"id":"https://openalex.org/I4210105683","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210105683"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"D\u00e9bora Delwing Dal Magro","raw_affiliation_strings":["Department of Natural Sciences; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga Blumenau SC Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Natural Sciences; Regional University of Blumenau; Rua Ant\u00f4nio da Veiga Blumenau SC Brazil","institution_ids":["https://openalex.org/I4210105683"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038359564"],"corresponding_institution_ids":["https://openalex.org/I4210105683"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":1.1134,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.74775641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"10","first_page":"506","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":1.0},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9490000009536743},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.640999972820282},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5730000138282776},{"id":"https://openalex.org/keywords/benzodiazepine-toxicity","display_name":"benzodiazepine toxicity","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2777352226","wikidata":"https://www.wikidata.org/wiki/Q7669516","display_name":"TBARS","level":4,"score":0.9143735766410828},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.8860592246055603},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7631793022155762},{"id":"https://openalex.org/C2777504301","wikidata":"https://www.wikidata.org/wiki/Q418230","display_name":"Thiobarbituric acid","level":4,"score":0.7175928354263306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7137629389762878},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6894148588180542},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6283804178237915},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6227297782897949},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.610378623008728},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.5776107907295227},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.5504013299942017},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47400057315826416},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4322045147418976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40217792987823486},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.2854079604148865},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25966355204582214},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20397913455963135},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19875717163085938}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017392","descriptor_name":"Thiobarbituric Acid Reactive Substances","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050050","descriptor_name":"Protein Carbonylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.21815","doi":"https://doi.org/10.1002/jbt.21815","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.21815","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:27111380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27111380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318868","display_name":"Universidade Regional de Blumenau","ror":"https://ror.org/01nsn0t21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W66397495","https://openalex.org/W108354466","https://openalex.org/W115018298","https://openalex.org/W183120241","https://openalex.org/W191793640","https://openalex.org/W1122013619","https://openalex.org/W1775749144","https://openalex.org/W1977913875","https://openalex.org/W1983310681","https://openalex.org/W1989925586","https://openalex.org/W1990613948","https://openalex.org/W1996175319","https://openalex.org/W2000977900","https://openalex.org/W2001361004","https://openalex.org/W2003188394","https://openalex.org/W2003753329","https://openalex.org/W2033788231","https://openalex.org/W2038020563","https://openalex.org/W2046928397","https://openalex.org/W2048023356","https://openalex.org/W2064289509","https://openalex.org/W2065555720","https://openalex.org/W2069192879","https://openalex.org/W2070046033","https://openalex.org/W2086561195","https://openalex.org/W2088866343","https://openalex.org/W2089425453","https://openalex.org/W2092279282","https://openalex.org/W2095073691","https://openalex.org/W2096856875","https://openalex.org/W2107919301","https://openalex.org/W2132477948","https://openalex.org/W2162710110","https://openalex.org/W2165201727"],"related_works":["https://openalex.org/W2550086413","https://openalex.org/W115018298","https://openalex.org/W1521869060","https://openalex.org/W66397495","https://openalex.org/W140244557","https://openalex.org/W2123701634","https://openalex.org/W2324663504","https://openalex.org/W2520127190","https://openalex.org/W2052858924","https://openalex.org/W2774356712"],"abstract_inverted_index":{"We":[0],"investigated":[1,39],"the":[2,20,23,33,40,49,68,107,115,121,135,141],"effects":[3,50],"of":[4,22,35,43,71,109,114,143,146],"acute":[5],"diazepam":[6],"(DZP)":[7],"administration":[8,129],"on":[9,19,48,120],"thiobarbituric":[10],"acid-reactive":[11],"substance":[12],"(TBARS)":[13],"levels,":[14],"protein":[15,99],"carbonyl":[16,100],"content,":[17],"and":[18,29,76,98,102],"activities":[21],"antioxidant":[24,41],"enzymes":[25],"catalase,":[26],"glutathione":[27],"peroxidase,":[28],"superoxide":[30],"dismutase":[31],"in":[32,106,134,140,149],"brain":[34,108,136],"rats.":[36,110],"Additionally,":[37],"we":[38],"role":[42],"chronic":[44],"pretreatment":[45],"with":[46],"simvastatin":[47],"provoked":[51],"by":[52,61,84,118],"DZP.":[53],"Simvastatin":[54,111],"was":[55,78],"administered":[56,79],"(1":[57],"or":[58,81],"10":[59],"mg/kg":[60,83],"oral":[62],"gavage)":[63],"for":[64],"30":[65],"days.":[66],"On":[67],"30th":[69],"day":[70],"treatment,":[72],"groups":[73,88],"were":[74,152],"randomized":[75],"DZP":[77,94,119,128],"(0.5":[80],"1.0":[82],"intraperitoneal":[85],"injection).":[86],"Control":[87],"received":[89],"saline.":[90],"Results":[91],"showed":[92],"that":[93,127],"enhanced":[95],"TBARS":[96],"levels":[97],"content":[101],"altered":[103],"enzymatic":[104],"activity":[105],"prevented":[112],"most":[113],"alterations":[116,148],"caused":[117],"oxidative":[122,132,150],"stress":[123,151],"parameters.":[124],"Data":[125],"indicate":[126],"causes":[130],"an":[131],"imbalance":[133],"areas":[137],"studied;":[138],"however,":[139],"presence":[142],"simvastatin,":[144],"some":[145],"these":[147],"prevented.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}