{"id":"https://openalex.org/W2343373067","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.7656","title":"Expression of protein kinase C beta (PKC\u00df) as a prognostic marker in non-small cell lung cancer (NSCLC) and mesothelioma","display_name":"Expression of protein kinase C beta (PKC\u00df) as a prognostic marker in non-small cell lung cancer (NSCLC) and mesothelioma","publication_year":2007,"publication_date":"2007-06-20","ids":{"openalex":"https://openalex.org/W2343373067","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.7656","mag":"2343373067"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.25.18_suppl.7656","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.7656","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.7656","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086287522","display_name":"Leonardo N. Faoro","orcid":"https://orcid.org/0000-0003-4270-5490","observed_orcids":["https://orcid.org/0000-0003-4270-5490"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Faoro","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Loganathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Loganathan","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086195902","display_name":"Aliya Noor Husain","orcid":"https://orcid.org/0000-0001-5492-7387","observed_orcids":["https://orcid.org/0000-0001-5492-7387"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Husain","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003394924","display_name":"Maria A. Westerhoff","orcid":"https://orcid.org/0000-0002-3094-0111","observed_orcids":["https://orcid.org/0000-0002-3094-0111"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Westerhoff","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013767253","display_name":"Varalakshmi Janamanchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Janamanchi","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Vokes","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003826371","display_name":"Ravi Salgia","orcid":"https://orcid.org/0000-0001-9643-7626","observed_orcids":["https://orcid.org/0000-0001-9643-7626"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Salgia","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"18_suppl","first_page":"7656","last_page":"7656"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prkcb","display_name":"protein kinase C beta","score":0.9769999980926514},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/mesothelioma","display_name":"mesothelioma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5569999814033508},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.7739999890327454},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8009999990463257},{"id":"https://openalex.org/keywords/large-cell-carcinoma","display_name":"large cell carcinoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vegf-signaling","display_name":"VEGF signaling","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-microarray","display_name":"tumor microarray","score":0.47999998927116394},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.859000027179718},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.3619999885559082},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"gene set enrichment analysis","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7248114943504333},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.7213107347488403},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.6939657330513},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6123734712600708},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5728406310081482},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5586453676223755},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4673044681549072},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.46560579538345337},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.44983986020088196},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4245797395706177},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4117323160171509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38297876715660095},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3691693842411041},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3575576841831207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21410319209098816},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2007.25.18_suppl.7656","doi":"https://doi.org/10.1200/jco.2007.25.18_suppl.7656","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.25.18_suppl.7656","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2381197697","https://openalex.org/W3155418920","https://openalex.org/W2279486874","https://openalex.org/W2373099525","https://openalex.org/W1966265295","https://openalex.org/W2146113536","https://openalex.org/W59185574","https://openalex.org/W2366262653","https://openalex.org/W2033657262","https://openalex.org/W3208396844"],"abstract_inverted_index":{"7656":[0],"Background:":[1],"The":[2],"protein":[3,10,48],"kinase":[4],"C":[5],"(PKC)":[6],"family":[7],"of":[8,29,60,101,147,318,329],"serine-threonine":[9],"kinases":[11],"has":[12],"been":[13],"shown":[14],"to":[15,42,98,200,289,342],"be":[16,43,333],"involved":[17],"in":[18,58,92,151,155,159,163,170,174,178,183,214,217,237,240,243,248,256,260,264,268,303,314,325],"tumor":[19,67,93],"cell":[20,71,80,84],"growth,":[21],"survival,":[22],"and":[23,87,103,109,124,131,181,223,246,305],"progression.":[24],"Tumor-induced":[25],"angiogenesis":[26],"requires":[27],"activation":[28],"PKCs,":[30],"particularly":[31],"PKC\u03b2,":[32],"through":[33],"vascular":[34],"endothelial":[35],"growth":[36],"factor":[37,313,324],"(VEGF)":[38],"pathways.":[39],"PKC\u03b2-2":[40],"appears":[41],"a":[44,310],"major":[45],"down-stream":[46],"signaling":[47],"for":[49,111,120,190,233,275,335],"the":[50,121,139,145,336],"VEGFR.":[51],"This":[52],"makes":[53],"PKC\u03b2":[54,300],"an":[55,321],"attractive":[56],"target":[57],"treatment":[59],"malignancies,":[61],"including":[62],"lung":[63,72],"cancer.":[64],"Methods:":[65],"135":[66],"samples":[68],"(111":[69],"Non-small":[70],"cancer":[73],"tissues":[74,253],"(52":[75],"adenocarcinomas":[76],"(AC),":[77],"34":[78],"large":[79],"(LC),":[81],"25":[82],"squamous":[83],"carcinoma":[85],"(SCC))":[86],"24":[88],"mesotheliomas":[89],"(MT))":[90],"arranged":[91],"microarrays":[94],"(TMAs)":[95],"were":[96,106,129],"subject":[97],"immunohistochemical":[99],"staining":[100,232],"PKC\u03b2-1":[102],"PKC\u03b2-2.":[104],"Results":[105],"analyzed":[107],"manually":[108],"scored":[110],"intensity":[112],"(1+,":[113],"2+,":[114],"3+).":[115],"Clinical":[116],"information":[117],"was":[118,136,149,168,188,211,235,273],"available":[119],"AC,":[122],"LC,":[123],"SCC":[125],"group.":[126],"Survival":[127],"curves":[128],"generated":[130],"median":[132,215],"survival":[133,187,203,216,272,292],"between":[134],"groups":[135],"compared":[137,199,288],"utilizing":[138],"Log-rank":[140],"methodology.":[141],"Results:":[142],"In":[143,230],"NSCLC":[144,304],"expression":[146,308,317],"PKC\u03b21":[148,194,234,307],"negative":[150,169,236,255],"1%":[152],"(1/107),":[153],"1+":[154,173,239,259],"14%":[156],"(15/107),":[157],"2+":[158,242,263],"43%":[160],"(46/107),":[161],"3+":[162,177,182,247,267],"42%":[164],"(45/107);":[165],"PKC\u03b22":[166,222,319],"immunostaining":[167],"28.4%":[171],"(29/102),":[172],"12.7%":[175],"(13/102),":[176],"23.6%":[179],"(24/102)":[180],"35.3%":[184],"(36/102).":[185],"Median":[186,271],"superior":[189,274],"patients":[191,218,276],"who":[192],"expressed":[193,221,302],"(2+":[195],"or":[196,285],"3+)":[197],"as":[198,287],"non-expressors":[201],"(median":[202,291],"1258":[204],"days":[205,294],"versus":[206,295],"124":[207],"days,":[208,297],"p<0.001).":[209,298],"There":[210],"no":[212],"difference":[213],"whose":[219,277],"tumors":[220,278],"those":[224],"that":[225],"did":[226,279],"not":[227,280],"express":[228,281],"it.":[229],"mesothelioma,":[231],"0,":[238,241],"8.3%":[244],"(2/24)":[245],"91.7%":[249],"(22/24).":[250],"For":[251],"PKC\u03b22,":[252],"stained":[254],"56.5%":[257],"(13/23),":[258],"21.8%":[261],"(5/23),":[262],"8.7%":[265],"(2/23),":[266],"13%":[269],"(3/23).":[270],"PKC-beta":[282],"2":[283],"(0":[284],"1+)":[286],"expressors":[290],"604":[293],"103":[296],"Conclusions:":[299],"is":[301,309,320],"mesothelioma.":[306,326],"favorable":[311],"prognostic":[312,323],"NSCLC,":[315],"whereas":[316],"adverse":[322],"Therapeutic":[327],"targeting":[328],"this":[330],"molecule":[331],"would":[332],"useful":[334],"future.":[337],"No":[338],"significant":[339],"financial":[340],"relationships":[341],"disclose.":[343]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}