{"id":"https://openalex.org/W2343348360","doi":"https://doi.org/10.1007/978-3-319-19294-9_8","title":"Amyloid Deposition in the Central Nervous System","display_name":"Amyloid Deposition in the Central Nervous System","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2343348360","doi":"https://doi.org/10.1007/978-3-319-19294-9_8","mag":"2343348360"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-19294-9_8","doi":"https://doi.org/10.1007/978-3-319-19294-9_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-19294-9_8","pdf_url":null,"source":{"id":"https://openalex.org/S4210174897","display_name":"Current clinical pathology","issn_l":"2197-781X","issn":["2197-781X","2197-7828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pathology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2567188833","display_name":"Amyloid and Related Disorders"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100605108","display_name":"Fausto J. Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-8662-1219","observed_orcids":["https://orcid.org/0000-0001-8662-1219"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fausto J. Rodriguez","raw_affiliation_strings":["Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD, 21231, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD, 21231, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090125195","display_name":"Maria Mrozowicz Picken","orcid":"https://orcid.org/0000-0002-8065-6178","observed_orcids":["https://orcid.org/0000-0002-8065-6178"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria M. Picken","raw_affiliation_strings":["Department of Pathology, Loyola University Medical Center, Loyola University Chicago, Building 110, Room 2242, 2160 South First Avenue, Maywood, IL, 60153, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Loyola University Medical Center, Loyola University Chicago, Building 110, Room 2242, 2160 South First Avenue, Maywood, IL, 60153, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000331309","display_name":"John Michael Lee","orcid":"https://orcid.org/0000-0001-8473-4674","observed_orcids":["https://orcid.org/0000-0001-8473-4674"]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Lee","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, NorthShore University Health System, Room 1914, 2650 Ridge Avenue, Evanston, IL, 60201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, NorthShore University Health System, Room 1914, 2650 Ridge Avenue, Evanston, IL, 60201, USA","institution_ids":["https://openalex.org/I1339509835"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100605108"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"],"apc_list":null,"apc_paid":null,"fwci":17.5664,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.97610514,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"121","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.6514000296592712,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.6514000296592712,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.32179999351501465,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.9390000104904175},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.9039999842643738},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8410000205039978},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7009999752044678},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/neuritic-plaques","display_name":"neuritic plaques","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cerebral-amyloid-angiopathy","display_name":"cerebral amyloid angiopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.7310000061988831},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.8489999771118164},{"id":"https://openalex.org/keywords/al-amyloid","display_name":"AL amyloid","score":0.7070000171661377},{"id":"https://openalex.org/keywords/amyloidoma","display_name":"amyloidoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/transthyretin-amyloidosis","display_name":"transthyretin amyloidosis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/systemic-amyloidosis","display_name":"systemic amyloidosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7879999876022339},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/fibril-formation","display_name":"fibril formation","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.7790827751159668},{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.7539716958999634},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6955442428588867},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.6948240399360657},{"id":"https://openalex.org/C80722340","wikidata":"https://www.wikidata.org/wiki/Q18297560","display_name":"Gelsolin","level":3,"score":0.6303440928459167},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5893296003341675},{"id":"https://openalex.org/C180081513","wikidata":"https://www.wikidata.org/wiki/Q4914721","display_name":"Biochemistry of Alzheimer's disease","level":5,"score":0.5435376763343811},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.46063292026519775},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.45931369066238403},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.43611493706703186},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.42144206166267395},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3652554750442505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34747982025146484},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34378719329833984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.337779700756073},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.31936055421829224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26699286699295044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19564706087112427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1567370891571045},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.13437896966934204},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.0},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-319-19294-9_8","doi":"https://doi.org/10.1007/978-3-319-19294-9_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-19294-9_8","pdf_url":null,"source":{"id":"https://openalex.org/S4210174897","display_name":"Current clinical pathology","issn_l":"2197-781X","issn":["2197-781X","2197-7828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Clinical Pathology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W23692640","https://openalex.org/W105153016","https://openalex.org/W1496803148","https://openalex.org/W1528620940","https://openalex.org/W1763829536","https://openalex.org/W1924633386","https://openalex.org/W1965760360","https://openalex.org/W1977390583","https://openalex.org/W1991414365","https://openalex.org/W1997103682","https://openalex.org/W2001640985","https://openalex.org/W2003686230","https://openalex.org/W2006666450","https://openalex.org/W2012078616","https://openalex.org/W2022165518","https://openalex.org/W2032576058","https://openalex.org/W2037224759","https://openalex.org/W2037590524","https://openalex.org/W2051028679","https://openalex.org/W2051941061","https://openalex.org/W2053349917","https://openalex.org/W2053675728","https://openalex.org/W2061267336","https://openalex.org/W2061690801","https://openalex.org/W2064367582","https://openalex.org/W2064772069","https://openalex.org/W2076227489","https://openalex.org/W2077589522","https://openalex.org/W2081598046","https://openalex.org/W2082573664","https://openalex.org/W2083046904","https://openalex.org/W2103440561","https://openalex.org/W2121151739","https://openalex.org/W2123957146","https://openalex.org/W2128228199","https://openalex.org/W2129949052","https://openalex.org/W2142134919","https://openalex.org/W2142287887","https://openalex.org/W2143461767","https://openalex.org/W2146729934","https://openalex.org/W2160008037","https://openalex.org/W2167765387","https://openalex.org/W2170068043","https://openalex.org/W2170253382","https://openalex.org/W2327214893"],"related_works":["https://openalex.org/W4213130780","https://openalex.org/W7221558454","https://openalex.org/W2098532656","https://openalex.org/W2026856895","https://openalex.org/W90549783","https://openalex.org/W48645661","https://openalex.org/W2504928878","https://openalex.org/W2070536520","https://openalex.org/W2049074281","https://openalex.org/W1986792544"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}