{"id":"https://openalex.org/W2343045213","doi":"https://doi.org/10.2147/ijn.s101030","title":"Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation","display_name":"Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2343045213","doi":"https://doi.org/10.2147/ijn.s101030","mag":"2343045213","pmid":"https://pubmed.ncbi.nlm.nih.gov/27217744","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4853011"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s101030","doi":"https://doi.org/10.2147/ijn.s101030","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s101030","pdf_url":"https://www.dovepress.com/getfile.php?fileID=30025","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=30025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101872548","display_name":"Xiaoling Fang","orcid":"https://orcid.org/0000-0002-8509-5867","observed_orcids":["https://orcid.org/0000-0002-8509-5867"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoling Fang","raw_affiliation_strings":["Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109846902","display_name":"Xiaoyan Zhang","orcid":"https://orcid.org/0000-0002-0300-8206","observed_orcids":["https://orcid.org/0000-0002-0300-8206"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyan Zhang","raw_affiliation_strings":["Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363477","display_name":"Xiaofei Wang","orcid":"https://orcid.org/0000-0002-8647-5271","observed_orcids":["https://orcid.org/0000-0002-8647-5271"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaofei Wang","raw_affiliation_strings":["Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025144789","display_name":"Weitong Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weitong Zhong","raw_affiliation_strings":["Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110823382","display_name":"Xiaoqing Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoqing Ren","raw_affiliation_strings":["Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072357652","display_name":"Xianyi Sha","orcid":"https://orcid.org/0000-0002-3134-6077","observed_orcids":["https://orcid.org/0000-0002-3134-6077","https://orcid.org/0000-0002-7107-0917","https://orcid.org/0000-0003-4574-4073"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4405271954","display_name":"Key Laboratory of Smart Drug Delivery, Ministry of Education","ror":"https://ror.org/03av49852","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianyi Sha","raw_affiliation_strings":["Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Smart Drug Delivery, Ministry of Education and People's Liberation Army of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025144789","https://openalex.org/A5072357652","https://openalex.org/A5100363477","https://openalex.org/A5101872548","https://openalex.org/A5109846902","https://openalex.org/A5110823382"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4405271954"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":2.9093,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.9061541,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"1643","last_page":"1643"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.796999990940094},{"id":"https://openalex.org/keywords/alpha-tocopheryl-succinate","display_name":"alpha-tocopheryl succinate","score":0.7630000114440918},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.7490000128746033},{"id":"https://openalex.org/keywords/stimuli-responsive-nanoparticles","display_name":"stimuli-responsive nanoparticles","score":0.6019999980926514},{"id":"https://openalex.org/keywords/tumor-accumulation","display_name":"tumor accumulation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6930000185966492},{"id":"https://openalex.org/keywords/type-iv-collagenase","display_name":"type IV collagenase","score":0.6129999756813049},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.3400000035762787},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.6209999918937683},{"id":"https://openalex.org/keywords/ht1080-cells","display_name":"HT1080 cells","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7374706864356995},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7365810871124268},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6820751428604126},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6246839761734009},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.6167629361152649},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.5360726714134216},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5105291604995728},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45147058367729187},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4499163329601288},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.43667203187942505},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3346841633319855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3128069043159485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2319149672985077},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1697324514389038},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.15205511450767517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10233521461486816},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08539879322052002},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024502","descriptor_name":"alpha-Tocopherol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066244","descriptor_name":"Proton Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s101030","doi":"https://doi.org/10.2147/ijn.s101030","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s101030","pdf_url":"https://www.dovepress.com/getfile.php?fileID=30025","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:27217744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27217744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4853011","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4853011/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ded3fa547de9447781da8ecc02e6f03d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ded3fa547de9447781da8ecc02e6f03d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2016, Iss default, Pp 1643-1661 (2016)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/26584","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/matrix-metalloproteinases-29-sensitive-peptide-conjugated-polymer-mice-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s101030","doi":"https://doi.org/10.2147/ijn.s101030","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s101030","pdf_url":"https://www.dovepress.com/getfile.php?fileID=30025","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3921637872","display_name":"\u6cbb\u7597\u591a\u836f\u8010\u836f\u80bf\u7624\u7684\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\u89e6\u53d1\u91ca\u653e\u80f6\u675f\u9012\u836f\u7cfb\u7edf\u6784\u5efa\u53ca\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"81373354","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2343045213.pdf","grobid_xml":"https://content.openalex.org/works/W2343045213.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1420516430","https://openalex.org/W1555862556","https://openalex.org/W1943317391","https://openalex.org/W1949636578","https://openalex.org/W1967587058","https://openalex.org/W1984294723","https://openalex.org/W1985169187","https://openalex.org/W1989714741","https://openalex.org/W1996917548","https://openalex.org/W2016834188","https://openalex.org/W2017052864","https://openalex.org/W2019837808","https://openalex.org/W2022785973","https://openalex.org/W2030031481","https://openalex.org/W2031886832","https://openalex.org/W2032580905","https://openalex.org/W2033486390","https://openalex.org/W2034534448","https://openalex.org/W2038449477","https://openalex.org/W2041040280","https://openalex.org/W2043132471","https://openalex.org/W2046785634","https://openalex.org/W2047601323","https://openalex.org/W2055196584","https://openalex.org/W2060265857","https://openalex.org/W2063763188","https://openalex.org/W2064444932","https://openalex.org/W2068956748","https://openalex.org/W2069360982","https://openalex.org/W2072969825","https://openalex.org/W2084287411","https://openalex.org/W2088142318","https://openalex.org/W2101312385","https://openalex.org/W2107529389","https://openalex.org/W2128657716","https://openalex.org/W2136267939","https://openalex.org/W2136428314","https://openalex.org/W2143775884","https://openalex.org/W2148883919","https://openalex.org/W2263415107","https://openalex.org/W2315776347","https://openalex.org/W2322972911","https://openalex.org/W2439457607"],"related_works":["https://openalex.org/W2752306846","https://openalex.org/W2940214340","https://openalex.org/W2031886832","https://openalex.org/W4293538870","https://openalex.org/W2889297391","https://openalex.org/W7098579003","https://openalex.org/W2483759957","https://openalex.org/W7172536846","https://openalex.org/W2132732108","https://openalex.org/W3048861964"],"abstract_inverted_index":{"Since":[0],"elevated":[1],"expression":[2],"of":[3,27,101,132,168,174,201,217,247],"matrix":[4],"metalloproteinase":[5],"(MMP)-2":[6],"and":[7,77,108,134,176,203,223,240,271],"MMP-9":[8],"is":[9],"commonly":[10],"observed":[11],"in":[12,24,60,165,192,209,227,243,248],"several":[13],"malignant":[14,44],"tumors,":[15],"MMPs":[16],"have":[17,33],"been":[18,34],"widely":[19],"reported":[20],"as":[21,71,93,119],"key":[22],"factors":[23],"the":[25,94,142,166,196,214,218],"design":[26],"drug":[28,49,161],"delivery":[29,50],"systems.":[30],"Several":[31],"strategies":[32],"proposed":[35,59],"to":[36,40,43,141],"develop":[37],"MMPs-responsive":[38],"nanoparticles":[39],"deliver":[41],"chemotherapeutics":[42],"solid":[45,260],"tumors.":[46],"A":[47],"stimuli-responsive":[48],"system,":[51],"which":[52],"could":[53,154],"be":[54,155],"cleaved":[55,157],"by":[56,86,158],"MMPs,":[57],"was":[58,91,116,163],"this":[61],"study.":[62],"By":[63],"inserting":[64],"an":[65],"MMP-2/9":[66],"cleavable":[67],"oligopeptide":[68],"GPVGLIGK-NH2":[69],"(GK8)":[70],"spacer":[72],"between":[73],"\u03b1-tocopherol":[74],"succinate":[75,106],"(\u03b1-TOS)":[76],"methoxy-polyethylene":[78],"glycol":[79,104],"molecular":[80],"weight":[81],"(MW":[82],"2000":[83],"Da)":[84],"activated":[85],"N-hydroxysuccinimide":[87],"(mPEG2K-NHS),":[88],"mPEG2K-GK8-\u03b1-TOS":[89],"(TGK)":[90],"synthesized":[92,118],"primary":[95],"ingredient":[96],"for":[97],"MMP-2/9-sensitive":[98,233],"micelles":[99,124,130,153,185,205,220,234,256,270],"composed":[100,131],"d-\u03b1-tocopheryl":[102],"polyethylene":[103],"1000":[105],"(TPGS)":[107],"TGK":[109,112,123,152,184,202,255],"(n:n":[110,136],"=40:60,":[111,137],"micelles).":[113],"mPEG2K-\u03b1-TOS":[114],"(T2K)":[115],"similarly":[117],"nonsensitive":[120,129,180],"control.":[121],"The":[122,232,245],"showed":[125,186],"better":[126],"stability":[127],"than":[128],"TPGS":[133],"T2K":[135,138,204,269],"micelles)":[139],"owing":[140],"inserted":[143],"peptide.":[144],"Fluorescence":[145],"resonance":[146],"energy":[147],"transfer":[148],"results":[149,246],"indicated":[150],"that":[151,254],"successfully":[156],"MMP-2/9.":[159],"Effective":[160],"release":[162],"demonstrated":[164,236],"presence":[167],"collagenase":[169],"type":[170],"IV,":[171],"a":[172,187],"mixture":[173],"MMP-2":[175],"MMP-9.":[177],"Compared":[178],"with":[179,268],"micelles,":[181],"docetaxel":[182],"(DTX)-loaded":[183],"fold":[188],"higher":[189],"cellular":[190],"uptake":[191],"HT1080":[193,228],"cells.":[194],"While":[195],"half-maximal":[197],"inhibitory":[198],"concentration":[199],"(IC50)":[200],"were":[206,221],"similar":[207],"(P>0.05)":[208],"MCF-7":[210],"cells":[211,229],"(MMP-2/9":[212,230],"underexpression),":[213],"IC50":[215],"values":[216],"aforementioned":[219],"0.064\u00b10.006":[222],"0.122\u00b10.009":[224],"\u03bcg/mL,":[225],"respectively,":[226],"overexpression).":[231],"also":[235],"desired":[237],"tumor":[238],"targeting":[239],"accumulation":[241],"ability":[242],"vivo.":[244],"vivo":[249],"antitumor":[250],"effect":[251],"evaluation":[252],"indicate":[253],"are":[257],"potent":[258],"against":[259],"tumors":[261],"while":[262],"maintaining":[263],"minimum":[264],"systemic":[265],"toxicity":[266],"compared":[267],"DTX.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}