{"id":"https://openalex.org/W2342575309","doi":"https://doi.org/10.1182/blood.v70.4.1111.1111","title":"The molecular species composition of phosphatidylcholine affects cellular properties in normal and sickle erythrocytes","display_name":"The molecular species composition of phosphatidylcholine affects cellular properties in normal and sickle erythrocytes","publication_year":1987,"publication_date":"1987-10-01","ids":{"openalex":"https://openalex.org/W2342575309","doi":"https://doi.org/10.1182/blood.v70.4.1111.1111","mag":"2342575309","pmid":"https://pubmed.ncbi.nlm.nih.gov/3651600"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v70.4.1111.1111","doi":"https://doi.org/10.1182/blood.v70.4.1111.1111","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.4.1111.1111","pdf_url":"https://ashpublications.org/blood/article-pdf/70/4/1111/1639967/1111.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/70/4/1111/1639967/1111.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047162260","display_name":"Frans A. Kuypers","orcid":"https://orcid.org/0000-0003-0731-1007","observed_orcids":["https://orcid.org/0000-0003-0731-1007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FA Kuypers","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070670135","display_name":"Danny Chiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Chiu","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034746599","display_name":"Narla Mohandas","orcid":"https://orcid.org/0000-0003-2271-5296","observed_orcids":["https://orcid.org/0000-0003-2271-5296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Mohandas","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025713708","display_name":"Ben Roelofsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Roelofsen","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109032210","display_name":"Jos A.F. Op den Kamp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JA Op den Kamp","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108348524","display_name":"Bertram H. Lubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Lubin","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.1312,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.92131809,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"70","issue":"4","first_page":"1111","last_page":"1118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.6952999830245972,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.18880000710487366,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-erythrocytes","display_name":"sickle erythrocytes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/phosphatidylcholine-molecular-species","display_name":"phosphatidylcholine molecular species","score":0.8920000195503235},{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.7070000171661377},{"id":"https://openalex.org/keywords/osmotic-fragility","display_name":"osmotic fragility","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cellular-hydration","display_name":"cellular hydration","score":0.7590000033378601},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.5699999928474426},{"id":"https://openalex.org/keywords/phospholipid-exchange","display_name":"phospholipid exchange","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ektacytometry","display_name":"ektacytometry","score":0.7400000095367432},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2780943371","wikidata":"https://www.wikidata.org/wiki/Q10860475","display_name":"POPC","level":4,"score":0.7990286946296692},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.7613645792007446},{"id":"https://openalex.org/C147509754","wikidata":"https://www.wikidata.org/wiki/Q3080327","display_name":"Erythrocyte fragility","level":3,"score":0.5988302826881409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5953266620635986},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4700685143470764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4467692971229553},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.43676093220710754},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.3284617066383362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28680163621902466},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.17435342073440552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11943879723548889}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004907","descriptor_name":"Erythrocyte Deformability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009995","descriptor_name":"Osmosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012805","descriptor_name":"Sickle Cell Trait","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012805","descriptor_name":"Sickle Cell Trait","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v70.4.1111.1111","doi":"https://doi.org/10.1182/blood.v70.4.1111.1111","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.4.1111.1111","pdf_url":"https://ashpublications.org/blood/article-pdf/70/4/1111/1639967/1111.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v70.4.1111.bloodjournal7041111","doi":"https://doi.org/10.1182/blood.v70.4.1111.bloodjournal7041111","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.4.1111.bloodjournal7041111","pdf_url":"https://ashpublications.org/blood/article-pdf/70/4/1111/365360/1111.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:3651600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3651600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v70.4.1111.1111","doi":"https://doi.org/10.1182/blood.v70.4.1111.1111","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v70.4.1111.1111","pdf_url":"https://ashpublications.org/blood/article-pdf/70/4/1111/1639967/1111.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life on land","score":0.5600000023841858}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1754442612","display_name":null,"funder_award_id":"HL20985","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G439031085","display_name":null,"funder_award_id":"HL 37593","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G84739426","display_name":null,"funder_award_id":"HL27059","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2342575309.pdf","grobid_xml":"https://content.openalex.org/works/W2342575309.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1486313261","https://openalex.org/W1556432187","https://openalex.org/W1582516167","https://openalex.org/W1973762235","https://openalex.org/W1986534624","https://openalex.org/W1988450880","https://openalex.org/W1992319346","https://openalex.org/W2022338330","https://openalex.org/W2039511387","https://openalex.org/W2054505726","https://openalex.org/W2078931238","https://openalex.org/W2079133297","https://openalex.org/W2089721987","https://openalex.org/W2091647374","https://openalex.org/W2107466815","https://openalex.org/W2186595494","https://openalex.org/W2299522784","https://openalex.org/W2409578844","https://openalex.org/W3021766009"],"related_works":["https://openalex.org/W1986534624","https://openalex.org/W1988450880","https://openalex.org/W2054505726","https://openalex.org/W7098821100","https://openalex.org/W2396871171","https://openalex.org/W2114904792","https://openalex.org/W2094427626","https://openalex.org/W2133099800","https://openalex.org/W2289816742","https://openalex.org/W2148486370"],"abstract_inverted_index":{"The":[0],"phosphatidylcholine":[1,18],"specific":[2],"transfer":[3],"protein":[4],"(PCTP)":[5],"from":[6],"bovine":[7],"liver":[8],"was":[9],"used":[10],"to":[11,81,123,141],"retailor":[12],"the":[13,21,148,159,171,175,185,189,202,207],"molecular":[14,33,203],"species":[15,34,204],"composition":[16,35,162,205],"of":[17,23,36,55,90,110,127,132,150,152,163,191,194,206],"(PC)":[19],"in":[20,32,63,66,72,97,113,174,179],"membrane":[22,208],"normal":[24,52,98],"(AA)":[25],"and":[26,45,86,165],"sickleable":[27],"(SS)":[28],"human":[29],"erythrocytes.":[30,181],"Changes":[31],"PC":[37,57,60,78,92,95,112,128,164],"altered":[38],"morphology":[39],"as":[40,42,47],"well":[41],"cellular":[43,87,124,142,192],"deformability":[44],"stability":[46],"measured":[48],"with":[49,58,69,76,116],"ektacytometry.":[50],"In":[51,107],"cells,":[53],"replacement":[54,75,109],"native":[56,91,111],"1-palmitoyl,2-arachidonoyl":[59],"(PAPC)":[61],"resulted":[62],"a":[64,167,168],"decrease":[65],"osmotic":[67,84],"fragility":[68,85],"no":[70,101],"change":[71],"hydration,":[73],"whereas":[74],"1,2-dipalmitoyl":[77],"(DPPC)":[79],"led":[80,122,140],"an":[82],"increased":[83],"hydration.":[88,125,143],"Replacement":[89],"by":[93,158,200],"1-palmitoyl,2-oleoyl":[94],"(POPC)":[96],"cells":[99,115,134,154,196],"had":[100],"apparent":[102],"effect":[103],"on":[104,136],"these":[105],"parameters.":[106],"contrast,":[108],"sickle":[114,153,180,195],"either":[117],"PAPC,":[118],"DPPC":[119],"or":[120],"POPC":[121],"Facilitation":[126],"exchange":[129],"between":[130],"subpopulations":[131],"SS":[133],"separated":[135],"buoyant":[137],"density":[138],"also":[139,183],"These":[144],"observations":[145],"suggest":[146],"that":[147,188],"state":[149,190],"hydration":[151,193],"can":[155],"be":[156,198],"modified":[157],"fatty":[160],"acyl":[161],"illustrate":[166],"role":[169],"for":[170],"lipid":[172],"core":[173],"observed":[176],"permeability":[177],"changes":[178],"They":[182],"raise":[184],"interesting":[186],"possibility":[187],"may":[197],"modulated":[199],"altering":[201],"phospholipids.":[209]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
