{"id":"https://openalex.org/W2342197935","doi":null,"title":"Understanding early animal evolution : genomics and cell fate specification in the ctenophore, Mnemiopsis leidyi","display_name":"Understanding early animal evolution : genomics and cell fate specification in the ctenophore, Mnemiopsis leidyi","publication_year":2010,"publication_date":"2010-12-01","ids":{"openalex":"https://openalex.org/W2342197935","mag":"2342197935"},"language":"en","primary_location":{"id":"pmh:oai:scholarspace.manoa.hawaii.edu:10125/101964","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10125/101964","pdf_url":null,"source":{"id":"https://openalex.org/S4306401722","display_name":"ScholarSpace (University of Hawaii at Manoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I117965899","host_organization_name":"University of Hawai\u02bbi at M\u0101noa","host_organization_lineage":["https://openalex.org/I117965899"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054623609","display_name":"Kevin Pang","orcid":"https://orcid.org/0000-0002-2365-9022","observed_orcids":["https://orcid.org/0000-0002-2365-9022"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kevin Pang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2365-9022","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054623609"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.22169999778270721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mnemiopsis-leidyi","display_name":"Mnemiopsis leidyi","score":0.9940000176429749},{"id":"https://openalex.org/keywords/early-animal-evolution","display_name":"early animal evolution","score":0.9290000200271606},{"id":"https://openalex.org/keywords/basal-metazoans","display_name":"basal metazoans","score":0.7820000052452087},{"id":"https://openalex.org/keywords/homeobox-genes","display_name":"homeobox genes","score":0.984000027179718},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/germ-cell-specification","display_name":"germ cell specification","score":0.9039999842643738},{"id":"https://openalex.org/keywords/vasa","display_name":"Vasa","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nanos","display_name":"Nanos","score":0.9950000047683716},{"id":"https://openalex.org/keywords/piwi","display_name":"Piwi","score":0.9860000014305115},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.7900000214576721},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6177137494087219},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5633258819580078},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.4619735777378082},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.33980751037597656},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.236821711063385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18585368990898132},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14539822936058044}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarspace.manoa.hawaii.edu:10125/101964","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10125/101964","pdf_url":null,"source":{"id":"https://openalex.org/S4306401722","display_name":"ScholarSpace (University of Hawaii at Manoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I117965899","host_organization_name":"University of Hawai\u02bbi at M\u0101noa","host_organization_lineage":["https://openalex.org/I117965899"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2342197935","doi":null,"is_oa":false,"landing_page_url":"https://scholarspace.manoa.hawaii.edu/bitstream/10125/101964/1/Pang_Kevin_r.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2164026798","https://openalex.org/W2123456802","https://openalex.org/W2165478882","https://openalex.org/W2150821870","https://openalex.org/W2021033468","https://openalex.org/W7096563669","https://openalex.org/W7096795010","https://openalex.org/W7097681288","https://openalex.org/W2144088079","https://openalex.org/W7136269172"],"abstract_inverted_index":{"In":[0,67],"recent":[1,282],"years,":[2],"molecular":[3],"phylogenetics":[4],"and":[5,38,64,93,102,112,143,175,183,244,284,293,321],"phylogenomics":[6],"have":[7,178,203,232,286,316],"suggested":[8],"that":[9,162,264],"ctenophores,":[10,28],"or":[11,257],"comb":[12],"jellies,":[13],"are":[14,48,147,189,198,221,329],"one":[15],"of":[16,27,55,75,119,122,141,156,223,269,310,325,332],"the":[17,23,32,53,59,79,117,123,139,163,224,228,246,266,308],"earliest":[18],"diverging":[19],"animals,":[20],"if":[21],"not":[22,251],"earliest.":[24],"The":[25],"placement":[26],"with":[29],"respect":[30],"to":[31,72,97,115,171,253,306],"other":[33,151,157],"\"basal":[34],"metazoans\"":[35],"(sponges,":[36],"cnidarians,":[37],"placozoans)":[39],"is":[40,138,167],"important":[41,49],"for":[42,50,206],"understanding":[43],"early":[44,274],"animal":[45,103,276],"evolution.":[46,104],"Ctenophores":[47],"learning":[51],"about":[52],"evolution":[54],"complex":[56],"features,":[57],"including":[58],"gut,":[60],"nervous":[61],"system,":[62],"muscle,":[63],"germ":[65,299,312,343],"cells.":[66,313],"this":[68],"dissertation,":[69],"we":[70,231,249,315],"hope":[71],"address":[73],"some":[74],"these":[76,270],"questions":[77],"using":[78],"lobate":[80],"ctenophore,":[81],"Mnemiopsis":[82],"leidyi,":[83],"an":[84,304],"emerging":[85],"model":[86],"organism.":[87],"We":[88,105,177,202,295],"utilized":[89,106],"genomic,":[90],"gene":[91,158],"expression,":[92],"experimental":[94],"embryological":[95],"techniques":[96,109],"better":[98],"understand":[99,307],"ctenophore":[100,164,311],"development":[101],"next-generation":[107],"sequencing":[108],"(mainly":[110],"454":[111],"Ilumina":[113],"sequencing)":[114],"sequence":[116],"genome":[118,124],"Mnemiopsis.":[120],"Searches":[121],"reveal":[125],"many":[126],"more":[127,169,281,330],"homeobox":[128],"genes":[129,207,302],"(76":[130],"in":[131,149,195,209,227,245,275,290,303,335,342],"total)":[132],"than":[133,173,341],"previously":[134],"described.":[135],"Most":[136],"notable":[137],"lack":[140],"Hox":[142],"ParaHox":[144],"genes,":[145,323],"which":[146],"found":[148],"all":[150],"animals":[152],"except":[153],"sponges.":[154],"Analyses":[155],"families":[159],"also":[160,179,296],"suggest":[161,263],"genomic":[165],"complement":[166],"much":[168],"similar":[170],"sponges":[172],"cnidarians":[174],"bilaterians.":[176],"identified":[180,204,234,317],"near-complete":[181],"Wnt/\u03b2-catenin":[182],"TGF-\u03b2":[184,200,247],"signaling":[185,271],"pathways.":[186],"While":[187,314],"there":[188,197],"relatively":[190],"few":[191],"Wnt":[192,229],"ligands":[193],"(4":[194],"total),":[196],"9":[199],"ligands.":[201],"orthologs":[205],"involved":[208],"ligand":[210],"secretion,":[211],"receptors,":[212],"as":[213,215],"well":[214],"intracellular":[216],"signal":[217],"transduction.":[218],"Notably":[219],"absent":[220],"most":[222],"secreted":[225],"antagonists:":[226],"pathway,":[230,248],"only":[233],"a":[235,280,288,333],"single":[236],"Secreted":[237],"Frizzled-related":[238],"protein":[239],"(no":[240],"Dickkopf,":[241],"WIF,":[242],"Cerberus)":[243],"were":[250,279],"able":[252],"detect":[254],"Chordin,":[255],"Noggin,":[256],"DAN":[258],"family":[259],"members.":[260],"This":[261],"would":[262],"while":[265],"core":[267],"components":[268],"pathways":[272],"evolved":[273],"evolution,":[277],"antagonists":[278],"innovation":[283],"may":[285],"played":[287],"role":[289,334],"bilaterian":[291],"diversity":[292],"complexity.":[294],"looked":[297],"at":[298],"cell":[300,338,344],"marker":[301],"effort":[305],"origin":[309],"multiple":[318],"Vasa,":[319],"Nanos,":[320],"Piwi":[322],"examination":[324],"their":[326],"expression":[327],"patterns":[328],"indicative":[331],"somatic":[336],"stem":[337],"specification":[339],"rather":[340],"specification.":[345]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}