{"id":"https://openalex.org/W2342099751","doi":null,"title":"An\u00e1lise da atividade da enzima delta-aminolevulinato desidratase (d-ALAD) no diabetes mellitus e no hipotireoidismo","display_name":"An\u00e1lise da atividade da enzima delta-aminolevulinato desidratase (d-ALAD) no diabetes mellitus e no hipotireoidismo","publication_year":2004,"publication_date":"2004-07-27","ids":{"openalex":"https://openalex.org/W2342099751","mag":"2342099751"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:1997383","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es do UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.ufsm.br/handle/1/11159","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049727505","display_name":"Jo\u00e3o Baptista D'andrea Souza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jo\u00e3o Baptista D'andrea Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049727505"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.07940000295639038,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta-aminolevulinic-acid-dehydratase","display_name":"delta-aminolevulinic acid dehydratase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8270000219345093},{"id":"https://openalex.org/keywords/primary-hypothyroidism","display_name":"primary hypothyroidism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.7990000247955322},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chlorpropamide","display_name":"chlorpropamide","score":0.8960000276565552},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glimepiride","display_name":"glimepiride","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9580000042915344},{"id":"https://openalex.org/keywords/heavy-metals","display_name":"heavy metals","score":0.47999998927116394},{"id":"https://openalex.org/keywords/lead","display_name":"lead","score":0.8259999752044678},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9980000257492065},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.8809999823570251},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6462910175323486},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4036006033420563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3606119751930237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35623711347579956},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2971053719520569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18512043356895447}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:1997383","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es do UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.ufsm.br:1/11159","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11159","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2342099751","doi":null,"is_oa":false,"landing_page_url":"http://cascavel.cpd.ufsm.br/tede/tde_arquivos/3/TDE-2007-07-06T093902Z-687/Publico/joao.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1997383","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11159","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es do UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W40113957","https://openalex.org/W66572528","https://openalex.org/W142495250","https://openalex.org/W150772031","https://openalex.org/W161706433","https://openalex.org/W1207588145","https://openalex.org/W1479810639","https://openalex.org/W1494322724","https://openalex.org/W1514591232","https://openalex.org/W1524100537","https://openalex.org/W1539261818","https://openalex.org/W1556304298","https://openalex.org/W1559486106","https://openalex.org/W1567125753","https://openalex.org/W1587278423","https://openalex.org/W1593421540","https://openalex.org/W1593538558","https://openalex.org/W1594856996","https://openalex.org/W1596458440","https://openalex.org/W1746650398","https://openalex.org/W1824833400","https://openalex.org/W1836373696","https://openalex.org/W1878740794","https://openalex.org/W1896185510","https://openalex.org/W1905282170","https://openalex.org/W1915188625","https://openalex.org/W1918045784","https://openalex.org/W1932277011","https://openalex.org/W1964586920","https://openalex.org/W1967305186","https://openalex.org/W1970320064","https://openalex.org/W1970436809","https://openalex.org/W1970936597","https://openalex.org/W1975920835","https://openalex.org/W1976314208","https://openalex.org/W1978611180","https://openalex.org/W1979949429","https://openalex.org/W1980165471","https://openalex.org/W1981517131","https://openalex.org/W1981944005","https://openalex.org/W1984465101","https://openalex.org/W1984830754","https://openalex.org/W1985169510","https://openalex.org/W1989514450","https://openalex.org/W1990353517","https://openalex.org/W1990424429","https://openalex.org/W1991152498","https://openalex.org/W1995180560","https://openalex.org/W1997017398","https://openalex.org/W1998198488","https://openalex.org/W1998614770","https://openalex.org/W2000129995","https://openalex.org/W2001192561","https://openalex.org/W2001591583","https://openalex.org/W2003476427","https://openalex.org/W2008889891","https://openalex.org/W2010822372","https://openalex.org/W2012619450","https://openalex.org/W2015404335","https://openalex.org/W2015875235","https://openalex.org/W2018174710","https://openalex.org/W2019003542","https://openalex.org/W2019656247","https://openalex.org/W2022208777","https://openalex.org/W2033704071","https://openalex.org/W2035417697","https://openalex.org/W2038908275","https://openalex.org/W2039533475","https://openalex.org/W2040005689","https://openalex.org/W2049584573","https://openalex.org/W2049591510","https://openalex.org/W2049730127","https://openalex.org/W2052696170","https://openalex.org/W2053815894","https://openalex.org/W2056462490","https://openalex.org/W2057485731","https://openalex.org/W2060895623","https://openalex.org/W2061643619","https://openalex.org/W2061953105","https://openalex.org/W2062389480","https://openalex.org/W2067675909","https://openalex.org/W2068793587","https://openalex.org/W2069461840","https://openalex.org/W2069588809","https://openalex.org/W2070311991","https://openalex.org/W2071637362","https://openalex.org/W2072914806","https://openalex.org/W2073945170","https://openalex.org/W2074853140","https://openalex.org/W2076569230","https://openalex.org/W2080136729","https://openalex.org/W2080306972","https://openalex.org/W2080775172","https://openalex.org/W2080904568","https://openalex.org/W2081953879","https://openalex.org/W2083562697","https://openalex.org/W2083786664","https://openalex.org/W2083912944","https://openalex.org/W2085357653","https://openalex.org/W2085612615","https://openalex.org/W2087185643","https://openalex.org/W2089878009","https://openalex.org/W2093435661","https://openalex.org/W2093979780","https://openalex.org/W2098169357","https://openalex.org/W2109939107","https://openalex.org/W2114507328","https://openalex.org/W2123788703","https://openalex.org/W2131679717","https://openalex.org/W2133406785","https://openalex.org/W2133548787","https://openalex.org/W2134023137","https://openalex.org/W2134845413","https://openalex.org/W2138928713","https://openalex.org/W2138994122","https://openalex.org/W2144732441","https://openalex.org/W2148101485","https://openalex.org/W2151464223","https://openalex.org/W2155083127","https://openalex.org/W2156492806","https://openalex.org/W2157222302","https://openalex.org/W2160802556","https://openalex.org/W2164063364","https://openalex.org/W2168723991","https://openalex.org/W2197681912","https://openalex.org/W2208810599","https://openalex.org/W2215017366","https://openalex.org/W2222559137","https://openalex.org/W2222617290","https://openalex.org/W2238669733","https://openalex.org/W2242900219","https://openalex.org/W2245434279","https://openalex.org/W2257062247","https://openalex.org/W2262929691","https://openalex.org/W2289923728","https://openalex.org/W2300695636","https://openalex.org/W2318516048","https://openalex.org/W2322913825","https://openalex.org/W2330973319","https://openalex.org/W2340763312","https://openalex.org/W2346770505","https://openalex.org/W2412182284","https://openalex.org/W2473765942","https://openalex.org/W2740824850"],"related_works":["https://openalex.org/W7120733445","https://openalex.org/W2029616926","https://openalex.org/W2050867160","https://openalex.org/W1979949429","https://openalex.org/W2262929691","https://openalex.org/W7018647193","https://openalex.org/W4281650870","https://openalex.org/W4300042936","https://openalex.org/W7029600905","https://openalex.org/W2521205314"],"abstract_inverted_index":{"The":[0,36,67],"activity":[1,48,68,121,182],"of":[2,19,38,49,69,88,122,143,147,164,183,189],"Delta-Aminolevulinate":[3],"Dehydratase":[4],"(d-ALA-D)":[5],"was":[6,130,157,167],"analyzed":[7],"in":[8,40,119,140,153,186,194,209],"patients":[9,20,94,108,155],"suffering":[10,95,109],"from":[11,170],"diabetes":[12,24,27,53,64,96],"mellitus":[13,54,65,97],"and":[14,33,80,102,124,192,198],"primary":[15,110],"hypothyroidism.":[16,84],"Five":[17],"groups":[18,42],"were":[21,113],"studied:":[22],"compensated":[23,29,63],"mellitus,":[25,28],"non-compensated":[26,31,52,72,83,190,196],"hypothyroidism,":[30],"hypothyroidism":[32,73,111],"control":[34,59,78],"group.":[35,66],"analysis":[37],"d-ALA-D":[39,50,70,135,184],"these":[41],"showed":[43,127],"the":[44,47,58,62,77,89,93,103,107,120,125,141,154,162,174,181,187,195,206],"following":[45],"results:":[46],"on":[51,71,134],"decreased":[55,193],"comparing":[56],"to":[57,61,76,82,115,205],"group,":[60],"increased":[74,185],"compared":[75],"group":[79,188],"also":[81],"In":[85],"vitro":[86],"analyses":[87],"drugs":[90],"used":[91,105],"by":[92,106],"(metformin,":[98],"chlorpropamide,":[99],"glibenclamide,":[100],"glimepiride)":[101],"drug":[104],"(thyroxine)":[112],"fulfilled":[114],"verify":[116],"some":[117],"change":[118],"d-ALA-D,":[123],"findings":[126],"that":[128,161,180],"there":[129],"not":[131,168],"any":[132],"changes":[133],"activity.":[136],"Metals":[137],"may":[138,199],"interfere":[139],"action":[142],"d-ALA-D.":[144],"Consequently,the":[145],"quantity":[146],"metals":[148,166],"(lead,":[149],"zinc,":[150],"copper)":[151],"present":[152],"blood":[156],"measured.":[158],"One":[159],"observed":[160,208],"amount":[163],"those":[165],"different,":[169],"a":[171],"statistical,":[172],"among":[173],"groups.":[175],"Therefore,":[176],"we":[177],"can":[178],"conclude":[179],"hipothyroidism":[191],"diabetes,":[197],"be":[200,203],"it":[201],"could":[202],"related":[204],"complications":[207],"such":[210],"pathologies":[211]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}