{"id":"https://openalex.org/W2342015244","doi":null,"title":"The role of geriatric assessment and frailty measurements in predicting surgical risk and survival in elderly patients with colorectal cancer : A prospective observational cohort study","display_name":"The role of geriatric assessment and frailty measurements in predicting surgical risk and survival in elderly patients with colorectal cancer : A prospective observational cohort study","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2342015244","mag":"2342015244"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/28000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/28000","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/28000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006753918","display_name":"Siri Rostoft","orcid":"https://orcid.org/0000-0002-4277-8641","observed_orcids":["https://orcid.org/0000-0002-4277-8641"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Siri Rostoft","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4277-8641","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006753918"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8510000109672546},{"id":"https://openalex.org/keywords/comprehensive-geriatric-assessment","display_name":"comprehensive geriatric assessment","score":0.9139999747276306},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9620000123977661},{"id":"https://openalex.org/keywords/postoperative-complications","display_name":"postoperative complications","score":0.843999981880188},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8870000243186951},{"id":"https://openalex.org/keywords/ecog-performance-status","display_name":"ECOG performance status","score":0.8939999938011169},{"id":"https://openalex.org/keywords/preoperative-frailty-assessment","display_name":"preoperative frailty assessment","score":0.5690000057220459},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9120000004768372},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.621999979019165},{"id":"https://openalex.org/keywords/walking-speed","display_name":"walking speed","score":0.9869999885559082},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.7599999904632568},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/malnutrition","display_name":"malnutrition","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8618839979171753},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.7207275629043579},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.56052565574646},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5587549805641174},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.5527448058128357},{"id":"https://openalex.org/C2777319248","wikidata":"https://www.wikidata.org/wiki/Q5550843","display_name":"Geriatric oncology","level":3,"score":0.5403850674629211},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5385772585868835},{"id":"https://openalex.org/C54183767","wikidata":"https://www.wikidata.org/wiki/Q10384","display_name":"Geriatrics","level":2,"score":0.5322480201721191},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4994785785675049},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4897754192352295},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4678438603878021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45550230145454407},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4410054683685303},{"id":"https://openalex.org/C2778595754","wikidata":"https://www.wikidata.org/wiki/Q177171","display_name":"Frailty syndrome","level":3,"score":0.4374653398990631},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.42481204867362976},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4148905277252197},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4063442647457123},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3570520281791687},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2909041561","wikidata":"https://www.wikidata.org/wiki/Q25099514","display_name":"Frailty Index","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/28000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/28000","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2342015244","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/28000/3/dravhandling-kristjansson.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/28000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/28000","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W104618508","https://openalex.org/W1524996874","https://openalex.org/W1525217260","https://openalex.org/W1750611917","https://openalex.org/W1799620269","https://openalex.org/W1847168837","https://openalex.org/W1974032748","https://openalex.org/W1975019358","https://openalex.org/W1978229612","https://openalex.org/W1978438328","https://openalex.org/W1979579704","https://openalex.org/W1987241610","https://openalex.org/W1989460280","https://openalex.org/W1995056174","https://openalex.org/W1997921783","https://openalex.org/W2013914113","https://openalex.org/W2015625030","https://openalex.org/W2024620182","https://openalex.org/W2030493046","https://openalex.org/W2038944059","https://openalex.org/W2040596866","https://openalex.org/W2043528279","https://openalex.org/W2046021994","https://openalex.org/W2052431972","https://openalex.org/W2067131061","https://openalex.org/W2067840329","https://openalex.org/W2086868063","https://openalex.org/W2093287455","https://openalex.org/W2100357902","https://openalex.org/W2101338610","https://openalex.org/W2107029525","https://openalex.org/W2107640783","https://openalex.org/W2108688205","https://openalex.org/W2112519660","https://openalex.org/W2116041825","https://openalex.org/W2122443513","https://openalex.org/W2139524087","https://openalex.org/W2145188374","https://openalex.org/W2145573611","https://openalex.org/W2152456824","https://openalex.org/W2163709153","https://openalex.org/W2164059021","https://openalex.org/W2167571044","https://openalex.org/W2169742106","https://openalex.org/W2339769063"],"related_works":["https://openalex.org/W2067840329","https://openalex.org/W3168503702","https://openalex.org/W7099435472","https://openalex.org/W4309467172","https://openalex.org/W2151335909","https://openalex.org/W7113242848","https://openalex.org/W2154194062","https://openalex.org/W2209686702","https://openalex.org/W2651607898","https://openalex.org/W4220807075"],"abstract_inverted_index":{"Background:":[0],"Colorectal":[1],"cancer":[2,49,740],"(CRC)":[3],"can":[4,647],"be":[5,93,672,713],"considered":[6],"a":[7,13,54,67,89,112,127,140,159,172,199,212,219,222,401,582,653,679,731],"disease":[8],"of":[9,16,18,111,123,142,150,161,178,193,225,236,250,278,306,310,326,336,344,363,367,404,465,470,476,496,524,532,630,657,682,686,719,734,739],"the":[10,23,39,107,121,147,156,164,176,234,237,265,337,361,368,413,416,431,434,567,595,683,714],"elderly,":[11],"with":[12,400,488,640],"median":[14,402],"age":[15,31,403,481],"diagnosis":[17],"72":[19],"years.":[20],"Surgery":[21],"is":[22,66,129,135,742],"main":[24],"treatment":[25,60],"for":[26,275,423,430,664,693],"colorectal":[27],"cancer.":[28],"As":[29,725],"chronological":[30],"does":[32],"not":[33,486],"accurately":[34],"reflect":[35],"physiological":[36],"reserves":[37],"in":[38,84,117,181,227,258,284,341,521,604,612,637,689,737],"heterogeneous":[40],"elderly":[41,118,182],"population,":[42],"it":[43],"has":[44],"been":[45],"suggested":[46],"that":[47],"older":[48,85,228,259],"patients":[50,91,162,184,261,420,427,439,441,456,478,642,650],"may":[51,92],"benefit":[52],"from":[53,126,198,280,678],"comprehensive":[55],"geriatric":[56,132],"assessment":[57,305],"(CGA)":[58],"before":[59],"decisions":[61],"are":[62,702],"made.":[63],"A":[64,301],"CGA":[65,113,128,174,200,220,646],"systematic":[68],"approach":[69],"aiming":[70],"to":[71,189,210,221,232,240,247,264,282,506,518,540,548,562,566,671,712],"assess":[72],"physical":[73,143,148,376,684],"function,":[74,80],"comorbidity,":[75,348,705],"polypharmacy,":[76],"nutritional":[77],"status,":[78],"cognitive":[79,349],"and":[81,114,175,196,201,231,244,256,294,313,318,381,392,395,450,473,482,508,528,542,575,578,589,625,632,708,722],"emotional":[82],"status":[83,207],"patients.":[86,119,615],"Based":[87],"on":[88,171,218],"CGA,":[90,303],"divided":[94],"into":[95,163,415],"three":[96,285,364,417,461],"groups:":[97],"Fit,":[98],"intermediate,":[99,167,449],"or":[100,168,334,353,365],"frail.":[101,454],"Few":[102],"prospective":[103],"studies":[104,738],"have":[105,652],"investigated":[106],"associations":[108],"between":[109,158,433,594],"elements":[110],"surgical":[115],"outcomes":[116,695],"Furthermore,":[120],"definition":[122],"\u201cfrailty\u201d":[124],"derived":[125],"controversial.":[130],"In":[131],"medicine,":[133],"frailty":[134,151,215,267,436,597,668,676,687],"more":[136,335,366,583,673],"commonly":[137],"defined":[138,330,359],"as":[139,331,360,444,448,453,697],"cluster":[141],"impairments":[144],"(often":[145],"called":[146],"phenotype":[149,685],"\u2013":[152],"PF).\\n\\nAims:":[153],"To":[154],"study":[155],"association":[157],"categorization":[160,414],"groups":[165],"fit,":[166,445],"frail":[169,477,638,649],"based":[170,217],"pre-operative":[173,213,302],"risk":[177,656],"post-operative":[179,194,242,388,619,659,720],"complications":[180,195,243,389,498,620,660,721],"CRC":[183,229,260,279],"who":[185,651],"were":[186,298,316,321,387,410,421,428,442,485,530,634],"electively":[187,273],"operated;":[188],"identify":[190,648],"independent":[191,494],"predictors":[192,531],"survival":[197],"Eastern":[202],"Cooperative":[203],"Oncology":[204],"Group":[205],"performance":[206],"(ECOG":[208],"PS);":[209],"compare":[211,248],"multi-domain":[214,667],"measurement":[216,669],"modified":[223,680],"version":[224,681],"PF":[226,357,609,626],"patients,":[230,467,472,607],"analyze":[233],"ability":[235],"two":[238,266,435,596],"measurements":[239,309,701],"predict":[241],"overall":[245,396,698,723],"survival;":[246],"levels":[249],"inflammatory":[251],"biomarkers":[252],"(CRP,":[253],"IL-6,":[254],"TNF-\u03b1),":[255],"Ddimer":[257],"classified":[262],"according":[263],"definitions.\\n\\nMethods:":[268],"Patients":[269,398],"\u2265":[270],"70":[271],"years":[272,406],"operated":[274],"all":[276,729],"stages":[277],"2006":[281],"2008":[283],"Norwegian":[286],"hospitals":[287],"(Ullevaal":[288],"University":[289,292,296],"Hospital,":[290,293],"Aker":[291],"Akershus":[295],"Hospital)":[297],"consecutively":[299],"included.":[300,411],"an":[304,493],"self-reported":[307],"health,":[308],"grip":[311,379],"strength":[312],"gait":[314,383],"speed":[315],"performed,":[317],"blood":[319],"samples":[320],"drawn":[322],"within":[323,643],"14":[324],"days":[325],"surgery.":[327],"CGA-frailty":[328,601,617],"was":[329,358,492,581,599,602,610],"fulfilling":[332],"one":[333],"following":[338,369],"criteria:":[339,370],"Dependency":[340,520],"personal":[342],"activities":[343,523],"daily":[345,355,525],"living,":[346],"severe":[347,393,458,497],"dysfunction,":[350],"depression,":[351,588,707],"malnutrition,":[352],">7":[354],"medications.":[356],"presence":[362],"Unintentional":[371],"weight":[372],"loss,":[373],"exhaustion,":[374],"low":[375],"activity,":[377],"impaired":[378,552,590,709],"strength,":[380],"slow":[382],"speed.":[384],"Outcome":[385],"measures":[386],"(any":[390],"complication":[391,534],"complications)":[394],"survival.\\n\\nResults:":[397],"(182)":[399],"80":[405],"(range,":[407],"70-94":[408],"years)":[409],"For":[412],"CGA-groups,":[418],"178":[419],"available":[422,429],"analyses,":[424],"while":[425,551,608],"176":[426],"comparison":[432],"classifications.":[437],"Twenty-one":[438],"(12%)":[440],"categorized":[443],"81":[446],"(46%)":[447],"76":[451],"(43%)":[452,606],"Eighty-three":[455],"experienced":[457],"complications,":[459],"including":[460],"deaths;":[462],"7/21":[463],"(33%)":[464],"fit":[466],"29/81":[468],"(36%)":[469],"intermediate":[471],"47/76":[474],"(62%)":[475],"(p=0.002).":[479],"Increasing":[480],"ASA":[483],"class":[484],"associated":[487],"complications.":[489],"Severe":[490,704],"comorbidity":[491],"predictor":[495,585],"(odds":[499],"ratio":[500,512],"[OR]":[501],"5.62;":[502],"95%":[503,515,537,545,559],"CI":[504,516,538,546,560],"2.18":[505],"14.50)":[507],"early":[509,555,576],"mortality":[510,556],"(hazard":[511],"[HR]":[513],"2.78;":[514],"1.50":[517],"5.17).":[519],"instrumental":[522],"living":[526],"(IADL)":[527],"depression":[529],"any":[533],"(OR":[535],"4.02;":[536],"1.24":[539,561],"13.09":[541],"OR":[543],"3.68;":[544],"0.96":[547],"14.08,":[549],"respectively)":[550],"nutrition":[553,710],"predicted":[554,572,618,627],"(HR":[557],"2.39,":[558],"4.61).":[563],"When":[564],"added":[565],"models,":[568],"ECOG":[569,579,726,735],"PS":[570,580,727,736],"independently":[571],"both":[573,644,700],"morbidity":[574],"mortality,":[577],"powerful":[584],"than":[586,675],"IADL-dependency,":[587,706],"nutrition.":[591],"The":[592],"agreement":[593],"classifications":[598],"poor.":[600],"identified":[603,611,677],"75":[605],"22":[613],"(13%)":[614],"Only":[616],"(p=":[621],"0.001).":[622],"Both":[623],"CGAfrailty":[624],"survival.":[628,724],"Levels":[629],"CRP":[631],"IL-6":[633],"significantly":[635,654],"higher":[636],"compared":[639],"non-frail":[641],"measures.\\n\\nConclusions:":[645],"increased":[655],"developing":[658],"after":[661],"elective":[662],"surgery":[663,741],"CRC.":[665],"This":[666],"appears":[670],"useful":[674],"criteria":[688],"predicting":[690],"morbidity,":[691],"but":[692],"long-term":[694],"such":[696],"survival,":[699],"predictive.":[703],"seem":[711],"most":[715],"important":[716],"CGAelements":[717],"predictive":[718],"predicts":[728],"outcomes,":[730],"consistent":[732],"use":[733],"recommended.":[743]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}