{"id":"https://openalex.org/W2341900790","doi":null,"title":"Dissecting the prostate cancer stem cell niche inside the bone marrow","display_name":"Dissecting the prostate cancer stem cell niche inside the bone marrow","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2341900790","mag":"2341900790"},"language":"en","primary_location":{"id":"mag:2341900790","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/88935/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055002056","display_name":"Kai Dun Tang","orcid":"https://orcid.org/0000-0002-1715-1572","observed_orcids":["https://orcid.org/0000-0002-1715-1572"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kai Dun Tang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1715-1572","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055002056"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.6039999723434448},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.6460000276565552},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8262454271316528},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6416800618171692},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5857768058776855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5473905801773071},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5203297138214111},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4835462272167206},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.46448713541030884},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45800280570983887},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.43955469131469727},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42708495259284973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3719403147697449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3403252363204956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25739872455596924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.05111551284790039}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2341900790","doi":null,"is_oa":false,"landing_page_url":"https://eprints.qut.edu.au/88935/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":199,"referenced_works":["https://openalex.org/W160983855","https://openalex.org/W1263532934","https://openalex.org/W1489915607","https://openalex.org/W1499083095","https://openalex.org/W1512873314","https://openalex.org/W1583758525","https://openalex.org/W1594020010","https://openalex.org/W1604996052","https://openalex.org/W1757407923","https://openalex.org/W1758777074","https://openalex.org/W1861502977","https://openalex.org/W1862594138","https://openalex.org/W1907219612","https://openalex.org/W1917059837","https://openalex.org/W1959606306","https://openalex.org/W1964305994","https://openalex.org/W1969224630","https://openalex.org/W1970614272","https://openalex.org/W1970919014","https://openalex.org/W1971084689","https://openalex.org/W1971261368","https://openalex.org/W1972774425","https://openalex.org/W1974348351","https://openalex.org/W1974679236","https://openalex.org/W1974756622","https://openalex.org/W1975025595","https://openalex.org/W1976237784","https://openalex.org/W1976769554","https://openalex.org/W1979847738","https://openalex.org/W1979878315","https://openalex.org/W1980723266","https://openalex.org/W1981406217","https://openalex.org/W1981711832","https://openalex.org/W1981817858","https://openalex.org/W1985753549","https://openalex.org/W1986308117","https://openalex.org/W1990931020","https://openalex.org/W1996027069","https://openalex.org/W1996634799","https://openalex.org/W1996675413","https://openalex.org/W1999178985","https://openalex.org/W1999249427","https://openalex.org/W1999520428","https://openalex.org/W2004135885","https://openalex.org/W2004870721","https://openalex.org/W2005448885","https://openalex.org/W2005658600","https://openalex.org/W2006771504","https://openalex.org/W2009231148","https://openalex.org/W2009886463","https://openalex.org/W2010649103","https://openalex.org/W2012587702","https://openalex.org/W2012884263","https://openalex.org/W2013746143","https://openalex.org/W2015173256","https://openalex.org/W2018165590","https://openalex.org/W2018651910","https://openalex.org/W2019522090","https://openalex.org/W2020046515","https://openalex.org/W2020073255","https://openalex.org/W2022810442","https://openalex.org/W2023041438","https://openalex.org/W2025044898","https://openalex.org/W2025319771","https://openalex.org/W2025453701","https://openalex.org/W2027012830","https://openalex.org/W2028593825","https://openalex.org/W2029065458","https://openalex.org/W2030900422","https://openalex.org/W2032353251","https://openalex.org/W2032670445","https://openalex.org/W2032738143","https://openalex.org/W2033303879","https://openalex.org/W2033603982","https://openalex.org/W2033799907","https://openalex.org/W2035521247","https://openalex.org/W2036380534","https://openalex.org/W2039015433","https://openalex.org/W2039628288","https://openalex.org/W2039748263","https://openalex.org/W2040393519","https://openalex.org/W2041237929","https://openalex.org/W2042450855","https://openalex.org/W2043034449","https://openalex.org/W2043578759","https://openalex.org/W2044801274","https://openalex.org/W2045159219","https://openalex.org/W2046234516","https://openalex.org/W2046558067","https://openalex.org/W2047373489","https://openalex.org/W2049984303","https://openalex.org/W2050696207","https://openalex.org/W2051025382","https://openalex.org/W2052531429","https://openalex.org/W2053322058","https://openalex.org/W2053615441","https://openalex.org/W2053970131","https://openalex.org/W2057280160","https://openalex.org/W2058112104","https://openalex.org/W2060610551","https://openalex.org/W2061541169","https://openalex.org/W2062069198","https://openalex.org/W2062336370","https://openalex.org/W2064717188","https://openalex.org/W2064844805","https://openalex.org/W2066123991","https://openalex.org/W2067206898","https://openalex.org/W2067219166","https://openalex.org/W2067829376","https://openalex.org/W2068499731","https://openalex.org/W2069026920","https://openalex.org/W2069417165","https://openalex.org/W2069601051","https://openalex.org/W2069749649","https://openalex.org/W2069781632","https://openalex.org/W2069906023","https://openalex.org/W2070793750","https://openalex.org/W2077173862","https://openalex.org/W2077781719","https://openalex.org/W2077841029","https://openalex.org/W2078791728","https://openalex.org/W2080162976","https://openalex.org/W2081263253","https://openalex.org/W2083274861","https://openalex.org/W2083832224","https://openalex.org/W2084904700","https://openalex.org/W2086239621","https://openalex.org/W2087228836","https://openalex.org/W2087861588","https://openalex.org/W2091443952","https://openalex.org/W2092995389","https://openalex.org/W2093818708","https://openalex.org/W2094755503","https://openalex.org/W2095812294","https://openalex.org/W2096745826","https://openalex.org/W2098017099","https://openalex.org/W2099613822","https://openalex.org/W2099636307","https://openalex.org/W2102188124","https://openalex.org/W2102356696","https://openalex.org/W2102969047","https://openalex.org/W2105373880","https://openalex.org/W2107264623","https://openalex.org/W2107863336","https://openalex.org/W2108060570","https://openalex.org/W2114236835","https://openalex.org/W2114817620","https://openalex.org/W2114853793","https://openalex.org/W2115021142","https://openalex.org/W2115226530","https://openalex.org/W2115806147","https://openalex.org/W2117778806","https://openalex.org/W2119302852","https://openalex.org/W2124688359","https://openalex.org/W2124994950","https://openalex.org/W2128238959","https://openalex.org/W2129172946","https://openalex.org/W2130160735","https://openalex.org/W2130955565","https://openalex.org/W2134605629","https://openalex.org/W2135236290","https://openalex.org/W2137267184","https://openalex.org/W2137782229","https://openalex.org/W2137958038","https://openalex.org/W2138804795","https://openalex.org/W2141091746","https://openalex.org/W2141417189","https://openalex.org/W2142112207","https://openalex.org/W2143327951","https://openalex.org/W2143995836","https://openalex.org/W2145519498","https://openalex.org/W2146241268","https://openalex.org/W2148842373","https://openalex.org/W2152364190","https://openalex.org/W2152988906","https://openalex.org/W2153195684","https://openalex.org/W2153878708","https://openalex.org/W2154430204","https://openalex.org/W2154608911","https://openalex.org/W2154977172","https://openalex.org/W2155199345","https://openalex.org/W2155447039","https://openalex.org/W2155507705","https://openalex.org/W2157211816","https://openalex.org/W2158767022","https://openalex.org/W2158903927","https://openalex.org/W2159715390","https://openalex.org/W2161810908","https://openalex.org/W2163360413","https://openalex.org/W2163925640","https://openalex.org/W2166889065","https://openalex.org/W2167946377","https://openalex.org/W2169752217","https://openalex.org/W2171456003","https://openalex.org/W2273971600","https://openalex.org/W2346423295","https://openalex.org/W2416021581","https://openalex.org/W2737321857","https://openalex.org/W7098392294"],"related_works":["https://openalex.org/W3143069899","https://openalex.org/W4244500648","https://openalex.org/W2036626214","https://openalex.org/W2765442113","https://openalex.org/W3088266417","https://openalex.org/W2006375773","https://openalex.org/W4301033838","https://openalex.org/W6940242868","https://openalex.org/W1979642052","https://openalex.org/W2990125601"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,11,47,77],"frequently":[2],"metastasizes":[3],"to":[4,14],"bone,":[5],"which":[6],"becomes":[7],"incurable;":[8],"yet":[9],"how":[10],"cells":[12,34],"manage":[13],"migrate":[15],"and":[16,32,43,49,71,78],"grow":[17],"inside":[18],"the":[19,36,41,66,80,84,88],"bone":[20,31,37],"remains":[21],"unknown.":[22],"In":[23],"this":[24],"study":[25],"I":[26],"have":[27,50,79],"discovered":[28],"that":[29,54],"both":[30],"fat":[33],"within":[35],"marrow":[38],"actively":[39],"promote":[40],"survival":[42],"expansion":[44],"of":[45,68,87],"prostate":[46,76],"cells,":[48],"subsequently":[51],"developed":[52],"approaches":[53,73],"can":[55],"effectively":[56],"inhibit":[57],"these":[58],"processes.":[59],"Therefore,":[60],"my":[61],"work":[62],"offers":[63],"opportunities":[64],"for":[65,82],"development":[67],"new":[69],"prognostic":[70],"therapeutic":[72],"against":[74],"metastatic":[75],"potential":[81],"improving":[83],"treatment":[85],"outcome":[86],"patients.":[89]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
