{"id":"https://openalex.org/W2341126117","doi":"https://doi.org/10.2217/epi-2015-0004","title":"Tagging Methyl-CpG-Binding Domain Proteins Reveals Different Spatiotemporal Expression and Supports Distinct Functions","display_name":"Tagging Methyl-CpG-Binding Domain Proteins Reveals Different Spatiotemporal Expression and Supports Distinct Functions","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2341126117","doi":"https://doi.org/10.2217/epi-2015-0004","mag":"2341126117","pmid":"https://pubmed.ncbi.nlm.nih.gov/27066839","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928502"},"language":"en","primary_location":{"id":"doi:10.2217/epi-2015-0004","doi":"https://doi.org/10.2217/epi-2015-0004","is_oa":false,"landing_page_url":"https://doi.org/10.2217/epi-2015-0004","pdf_url":null,"source":{"id":"https://openalex.org/S42283280","display_name":"Epigenomics","issn_l":"1750-1911","issn":["1750-1911","1750-192X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928502","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065166129","display_name":"Kathleen H. Wood","orcid":"https://orcid.org/0000-0001-6566-4885","observed_orcids":["https://orcid.org/0000-0001-6566-4885"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen H Wood","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021817138","display_name":"Brian S. Johnson","orcid":"https://orcid.org/0000-0003-3711-5920","observed_orcids":["https://orcid.org/0000-0003-3711-5920"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian S Johnson","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061192490","display_name":"Sarah A. Welsh","orcid":"https://orcid.org/0000-0003-2251-1111","observed_orcids":["https://orcid.org/0000-0003-2251-1111"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A Welsh","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899563","display_name":"Jun Y. Lee","orcid":"https://orcid.org/0000-0002-6266-7957","observed_orcids":["https://orcid.org/0000-0002-6266-7957"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Y Lee","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711126","display_name":"Yue Cui","orcid":"https://orcid.org/0000-0002-0313-4472","observed_orcids":["https://orcid.org/0000-0002-0313-4472"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Cui","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070321357","display_name":"Elizabeth N. Krizman","orcid":"https://orcid.org/0000-0001-8529-587X","observed_orcids":["https://orcid.org/0000-0001-8529-587X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Krizman","raw_affiliation_strings":["Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057419336","display_name":"Edward S. Brodkin","orcid":"https://orcid.org/0000-0003-1417-7838","observed_orcids":["https://orcid.org/0000-0003-1417-7838"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward S Brodkin","raw_affiliation_strings":["Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022907334","display_name":"Julie A. Blendy","orcid":"https://orcid.org/0000-0003-1705-9001","observed_orcids":["https://orcid.org/0000-0003-1705-9001"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A Blendy","raw_affiliation_strings":["Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088576139","display_name":"Michael B. Robinson","orcid":"https://orcid.org/0000-0003-0162-2218","observed_orcids":["https://orcid.org/0000-0003-0162-2218","https://orcid.org/0000-0002-6620-9830"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B Robinson","raw_affiliation_strings":["Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA19104, USA","Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Philadelphia Research Institute, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033201701","display_name":"Marisa S. Bartolomei","orcid":"https://orcid.org/0000-0001-9410-5222","observed_orcids":["https://orcid.org/0000-0001-9410-5222"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marisa S Bartolomei","raw_affiliation_strings":["Department of Cell &amp; Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA191041, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell &amp; Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA191041, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014989628","display_name":"Zhaolan Zhou","orcid":"https://orcid.org/0000-0003-1401-0296","observed_orcids":["https://orcid.org/0000-0003-1401-0296"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhaolan Zhou","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014989628"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.6993,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.83652132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"455","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyl-cpg-binding-domain-proteins","display_name":"methyl-CpG binding domain proteins","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mbd2","display_name":"MBD2","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mbd1","display_name":"MBD1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/spatiotemporal-gene-expression","display_name":"spatiotemporal gene expression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.8299999833106995},{"id":"https://openalex.org/keywords/behavioral-phenotypes","display_name":"behavioral phenotypes","score":0.8489999771118164},{"id":"https://openalex.org/keywords/brain-function","display_name":"brain function","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8090435862541199},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6387538313865662},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6156584620475769},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4992971420288086},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.49603351950645447},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.49102258682250977},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.473540723323822},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.47327399253845215},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.43821391463279724},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4165952205657959},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4157969355583191},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4001469612121582},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3865219056606293},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.29883915185928345}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001679","descriptor_name":"Biogenic Amines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055879","descriptor_name":"Gene Knock-In Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056245","descriptor_name":"Mi-2 Nucleosome Remodeling and Deacetylase Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056245","descriptor_name":"Mi-2 Nucleosome Remodeling and Deacetylase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057507","descriptor_name":"Mice, 129 Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062211","descriptor_name":"Spatio-Temporal Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2217/epi-2015-0004","doi":"https://doi.org/10.2217/epi-2015-0004","is_oa":false,"landing_page_url":"https://doi.org/10.2217/epi-2015-0004","pdf_url":null,"source":{"id":"https://openalex.org/S42283280","display_name":"Epigenomics","issn_l":"1750-1911","issn":["1750-1911","1750-192X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4928502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"Text"},{"id":"pmid:27066839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27066839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4928502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4928502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Epigenomics","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1273486473","display_name":"Developmental Trajectories of Negative Symptoms in Schizophrenia","funder_award_id":"P50MH096891","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1663021542","display_name":"The Intellectual and Developmental Disabilities Research Center at CHOP/Penn","funder_award_id":"U54HD086984","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G238342678","display_name":null,"funder_award_id":"U54HD086984","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G4257857766","display_name":"Predoctoral Training Program in Genetics","funder_award_id":"T32GM008216","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7802402020","display_name":"Defining the Epigenetic Architecture Associated with Early-Life Stress","funder_award_id":"R01MH091850","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8596008389","display_name":"Intellectual and Developmental Disablities Research Center","funder_award_id":"P30HD018655","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000872793","display_name":"Center of Excellence in Environmental Toxicology","funder_award_id":"P30ES013508","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332591","display_name":"Intellectual and Developmental Disabilities Research Center","ror":"https://ror.org/02pttbw34"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1023621276","https://openalex.org/W1504663603","https://openalex.org/W1552016186","https://openalex.org/W1556074533","https://openalex.org/W1559742681","https://openalex.org/W1637312052","https://openalex.org/W1674079630","https://openalex.org/W1784857457","https://openalex.org/W1951484887","https://openalex.org/W1973871665","https://openalex.org/W1975964055","https://openalex.org/W1976507388","https://openalex.org/W1982279452","https://openalex.org/W1984589574","https://openalex.org/W1985634754","https://openalex.org/W1987557775","https://openalex.org/W1997866877","https://openalex.org/W2001936578","https://openalex.org/W2006285540","https://openalex.org/W2013655994","https://openalex.org/W2014817033","https://openalex.org/W2021090329","https://openalex.org/W2023879783","https://openalex.org/W2027703149","https://openalex.org/W2029239227","https://openalex.org/W2030513330","https://openalex.org/W2035188076","https://openalex.org/W2035770994","https://openalex.org/W2039276157","https://openalex.org/W2040875973","https://openalex.org/W2040889890","https://openalex.org/W2043335534","https://openalex.org/W2044798039","https://openalex.org/W2046495454","https://openalex.org/W2046812959","https://openalex.org/W2053056530","https://openalex.org/W2062976968","https://openalex.org/W2071188966","https://openalex.org/W2074370892","https://openalex.org/W2079706646","https://openalex.org/W2081756408","https://openalex.org/W2081883263","https://openalex.org/W2085010777","https://openalex.org/W2085030535","https://openalex.org/W2086532160","https://openalex.org/W2088229389","https://openalex.org/W2091196623","https://openalex.org/W2098717784","https://openalex.org/W2102518102","https://openalex.org/W2107005658","https://openalex.org/W2107749421","https://openalex.org/W2110492802","https://openalex.org/W2111893274","https://openalex.org/W2114970231","https://openalex.org/W2117569283","https://openalex.org/W2120873167","https://openalex.org/W2122522583","https://openalex.org/W2127311839","https://openalex.org/W2128065392","https://openalex.org/W2132053987","https://openalex.org/W2133619594","https://openalex.org/W2134256373","https://openalex.org/W2134450913","https://openalex.org/W2139401049","https://openalex.org/W2141754094","https://openalex.org/W2145432449","https://openalex.org/W2151591434","https://openalex.org/W2152642144","https://openalex.org/W2153900602","https://openalex.org/W2155563035","https://openalex.org/W2156435597","https://openalex.org/W2157458089","https://openalex.org/W2158997389","https://openalex.org/W2160461365","https://openalex.org/W2161098391","https://openalex.org/W2169800491","https://openalex.org/W2170356111","https://openalex.org/W2171449998","https://openalex.org/W2340453688","https://openalex.org/W4298408699"],"related_works":["https://openalex.org/W2462462365","https://openalex.org/W2966104333","https://openalex.org/W2398319251","https://openalex.org/W2153900602","https://openalex.org/W4412707948","https://openalex.org/W2161098391","https://openalex.org/W2246984933","https://openalex.org/W6926369757","https://openalex.org/W1986193321","https://openalex.org/W2125314144"],"abstract_inverted_index":{"AIM:":[0],"DNA":[1],"methylation":[2],"is":[3,91],"recognized":[4],"by":[5],"methyl-CpG-binding":[6],"domain":[7],"(MBD)":[8],"proteins.":[9],"Multiple":[10],"MBDs":[11,39],"are":[12,26,69],"linked":[13],"to":[14,78,117],"neurodevelopmental":[15],"disorders":[16],"in":[17,72,94,105,121],"humans":[18],"and":[19,34,40,55,59,98,113],"mice.":[20,75],"However,":[21],"the":[22],"functions":[23,103,120],"of":[24,38,63],"MBD2":[25,56,81,90,119],"poorly":[27],"understood.":[28],"We":[29,48,108],"characterized":[30],"Mbd2":[31,73],"knockout":[32,74],"mice":[33],"determined":[35],"spatiotemporal":[36],"expression":[37,84],"MBD2-NuRD":[41],"(nucleosome":[42],"remodeling":[43],"deacetylase)":[44],"interactions.":[45],"EXPERIMENTAL":[46],"PROCEDURES:":[47],"analyzed":[49],"behavioral":[50,67],"phenotypes,":[51],"generated":[52],"biotin-tagged":[53],"MBD1":[54],"knockin":[57],"mice,":[58],"performed":[60],"biochemical":[61],"studies":[62],"MBD2-NuRD.":[64],"RESULTS:":[65],"Most":[66],"measures":[68],"minimally":[70],"affected":[71],"In":[76],"contrast":[77],"other":[79],"MBDs,":[80,89],"shows":[82],"distinct":[83],"patterns.":[85],"CONCLUSION:":[86],"Unlike":[87],"most":[88],"ubiquitously":[92],"expressed":[93],"all":[95],"tissues":[96],"examined":[97],"appears":[99],"dispensable":[100],"for":[101],"brain":[102],"measured":[104],"this":[106],"study.":[107],"provide":[109],"novel":[110],"genetic":[111],"tools":[112],"reveal":[114],"new":[115],"directions":[116],"investigate":[118],"vivo.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
