{"id":"https://openalex.org/W234111982","doi":null,"title":"Differential effects of nylon fibre adherence on the production of superoxide anion by human polymorphonuclear neutrophilic granulocytes stimulated with chemoattractants, ionophore A23187 and phorbol myristate acetate.","display_name":"Differential effects of nylon fibre adherence on the production of superoxide anion by human polymorphonuclear neutrophilic granulocytes stimulated with chemoattractants, ionophore A23187 and phorbol myristate acetate.","publication_year":1987,"publication_date":"1987-07-01","ids":{"openalex":"https://openalex.org/W234111982","mag":"234111982","pmid":"https://pubmed.ncbi.nlm.nih.gov/2820637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542246"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1542246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542246","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109960758","display_name":"E. Kownatzki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Kownatzki","raw_affiliation_strings":["Universit\u00e4ts-Hautklinik, Freiburg, West Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4ts-Hautklinik, Freiburg, West Germany","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028365986","display_name":"Sibylle Uhrich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Uhrich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1106,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76956919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"1","first_page":"213","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8240000009536743},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nylon-fibers","display_name":"nylon fibers","score":0.4690000116825104},{"id":"https://openalex.org/keywords/chemoattractants","display_name":"chemoattractants","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.8450000286102295},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.7269999980926514},{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9580000042915344},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9229999780654907},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.7799999713897705},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cytochrome-c-reduction","display_name":"cytochrome c reduction","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.9378774166107178},{"id":"https://openalex.org/C2779014961","wikidata":"https://www.wikidata.org/wiki/Q415168","display_name":"Ionophore","level":3,"score":0.7948716282844543},{"id":"https://openalex.org/C2776685179","wikidata":"https://www.wikidata.org/wiki/Q2704449","display_name":"Leukotriene B4","level":3,"score":0.6242959499359131},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.6048601269721985},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.5881503224372864},{"id":"https://openalex.org/C2909761558","wikidata":"https://www.wikidata.org/wiki/Q416716","display_name":"Tetradecanoylphorbol Acetate","level":4,"score":0.5249443054199219},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.507773220539093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48990219831466675},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.4636114537715912},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.4630700647830963},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.46226397156715393},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.44626539945602417},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33724892139434814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3089001178741455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30325546860694885},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.23818418383598328},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.17968639731407166},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1638326644897461},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.11444893479347229},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09251832962036133},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009757","descriptor_name":"Nylons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1542246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:2820637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2820637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:234111982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2820637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1542246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W155097202","https://openalex.org/W231433954","https://openalex.org/W1506662402","https://openalex.org/W1547153486","https://openalex.org/W1550451325","https://openalex.org/W1607671096","https://openalex.org/W1968325967","https://openalex.org/W1972874692","https://openalex.org/W1977363772","https://openalex.org/W1979641440","https://openalex.org/W2001692359","https://openalex.org/W2002811764","https://openalex.org/W2011911983","https://openalex.org/W2016736433","https://openalex.org/W2019683392","https://openalex.org/W2023122744","https://openalex.org/W2027347410","https://openalex.org/W2038583951","https://openalex.org/W2042350701","https://openalex.org/W2042749680","https://openalex.org/W2054039543","https://openalex.org/W2054268009","https://openalex.org/W2056225363","https://openalex.org/W2059995094","https://openalex.org/W2066918889","https://openalex.org/W2079790969","https://openalex.org/W2080382959","https://openalex.org/W2104425049","https://openalex.org/W2112217048","https://openalex.org/W2146800979","https://openalex.org/W2150781890","https://openalex.org/W2169949874","https://openalex.org/W2328047889","https://openalex.org/W2339767841","https://openalex.org/W2342560683","https://openalex.org/W2401077755","https://openalex.org/W2409904090","https://openalex.org/W2411164904","https://openalex.org/W2412920082","https://openalex.org/W2413567968","https://openalex.org/W2414074028","https://openalex.org/W2414524312","https://openalex.org/W2415645842","https://openalex.org/W2418470223","https://openalex.org/W2420511803","https://openalex.org/W2443075343","https://openalex.org/W2443593516","https://openalex.org/W2468122454"],"related_works":["https://openalex.org/W2019683392","https://openalex.org/W2088768564","https://openalex.org/W2082891371","https://openalex.org/W2470772391","https://openalex.org/W2614428868","https://openalex.org/W2026525451","https://openalex.org/W2953832174","https://openalex.org/W2004248580","https://openalex.org/W2050419375","https://openalex.org/W2075635704"],"abstract_inverted_index":{"Human":[0],"polymorphonuclear":[1],"neutrophilic":[2],"granulocytes":[3],"were":[4,34],"made":[5],"adherent":[6,57,106,150],"by":[7,28,56],"passing":[8],"them":[9],"over":[10],"protein-coated":[11],"nylon":[12],"fibre":[13],"columns":[14],"and":[15,43,85,111,114],"compared":[16],"with":[17,36,78,94,140],"suspended":[18,74,109],"cells":[19,33,58,66,75],"for":[20],"their":[21],"production":[22,55,136],"of":[23,62,71,128,137],"superoxide":[24,72,103],"anion":[25],"as":[26],"measured":[27],"cytochrome":[29],"C":[30],"reduction.":[31],"The":[32],"stimulated":[35,77],"chemotactic":[37],"factors,":[38],"the":[39,44,60,86,134],"ionophore":[40,80],"A":[41,81],"23187,":[42,82],"tumour":[45],"promoter":[46],"phorbol":[47,95],"myristate":[48,96],"acetate.":[49],"There":[50],"was":[51],"no":[52],"increased":[53],"O2-.":[54],"in":[59,101,147],"absence":[61],"a":[63,115],"stimulus.":[64],"Adherent":[65],"produced":[67],"considerably":[68],"higher":[69,102],"amounts":[70,127],"than":[73,107],"when":[76],"formyl-methionyl-leucyl-phenylalanine,":[79],"C5a,":[83],"C5adesArg,":[84],"platelet":[87],"activating":[88],"factor":[89],"1-o-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine.":[90],"In":[91],"contrast,":[92],"stimulation":[93],"acetate":[97],"did":[98,119],"not":[99,120],"result":[100],"release":[104,125],"from":[105,108],"cells,":[110],"leukotriene":[112],"B4":[113],"mononuclear":[116],"cell-derived":[117],"chemotaxin":[118],"stimulate":[121],"either":[122],"cell":[123],"to":[124,144],"significant":[126],"superoxide.":[129],"It":[130],"is":[131],"suggested":[132],"that":[133],"augmented":[135],"oxygen":[138],"radicals":[139],"certain":[141],"stimuli":[142],"contributes":[143],"inflammatory":[145],"symptoms":[146],"situations":[148],"involving":[149],"granulocytes.":[151]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}