{"id":"https://openalex.org/W2341069230","doi":"https://doi.org/10.5642/aliso.20153302.03","title":"An Evolutionary Perspective on Human Cross-sensitivity to Tree Nut and Seed Allergens","display_name":"An Evolutionary Perspective on Human Cross-sensitivity to Tree Nut and Seed Allergens","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2341069230","doi":"https://doi.org/10.5642/aliso.20153302.03","mag":"2341069230"},"language":"en","primary_location":{"id":"doi:10.5642/aliso.20153302.03","doi":"https://doi.org/10.5642/aliso.20153302.03","is_oa":true,"landing_page_url":"https://doi.org/10.5642/aliso.20153302.03","pdf_url":"https://scholarship.claremont.edu/cgi/viewcontent.cgi?article=1192&context=aliso","source":{"id":"https://openalex.org/S12427304","display_name":"Aliso","issn_l":"0065-6275","issn":["0065-6275","2327-2929"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316594","host_organization_name":"California Botanic Garden","host_organization_lineage":["https://openalex.org/P4310316594"],"host_organization_lineage_names":["California Botanic Garden"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aliso","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://scholarship.claremont.edu/cgi/viewcontent.cgi?article=1192&context=aliso","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034039804","display_name":"Amanda E. Fisher","orcid":"https://orcid.org/0000-0002-9928-9558","observed_orcids":["https://orcid.org/0000-0002-9928-9558"]},"institutions":[{"id":"https://openalex.org/I136722135","display_name":"Claremont Graduate University","ror":"https://ror.org/0157pnt69","country_code":"US","type":"education","lineage":["https://openalex.org/I136722135"]},{"id":"https://openalex.org/I2801011858","display_name":"Rancho Santa Ana Botanic Garden","ror":"https://ror.org/01n260e81","country_code":"US","type":"archive","lineage":["https://openalex.org/I2801011858"]},{"id":"https://openalex.org/I59897056","display_name":"California State University, Long Beach","ror":"https://ror.org/0080fxk18","country_code":"US","type":"education","lineage":["https://openalex.org/I59897056"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda Fisher","raw_affiliation_strings":["Rancho Santa Ana Botanic Garden, Claremont, California","California State University, Long Beach, 1250 Bellflower Boulevard, Long Beach, California 90840);","Rancho Santa Ana Botanic Garden and Claremont Graduate University, 1500 North College Avenue, Claremont, California 91711 (Current affiliation: Department of Biological Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rancho Santa Ana Botanic Garden, Claremont, California","institution_ids":["https://openalex.org/I2801011858"]},{"raw_affiliation_string":"California State University, Long Beach, 1250 Bellflower Boulevard, Long Beach, California 90840);","institution_ids":["https://openalex.org/I59897056"]},{"raw_affiliation_string":"Rancho Santa Ana Botanic Garden and Claremont Graduate University, 1500 North College Avenue, Claremont, California 91711 (Current affiliation: Department of Biological Sciences,","institution_ids":["https://openalex.org/I136722135","https://openalex.org/I2801011858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000461971","display_name":"Annalise M. Nawrocki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177881444","display_name":"Pomona College","ror":"https://ror.org/0074grg94","country_code":"US","type":"education","lineage":["https://openalex.org/I177881444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annalise Nawrocki","raw_affiliation_strings":["Pomona College, Claremont, California","Pomona College, 333 North College Way, Claremont, California 91711"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pomona College, Claremont, California","institution_ids":["https://openalex.org/I177881444"]},{"raw_affiliation_string":"Pomona College, 333 North College Way, Claremont, California 91711","institution_ids":["https://openalex.org/I177881444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034039804"],"corresponding_institution_ids":["https://openalex.org/I136722135","https://openalex.org/I2801011858","https://openalex.org/I59897056"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"33","issue":"2","first_page":"91","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tree-nut-allergy","display_name":"tree nut allergy","score":0.984000027179718},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cross-sensitivity","display_name":"cross-sensitivity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/seed-storage-proteins","display_name":"seed storage proteins","score":0.75},{"id":"https://openalex.org/keywords/vicilin","display_name":"vicilin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/legumin","display_name":"legumin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/2s-albumin","display_name":"2S albumin","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-sequence-similarity","display_name":"protein sequence similarity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/ige-epitopes","display_name":"IgE epitopes","score":0.6830000281333923},{"id":"https://openalex.org/keywords/almond","display_name":"almond","score":0.3160000145435333},{"id":"https://openalex.org/keywords/peanut","display_name":"groundnut","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2777307526","wikidata":"https://www.wikidata.org/wiki/Q83132633","display_name":"Vicilin","level":4,"score":0.8562947511672974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7634888887405396},{"id":"https://openalex.org/C129794360","wikidata":"https://www.wikidata.org/wiki/Q5243868","display_name":"Legumin","level":4,"score":0.7516233921051025},{"id":"https://openalex.org/C2779142602","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross-reactivity","level":4,"score":0.7153105735778809},{"id":"https://openalex.org/C206391251","wikidata":"https://www.wikidata.org/wiki/Q1186738","display_name":"Nut","level":2,"score":0.6948369741439819},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.6046280264854431},{"id":"https://openalex.org/C2909743892","wikidata":"https://www.wikidata.org/wiki/Q81671","display_name":"Brazil nut","level":2,"score":0.5360088348388672},{"id":"https://openalex.org/C97564808","wikidata":"https://www.wikidata.org/wiki/Q425526","display_name":"Storage protein","level":3,"score":0.5002639293670654},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.49132004380226135},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.48596417903900146},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4348146915435791},{"id":"https://openalex.org/C2780596994","wikidata":"https://www.wikidata.org/wiki/Q769479","display_name":"Oral allergy syndrome","level":4,"score":0.4281381368637085},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4087332487106323},{"id":"https://openalex.org/C3020064264","wikidata":"https://www.wikidata.org/wiki/Q1760689","display_name":"Cross reactions","level":3,"score":0.40019503235816956},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3641866445541382},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32876238226890564},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19295382499694824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16381427645683289},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15364128351211548},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.11228930950164795},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5642/aliso.20153302.03","doi":"https://doi.org/10.5642/aliso.20153302.03","is_oa":true,"landing_page_url":"https://doi.org/10.5642/aliso.20153302.03","pdf_url":"https://scholarship.claremont.edu/cgi/viewcontent.cgi?article=1192&context=aliso","source":{"id":"https://openalex.org/S12427304","display_name":"Aliso","issn_l":"0065-6275","issn":["0065-6275","2327-2929"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316594","host_organization_name":"California Botanic Garden","host_organization_lineage":["https://openalex.org/P4310316594"],"host_organization_lineage_names":["California Botanic Garden"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aliso","raw_type":"journal-article"},{"id":"pmh:oai:scholarship.claremont.edu:aliso-1192","doi":null,"is_oa":true,"landing_page_url":"https://scholarship.claremont.edu/aliso/vol33/iss2/3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196412","display_name":"Scholarship - Claremont (Claremont Colleges)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I872248612","host_organization_name":"Claremont Colleges","host_organization_lineage":["https://openalex.org/I872248612"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aliso: A Journal of Systematic and Floristic Botany","raw_type":"text"}],"best_oa_location":{"id":"doi:10.5642/aliso.20153302.03","doi":"https://doi.org/10.5642/aliso.20153302.03","is_oa":true,"landing_page_url":"https://doi.org/10.5642/aliso.20153302.03","pdf_url":"https://scholarship.claremont.edu/cgi/viewcontent.cgi?article=1192&context=aliso","source":{"id":"https://openalex.org/S12427304","display_name":"Aliso","issn_l":"0065-6275","issn":["0065-6275","2327-2929"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316594","host_organization_name":"California Botanic Garden","host_organization_lineage":["https://openalex.org/P4310316594"],"host_organization_lineage_names":["California Botanic Garden"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aliso","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2341069230.pdf","grobid_xml":"https://content.openalex.org/works/W2341069230.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W95952207","https://openalex.org/W1519266993","https://openalex.org/W1552965051","https://openalex.org/W1560107570","https://openalex.org/W1797955398","https://openalex.org/W1847210463","https://openalex.org/W1925752674","https://openalex.org/W1964988755","https://openalex.org/W1966863022","https://openalex.org/W1967420468","https://openalex.org/W1967813421","https://openalex.org/W1968323951","https://openalex.org/W1968491906","https://openalex.org/W1970848829","https://openalex.org/W1977800771","https://openalex.org/W1978362455","https://openalex.org/W1979745732","https://openalex.org/W1980622705","https://openalex.org/W1985059963","https://openalex.org/W1988580681","https://openalex.org/W1989054369","https://openalex.org/W1991432913","https://openalex.org/W1994524462","https://openalex.org/W1994633950","https://openalex.org/W2004298900","https://openalex.org/W2005259120","https://openalex.org/W2005380356","https://openalex.org/W2013067789","https://openalex.org/W2015047311","https://openalex.org/W2019059122","https://openalex.org/W2020361426","https://openalex.org/W2020538616","https://openalex.org/W2022052123","https://openalex.org/W2023376366","https://openalex.org/W2024174917","https://openalex.org/W2026062398","https://openalex.org/W2028302194","https://openalex.org/W2028923168","https://openalex.org/W2029290971","https://openalex.org/W2030744149","https://openalex.org/W2031243237","https://openalex.org/W2032629174","https://openalex.org/W2036742773","https://openalex.org/W2042976839","https://openalex.org/W2044586491","https://openalex.org/W2047810967","https://openalex.org/W2049653620","https://openalex.org/W2050113306","https://openalex.org/W2050262488","https://openalex.org/W2057508462","https://openalex.org/W2059862758","https://openalex.org/W2060398753","https://openalex.org/W2061864335","https://openalex.org/W2062864090","https://openalex.org/W2064119141","https://openalex.org/W2064442294","https://openalex.org/W2069551150","https://openalex.org/W2071244293","https://openalex.org/W2071795136","https://openalex.org/W2073067470","https://openalex.org/W2074808914","https://openalex.org/W2074885895","https://openalex.org/W2076209632","https://openalex.org/W2076278773","https://openalex.org/W2077848370","https://openalex.org/W2079208358","https://openalex.org/W2082476115","https://openalex.org/W2084192987","https://openalex.org/W2086289695","https://openalex.org/W2087076103","https://openalex.org/W2091083150","https://openalex.org/W2091255857","https://openalex.org/W2093667755","https://openalex.org/W2096270834","https://openalex.org/W2096919592","https://openalex.org/W2101039528","https://openalex.org/W2107661462","https://openalex.org/W2108038171","https://openalex.org/W2116809392","https://openalex.org/W2117023925","https://openalex.org/W2117860661","https://openalex.org/W2118268072","https://openalex.org/W2119582771","https://openalex.org/W2120352915","https://openalex.org/W2121175961","https://openalex.org/W2121709897","https://openalex.org/W2123994079","https://openalex.org/W2128221045","https://openalex.org/W2130261600","https://openalex.org/W2137516648","https://openalex.org/W2140564789","https://openalex.org/W2140920388","https://openalex.org/W2141094175","https://openalex.org/W2143418905","https://openalex.org/W2144654387","https://openalex.org/W2145697624","https://openalex.org/W2146622552","https://openalex.org/W2147477489","https://openalex.org/W2149531726","https://openalex.org/W2150148535","https://openalex.org/W2153592178","https://openalex.org/W2153793488","https://openalex.org/W2158492783","https://openalex.org/W2159017882","https://openalex.org/W2166270629","https://openalex.org/W2166432938","https://openalex.org/W2168518560","https://openalex.org/W2169371590","https://openalex.org/W2170036507","https://openalex.org/W2171217030","https://openalex.org/W2320637870","https://openalex.org/W2388256267","https://openalex.org/W2593151528","https://openalex.org/W3185266875","https://openalex.org/W4212987831","https://openalex.org/W4235061478","https://openalex.org/W4243553809","https://openalex.org/W4244654643"],"related_works":["https://openalex.org/W2033787081","https://openalex.org/W2161851751","https://openalex.org/W7100591180","https://openalex.org/W2169977549","https://openalex.org/W2137516648","https://openalex.org/W7111780824","https://openalex.org/W7112728139","https://openalex.org/W2117860661","https://openalex.org/W3026141146","https://openalex.org/W2088750532"],"abstract_inverted_index":{"Tree":[0],"nut":[1,66,74,84,232,284,316],"allergies":[2,11,85,289],"are":[3,18,28,214,290,297],"some":[4],"of":[5,35,47,101,113,155,167,186,210,220,254,304,309],"the":[6,13,56,98,111,141,147,152,164,194,204,211,217,255,266,302],"most":[7],"common":[8],"and":[9,123,160,174,190,197,273,285,307],"serious":[10],"in":[12,45,55,81,97,131,151,203,270,292,311],"United":[14],"States.":[15],"Patients":[16],"who":[17,313],"sensitive":[19],"to":[20,23,30,64,118,120,193,235,282,299],"nuts":[21,27,157],"or":[22,242],"seeds":[24,132],"commonly":[25],"called":[26],"advised":[29],"avoid":[31],"consuming":[32],"a":[33,114,293],"variety":[34],"different":[36,102],"species,":[37],"even":[38],"though":[39],"these":[40,192],"may":[41,86,133,263],"be":[42,87,236,264],"distantly":[43,230],"related":[44,231],"terms":[46],"their":[48,187,259],"evolutionary":[49,208],"history.":[50],"This":[51],"is":[52,201],"because":[53],"studies":[54,296],"literature":[57],"report":[58],"that":[59,79,128,139,149,200,229,252],"patients":[60,82,312],"often":[61],"display":[62],"sensitivity":[63],"multiple":[65],"species":[67,103,178,222,233],"(cross-sensitivity)":[68],"if":[69,107,288],"they":[70],"have":[71,134],"an":[72,90],"existing":[73],"allergy.":[75],"These":[76],"reports":[77],"suggest":[78,251],"cross-sensitivity":[80,159,196,310],"with":[83,94,216],"caused":[88],"by":[89,162],"IgE":[91,108],"antibody":[92],"reacting":[93],"epitopes":[95],"present":[96,291],"seed":[99,286],"proteins":[100,130,171,213,256,306],"(cross-reactivity),":[104],"for":[105],"example,":[106],"isolated":[109],"from":[110,177,315],"serum":[112],"patient":[115],"were":[116],"able":[117],"bind":[119],"both":[121],"almond":[122],"peanut":[124],"allergens.":[125],"We":[126,183],"hypothesize":[127],"allergenic":[129,156,169,305],"similar":[135,239],"amino":[136,245,260],"acid":[137,246,261],"sequences":[138,154,262],"cause":[140],"observed":[142,268],"cross-sensitivity.":[143],"Here,":[144],"we":[145,225],"test":[146],"hypothesis":[148],"similarity":[150],"protein":[153],"drives":[158],"cross-reactivity":[161,198,267],"reconstructing":[163],"gene":[165],"trees":[166],"three":[168,212],"seed-storage":[170],"(vicilin,":[172],"legumin,":[173,241],"2S":[175,243],"albumin)":[176],"sampled":[179],"across":[180],"vascular":[181],"plants.":[182],"generate":[184],"estimates":[185],"phylogenetic":[188],"relationships":[189,209],"compare":[191],"allergen":[195],"data":[199,249],"reported":[202,234],"literature.":[205],"In":[206],"general,":[207],"congruent":[215],"current":[218,279],"understanding":[219],"plant":[221],"relationships.":[223],"However,":[224],"find":[226],"little":[227],"evidence":[228],"cross-reactive":[237],"share":[238],"vicilin,":[240],"albumin":[244],"sequences.":[247],"Our":[248,276],"thus":[250],"features":[253],"other":[257],"than":[258],"driving":[265],"during":[269],"vitro":[271],"tests":[272],"skin":[274],"tests.":[275],"results":[277],"support":[278],"treatment":[280],"guidelines":[281],"limit":[283],"consumption":[287],"patient.":[294],"More":[295],"necessary":[298],"better":[300],"understand":[301],"characteristics":[303],"patterns":[308],"suffer":[314],"allergies.":[317]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
