{"id":"https://openalex.org/W2341067337","doi":null,"title":"for the Treatment of Alzheimer's Disease","display_name":"for the Treatment of Alzheimer's Disease","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2341067337","mag":"2341067337"},"language":"en","primary_location":{"id":"mag:2341067337","doi":null,"is_oa":false,"landing_page_url":"https://www.jpsmjournal.com/article/S0885-3924(02)00374-3/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108408168","display_name":"Paul S. S. Aisen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul Aisen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108408168"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/rofecoxib","display_name":"rofecoxib","score":0.8019999861717224},{"id":"https://openalex.org/keywords/naproxen","display_name":"naproxen","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8498176336288452},{"id":"https://openalex.org/C2778582115","wikidata":"https://www.wikidata.org/wiki/Q411412","display_name":"Rofecoxib","level":4,"score":0.7487762570381165},{"id":"https://openalex.org/C2779046751","wikidata":"https://www.wikidata.org/wiki/Q421076","display_name":"Tacrine","level":4,"score":0.6153361797332764},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5685154795646667},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5666965842247009},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5496585369110107},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5206084251403809},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.5026047229766846},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.454415887594223},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4457224905490875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32733309268951416},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3223574459552765},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.3188081681728363},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.24102085828781128},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.09169122576713562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2341067337","doi":null,"is_oa":false,"landing_page_url":"https://www.jpsmjournal.com/article/S0885-3924(02)00374-3/pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W38748857","https://openalex.org/W97692387","https://openalex.org/W180059560","https://openalex.org/W1953027527","https://openalex.org/W1969516175","https://openalex.org/W1977207335","https://openalex.org/W1980565738","https://openalex.org/W1982637771","https://openalex.org/W1983479763","https://openalex.org/W1991743392","https://openalex.org/W1992808511","https://openalex.org/W1993213847","https://openalex.org/W1995198341","https://openalex.org/W2003362379","https://openalex.org/W2008424322","https://openalex.org/W2037883479","https://openalex.org/W2039453997","https://openalex.org/W2042690206","https://openalex.org/W2042706422","https://openalex.org/W2046454316","https://openalex.org/W2052651471","https://openalex.org/W2053177676","https://openalex.org/W2060735852","https://openalex.org/W2062011408","https://openalex.org/W2068477037","https://openalex.org/W2074381507","https://openalex.org/W2076334107","https://openalex.org/W2082452384","https://openalex.org/W2082736694","https://openalex.org/W2085680573","https://openalex.org/W2085969237","https://openalex.org/W2120673137","https://openalex.org/W2130063365","https://openalex.org/W2136439668","https://openalex.org/W2140131793","https://openalex.org/W2147710510","https://openalex.org/W2151749372","https://openalex.org/W2163110760","https://openalex.org/W2312933856","https://openalex.org/W2980623457"],"related_works":["https://openalex.org/W1966012148","https://openalex.org/W1531467877","https://openalex.org/W166560457","https://openalex.org/W2037099926","https://openalex.org/W1591558381","https://openalex.org/W2109728136","https://openalex.org/W156635292","https://openalex.org/W1968431776","https://openalex.org/W2004111033","https://openalex.org/W2012109987"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,157],"disease":[1],"(AD)":[2],"is":[3,51,75,98,123,162],"a":[4,58,134,174,178],"worldwide":[5],"problem":[6],"that":[7,57,77,91,120],"affects":[8],"5":[9],"million":[10],"people":[11],"in":[12,22,65,107,127,136,154,190],"the":[13,18,23,31,45,66,128,183,204,213],"United":[14],"States":[15],"alone.":[16],"Until":[17],"approval":[19],"of":[20,34,47,60,68,85,93,124,185,206,217],"tacrine":[21],"mid-1990s,":[24],"there":[25],"was":[26],"no":[27],"effective":[28,48],"therapy":[29,38,50],"for":[30,113,212],"cognitive":[32,105,186],"symptoms":[33],"AD.":[35,108,155,191,218],"Although":[36,109],"cholinergic":[37],"provides":[39],"modest":[40],"but":[41],"significant":[42],"symptomatic":[43],"relief,":[44],"development":[46],"disease-modifying":[49],"essential.":[52],"It":[53],"has":[54],"been":[55],"demonstrated":[56,119],"number":[59],"inflammatory":[61,129],"processes":[62],"are":[63],"active":[64],"brain":[67],"patients":[69],"with":[70,100,195],"AD,":[71],"and":[72,131,187,208,215],"therefore":[73],"it":[74],"believed":[76],"an":[78,145,164],"anti-inflammatory":[79,95],"regimen":[80],"may":[81,132,143],"offer":[82],"some":[83],"degree":[84],"neuroprotection.":[86],"Several":[87],"studies":[88,198],"have":[89,118,133,144],"indicated":[90],"use":[92],"nonsteroidal":[94],"drugs":[96],"(NSAIDs)":[97],"associated":[99],"delayed":[101],"onset":[102],"and/or":[103],"slowed":[104],"decline":[106,189],"not":[110],"currently":[111,199],"approved":[112],"this":[114],"condition,":[115],"recent":[116],"findings":[117],"cyclooxygenase":[121],"(COX)-2":[122],"primary":[125],"importance":[126],"response":[130],"role":[135],"neurodegeneration.":[137],"Therefore,":[138],"selective":[139,207],"COX-2":[140],"inhibitors":[141,211],"(coxibs)":[142],"advantage":[146],"over":[147],"traditional":[148],"NSAIDs":[149],"as":[150],"potential":[151],"therapeutic":[152],"agents":[153],"The":[156],"Disease":[158],"Cooperative":[159],"Study":[160],"(ADCS)":[161],"conducting":[163],"ongoing":[165],"multicenter,":[166],"double-blind,":[167],"placebo-controlled":[168],"trial":[169],"to":[170],"determine":[171,203],"whether":[172],"rofecoxib,":[173],"coxib,":[175],"or":[176],"naproxen,":[177],"nonselective":[179,209],"NSAID,":[180],"will":[181,202],"slow":[182],"rate":[184],"clinical":[188,197],"This":[192],"study,":[193],"along":[194],"other":[196],"under":[200],"way,":[201],"utility":[205],"COX":[210],"prevention":[214],"treatment":[216],"J":[219],"Pain":[220,228],"Symptom":[221],"Manage":[222],"2002;":[223],"23:S35\u2010540.":[224],"\u00a9":[225],"U.S.":[226],"Cancer":[227],"Relief":[229],"Committee,":[230],"2002":[231],".":[232]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
