{"id":"https://openalex.org/W2340974673","doi":"https://doi.org/10.1097/fjc.0000000000000400","title":"Modulation by Central MAPKs/PI3K/sGc of the TNF-\u03b1/iNOS-dependent Hypotension and Compromised Cardiac Autonomic Control in Endotoxic Rats","display_name":"Modulation by Central MAPKs/PI3K/sGc of the TNF-\u03b1/iNOS-dependent Hypotension and Compromised Cardiac Autonomic Control in Endotoxic Rats","publication_year":2016,"publication_date":"2016-04-23","ids":{"openalex":"https://openalex.org/W2340974673","doi":"https://doi.org/10.1097/fjc.0000000000000400","mag":"2340974673","pmid":"https://pubmed.ncbi.nlm.nih.gov/27110744"},"language":"en","primary_location":{"id":"doi:10.1097/fjc.0000000000000400","doi":"https://doi.org/10.1097/fjc.0000000000000400","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000000400","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054690152","display_name":"Marwa Y. Sallam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Marwa Y. Sallam","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030806129","display_name":"Sahar M. El\u2010Gowilly","orcid":"https://orcid.org/0000-0002-7469-1647","observed_orcids":["https://orcid.org/0000-0002-7469-1647"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahar M. El-Gowilly","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058780160","display_name":"Abdel\u2010Galil A Abdel\u2010Galil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdel-Galil A. Abdel-Galil","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045120949","display_name":"Mahmoud M. El\u2010Mas","orcid":"https://orcid.org/0000-0001-8855-7070","observed_orcids":["https://orcid.org/0000-0001-8855-7070"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mahmoud M. El-Mas","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84524832"],"apc_list":null,"apc_paid":null,"fwci":1.8291,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.86352917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"68","issue":"2","first_page":"171","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.8050000071525574},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8040000200271606},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase","display_name":"soluble guanylate cyclase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.7459999918937683},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cardiac-autonomic-control","display_name":"cardiac autonomic control","score":0.859000027179718},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8980000019073486},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pentoxifylline","display_name":"pentoxifylline","score":0.9100000262260437},{"id":"https://openalex.org/keywords/aminoguanidine","display_name":"aminoguanidine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sb203580","display_name":"SB203580","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9129999876022339},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.553235650062561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5383284091949463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5357310771942139},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.5239467620849609},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5141985416412354},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5130301713943481},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4881077706813812},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.48532503843307495},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4833957254886627},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44463613629341125},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.44405993819236755},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.41407862305641174},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39679425954818726},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.3357403874397278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23831915855407715},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22491514682769775},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06849455833435059}],"mesh":[{"descriptor_ui":"D000071756","descriptor_name":"Soluble Guanylyl Cyclase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071756","descriptor_name":"Soluble Guanylyl Cyclase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013610","descriptor_name":"Tachycardia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013610","descriptor_name":"Tachycardia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013610","descriptor_name":"Tachycardia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013610","descriptor_name":"Tachycardia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D019446","descriptor_name":"Endotoxemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058539","descriptor_name":"Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/fjc.0000000000000400","doi":"https://doi.org/10.1097/fjc.0000000000000400","is_oa":false,"landing_page_url":"https://doi.org/10.1097/fjc.0000000000000400","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:27110744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27110744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1489618729","https://openalex.org/W1571353934","https://openalex.org/W1590680361","https://openalex.org/W1822061653","https://openalex.org/W1861384455","https://openalex.org/W1971081661","https://openalex.org/W1975398455","https://openalex.org/W1975827811","https://openalex.org/W1978298731","https://openalex.org/W1979952002","https://openalex.org/W1979978809","https://openalex.org/W1985408105","https://openalex.org/W1986040433","https://openalex.org/W1986738619","https://openalex.org/W1989448739","https://openalex.org/W1990930862","https://openalex.org/W1995525413","https://openalex.org/W1995546623","https://openalex.org/W1996163396","https://openalex.org/W2001057909","https://openalex.org/W2002603390","https://openalex.org/W2010835913","https://openalex.org/W2013864208","https://openalex.org/W2015548605","https://openalex.org/W2023964913","https://openalex.org/W2024456541","https://openalex.org/W2025368956","https://openalex.org/W2028425331","https://openalex.org/W2029307566","https://openalex.org/W2032879843","https://openalex.org/W2036917166","https://openalex.org/W2041367442","https://openalex.org/W2043359506","https://openalex.org/W2058077141","https://openalex.org/W2069368135","https://openalex.org/W2069769057","https://openalex.org/W2076152677","https://openalex.org/W2079613572","https://openalex.org/W2090154307","https://openalex.org/W2101390983","https://openalex.org/W2107495112","https://openalex.org/W2113499574","https://openalex.org/W2116232103","https://openalex.org/W2121904190","https://openalex.org/W2122646957","https://openalex.org/W2131606780","https://openalex.org/W2134946288","https://openalex.org/W2135514207","https://openalex.org/W2137709326","https://openalex.org/W2137890894","https://openalex.org/W2149987245","https://openalex.org/W2154939734","https://openalex.org/W2161383670","https://openalex.org/W2167714192","https://openalex.org/W2167741567","https://openalex.org/W2224257149","https://openalex.org/W2271092295","https://openalex.org/W2369912292","https://openalex.org/W2405216392","https://openalex.org/W3158628908","https://openalex.org/W4406499664","https://openalex.org/W6713658839"],"related_works":["https://openalex.org/W1615715539","https://openalex.org/W2165022559","https://openalex.org/W138042462","https://openalex.org/W5832809","https://openalex.org/W2128358009","https://openalex.org/W2039536212","https://openalex.org/W2061027481","https://openalex.org/W3174653977","https://openalex.org/W2398924459","https://openalex.org/W2060524902"],"abstract_inverted_index":{"Reduced":[0],"blood":[1],"pressure":[2],"(BP)":[3],"and":[4,26,51,81,92,100,105,107,115,134,149,156,202],"cardiac":[5],"autonomic":[6],"activity":[7],"are":[8,18],"early":[9],"manifestations":[10],"of":[11,39,42,77,85,96,103,121,137,142,159,179],"endotoxemia.":[12],"We":[13],"investigated":[14],"whether":[15],"these":[16,43],"effects":[17,182],"modulated":[19],"by":[20,58,171],"central":[21,191],"mitogen-activated":[22],"protein":[23],"kinases":[24],"(MAPKs)":[25],"related":[27],"phosphoinositide-3-kinase":[28],"(PI3K)/soluble":[29],"guanylate":[30],"cyclase":[31],"(sGC)":[32],"signaling":[33],"in":[34,88,167,200],"conscious":[35],"rats.":[36],"The":[37,119],"effect":[38],"pharmacologic":[40],"inhibition":[41,120,170],"molecular":[44],"substrates":[45],"on":[46],"BP,":[47],"heart":[48,52],"rate":[49,53],"(HR),":[50],"variability":[54],"(HRV)":[55],"responses":[56],"evoked":[57],"intravascular":[59],"lipopolysaccharide":[60],"(LPS)":[61],"(10":[62],"mg/kg)":[63],"were":[64],"assessed.":[65],"LPS":[66,160,181],"(1)":[67],"lowered":[68],"BP":[69,201],"(2)":[70],"increased":[71],"HR,":[72],"(3)":[73],"reduced":[74],"time":[75],"[SD":[76],"beat-to-beat":[78],"intervals":[79,90],"(SDNN),":[80],"root":[82],"mean":[83],"square":[84],"successive":[86],"differences":[87],"R-R":[89],"(rMSSD)],":[91],"frequency":[93],"domain":[94],"indices":[95],"HRV":[97,203],"(total":[98],"power":[99],"spectral":[101],"bands":[102],"low":[104],"high-frequency),":[106],"(4)":[108],"elevated":[109],"serum":[110],"tumor":[111],"necrosis":[112],"factor-\u03b1":[113],"(TNF-\u03b1)":[114],"interleukin-6":[116],"(IL-6)":[117],"levels.":[118],"TNF-\u03b1":[122],"(pentoxifylline)":[123],"or":[124],"inducible":[125],"nitric":[126],"oxide":[127],"synthase":[128],"(iNOS,":[129],"aminoguanidine)":[130],"abolished":[131],"hemodynamic,":[132],"HRV,":[133],"inflammatory":[135],"actions":[136,158],"LPS.":[138],"Intracisternal":[139],"(i.c.)":[140],"injection":[141],"ODQ":[143],"(sGC":[144],"inhibitor),":[145,148],"wortmannin":[146],"(PI3K":[147],"SP600125":[150],"(MAPKJNK":[151],"inhibitor)":[152],"mitigated":[153],"the":[154,180,197],"hypotensive":[155],"tachycardic":[157],"but":[161],"failed":[162],"to":[163,196],"affect":[164],"associated":[165],"decreases":[166],"HRV.":[168],"MAPKp38":[169],"i.c.":[172,186],"SB203580":[173],"produced":[174],"exactly":[175],"opposite":[176],"effects.":[177],"None":[178],"was":[183],"altered":[184],"after":[185],"PD98059":[187],"(MAPKERK1/2":[188],"inhibitor).":[189],"Overall,":[190],"MAPKs/PI3K/sGC":[192],"pathways":[193],"variably":[194],"contribute":[195],"TNF-\u03b1/iNOS-dependent":[198],"reductions":[199],"seen":[204],"during":[205],"endotoxic":[206],"shock.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}