{"id":"https://openalex.org/W2340799345","doi":"https://doi.org/10.3233/jbr-160121","title":"The in vitro evaluation of isolated procyanidins as modulators of cytokine-induced eotaxin production in human alveolar epithelial cells","display_name":"The in vitro evaluation of isolated procyanidins as modulators of cytokine-induced eotaxin production in human alveolar epithelial cells","publication_year":2016,"publication_date":"2016-02-25","ids":{"openalex":"https://openalex.org/W2340799345","doi":"https://doi.org/10.3233/jbr-160121","mag":"2340799345"},"language":"en","primary_location":{"id":"doi:10.3233/jbr-160121","doi":"https://doi.org/10.3233/jbr-160121","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jbr-160121","pdf_url":"https://content.iospress.com:443/download/journal-of-berry-research/jbr121?id=journal-of-berry-research%2Fjbr121","source":{"id":"https://openalex.org/S2764976854","display_name":"Journal of Berry Research","issn_l":"1878-5093","issn":["1878-5093","1878-5123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Berry Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://content.iospress.com:443/download/journal-of-berry-research/jbr121?id=journal-of-berry-research%2Fjbr121","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038709097","display_name":"Sara L. Coleman","orcid":"https://orcid.org/0000-0003-4680-4285","observed_orcids":["https://orcid.org/0000-0003-4680-4285"]},"institutions":[{"id":"https://openalex.org/I1320288732","display_name":"Plant & Food Research","ror":"https://ror.org/02bchch95","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I1320288732","https://openalex.org/I4405260297"]},{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Sara L. Coleman","raw_affiliation_strings":["Food and Wellness Group, The New Zealand Institute for Plant & Food Research Ltd, Palmerston North, New Zealand","Massey University Institute of Food Science and Technology, School of Food and Nutrition, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Wellness Group, The New Zealand Institute for Plant & Food Research Ltd, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I1320288732"]},{"raw_affiliation_string":"Massey University Institute of Food Science and Technology, School of Food and Nutrition, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018200032","display_name":"Roger D. Hurst","orcid":"https://orcid.org/0000-0002-4097-1368","observed_orcids":["https://orcid.org/0000-0002-4097-1368"]},"institutions":[{"id":"https://openalex.org/I1320288732","display_name":"Plant & Food Research","ror":"https://ror.org/02bchch95","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I1320288732","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Roger D. Hurst","raw_affiliation_strings":["Food and Wellness Group, The New Zealand Institute for Plant & Food Research Ltd, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Wellness Group, The New Zealand Institute for Plant & Food Research Ltd, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I1320288732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005984727","display_name":"Gregory M. Sawyer","orcid":"https://orcid.org/0000-0002-8784-9327","observed_orcids":["https://orcid.org/0000-0002-8784-9327"]},"institutions":[{"id":"https://openalex.org/I1320288732","display_name":"Plant & Food Research","ror":"https://ror.org/02bchch95","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I1320288732","https://openalex.org/I4405260297"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Gregory M. Sawyer","raw_affiliation_strings":["Food and Wellness Group, The New Zealand Institute for Plant & Food Research Ltd, Palmerston North, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Wellness Group, The New Zealand Institute for Plant & Food Research Ltd, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I1320288732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042247935","display_name":"Marlena C. Kruger","orcid":"https://orcid.org/0000-0002-8646-9672","observed_orcids":["https://orcid.org/0000-0002-8646-9672"]},"institutions":[{"id":"https://openalex.org/I51158804","display_name":"Massey University","ror":"https://ror.org/052czxv31","country_code":"NZ","type":"education","lineage":["https://openalex.org/I51158804"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Marlena C. Kruger","raw_affiliation_strings":["Massey University Institute of Food Science and Technology, School of Food and Nutrition, Palmerston North, New Zealand","E-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massey University Institute of Food Science and Technology, School of Food and Nutrition, Palmerston North, New Zealand","institution_ids":["https://openalex.org/I51158804"]},{"raw_affiliation_string":"E-mail:","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038709097"],"corresponding_institution_ids":["https://openalex.org/I1320288732","https://openalex.org/I51158804"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":{"value":4150,"currency":"USD","value_usd":4150},"fwci":1.3436,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.80774504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"2","first_page":"115","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/procyanidins","display_name":"procyanidins","score":1.0},{"id":"https://openalex.org/keywords/eotaxin","display_name":"eotaxin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.6880000233650208},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/eosinophil-migration","display_name":"eosinophil migration","score":0.8980000019073486},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/procyanidin-a2","display_name":"procyanidin A2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/procyanidin-b2","display_name":"procyanidin B2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/procyanidin-b1","display_name":"procyanidin B1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.828000009059906},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2780590879","wikidata":"https://www.wikidata.org/wiki/Q5009606","display_name":"CCL11","level":5,"score":0.9064024090766907},{"id":"https://openalex.org/C2777716647","wikidata":"https://www.wikidata.org/wiki/Q5381961","display_name":"Eotaxin","level":4,"score":0.8332858085632324},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7022764682769775},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5835790634155273},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.5418340563774109},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5314218997955322},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5157020688056946},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5146101713180542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5127997994422913},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4426555633544922},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42506468296051025},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.40201079845428467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.250978946685791},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21894225478172302},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.2037418782711029},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19802358746528625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13031437993049622}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/jbr-160121","doi":"https://doi.org/10.3233/jbr-160121","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jbr-160121","pdf_url":"https://content.iospress.com:443/download/journal-of-berry-research/jbr121?id=journal-of-berry-research%2Fjbr121","source":{"id":"https://openalex.org/S2764976854","display_name":"Journal of Berry Research","issn_l":"1878-5093","issn":["1878-5093","1878-5123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Berry Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3233/jbr-160121","doi":"https://doi.org/10.3233/jbr-160121","is_oa":true,"landing_page_url":"https://doi.org/10.3233/jbr-160121","pdf_url":"https://content.iospress.com:443/download/journal-of-berry-research/jbr121?id=journal-of-berry-research%2Fjbr121","source":{"id":"https://openalex.org/S2764976854","display_name":"Journal of Berry Research","issn_l":"1878-5093","issn":["1878-5093","1878-5123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Berry Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320816","display_name":"Massey University","ror":"https://ror.org/052czxv31"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2340799345.pdf","grobid_xml":"https://content.openalex.org/works/W2340799345.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W642101920","https://openalex.org/W1530405706","https://openalex.org/W1995321922","https://openalex.org/W2002275583","https://openalex.org/W2006926075","https://openalex.org/W2014080974","https://openalex.org/W2025140256","https://openalex.org/W2034766225","https://openalex.org/W2054789114","https://openalex.org/W2055226402","https://openalex.org/W2055620043","https://openalex.org/W2059315552","https://openalex.org/W2064710811","https://openalex.org/W2069623463","https://openalex.org/W2090492670","https://openalex.org/W2092119381","https://openalex.org/W2092790181","https://openalex.org/W2117582728","https://openalex.org/W2120026749","https://openalex.org/W2129249696","https://openalex.org/W2137553082","https://openalex.org/W2144165078","https://openalex.org/W2148026781","https://openalex.org/W2160287057","https://openalex.org/W2298025699","https://openalex.org/W4313309880"],"related_works":["https://openalex.org/W2555994544","https://openalex.org/W2770853059","https://openalex.org/W2584936291","https://openalex.org/W2487679169","https://openalex.org/W4308772697","https://openalex.org/W2604579878","https://openalex.org/W2034766225","https://openalex.org/W2994737288","https://openalex.org/W2014080974","https://openalex.org/W3097929571"],"abstract_inverted_index":{"BACKGROUND:":[0],"Populations":[1],"that":[2,170],"consume":[3],"procyanidin-rich":[4],"diets":[5],"are":[6],"less":[7],"susceptible":[8],"to":[9,45,78,87,93,115,122,128],"inflammatory":[10,16,95,130],"disease.":[11],"Allergic":[12],"asthma":[13],"is":[14,179],"an":[15,94],"lung":[17,70,176],"disease":[18],"perpetuated":[19],"by":[20,175,194],"a":[21,43,58,163,189],"hyperreactive":[22],"airway":[23,50,211],"epithelium":[24],"and":[25,38,74,144,154,196],"eosinophil":[26,34],"infiltration":[27],"into":[28,36,204],"the":[29,47,76,129,139,171,183],"lung.":[30],"Eotaxin-1":[31],"(CCL11)":[32],"mediates":[33],"migration":[35],"tissues":[37],"its":[39],"modulation":[40],"could":[41],"represent":[42],"means":[44,59],"assist":[46],"management":[48],"of":[49,60,97,151,162,173,192],"inflammation.":[51,212],"OBJECTIVE:":[52],"Here":[53],"we":[54],"evaluated":[55],"procyanidins":[56,88,142,152],"as":[57],"modulating":[61],"CCL11":[62,80,117,136,174,193],"production":[63,81],"in":[64,82],"vitro.":[65,83],"METHODS:":[66],"We":[67,187],"used":[68,114],"human":[69],"epithelial":[71,177],"cells":[72,178],"(A549)":[73],"optimized":[75],"conditions":[77],"induce":[79],"Cells":[84,120],"were":[85],"exposed":[86,121],"for":[89,106,208],"6":[90],"h":[91],"prior":[92,127],"insult":[96],"5":[98,102,123],"ng/mL":[99,103],"IL-4":[100],"with":[101],"TNF":[104],"\u03b1":[105],"48":[107],"h.":[108],"An":[109],"enzyme-linked":[110],"immunosorbent":[111],"assay":[112],"was":[113],"measure":[116],"production.":[118,137],"RESULTS:":[119],"\u03bcM":[124,157],"procyanidin":[125],"A2":[126,153],"challenge":[131],"showed":[132],"significantly":[133],"inhibited":[134],"(36%)":[135],"Under":[138],"same":[140],"conditions,":[141],"B1":[143],"B2":[145,155],"elicited":[146],"no":[147,160],"effect.":[148],"Furthermore,":[149],"combinations":[150],"(5":[156],"total)":[158],"demonstrated":[159],"evidence":[161,200],"synergistic":[164],"interaction.":[165],"CONCLUSIONS:":[166],"These":[167],"data":[168],"demonstrate":[169,188],"regulation":[172],"not":[180],"ubiquitous":[181],"among":[182],"three":[184],"investigated":[185],"procyanidins.":[186,198],"differential":[190],"inhibition":[191],"A-type":[195],"B-type":[197],"This":[199],"supports":[201],"further":[202],"studies":[203],"procyanidins,":[205],"specifically":[206],"A-type,":[207],"managing":[209],"inappropriate":[210]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}