{"id":"https://openalex.org/W2340545341","doi":"https://doi.org/10.1002/cmdc.201600036","title":"Evaluating p97 Inhibitor Analogues for Potency against p97\u2013p37 and p97\u2013Npl4\u2013Ufd1 Complexes","display_name":"Evaluating p97 Inhibitor Analogues for Potency against p97\u2013p37 and p97\u2013Npl4\u2013Ufd1 Complexes","publication_year":2016,"publication_date":"2016-04-04","ids":{"openalex":"https://openalex.org/W2340545341","doi":"https://doi.org/10.1002/cmdc.201600036","mag":"2340545341","pmid":"https://pubmed.ncbi.nlm.nih.gov/27043824","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9049307"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201600036","doi":"https://doi.org/10.1002/cmdc.201600036","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201600036","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9049307","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062168574","display_name":"Lin Gui","orcid":"https://orcid.org/0000-0002-8054-9524","observed_orcids":["https://orcid.org/0000-0002-8054-9524"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Lin Gui","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, 100069 PR China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, 100069 PR China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357468","display_name":"Xiaoyi Zhang","orcid":"https://orcid.org/0000-0002-4988-819X","observed_orcids":["https://orcid.org/0000-0002-4988-819X"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaoyi Zhang","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, 100069 PR China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, 100069 PR China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064607739","display_name":"Kelin Li","orcid":"https://orcid.org/0000-0002-8630-2928","observed_orcids":["https://orcid.org/0000-0002-8630-2928"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelin Li","raw_affiliation_strings":["Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087938892","display_name":"Kevin J. Frankowski","orcid":"https://orcid.org/0000-0002-7173-6352","observed_orcids":["https://orcid.org/0000-0002-7173-6352"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Frankowski","raw_affiliation_strings":["Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA","institution_ids":["https://openalex.org/I146416000"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100655198","display_name":"Shan Li","orcid":"https://orcid.org/0000-0002-9544-9550","observed_orcids":["https://orcid.org/0000-0002-9544-9550"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Shan Li","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, 100069 PR China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]},{"raw_affiliation_string":"School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, 100069 PR China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109072877","display_name":"Daniel Wong","orcid":"https://orcid.org/0000-0002-7718-1685","observed_orcids":["https://orcid.org/0000-0002-7718-1685"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Wong","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009847543","display_name":"Derek R. Moen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek R. Moen","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005290325","display_name":"Patrick R. Porubsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Porubsky","raw_affiliation_strings":["Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077744427","display_name":"Henry J. Lin","orcid":"https://orcid.org/0000-0001-6771-0486","observed_orcids":["https://orcid.org/0000-0001-6771-0486"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry J. Lin","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049300475","display_name":"Frank J. Schoenen","orcid":"https://orcid.org/0000-0003-2711-1117","observed_orcids":["https://orcid.org/0000-0003-2711-1117"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank J. Schoenen","raw_affiliation_strings":["Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Specialized Chemistry Center, University of Kansas, 2034 Becker Drive, Lawrence, KS, 66047-3761 USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016443408","display_name":"Tsui\u2010Fen Chou","orcid":"https://orcid.org/0000-0003-2410-2186","observed_orcids":["https://orcid.org/0000-0003-2410-2186"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tsui\u2010Fen Chou","raw_affiliation_strings":["Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA"],"raw_orcid":"https://orcid.org/0000-0003-2410-2186","affiliations":[{"raw_affiliation_string":"Division of Medical Genetics, Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, 1124 W. Carson St, Torrance, CA, 90502 USA","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016443408"],"corresponding_institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.905,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85343127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"9","first_page":"953","last_page":"957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valosin-containing-protein","display_name":"VCP","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p37","display_name":"p37","score":0.7059999704360962},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.7710000276565552},{"id":"https://openalex.org/keywords/atpase-activity","display_name":"ATPase activity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/inhibitor-potency","display_name":"inhibitor potency","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.6948934197425842},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5308631062507629},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5255146026611328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4863482117652893},{"id":"https://openalex.org/C101635128","wikidata":"https://www.wikidata.org/wiki/Q4649768","display_name":"AAA proteins","level":4,"score":0.46241331100463867},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4161606729030609},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41000792384147644},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.3996947109699249},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359852433204651},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23338782787322998},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16011232137680054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07247740030288696}],"mesh":[{"descriptor_ui":"D000074405","descriptor_name":"Valosin Containing Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cmdc.201600036","doi":"https://doi.org/10.1002/cmdc.201600036","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201600036","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:27043824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27043824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9049307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9049307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"},{"id":"pmh:oai:authors.library.caltech.edu:114038","doi":null,"is_oa":false,"landing_page_url":"https://authors.library.caltech.edu/114038/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9049307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9049307","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8280968127","display_name":"University of Kansas Specialized Chemistry Center","funder_award_id":"U54HG005031","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1527254461","https://openalex.org/W1649950618","https://openalex.org/W1974256456","https://openalex.org/W1977455683","https://openalex.org/W1983350301","https://openalex.org/W1983633543","https://openalex.org/W1985286323","https://openalex.org/W1986033053","https://openalex.org/W1991989590","https://openalex.org/W1994246241","https://openalex.org/W1994963031","https://openalex.org/W2004585702","https://openalex.org/W2011269026","https://openalex.org/W2014540581","https://openalex.org/W2014697177","https://openalex.org/W2017764563","https://openalex.org/W2018325704","https://openalex.org/W2033088972","https://openalex.org/W2040833814","https://openalex.org/W2042708317","https://openalex.org/W2047455709","https://openalex.org/W2048668745","https://openalex.org/W2056730111","https://openalex.org/W2079939478","https://openalex.org/W2080378383","https://openalex.org/W2088226484","https://openalex.org/W2133406524","https://openalex.org/W2156739666","https://openalex.org/W2167769875","https://openalex.org/W2168838455","https://openalex.org/W2262506123"],"related_works":["https://openalex.org/W1549974751","https://openalex.org/W1431630627","https://openalex.org/W4313641118","https://openalex.org/W4295439402","https://openalex.org/W4237234475","https://openalex.org/W3205152683","https://openalex.org/W3120441629","https://openalex.org/W2079939478","https://openalex.org/W7164380724","https://openalex.org/W2899354376"],"abstract_inverted_index":{"We":[0,43,75],"previously":[1],"found":[2],"that":[3,61],"the":[4,10,51,65,70,86,101,112,117,148],"p97":[5,15,37,72,78,90,124,128,135,140,152],"cofactor,":[6],"p47,":[7,63,104],"significantly":[8,110],"decreased":[9],"potency":[11],"of":[12,54,62,89,93,103,114,116,132,150],"some":[13],"ATP-competitive":[14],"inhibitors":[16,133],"such":[17],"as":[18,137],"ML240":[19],"[2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine]":[20],"and":[21,41,64,92,95,106,130],"ML241":[22],"[2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8":[23],"tetrahydroquinazolin-4-amine].":[24],"In":[25,98],"this":[26],"study,":[27],"we":[28],"aimed":[29],"to":[30,60,84,100,139,146],"evaluate":[31],"inhibitor":[32,79],"potencies":[33,113],"against":[34],"two":[35,47],"additional":[36],"cofactor":[38,48,73],"complexes,":[39,49,136],"p97-p37":[40,94],"p97-Npl4-Ufd1.":[42],"focused":[44],"on":[45,134],"these":[46],"because":[50],"protein":[52],"sequence":[53],"p37":[55,105],"is":[56,69],"50":[57],"%":[58],"identical":[59],"Npl4-Ufd1":[66],"heterodimer":[67],"(NU)":[68],"most-studied":[71],"complex.":[74],"screened":[76],"200":[77],"analogues":[80],"for":[81],"their":[82],"ability":[83],"inhibit":[85],"ATPase":[87],"activity":[88],"alone":[91],"p97-NU":[96],"complexes.":[97],"contrast":[99],"effect":[102],"NU":[107],"did":[108],"not":[109],"change":[111],"most":[115],"compounds.":[118],"These":[119],"results":[120],"highlight":[121],"differences":[122],"among":[123],"cofactors":[125],"in":[126],"influencing":[127],"conformation":[129],"effects":[131],"compared":[138],"alone.":[141],"Continued":[142],"efforts":[143],"are":[144],"needed":[145],"advance":[147],"development":[149],"complex-specific":[151],"inhibitors.":[153]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}