{"id":"https://openalex.org/W2340424973","doi":"https://doi.org/10.1056/nejm199808063390603","title":"A Comparison of Budesonide and Mesalamine for Active Crohn's Disease","display_name":"A Comparison of Budesonide and Mesalamine for Active Crohn's Disease","publication_year":1998,"publication_date":"1998-08-06","ids":{"openalex":"https://openalex.org/W2340424973","doi":"https://doi.org/10.1056/nejm199808063390603","mag":"2340424973","pmid":"https://pubmed.ncbi.nlm.nih.gov/9691103"},"language":"en","primary_location":{"id":"doi:10.1056/nejm199808063390603","doi":"https://doi.org/10.1056/nejm199808063390603","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm199808063390603","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074399403","display_name":"Ole \u00d8stergaard Thomsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ole \u00d8stergaard Thomsen","raw_affiliation_strings":["Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2801827564"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073565953","display_name":"Antoine Cortot","orcid":"https://orcid.org/0000-0002-1067-8996","observed_orcids":["https://orcid.org/0000-0002-1067-8996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antoine Cortot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108412159","display_name":"Derek P. Jewell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek Jewell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102950755","display_name":"JOHN PAUL WRIGHT","orcid":"https://orcid.org/0000-0002-5557-6168","observed_orcids":["https://orcid.org/0000-0002-5557-6168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108474163","display_name":"Trevor A. Winter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevor Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068111639","display_name":"Fernando Tavarela Veloso","orcid":"https://orcid.org/0000-0002-0236-9851","observed_orcids":["https://orcid.org/0000-0002-0236-9851"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernando Tavarela Veloso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114145395","display_name":"Morten Vatn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morten Vatn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111980744","display_name":"Tore Persson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tore Persson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Eva Pettersson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Pettersson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.8384,"has_fulltext":false,"cited_by_count":327,"citation_normalized_percentile":{"value":0.99163698,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"339","issue":"6","first_page":"370","last_page":"374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/budesonide","display_name":"budesonide","score":0.9909999966621399},{"id":"https://openalex.org/keywords/5-aminosalicylic-acid","display_name":"5-aminosalicylic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.7789999842643738},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8429999947547913},{"id":"https://openalex.org/keywords/crohn-s-disease-activity-index","display_name":"CDAI","score":0.8679999709129333},{"id":"https://openalex.org/keywords/plasma-cortisol","display_name":"plasma cortisol","score":0.7229999899864197},{"id":"https://openalex.org/keywords/acth-stimulation-test","display_name":"ACTH stimulation test","score":0.9440000057220459},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.671999990940094},{"id":"https://openalex.org/keywords/ileal-disease","display_name":"ileal disease","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C2776136866","wikidata":"https://www.wikidata.org/wiki/Q422212","display_name":"Budesonide","level":3,"score":0.963821530342102},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9356540441513062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7213505506515503},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6728941202163696},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6627384424209595},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6396962404251099},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5342772006988525},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.49779748916625977},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.48571333289146423},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4574529230594635},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36774468421936035}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019804","descriptor_name":"Mesalamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019819","descriptor_name":"Budesonide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019819","descriptor_name":"Budesonide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm199808063390603","doi":"https://doi.org/10.1056/nejm199808063390603","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm199808063390603","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:9691103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9691103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1573810982","https://openalex.org/W1761355724","https://openalex.org/W1921843724","https://openalex.org/W1976450674","https://openalex.org/W1982834592","https://openalex.org/W2027812459","https://openalex.org/W2141570612","https://openalex.org/W2267316820","https://openalex.org/W2315020282","https://openalex.org/W2331622494","https://openalex.org/W2335853094","https://openalex.org/W2342066803","https://openalex.org/W2419090247","https://openalex.org/W3112583453","https://openalex.org/W3149527659","https://openalex.org/W6768621889"],"related_works":["https://openalex.org/W3025470118","https://openalex.org/W2076476900","https://openalex.org/W2342066803","https://openalex.org/W2123667451","https://openalex.org/W2027663530","https://openalex.org/W2144058826","https://openalex.org/W2050978925","https://openalex.org/W2331622494","https://openalex.org/W1971012473","https://openalex.org/W2743653688"],"abstract_inverted_index":{"BACKGROUND:":[0],"Crohn's":[1,28,56,109,262],"disease":[2,29,65,263],"is":[3],"often":[4],"treated":[5],"with":[6,26,48,182,194,260],"glucocorticoids":[7],"or":[8,36,105,270],"mesalamine.":[9,288],"We":[10],"compared":[11,181],"the":[12,31,33,55,108,115,129,142,149,153,171,175,186,200,221,265,267],"efficacy":[13,94],"and":[14,20,67,79,145,164,234,243],"safety":[15],"of":[16,50,75,85,103,117,126,131,136,159,178,192,219,231,237,275,287],"controlled-ileal-release":[17,273],"budesonide":[18,76,143,172,207,276],"capsules":[19],"slow-release":[21,285],"mesalamine":[22,86,150,187],"tablets":[23],"in":[24,141,148,170,185,199,228,250,252,280],"patients":[25,47,119,169,184,193,214,233,239,259],"active":[27,261],"affecting":[30,264],"ileum,":[32,266],"ascending":[34,268],"colon,":[35,269],"both.":[37],"METHODS:":[38],"In":[39,114,258],"a":[40,101,272,284],"double-blind,":[41],"multicenter":[42],"trial,":[43],"we":[44],"enrolled":[45],"182":[46],"scores":[49,62],"200":[51],"to":[52,71,81,206,254],"400":[53],"on":[54,107],"Disease":[57,110],"Activity":[58,111],"Index":[59],"(with":[60],"higher":[61],"indicating":[63],"greater":[64],"activity)":[66],"randomly":[68],"assigned":[69,205],"93":[70],"receive":[72,82],"9":[73],"mg":[74],"once":[77],"daily":[78,88],"89":[80],"2":[83],"g":[84],"twice":[87],"for":[89],"16":[90,157,176,217],"weeks.":[91],"The":[92,190],"primary":[93],"variable":[95],"was":[96,226,277],"clinical":[97],"remission,":[98],"defined":[99],"as":[100,180],"score":[102],"150":[104],"less":[106],"Index.":[112],"RESULTS:":[113],"analysis":[116],"all":[118],"who":[120,215],"received":[121],"at":[122],"least":[123],"one":[124],"dose":[125],"study":[127],"drug,":[128],"rates":[130,155],"remission":[132,282],"after":[133,156],"8":[134],"weeks":[135,158,177,218],"treatment":[137,160],"were":[138,161,197],"69":[139],"percent":[140,147,163,166,230,236,242],"group":[144,151,173,188],"45":[146],"(P=0.001);":[152],"respective":[154],"62":[162],"36":[165],"(P<0.001).":[167,189],"Seventy-seven":[168],"completed":[174,216],"treatment,":[179,220],"50":[183],"numbers":[191],"adverse":[195,211],"events":[196],"similar":[198],"two":[201],"groups,":[202],"but":[203],"those":[204],"had":[208,247],"fewer":[209],"severe":[210],"events.":[212],"Among":[213],"morning":[222],"plasma":[223],"cortisol":[224,251],"value":[225],"normal":[227,248],"67":[229],"budesonide-treated":[232],"83":[235],"mesalamine-treated":[238],"(P=0.06);":[240],"90":[241],"100":[244],"percent,":[245],"respectively,":[246],"increases":[249],"response":[253],"cosyntropin":[255],"(P=0.02).":[256],"CONCLUSIONS:":[257],"both,":[271],"formulation":[274,286],"more":[278],"effective":[279],"inducing":[281],"than":[283]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
