{"id":"https://openalex.org/W2340422693","doi":null,"title":"[Frontiers in vitamin D; basic research and clinical application. Vitamin D and secondary hyperparathyroidism].","display_name":"[Frontiers in vitamin D; basic research and clinical application. Vitamin D and secondary hyperparathyroidism].","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2340422693","mag":"2340422693","pmid":"https://pubmed.ncbi.nlm.nih.gov/22040818"},"language":"ja","primary_location":{"id":"pmid:22040818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22040818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108387635","display_name":"Hisae Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisae Tanaka","raw_affiliation_strings":["Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079345118","display_name":"Hirotaka Komaba","orcid":"https://orcid.org/0000-0002-1704-4507","observed_orcids":["https://orcid.org/0000-0002-1704-4507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirotaka Komaba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086510056","display_name":"Masafumi Fukagawa","orcid":"https://orcid.org/0000-0002-7832-2339","observed_orcids":["https://orcid.org/0000-0002-7832-2339"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masafumi Fukagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2434,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66897992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"11","first_page":"27","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8889999985694885},{"id":"https://openalex.org/keywords/secondary-hyperparathyroidism","display_name":"secondary hyperparathyroidism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.9539999961853027},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d","display_name":"1,25-dihydroxyvitamin D","score":0.9789999723434448},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9860000014305115},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.7089999914169312},{"id":"https://openalex.org/keywords/active-vitamin-d-analogs","display_name":"active vitamin D analogs","score":0.7940000295639038},{"id":"https://openalex.org/keywords/paricalcitol","display_name":"paricalcitol","score":0.9750000238418579},{"id":"https://openalex.org/keywords/maxacalcitol","display_name":"maxacalcitol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/doxercalciferol","display_name":"doxercalciferol","score":0.9900000095367432},{"id":"https://openalex.org/keywords/phosphate-retention","display_name":"phosphate retention","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.9378663301467896},{"id":"https://openalex.org/C2779524405","wikidata":"https://www.wikidata.org/wiki/Q155746","display_name":"Paricalcitol","level":5,"score":0.8677493333816528},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.8463665246963501},{"id":"https://openalex.org/C2775945674","wikidata":"https://www.wikidata.org/wiki/Q1344835","display_name":"Hyperparathyroidism","level":2,"score":0.6300920248031616},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5206995606422424},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49800682067871094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4795767664909363},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.4746038317680359},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4560229480266571},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.454462468624115},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.4314318895339966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.427510142326355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42592817544937134}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006962","descriptor_name":"Hyperparathyroidism, Secondary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:22040818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22040818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"Journal Article"},{"id":"mag:2340422693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22040818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405887287","https://openalex.org/W4401566090","https://openalex.org/W2104603071","https://openalex.org/W2401717859","https://openalex.org/W2902528715","https://openalex.org/W3031141075","https://openalex.org/W809924","https://openalex.org/W2015341747","https://openalex.org/W7100277331","https://openalex.org/W2136991956"],"abstract_inverted_index":{"In":[0,62],"chronic":[1],"kidney":[2],"disease":[3],"(CKD)":[4],",":[5],"phosphate":[6,118,126],"retention":[7],"and":[8,53,111,117,125,143],"low":[9],"1,":[10,107],"25-dihydroxyvitamin":[11],"D":[12,71,90,138,157],"[1,":[13],"25":[14,108],"(OH)":[15,73,109],"\u2082D]":[16],"due":[17],"to":[18,31,33,84,161],"a":[19],"decrease":[20],"in":[21,147,154],"the":[22,34,58,66,81,96,101,115,122],"number":[23],"of":[24,36,43,57,60,68,98,104],"functioning":[25],"nephrons":[26],"had":[27],"long":[28],"been":[29],"considered":[30],"contribute":[32],"pathogenesis":[35],"secondary":[37],"hyperparathyroidism":[38],"(SHPT)":[39],".":[40],"The":[41],"discovery":[42],"fibroblast":[44],"growth":[45],"factor":[46],"23":[47],"(FGF23)":[48],"drastically":[49],"changed":[50],"our":[51],"understanding":[52],"provided":[54],"new":[55,155],"implication":[56],"development":[59],"SHPT.":[61,99],"addition,":[63],"CKD":[64],"impairs":[65],"maintenance":[67],"normal":[69],"25-hydoxyvitamin":[70],"[25":[72],"D]":[74],"levels":[75,119],"which":[76],"can":[77],"act":[78],"directly":[79],"on":[80],"parathyroid":[82],"glands":[83],"repress":[85],"PTH":[86,130],"synthesis.":[87],"Active":[88],"vitamin":[89,105,137,156],"therapy":[91],"is":[92],"widely":[93],"used":[94],"for":[95],"treatment":[97],"However,":[100],"active":[102],"form":[103],"D,":[106],"\u2082D":[110],"its":[112],"analogs":[113,139],"increase":[114],"calcium":[116,124],"by":[120],"increasing":[121],"intestinal":[123],"absorption.":[127],"To":[128],"suppress":[129],"secretion":[131],"without":[132],"these":[133],"potential":[134],"complications,":[135],"several":[136],"including":[140],"paricalcitol,":[141],"maxacalcitol":[142],"doxercalciferol":[144],"are":[145,159],"already":[146],"clinical":[148],"use.":[149],"A":[150],"novel":[151],"therapeutic":[152],"concept":[153],"therapies":[158],"expected":[160],"improve":[162],"patient":[163],"outcome.":[164]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}