{"id":"https://openalex.org/W2340407599","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5513","title":"Phase II induction cetuximab (C225), paclitaxel (P), and carboplatin (C) followed by chemoradiation with C225, P, C, and RT 68-72Gy for stage III/IV head and neck squamous cancer: Primary site organ preservation and disease control at 2 years (ECOG, E2303).","display_name":"Phase II induction cetuximab (C225), paclitaxel (P), and carboplatin (C) followed by chemoradiation with C225, P, C, and RT 68-72Gy for stage III/IV head and neck squamous cancer: Primary site organ preservation and disease control at 2 years (ECOG, E2303).","publication_year":2010,"publication_date":"2010-05-20","ids":{"openalex":"https://openalex.org/W2340407599","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5513","mag":"2340407599"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2010.28.15_suppl.5513","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5513","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.5513","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109561731","display_name":"Harold J. Wanebo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. J. Wanebo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043100004","display_name":"Musie S Ghebremichael","orcid":"https://orcid.org/0000-0002-8572-1944","observed_orcids":["https://orcid.org/0000-0002-8572-1944"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. S. Ghebremichael","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023000705","display_name":"Barbara Ann Burtness","orcid":"https://orcid.org/0000-0003-4660-1859","observed_orcids":["https://orcid.org/0000-0003-4660-1859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Burtness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058702476","display_name":"John Andrew Ridge","orcid":"https://orcid.org/0000-0002-5527-3546","observed_orcids":["https://orcid.org/0000-0002-5527-3546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Ridge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855870","display_name":"Stuart Spencer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Spencer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109353591","display_name":"F. Rosen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. R. Rosen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110358762","display_name":"M Hancock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. R. Hancock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066813002","display_name":"Khaled A. Tolba","orcid":"https://orcid.org/0000-0001-5493-1474","observed_orcids":["https://orcid.org/0000-0001-5493-1474"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. A. Tolba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034392417","display_name":"Arlene A. Forastiere","orcid":"https://orcid.org/0000-0003-2238-3682","observed_orcids":["https://orcid.org/0000-0003-2238-3682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Forastiere","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"15_suppl","first_page":"5513","last_page":"5513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9779999852180481},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9559999704360962},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/organ-preservation","display_name":"organ preservation","score":0.6169999837875366},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.8840000033378601},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.8130000233650208},{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/disease-control","display_name":"disease control","score":0.5139999985694885},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.49000000953674316},{"id":"https://openalex.org/keywords/egfr-inhibition","display_name":"EGFR inhibition","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9282755255699158},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8141729831695557},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.7271289229393005},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.532561182975769},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.5082466006278992},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.49079570174217224},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4774635136127472},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.44011273980140686},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.41127872467041016},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39447951316833496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3861004710197449},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3786174952983856},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3250732719898224},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.31208187341690063},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.2976910173892975},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28426992893218994},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.14180901646614075},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2010.28.15_suppl.5513","doi":"https://doi.org/10.1200/jco.2010.28.15_suppl.5513","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2010.28.15_suppl.5513","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2245761030","https://openalex.org/W2129707741","https://openalex.org/W7099828720","https://openalex.org/W158885359","https://openalex.org/W2591424056","https://openalex.org/W2883813777","https://openalex.org/W2253347316","https://openalex.org/W2001379962","https://openalex.org/W7208791067","https://openalex.org/W2947968092"],"abstract_inverted_index":{"5513":[0],"Background:":[1],"C225":[2,14,19,88,302,307],"plus":[3,18,308],"RT":[4,8,21],"improved":[5],"survival":[6,270,278],"vs.":[7],"alone":[9],"(Bonner,":[10],"2009).":[11],"E2303":[12],"evaluated":[13],"with":[15,30,184,326],"induction":[16,162],"CT":[17,86,304],"and":[20,27,40,60,117,163,210,228,303,320,333,339,349],"(CRT)":[22],"in":[23,193,204,216,242,289,294,317,323],"stage":[24,68,290,295],"III/IV":[25,69],"head":[26],"neck":[28],"SCC":[29],"focus":[31],"on":[32],"event":[33],"free":[34,277],"survival,":[35],"pathologic":[36],"complete":[37],"response":[38,322],"(pCR)":[39],"toxicity.":[41,53],"Restaging":[42,100],"biopsy":[43,104],"showed":[44],"high":[45],"pCR":[46],"after":[47,124,187,201],"C225/CRT":[48],"50":[49,135],"Gy":[50],"w/":[51],"low":[52],"We":[54],"now":[55],"report":[56],"2-yr":[57,350],"disease":[58,122,263],"control":[59,264],"organ":[61,346],"preservation":[62],"rates.":[63],"Methods:":[64],"IRB":[65],"consented":[66],"resectable":[67],"(21/42)":[70],"patients":[71],"(pts)":[72],"sites-":[73],"(oropharynx,":[74],"61%,":[75],"larynx":[76],"22%":[77],"other":[78],"16%)":[79],"had":[80,113,153,161,235],"triple":[81],"endoscopy,":[82],"gastrostomy,":[83],"CT/MRI.":[84],"Induction":[85,301],"was":[87,106,140,191,214,240,249,267,280,292,298],"(400mg/m2":[89],"wk1,":[90],"then":[91],"250mg/m2),":[92],"P":[93,128],"90mg/m2,":[94],"C":[95,130],"(AUC=2)/":[96],"wk":[97,108,119,142,199],"\u00d7":[98,133],"6.":[99],"primary":[101,313],"site":[102,314,347],"(PS)":[103],"(bx)":[105],"done":[107],"8,":[109],"if":[110,121],"the":[111,151],"pt":[112,152],"a":[114,311,327],"clinical":[115,185],"CR":[116,186,316],"at":[118,198,265],"14":[120,143,200],"persisted":[123],"CRT":[125,146,309],"(C225":[126],"250mg/m2,":[127],"30mg/m2,":[129],"(AUC=1)":[131],"wkly":[132],"6,":[134],"Gy).":[136],"If":[137,149],"PS":[138,189],"bx":[139,190],"negative":[141],"pts":[144,165,175,182,206,218,227,234,244,319,325],"completed":[145],"(68-72":[147],"Gy);":[148],"positive,":[150],"surgery.":[154],"Results:":[155],"Of":[156,180],"74":[157],"enrolled":[158],"pts,":[159],"70":[160,169],"68":[164],"CRT.":[166],"(13%":[167],"<":[168],"Gy,":[170],"87%":[171],"\u226570Gy":[172],"):":[173],"63":[174,233],"were":[176],"eligible":[177,232,324],"for":[178],"analysis.":[179],"41":[181],"(59%)":[183],"induction,":[188],"neg.":[192],"24":[194],"(59%":[195],"pCR);":[196],"Re-bx":[197],"chemo-RT":[202],"(50Gy)":[203],"34":[205],"(15":[207],"previous":[208],"bx'd":[209],"19":[211],"initial":[212],"non-responders)":[213],"neg":[215],"33":[217],"(97%).":[219],"Thus":[220],"57":[221],"of":[222,230,247,331,335],"60":[223],"(95%)":[224],"re":[225],"biopsied":[226,318],"91%":[229,321],"all":[231],"pCR.":[236],"Neck":[237],"dissection":[238],"(n=34)":[239],"positive":[241],"11":[243,254],"(32%).":[245],"Pattern":[246],"failure":[248],"noted":[250],"as:":[251],"Local":[252],"recurrence":[253],"(17.5%),":[255],"regional":[256],"5":[257,260],"(8%),":[258],"distant":[259],"(8%).":[261],"Primary":[262],"2yr":[266,274],"83%.":[268],"Overall":[269],"(OS):":[271],"1yr":[272,281],"97%,":[273],"82%;":[275],"progression":[276],"(PFS)":[279],"82%,":[282,332],"2":[283,286,328],"yr":[284,287,329],"66%.":[285,336],"PFS":[288,334],"III":[291],"62%;":[293],"IV":[296],"it":[297],"68%.":[299],"Conclusions:":[300],"followed":[305],"by":[306],"induces":[310],"95%":[312],"path":[315],"OS":[330],"This":[337],"therapy":[338],"management":[340],"approach":[341],"produced":[342],"promising":[343],"local":[344],"control,":[345],"preservation,":[348],"survival.":[351],"Author":[352],"Disclosure":[353],"Employment":[354],"or":[355,359],"Leadership":[356],"Position":[357],"Consultant":[358],"Advisory":[360],"Role":[361],"Stock":[362],"Ownership":[363],"Honoraria":[364],"Research":[365],"Funding":[366],"Expert":[367],"Testimony":[368],"Other":[369],"Remuneration":[370],"Bristol-Myers":[371,380],"Squibb,":[372],"GenMab":[373],"AACR,":[374],"ASCO,":[375],"IMER,":[376],"NCCN,":[377],"Pfizer":[378],"Amgen,":[379],"Squibb":[381]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
