{"id":"https://openalex.org/W2340340783","doi":"https://doi.org/10.1080/00325481.1968.11693257","title":"Diagnosis and Treatment of Antibody Deficiency Syndromes","display_name":"Diagnosis and Treatment of Antibody Deficiency Syndromes","publication_year":1968,"publication_date":"1968-05-01","ids":{"openalex":"https://openalex.org/W2340340783","doi":"https://doi.org/10.1080/00325481.1968.11693257","mag":"2340340783","pmid":"https://pubmed.ncbi.nlm.nih.gov/4172766"},"language":"en","primary_location":{"id":"doi:10.1080/00325481.1968.11693257","doi":"https://doi.org/10.1080/00325481.1968.11693257","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00325481.1968.11693257","pdf_url":null,"source":{"id":"https://openalex.org/S11800902","display_name":"Postgraduate Medicine","issn_l":"0032-5481","issn":["0032-5481","1941-9260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postgraduate Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111433586","display_name":"Fred S. Rosen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred S. Rosen","raw_affiliation_strings":["Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":null,"display_name":"Charles A. Janeway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Janeway","raw_affiliation_strings":["Harvard Medical School, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.18580193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"43","issue":"5","first_page":"188","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunoglobulin-deficiency","display_name":"antibody deficiency","score":0.9850000143051147},{"id":"https://openalex.org/keywords/congenital-agammaglobulinemia","display_name":"congenital agammaglobulinemia","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pyogenic-infection","display_name":"pyogenic infection","score":0.6480000019073486},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/failure-to-thrive","display_name":"failure to thrive","score":0.9559999704360962},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9589343070983887},{"id":"https://openalex.org/C2776917539","wikidata":"https://www.wikidata.org/wiki/Q1497481","display_name":"Failure to thrive","level":2,"score":0.8742169141769409},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5546488165855408},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5179137587547302},{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.45153671503067017},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.45084714889526367},{"id":"https://openalex.org/C2777805810","wikidata":"https://www.wikidata.org/wiki/Q1047559","display_name":"Hypogammaglobulinemia","level":3,"score":0.4325698912143707},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43076205253601074},{"id":"https://openalex.org/C2908814852","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunologic Deficiency Syndromes","level":3,"score":0.4136224091053009},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1824226677417755},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08330130577087402}],"mesh":[{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000151","qualifier_name":"congenital","is_major_topic":false},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000361","descriptor_name":"Agammaglobulinemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005719","descriptor_name":"gamma-Globulins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/00325481.1968.11693257","doi":"https://doi.org/10.1080/00325481.1968.11693257","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00325481.1968.11693257","pdf_url":null,"source":{"id":"https://openalex.org/S11800902","display_name":"Postgraduate Medicine","issn_l":"0032-5481","issn":["0032-5481","1941-9260"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postgraduate Medicine","raw_type":"journal-article"},{"id":"pmid:4172766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4172766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postgraduate medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412493789","https://openalex.org/W2102479327","https://openalex.org/W2056396784","https://openalex.org/W1965911375","https://openalex.org/W1994698700","https://openalex.org/W1550408695","https://openalex.org/W124404536","https://openalex.org/W2052477516","https://openalex.org/W2071852773","https://openalex.org/W2185971115"],"abstract_inverted_index":{"Antibody":[0],"deficiency":[1],"syndromes":[2],"include":[3],"congenital":[4,15],"agammaglobulinemia,":[5,7],"acquired":[6,31],"and":[8,46,55,58],"hereditary":[9],"thymic":[10],"dysplasia.":[11],"Infants":[12],"with":[13],"the":[14,21],"type":[16,32],"usually":[17],"are":[18],"well":[19],"for":[20],"first":[22],"nine":[23],"months,":[24],"but":[25],"pyogenic":[26],"infections":[27],"then":[28],"develop.":[29],"The":[30],"may":[33],"be":[34],"primary":[35],"disease":[36],"or":[37],"secondary":[38],"to":[39,53],"lymphomas.":[40],"Thymic":[41],"dysplasia":[42],"occurs":[43],"in":[44],"infants":[45],"is":[47],"characterized":[48],"by":[49],"persistent":[50],"lymphopenia,":[51],"failure":[52],"thrive,":[54],"recurrent":[56],"bacterial":[57],"viral":[59],"infections.":[60]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}