{"id":"https://openalex.org/W2340279681","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.897.12","title":"Structure/Function Characterization of S100B Inhibitors at Sites 2/3 within Malignant Melanoma","display_name":"Structure/Function Characterization of S100B Inhibitors at Sites 2/3 within Malignant Melanoma","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2340279681","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.897.12","mag":"2340279681"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.897.12","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.897.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.897.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029463093","display_name":"Michael C. Cavalier","orcid":"https://orcid.org/0000-0001-7336-1219","observed_orcids":["https://orcid.org/0000-0001-7336-1219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Cavalier","raw_affiliation_strings":["Center for Biomolecular Therapeutics Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Stillwater OK United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomolecular Therapeutics Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Stillwater OK United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109193623","display_name":"Paul T. Wilder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Wilder","raw_affiliation_strings":["Center for Biomolecular Therapeutics Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Stillwater OK United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomolecular Therapeutics Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Stillwater OK United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075007584","display_name":"Thomas H. Charpentier","orcid":"https://orcid.org/0000-0002-7487-6051","observed_orcids":["https://orcid.org/0000-0002-7487-6051"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Charpentier","raw_affiliation_strings":["Department of Biochemistry Thomas Jefferson University Philadelphia PA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry Thomas Jefferson University Philadelphia PA United States","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033818354","display_name":"David J. Weber","orcid":"https://orcid.org/0000-0002-8824-1110","observed_orcids":["https://orcid.org/0000-0002-8824-1110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Weber","raw_affiliation_strings":["Center for Biomolecular Therapeutics Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Stillwater OK United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomolecular Therapeutics Department of Biochemistry and Molecular Biology University of Maryland School of Medicine Stillwater OK United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13293115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100b","display_name":"S100B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6809999942779541},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.7429999709129333},{"id":"https://openalex.org/keywords/p53-degradation","display_name":"p53 degradation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5699999928474426},{"id":"https://openalex.org/keywords/lead-compounds","display_name":"lead compounds","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6615234613418579},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5998237133026123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5472790598869324},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.507822573184967},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49622422456741333},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4957176446914673},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.48364150524139404},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.44732967019081116},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38582858443260193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32703498005867004},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32040834426879883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3024677634239197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.897.12","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.897.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.897.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1982327046","https://openalex.org/W2483857764","https://openalex.org/W2121236207","https://openalex.org/W7095781771","https://openalex.org/W1987871496","https://openalex.org/W2397131095","https://openalex.org/W2080879309","https://openalex.org/W2061963598","https://openalex.org/W2290985451","https://openalex.org/W2071350260"],"abstract_inverted_index":{"S100B":[0,33,41,85],"is":[1,24],"not":[2],"merely":[3],"a":[4,19,72,110],"prognostic":[5],"indicator":[6],"within":[7],"Malignant":[8],"Melanoma":[9],"(MM),":[10],"but":[11],"it":[12],"promotes":[13],"the":[14,68,81,126],"degradation":[15],"of":[16,32,40,84,112,129,188],"p53":[17,45],"through":[18],"calcium\u2010dependent":[20],"protein\u2010protein":[21],"interaction.":[22],"It":[23],"also":[25,167,191],"now":[26],"known":[27],"that":[28,190],"small":[29],"molecule":[30],"inhibitors":[31,165],"(known":[34],"as":[35,71,171,181],"SBiXs)":[36],"and":[37,48,94,96,118,123,134,153,185],"RNA":[38],"interference":[39],"expression":[42],"restore":[43],"both":[44],"protein":[46],"levels":[47],"normal":[49],"transcriptional":[50],"activation/apoptosis":[51],"activities":[52],"in":[53,120],"MM,":[54],"which":[55,101,140],"typically":[56],"has":[57],"wild\u2010type":[58],"p53.":[59],"For":[60],"these":[61],"reasons,":[62],"we":[63],"aim":[64],"to":[65,98,148,156],"specifically":[66],"inhibit":[67],"S100B\u2010p53":[69],"interaction":[70],"potential":[73],"therapy":[74],"for":[75,176],"MM.":[76],"Our":[77],"efforts":[78,97],"at":[79],"probing":[80],"binding":[82,89,131],"surface":[83],"revealed":[86],"three":[87,105],"persistent":[88],"sites":[90,106],"(Sites":[91],"1,":[92],"2,":[93],"3),":[95],"discover/synthesize":[99],"SBiXs":[100,130],"simultaneously":[102],"bind":[103],"all":[104],"are":[107,151,162],"underway.":[108],"Using":[109],"combination":[111],"structural":[113],"biology":[114],"techniques":[115],"(X\u2010ray":[116],"crystallography":[117],"NMR),":[119],"vitro":[121],"binding,":[122],"cellular":[124],"assays,":[125],"structure/function":[127],"characterization":[128],"Sites":[132],"2":[133],"3":[135],"were":[136],"investigated.":[137],"The":[138],"SBiXs,":[139],"exhibit":[141],"dissociation":[142],"constants":[143],"ranging":[144],"from":[145],"40":[146],"nM":[147],"100":[149],"\u03bcM,":[150],"compared":[152],"their":[154],"ability":[155],"be":[157],"extended":[158],"into":[159],"Site":[160],"1":[161],"discussed.":[163],"Such":[164],"may":[166],"have":[168,192],"therapeutic":[169],"value":[170],"early":[172],"stage":[173],"lead":[174],"compounds":[175],"treating":[177],"other":[178],"cancers":[179],"such":[180],"astrocytoma,":[182],"renal":[183],"tumors,":[184],"some":[186],"forms":[187],"leukemia":[189],"elevated":[193],"S100B.":[194]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}