{"id":"https://openalex.org/W2340218025","doi":"https://doi.org/10.1007/s00268-016-3506-1","title":"Pharmacological Modulation of Ischemic\u2010Reperfusion Injury during Pringle Maneuver in Hepatic Surgery. A Prospective Randomized Pilot Study","display_name":"Pharmacological Modulation of Ischemic\u2010Reperfusion Injury during Pringle Maneuver in Hepatic Surgery. A Prospective Randomized Pilot Study","publication_year":2016,"publication_date":"2016-04-19","ids":{"openalex":"https://openalex.org/W2340218025","doi":"https://doi.org/10.1007/s00268-016-3506-1","mag":"2340218025","pmid":"https://pubmed.ncbi.nlm.nih.gov/27094558"},"language":"en","primary_location":{"id":"doi:10.1007/s00268-016-3506-1","doi":"https://doi.org/10.1007/s00268-016-3506-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00268-016-3506-1","pdf_url":null,"source":{"id":"https://openalex.org/S60318618","display_name":"World Journal of Surgery","issn_l":"0364-2313","issn":["0364-2313","1432-2323"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089940988","display_name":"Matteo Donadon","orcid":"https://orcid.org/0000-0003-0296-7648","observed_orcids":["https://orcid.org/0000-0003-0296-7648"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Donadon","raw_affiliation_strings":["Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030557470","display_name":"Andrea Forastieri Molinari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Forastieri Molinari","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032795341","display_name":"Francesco Corazzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Corazzi","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054649176","display_name":"Laura Rocchi","orcid":"https://orcid.org/0000-0002-2444-1359","observed_orcids":["https://orcid.org/0000-0002-2444-1359"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Rocchi","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037565506","display_name":"Annapaola Zito","orcid":"https://orcid.org/0000-0003-3198-3655","observed_orcids":["https://orcid.org/0000-0003-3198-3655"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Zito","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070931979","display_name":"Matteo Cimino","orcid":"https://orcid.org/0000-0003-0838-964X","observed_orcids":["https://orcid.org/0000-0003-0838-964X"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Cimino","raw_affiliation_strings":["Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069704648","display_name":"Guido Costa","orcid":"https://orcid.org/0000-0003-3986-8790","observed_orcids":["https://orcid.org/0000-0003-3986-8790"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Costa","raw_affiliation_strings":["Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110354032","display_name":"Ferdinando Raimondi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ferdinando Raimondi","raw_affiliation_strings":["Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Intensive Care, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064605526","display_name":"Guido Torzilli","orcid":"https://orcid.org/0000-0001-5798-5021","observed_orcids":["https://orcid.org/0000-0001-5798-5021"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Guido Torzilli","raw_affiliation_strings":["Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and General Surgery, Humanitas University, Humanitas Research Hospital, Via Manzoni, 56, 20089, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064605526"],"corresponding_institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":4.2588,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.93760346,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"40","issue":"9","first_page":"2202","last_page":"2212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pringle-maneuver","display_name":"Pringle maneuver","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hepatic-ischemia-reperfusion-injury","display_name":"hepatic ischemia-reperfusion injury","score":0.8690000176429749},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.949999988079071},{"id":"https://openalex.org/keywords/methylprednisolone","display_name":"methylprednisolone","score":1.0},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.5339999794960022},{"id":"https://openalex.org/keywords/postoperative-morbidity","display_name":"postoperative morbidity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8714030981063843},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.8623932003974915},{"id":"https://openalex.org/C2780120127","wikidata":"https://www.wikidata.org/wiki/Q743664","display_name":"Abdominal surgery","level":2,"score":0.7687854170799255},{"id":"https://openalex.org/C160022790","wikidata":"https://www.wikidata.org/wiki/Q2964004","display_name":"Cardiothoracic surgery","level":2,"score":0.7398872375488281},{"id":"https://openalex.org/C2777010666","wikidata":"https://www.wikidata.org/wiki/Q1498222","display_name":"Vascular surgery","level":3,"score":0.6781129837036133},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5334254503250122},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5308811664581299},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4215502142906189},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3727622628211975},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3605082035064697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33077701926231384}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013525","descriptor_name":"Surgical Instruments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014111","descriptor_name":"Tourniquets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00268-016-3506-1","doi":"https://doi.org/10.1007/s00268-016-3506-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00268-016-3506-1","pdf_url":null,"source":{"id":"https://openalex.org/S60318618","display_name":"World Journal of Surgery","issn_l":"0364-2313","issn":["0364-2313","1432-2323"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:27094558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27094558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W24224509","https://openalex.org/W38933356","https://openalex.org/W41500261","https://openalex.org/W56274251","https://openalex.org/W88960155","https://openalex.org/W119782773","https://openalex.org/W827192144","https://openalex.org/W1568450830","https://openalex.org/W1581393874","https://openalex.org/W1965041723","https://openalex.org/W1975468952","https://openalex.org/W1976906557","https://openalex.org/W1982743633","https://openalex.org/W1993359365","https://openalex.org/W1993434915","https://openalex.org/W1994270849","https://openalex.org/W1995317658","https://openalex.org/W1995927535","https://openalex.org/W2003798711","https://openalex.org/W2004731417","https://openalex.org/W2008929420","https://openalex.org/W2011305280","https://openalex.org/W2014843386","https://openalex.org/W2017783964","https://openalex.org/W2022457552","https://openalex.org/W2024007859","https://openalex.org/W2025428888","https://openalex.org/W2026731209","https://openalex.org/W2034186674","https://openalex.org/W2035574714","https://openalex.org/W2035763660","https://openalex.org/W2039736520","https://openalex.org/W2041334088","https://openalex.org/W2041956518","https://openalex.org/W2048779183","https://openalex.org/W2051602839","https://openalex.org/W2053544188","https://openalex.org/W2055011681","https://openalex.org/W2069369653","https://openalex.org/W2071128441","https://openalex.org/W2078185937","https://openalex.org/W2078618074","https://openalex.org/W2079095443","https://openalex.org/W2093469955","https://openalex.org/W2094466065","https://openalex.org/W2095667462","https://openalex.org/W2096998881","https://openalex.org/W2097744068","https://openalex.org/W2103310685","https://openalex.org/W2108696783","https://openalex.org/W2110850422","https://openalex.org/W2126426006","https://openalex.org/W2158501840","https://openalex.org/W2474582604","https://openalex.org/W2481029616","https://openalex.org/W2739873258","https://openalex.org/W4247973288","https://openalex.org/W6601688896"],"related_works":["https://openalex.org/W2050497882","https://openalex.org/W4394914775","https://openalex.org/W2262623192","https://openalex.org/W2905004915","https://openalex.org/W2017783964","https://openalex.org/W2997082388","https://openalex.org/W2782439503","https://openalex.org/W2077678561","https://openalex.org/W2050243948","https://openalex.org/W1490675430"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,33,72,80,92,155],"Pringle":[2,149,164,184],"maneuver,":[3],"which":[4,27],"is":[5,169],"performed":[6],"during":[7,57,166],"liver":[8,17,54,108,133,176,208],"surgery":[9],"to":[10,30,162,193,198],"reduce":[11],"blood":[12],"loss,":[13],"may":[14,28],"result":[15],"in":[16,21,50,65,86,98,116,136,175,207],"ischemia/reperfusion":[18],"injury":[19],"resulting":[20],"metabolic,":[22],"immunological,":[23],"and":[24,47,90,100,197,205],"microvascular":[25],"changes,":[26],"lead":[29],"hepatocellular":[31],"damage.":[32],"aim":[34],"of":[35,41,44,53,132,157,203],"this":[36],"study":[37],"was":[38,83,95,114,127],"the":[39,42,51,84,96,104,124,145,148,163,183,200],"investigation":[40],"effects":[43],"N-acetylcysteine":[45],"(NAC)":[46],"methylprednisolone":[48],"(MET)":[49],"modulation":[52],"warm":[55],"ischemia":[56],"hepatic":[58,167],"resection.":[59],"METHODS:":[60],"Forty-eight":[61],"patients":[62,73,106,120,137],"were":[63],"enrolled":[64],"a":[66,128],"pilot":[67],"double-blind,":[68],"randomized":[69],"clinical":[70],"trial.":[71],"received":[74],"either":[75],"NAC,":[76],"MET,":[77],"or":[78,141,159],"placebo.":[79],"primary":[81],"endpoint":[82,94],"reduction":[85],"postoperative":[87,173],"alanine":[88],"aminotransferase":[89],"bilirubin.":[91],"secondary":[93],"difference":[97],"morbidity":[99],"mortality.":[101,112],"RESULTS:":[102],"All":[103],"48":[105],"had":[107],"resection":[109,168],"with":[110,139,144,171,180],"no":[111],"Morbidity":[113],"observed":[115],"8":[117],"(16":[118],"%)":[119],"equally":[121],"distributed":[122],"among":[123],"groups.":[125],"There":[126],"significant":[129],"favorable":[130],"recovery":[131],"function":[134,177],"tests":[135,178],"treated":[138],"NAC":[140,158,204],"MET":[142,160,206],"compared":[143,179],"placebo":[146,181],"when":[147,182],"maneuver":[150,165,185],"exceeded":[151,186],"70":[152,187],"min.":[153,188],"CONCLUSIONS:":[154],"administration":[156],"prior":[161],"associated":[170],"lower":[172],"aberration":[174],"Larger":[189],"studies":[190],"are":[191],"required":[192],"validate":[194],"our":[195],"findings":[196],"investigate":[199],"specific":[201],"role":[202],"surgery.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
