{"id":"https://openalex.org/W2340179564","doi":"https://doi.org/10.1056/nejm197804062981402","title":"Prophylactic Doxycycline for Travelers' Diarrhea","display_name":"Prophylactic Doxycycline for Travelers' Diarrhea","publication_year":1978,"publication_date":"1978-04-06","ids":{"openalex":"https://openalex.org/W2340179564","doi":"https://doi.org/10.1056/nejm197804062981402","mag":"2340179564","pmid":"https://pubmed.ncbi.nlm.nih.gov/342962"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197804062981402","doi":"https://doi.org/10.1056/nejm197804062981402","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197804062981402","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041377151","display_name":"David Allen Sack","orcid":"https://orcid.org/0000-0002-9338-5119","observed_orcids":["https://orcid.org/0000-0002-9338-5119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Sack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046217641","display_name":"Donald Kaminsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald C. Kaminsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110011702","display_name":"R. Bradley Sack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Bradley Sack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078531181","display_name":"Itotia Jn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. N. Itotia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103733465","display_name":"Ray R. Arthur","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ray R. Arthur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111531281","display_name":"Albert Z. Kapikian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albert Z. Kapikian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088122020","display_name":"Frits \u00d8rskov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frits \u00d8rskov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078302103","display_name":"Ida \u00d8rskov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ida \u00d8rskov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":35.9047,"has_fulltext":false,"cited_by_count":217,"citation_normalized_percentile":{"value":0.99922857,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"298","issue":"14","first_page":"758","last_page":"763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.9520000219345093},{"id":"https://openalex.org/keywords/traveler-s-diarrhea","display_name":"traveler's diarrhea","score":0.8999999761581421},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/peace-corps-volunteers","display_name":"Peace Corps volunteers","score":0.8640000224113464},{"id":"https://openalex.org/keywords/enterotoxigenic-escherichia-coli","display_name":"enterotoxigenic Escherichia coli","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tetracycline-resistance","display_name":"tetracycline resistance","score":0.8880000114440918},{"id":"https://openalex.org/keywords/kenya","display_name":"Kenya","score":0.4970000088214874},{"id":"https://openalex.org/keywords/diarrhea-prevention","display_name":"diarrhea prevention","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C2777179404","wikidata":"https://www.wikidata.org/wiki/Q422442","display_name":"Doxycycline","level":3,"score":0.9870305061340332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8405433297157288},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8348549604415894},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.7454886436462402},{"id":"https://openalex.org/C2780923616","wikidata":"https://www.wikidata.org/wiki/Q193045","display_name":"Tetracycline","level":3,"score":0.7079679369926453},{"id":"https://openalex.org/C2779403890","wikidata":"https://www.wikidata.org/wiki/Q138885","display_name":"Traveler's diarrhea","level":3,"score":0.70567387342453},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6404081583023071},{"id":"https://openalex.org/C2777871010","wikidata":"https://www.wikidata.org/wiki/Q265214","display_name":"Enterotoxigenic Escherichia coli","level":5,"score":0.44527700543403625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4251909852027893},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.25011080503463745},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.18247932195663452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0870324969291687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.058913856744766235},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004318","descriptor_name":"Doxycycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007630","descriptor_name":"Kenya","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014195","descriptor_name":"Travel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197804062981402","doi":"https://doi.org/10.1056/nejm197804062981402","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197804062981402","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:342962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/342962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W40889678","https://openalex.org/W1534674531","https://openalex.org/W1575776074","https://openalex.org/W1577643002","https://openalex.org/W1771646220","https://openalex.org/W1921697367","https://openalex.org/W1945268492","https://openalex.org/W1968083102","https://openalex.org/W1971098120","https://openalex.org/W1975200612","https://openalex.org/W1987231123","https://openalex.org/W1992749175","https://openalex.org/W1992966472","https://openalex.org/W1994527488","https://openalex.org/W1997882612","https://openalex.org/W2027174863","https://openalex.org/W2031254433","https://openalex.org/W2032138059","https://openalex.org/W2039272407","https://openalex.org/W2043891142","https://openalex.org/W2055979935","https://openalex.org/W2060911345","https://openalex.org/W2064028645","https://openalex.org/W2066425473","https://openalex.org/W2068265574","https://openalex.org/W2069081823","https://openalex.org/W2095782160","https://openalex.org/W2102678710","https://openalex.org/W2136931384","https://openalex.org/W2139066727","https://openalex.org/W2145974274","https://openalex.org/W2153113333","https://openalex.org/W2222999097","https://openalex.org/W2340470221","https://openalex.org/W4232337095"],"related_works":["https://openalex.org/W2409916476","https://openalex.org/W2037745594","https://openalex.org/W2178040867","https://openalex.org/W4762125","https://openalex.org/W2102998180","https://openalex.org/W1495565843","https://openalex.org/W4205795856","https://openalex.org/W183383422","https://openalex.org/W2410343549","https://openalex.org/W2415612883"],"abstract_inverted_index":{"We":[0,129],"performed":[1],"a":[2],"randomized":[3],"double-blind":[4],"study":[5],"to":[6,73,111,117],"determine":[7],"the":[8,64,81,89,94,125],"efficacy":[9],"of":[10,50,56,106,137],"doxycycline":[11,35,59,112,132],"(100":[12],"mg":[13],"daily)":[14],"in":[15,29,101],"preventing":[16],"travelers'":[17,61,138],"diarrhea":[18,62],"among":[19,124],"39":[20],"Peace":[21],"Corps":[22],"volunteers":[23,32],"during":[24,63],"their":[25],"first":[26],"five":[27],"weeks":[28,40],"Kenya.":[30],"The":[31,70],"took":[33],"either":[34],"or":[36,113],"placebo":[37,53,95],"for":[38,44,75],"three":[39],"and":[41,54,119],"were":[42,109],"observed":[43],"an":[45],"additional":[46],"two":[47],"weeks.":[48],"Nine":[49],"21":[51],"taking":[52,58,103],"one":[55,78],"18":[57],"had":[60],"treatment":[65],"period":[66],"(P":[67],"=":[68],"0.012).":[69],"protection":[71],"seemed":[72],"persist":[74],"at":[76],"least":[77],"week":[79],"after":[80],"drug":[82],"was":[83,88,98,122],"stopped.":[84],"Enterotoxigenic":[85],"Escherichia":[86],"coli":[87],"only":[90],"pathogen":[91],"isolated":[92],"from":[93],"group,":[96],"but":[97],"not":[99],"detected":[100],"persons":[102],"doxycycline.":[104],"None":[105],"these":[107],"organisms":[108],"resistant":[110],"tetracycline,":[114],"whereas":[115],"resistance":[116],"tetracyclines":[118],"other":[120],"antibiotics":[121],"common":[123],"nonenterotoxigenic":[126],"Esch.":[127],"coli.":[128],"conclude":[130],"that":[131],"effectively":[133],"prevented":[134],"most":[135],"episodes":[136],"dirrhea.":[139]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
