{"id":"https://openalex.org/W2339915115","doi":null,"title":"Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells.","display_name":"Anticancer mechanism of plumbagin, a natural compound, on non-small cell lung cancer cells.","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2339915115","mag":"2339915115","pmid":"https://pubmed.ncbi.nlm.nih.gov/18507021"},"language":"en","primary_location":{"id":"pmid:18507021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18507021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064635179","display_name":"Rohini Gomathinayagam","orcid":"https://orcid.org/0000-0001-7626-3403","observed_orcids":["https://orcid.org/0000-0001-7626-3403"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohini Gomathinayagam","raw_affiliation_strings":["Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY 40536-0200, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY 40536-0200, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110294788","display_name":"Sowmyalakshmi Srinivasan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivasan Sowmyalakshmi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033076883","display_name":"Firdaus Mardhatillah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Firdaus Mardhatillah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115599537","display_name":"Raj Kumar","orcid":"https://orcid.org/0000-0002-5613-8266","observed_orcids":["https://orcid.org/0000-0002-5613-8266","https://orcid.org/0000-0003-3917-8773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raj Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023973192","display_name":"Mohammad Abdulkader Akbarsha","orcid":"https://orcid.org/0000-0002-4313-9606","observed_orcids":["https://orcid.org/0000-0002-4313-9606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad A Akbarsha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077759533","display_name":"Chendil Damodaran","orcid":"https://orcid.org/0000-0002-9902-7101","observed_orcids":["https://orcid.org/0000-0002-9902-7101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chendil Damodaran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.9052,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.96799212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"28","issue":"2A","first_page":"785","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.1152999997138977,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.05299999937415123,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plumbagin","display_name":"plumbagin","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8059999942779541},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7710000276565552},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9860000014305115},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.8190000057220459},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9860000014305115},{"id":"https://openalex.org/keywords/jnk-p38-signaling","display_name":"JNK/p38 signaling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9629999995231628},{"id":"https://openalex.org/keywords/h460-cells","display_name":"H460 cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2780532915","wikidata":"https://www.wikidata.org/wiki/Q2550553","display_name":"Plumbagin","level":2,"score":0.9894221425056458},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7790537476539612},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5977748036384583},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5067313313484192},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5024869441986084},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4878518581390381},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44182682037353516},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4393531382083893},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.43639522790908813},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4337088167667389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4221365451812744},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41784390807151794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4129769802093506},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3313508629798889},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.24053114652633667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20683351159095764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07237944006919861},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009285","descriptor_name":"Naphthoquinones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048670","descriptor_name":"MAP Kinase Kinase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18507021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18507021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2339915115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18507021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W141627170","https://openalex.org/W172290249","https://openalex.org/W175540666","https://openalex.org/W1492468642","https://openalex.org/W1565712144","https://openalex.org/W1745634660","https://openalex.org/W1964675032","https://openalex.org/W1965814380","https://openalex.org/W1965895804","https://openalex.org/W1976601376","https://openalex.org/W1983466646","https://openalex.org/W1985264467","https://openalex.org/W1990320961","https://openalex.org/W1993534135","https://openalex.org/W2017986614","https://openalex.org/W2021808416","https://openalex.org/W2028501194","https://openalex.org/W2031554805","https://openalex.org/W2034371559","https://openalex.org/W2037256881","https://openalex.org/W2038259382","https://openalex.org/W2044772464","https://openalex.org/W2045127265","https://openalex.org/W2064047613","https://openalex.org/W2068932627","https://openalex.org/W2072623574","https://openalex.org/W2075962843","https://openalex.org/W2077754831","https://openalex.org/W2080125477","https://openalex.org/W2084843095","https://openalex.org/W2087861588","https://openalex.org/W2101697551","https://openalex.org/W2102752109","https://openalex.org/W2108398180","https://openalex.org/W2112849045","https://openalex.org/W2114259345","https://openalex.org/W2119239908","https://openalex.org/W2135550035","https://openalex.org/W2136046634","https://openalex.org/W2139819066","https://openalex.org/W2156251634","https://openalex.org/W2170585607","https://openalex.org/W2171924781","https://openalex.org/W2180159320","https://openalex.org/W2187004087","https://openalex.org/W4254263906","https://openalex.org/W4294923454"],"related_works":["https://openalex.org/W3157387486","https://openalex.org/W2099336491","https://openalex.org/W4414982400","https://openalex.org/W2587899185","https://openalex.org/W2300140177","https://openalex.org/W1982258251","https://openalex.org/W3032569641","https://openalex.org/W3108432564","https://openalex.org/W3005154666","https://openalex.org/W3026716148"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lung":[1],"cancer":[2,28],"is":[3],"the":[4,11,66,92,103,123,134,150,159,173],"leading":[5,153],"cause":[6],"of":[7,69,94,105,125,161,181],"cancer-related":[8],"deaths":[9],"in":[10,21,116,133,144,158],"United":[12],"States.":[13],"Prevailing":[14],"treatment":[15],"options":[16,39],"have":[17],"limited":[18],"therapeutic":[19,38],"success":[20],"lung":[22,27,44],"cancer,":[23],"particularly":[24],"non-small":[25],"cell":[26,73,78,130],"(NSCLC),":[29],"as":[30],"it":[31,148],"becomes":[32],"resistant":[33],"to":[34,98,154],"therapy.":[35],"Hence,":[36],"better":[37],"are":[40],"immediately":[41],"required":[42],"for":[43,54],"cancer.":[45],"Plumbagin,":[46],"a":[47],"natural":[48],"compound":[49],"has":[50],"been":[51],"recently":[52],"examined":[53],"its":[55,108],"anticancer":[56,67,166],"effect":[57,68],"on":[58,71,168],"different":[59],"cancers.":[60],"MATERIALS":[61],"AND":[62],"METHODS:":[63],"To":[64],"determine":[65],"plumbagin":[70,121],"NSCLC":[72,169],"lines":[74],"H460":[75,95,117,145],"and":[76,83,101,107,114,127,142,175],"A549,":[77],"viability,":[79],"apoptotic,":[80],"Western":[81],"blot":[82],"reporter":[84],"assays":[85],"were":[86],"performed.":[87],"RESULTS:":[88],"Plumbagin":[89,164],"significantly":[90],"inhibited":[91],"growth":[93],"cells":[96,170],"compared":[97],"A549":[99],"cells,":[100],"down-regulated":[102],"expression":[104,124],"EGFR/Neu":[106],"downstream":[109],"signaling":[110,177],"(Akt,":[111],"NF-kappaB,":[112],"Bcl-2":[113],"survivin)":[115],"cells.":[118,146],"In":[119],"addition,":[120],"up-regulated":[122],"p53":[126],"p21(CIP1/WAF1)":[128],"causing":[129],"cycle":[131],"arrest":[132],"G2/M-phase":[135],"by":[136,171],"down-regulating":[137],"G2/M":[138],"regulatory":[139],"proteins":[140],"(cyclinB1":[141],"Cdc25B)":[143],"Furthermore,":[147],"activated":[149],"JNK/p38":[151],"signaling,":[152],"caspase-3":[155],"activation":[156],"resulting":[157],"induction":[160,180],"apoptosis.":[162,182],"CONCLUSION:":[163],"exerted":[165],"activity":[167],"modulating":[172],"pro-survival":[174],"pro-apoptotic":[176],"that":[178],"causes":[179]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}