{"id":"https://openalex.org/W2339859430","doi":"https://doi.org/10.1212/wnl.86.16_supplement.p5.324","title":"The Gut Microbiome Affects the Progression of Disease in a Murine Model of Secondary Progressive MS (P5.324)","display_name":"The Gut Microbiome Affects the Progression of Disease in a Murine Model of Secondary Progressive MS (P5.324)","publication_year":2016,"publication_date":"2016-04-05","ids":{"openalex":"https://openalex.org/W2339859430","doi":"https://doi.org/10.1212/wnl.86.16_supplement.p5.324","mag":"2339859430"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.86.16_supplement.p5.324","doi":"https://doi.org/10.1212/wnl.86.16_supplement.p5.324","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.86.16_supplement.p5.324","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032501205","display_name":"Javier Ochoa\u2010Rep\u00e1raz","orcid":"https://orcid.org/0000-0001-9610-3175","observed_orcids":["https://orcid.org/0000-0001-9610-3175"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I159107703","display_name":"Eastern Washington University","ror":"https://ror.org/002g57a93","country_code":"US","type":"education","lineage":["https://openalex.org/I159107703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Ochoa-Reparaz","raw_affiliation_strings":["Eastern Washington University Eastern Washington University, Cheney WA United States","Geisel School of Medicine Dartmouth College, Hanover NH United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Washington University Eastern Washington University, Cheney WA United States","institution_ids":["https://openalex.org/I159107703"]},{"raw_affiliation_string":"Geisel School of Medicine Dartmouth College, Hanover NH United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041990204","display_name":"Sara L. Colpitts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Colpitts","raw_affiliation_strings":["Geisel School of Medicine Dartmouth College, Hanover NH United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geisel School of Medicine Dartmouth College, Hanover NH United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054616237","display_name":"Eli J. Kasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli Kasper","raw_affiliation_strings":["Geisel School of Medicine Dartmouth College, Hanover NH United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geisel School of Medicine Dartmouth College, Hanover NH United States","institution_ids":["https://openalex.org/I107672454"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012960055","display_name":"Abby Keever","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159107703","display_name":"Eastern Washington University","ror":"https://ror.org/002g57a93","country_code":"US","type":"education","lineage":["https://openalex.org/I159107703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abby Keever","raw_affiliation_strings":["Eastern Washington University Eastern Washington University, Cheney WA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Washington University Eastern Washington University, Cheney WA United States","institution_ids":["https://openalex.org/I159107703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081004765","display_name":"Caleb Liljenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159107703","display_name":"Eastern Washington University","ror":"https://ror.org/002g57a93","country_code":"US","type":"education","lineage":["https://openalex.org/I159107703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Liljenberg","raw_affiliation_strings":["Eastern Washington University Eastern Washington University, Cheney WA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Washington University Eastern Washington University, Cheney WA United States","institution_ids":["https://openalex.org/I159107703"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109191295","display_name":"Lloyd H. Kasper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lloyd Kasper","raw_affiliation_strings":["Geisel School of Medicine Dartmouth College, Hanover NH United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geisel School of Medicine Dartmouth College, Hanover NH United States","institution_ids":["https://openalex.org/I107672454"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2211,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54748144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"86","issue":"16_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6669999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9729999899864197},{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.7350000143051147},{"id":"https://openalex.org/keywords/polysaccharide-a","display_name":"polysaccharide A","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bacteroides-fragilis","display_name":"Bacteroides fragilis","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.6499999761581421},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.7509999871253967},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8989999890327454},{"id":"https://openalex.org/keywords/host-microbiota-interactions","display_name":"host-microbiota interactions","score":0.859000027179718},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.7694962620735168},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7171266078948975},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5781065225601196},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4575348198413849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26592740416526794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2582739293575287},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23209235072135925}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.86.16_supplement.p5.324","doi":"https://doi.org/10.1212/wnl.86.16_supplement.p5.324","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1212/wnl.86.16_supplement.p5.324","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2736052887","https://openalex.org/W2942689716","https://openalex.org/W3156129427","https://openalex.org/W3028246676","https://openalex.org/W3126906312","https://openalex.org/W4313382073","https://openalex.org/W3087541471","https://openalex.org/W2952031680","https://openalex.org/W7112254291","https://openalex.org/W3158827345"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2,279],"whether":[3,186,280],"the":[4,13,16,23,29,46,81,89,114,123,130,147,151,175,195,201,204,216,219,222,254,268,271,276,284,297],"transition":[5],"from":[6],"relapsing":[7],"to":[8,85,180,242,278],"progressive":[9,135,205],"experimental":[10,32,65,263],"MS":[11,103,143],"modifies":[12],"composition":[14],"of":[15,25,31,34,75,137,141,154,169,191,203,207,218,225,262,270,291],"gut":[17,26,41,57,96,124,148,285],"microbiome.":[18,272],"BACKGROUND:":[19],"Recent":[20],"findings":[21],"reveal":[22],"importance":[24],"microbes":[27,42],"in":[28,44,63,70,80,88,95,102,150,209,250,283,289],"development":[30],"models":[33],"CNS":[35,264],"inflammatory":[36,132,265],"demyelination.":[37],"We":[38,120,145],"demonstrated":[39],"that":[40,113,122,171,215,256],"and":[43,60,93,133,194,221],"particular":[45],"symbiont":[47],"factor":[48],"polysaccharide-A":[49],"(PSA)":[50],"produced":[51],"by":[52,296],"Bacteroides":[53],"fragilis":[54],"significantly":[55],"influence":[56],"immune":[58],"responses":[59],"drive":[61],"protection":[62],"relapsing-remitting":[64],"autoimmune":[66],"encephalomyelitis":[67],"(EAE).":[68],"Furthermore,":[69],"mice":[71,158,226],"with":[72,107,159,188,197,228,233,236],"EAE,":[73],"onset":[74],"disease":[76,170,292],"promotes":[77],"significant":[78],"changes":[79,94],"intestinal":[82],"permeability":[83],"due":[84],"molecular":[86],"modifications":[87],"epithelial":[90],"tight":[91],"junctions,":[92],"microbial":[97],"abundances":[98,127],"have":[99],"been":[100],"observed":[101],"patients":[104],"when":[105,240],"compared":[106,146,241],"healthy":[108],"individuals.":[109],"These":[110],"observations":[111],"suggest":[112],"host-microbiota":[115],"interaction":[116],"is":[117,258],"bi-directional.":[118],"METHODS:":[119],"hypothesized":[121],"microbiota":[125],"relative":[126],"differ":[128],"between":[129],"acute":[131],"chronic":[134],"stages":[136],"a":[138,166,189,259],"murine":[139],"model":[140,153,164],"secondary-progressive":[142],"(SP-EAE).":[144],"microbiome":[149],"EAE":[152,208,244],"Non-Obese":[155],"Diabetic":[156],"(NOD)":[157],"non-EAE":[160],"mice.":[161,211,246],"The":[162],"NOD":[163,210,245],"shows":[165],"bi-phasic":[167],"pattern":[168],"more":[172],"closely":[173],"resembles":[174],"human":[176],"condition":[177],"(RR-MS":[178],"transitioning":[179],"SP-MS).":[181],"In":[182],"addition,":[183],"we":[184],"evaluated":[185],"treatment":[187,196,235],"cocktail":[190],"broad-spectrum":[192],"antibiotics":[193],"PSA":[198],"would":[199],"modify":[200],"outcome":[202],"stage":[206],"RESULTS:":[212],"Results":[213,248],"showed":[214],"trend":[217],"mortality":[220],"clinical":[223],"scores":[224],"treated":[227],"antibiotics,":[229],"as":[230,232],"well":[231],"oral":[234],"PSA,":[237],"were":[238],"reduced":[239],"untreated":[243],"CONCLUSIONS:":[247],"obtained":[249],"this":[251],"work":[252],"support":[253],"hypothesis":[255],"there":[257],"reciprocal":[260],"effect":[261],"demyelination":[266],"on":[267],"modification":[269],"Our":[273],"studies":[274],"provide":[275],"foundation":[277],"therapeutic":[281],"intervention":[282],"might":[286],"be":[287],"beneficial":[288],"terms":[290],"progression.":[293],"Study":[294],"supported":[295],"NMSS.":[298]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2016-06-24T00:00:00"}
