{"id":"https://openalex.org/W2339838622","doi":"https://doi.org/10.1093/jnci/79.5.983","title":"Augmentation of Interleukin-2 Immunotherapeutic Effects by Lymphokine-Activated Killer Cells and Allogeneic Stimulation in Murine Tumor Cells","display_name":"Augmentation of Interleukin-2 Immunotherapeutic Effects by Lymphokine-Activated Killer Cells and Allogeneic Stimulation in Murine Tumor Cells","publication_year":1987,"publication_date":"1987-11-01","ids":{"openalex":"https://openalex.org/W2339838622","doi":"https://doi.org/10.1093/jnci/79.5.983","mag":"2339838622","pmid":"https://pubmed.ncbi.nlm.nih.gov/3500357"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/79.5.983","doi":"https://doi.org/10.1093/jnci/79.5.983","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/79.5.983","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052579165","display_name":"Alexander M.M. Eggermont","orcid":"https://orcid.org/0000-0002-4278-040X","observed_orcids":["https://orcid.org/0000-0002-4278-040X","https://orcid.org/0000-0001-7458-4326"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander M. M. Eggermont","raw_affiliation_strings":["Surgery Branch, National Cancer Institute, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery Branch, National Cancer Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111834449","display_name":"E P Steller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Philip Steller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080879176","display_name":"R. T. Ottow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reyer T. Ottow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110064515","display_name":"Wilbert J. Matthews","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilbert Matthews, Jr.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043918821","display_name":"Paul Hendrick Sugarbaker","orcid":"https://orcid.org/0000-0002-2431-7366","observed_orcids":["https://orcid.org/0000-0002-2431-7366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul H. Sugarbaker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":1.11,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79043507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"5","first_page":"983","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.6689000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.2712000012397766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.972000002861023},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/allogeneic-stimulation","display_name":"allogeneic stimulation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/alloimmunity","display_name":"alloimmunity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/intraperitoneal-tumor","display_name":"intraperitoneal tumor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antitumor-cytotoxicity","display_name":"tumor cytotoxicity","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.9017744064331055},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.6834836006164551},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.6607311964035034},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.6169962286949158},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5867230892181396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5605044960975647},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5261368751525879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46348243951797485},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.4312693178653717},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.30893248319625854},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3069644868373871},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.20298928022384644},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.13397976756095886}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007116","descriptor_name":"Immunization, Passive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/jnci/79.5.983","doi":"https://doi.org/10.1093/jnci/79.5.983","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/79.5.983","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:3500357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3500357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100220046","https://openalex.org/W2434483495","https://openalex.org/W2008477721","https://openalex.org/W47643850","https://openalex.org/W1754609158","https://openalex.org/W2080350969","https://openalex.org/W2318135991","https://openalex.org/W200371019","https://openalex.org/W2062994527","https://openalex.org/W2083489699"],"abstract_inverted_index":{"Interleukin-2":[0],"(IL-2)":[1],"and":[2,11,163,172,234],"lymphokine-activated":[3],"killer":[4],"(LAK)":[5],"cells":[6,48,60,113,214],"were":[7,33,61],"used":[8],"in":[9,15,97,166,228],"intraperitoneal":[10,56,98],"pulmonary":[12],"tumor":[13,99,124,153,174,184,219],"models":[14],"C57BL/6":[16],"mice.":[17],"To":[18],"maintain":[19],"the":[20,43,83,105,141,149,152,181,188,194,208,224,229],"immunotherapeutic":[21],"effects":[22],"of":[23,46,55,69,78,85,89,117,144,148,160,170,183,191,210,232],"IL-2":[24,37,90,192,233],"plus":[25],"LAK":[26,47,59,79,92,112,138,213,216,235],"treatment":[27],"but":[28],"reduce":[29],"its":[30],"toxicity,":[31],"ways":[32],"sought":[34],"to":[35,104,136,206],"augment":[36],"effects.":[38],"The":[39],"investigation":[40],"showed":[41],"that":[42,119,200],"adoptive":[44],"transfer":[45],"was":[49,73,100,155,198],"a":[50,130,203],"prerequisite":[51],"for":[52],"successful":[53],"therapy":[54],"cancer.":[57],"When":[58],"given":[62,168],"on":[63],"consecutive":[64],"days":[65],"within":[66,180],"one":[67],"course":[68],"immunotherapy,":[70],"antitumor":[71,189],"efficacy":[72],"augmented":[74],"with":[75,82],"additional":[76],"doses":[77],"cells.":[80,139],"However,":[81],"reduction":[84,96,106],"1":[86,126],"complete":[87],"cycle":[88],"+":[91],"cells,":[93],"no":[94],"further":[95,230],"observed":[101],"as":[102,134],"compared":[103,135],"after":[107],"2":[108],"or":[109,215],"4":[110],"cycles.":[111],"generated":[114],"from":[115],"splenocytes":[116],"mice":[118,167],"had":[120],"received":[121],"an":[122,145],"allogeneic":[123,146,173],"challenge":[125],"week":[127],"earlier":[128],"exerted":[129],"highly":[131],"increased":[132],"cytotoxicity":[133],"normal":[137],"Furthermore,":[140],"potentiation":[142],"effect":[143,190],"response":[147,179],"host":[150],"at":[151],"site":[154],"demonstrated":[156],"by":[157],"decreased":[158],"numbers":[159],"lung":[161],"implants":[162],"improved":[164],"survival":[165],"mixtures":[169],"syngeneic":[171,195],"cell":[175],"suspensions.":[176],"An":[177],"alloimmune":[178],"microenvironment":[182],"tissue":[185],"markedly":[186],"enhanced":[187],"against":[193],"tumor.":[196],"It":[197],"concluded":[199],"there":[201],"is":[202],"fundamental":[204],"need":[205],"improve":[207],"recruitment":[209],"adoptively":[211],"transferred":[212],"precursors":[217],"into":[218],"tissue.":[220],"This":[221],"may":[222],"be":[223],"next":[225],"step":[226],"required":[227],"development":[231],"immunotherapy.":[236]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}