{"id":"https://openalex.org/W2339815604","doi":"https://doi.org/10.1056/nejm197311152892001","title":"Diphenylhydantoin and Selected Congenital Malformations","display_name":"Diphenylhydantoin and Selected Congenital Malformations","publication_year":1973,"publication_date":"1973-11-15","ids":{"openalex":"https://openalex.org/W2339815604","doi":"https://doi.org/10.1056/nejm197311152892001","mag":"2339815604","pmid":"https://pubmed.ncbi.nlm.nih.gov/4742220"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197311152892001","doi":"https://doi.org/10.1056/nejm197311152892001","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197311152892001","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047930939","display_name":"Richard R. Monson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard R. Monson","raw_affiliation_strings":["Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012309432","display_name":"Lynn A. Rosenberg","orcid":"https://orcid.org/0000-0003-2760-2987","observed_orcids":["https://orcid.org/0000-0003-2760-2987"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Rosenberg","raw_affiliation_strings":["Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109137062","display_name":"Stuart C. Hartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart C. Hartz","raw_affiliation_strings":["Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109808576","display_name":"Samuel Shapiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Shapiro","raw_affiliation_strings":["Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103628771","display_name":"Olli P. Heinonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olli P. Heinonen","raw_affiliation_strings":["Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073435608","display_name":"Dennis Slone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis Slone","raw_affiliation_strings":["Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Medical Center and the Department of Epidemiology. Harvard School of Public Health (address reprint requests to Dr. Slone at 400 Totten Pond Rd., Waltham, Mass. 02154)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.8836,"has_fulltext":false,"cited_by_count":238,"citation_normalized_percentile":{"value":0.99525016,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"289","issue":"20","first_page":"1049","last_page":"1052"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.9610000252723694},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.5189999938011169},{"id":"https://openalex.org/keywords/prenatal-drug-exposure","display_name":"prenatal drug exposure","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8751006722450256},{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.7655318975448608},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6657631397247314},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6309570074081421},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6306107044219971},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5736499428749084},{"id":"https://openalex.org/C65290608","wikidata":"https://www.wikidata.org/wiki/Q631521","display_name":"Teratology","level":4,"score":0.5390834808349609},{"id":"https://openalex.org/C3019607859","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital malformations","level":3,"score":0.5345446467399597},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5248078107833862},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4944801330566406},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.41968628764152527},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4136737585067749},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13600388169288635},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13543236255645752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001724","descriptor_name":"Birth Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008423","descriptor_name":"Maternal Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010298","descriptor_name":"Parity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012959","descriptor_name":"Socioeconomic Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejm197311152892001","doi":"https://doi.org/10.1056/nejm197311152892001","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197311152892001","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:4742220","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4742220","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/766580","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10822/766580","pdf_url":null,"source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eweb:6233","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1574677842","https://openalex.org/W1973332685","https://openalex.org/W1973783180","https://openalex.org/W2021486790","https://openalex.org/W2039805968","https://openalex.org/W2042185181","https://openalex.org/W2071631995","https://openalex.org/W2145714555","https://openalex.org/W2147293814","https://openalex.org/W2158970884","https://openalex.org/W2395246609","https://openalex.org/W2473438596","https://openalex.org/W2595426508","https://openalex.org/W2614552076","https://openalex.org/W4242601240"],"related_works":["https://openalex.org/W4235227653","https://openalex.org/W2066127064","https://openalex.org/W1786366787","https://openalex.org/W2085299245","https://openalex.org/W1979432994","https://openalex.org/W2086663422","https://openalex.org/W2084589485","https://openalex.org/W2092039284","https://openalex.org/W2053188393","https://openalex.org/W4389444513"],"abstract_inverted_index":{"In":[0],"a":[1],"cohort":[2],"of":[3,7,13,23,52,78,89,94,147,150,154],"50,897":[4],"pregnancies,":[5],"frequencies":[6],"malformations,":[8],"selected":[9],"on":[10],"the":[11,16,49,102,114,124,144,148],"basis":[12],"reports":[14],"in":[15,44,63,76,92,123],"literature,":[17],"were":[18,98],"compared":[19],"between":[20,127],"four":[21],"groups":[22],"children":[24,46,65,77,93,128,137],"born":[25,31,66,138],"to":[26,32,54,67,84,101,112,131,139],"epileptic":[27,79,105],"mothers":[28,80,96,141],"and":[29,91,136],"those":[30],"nonepileptic":[33,68,140],"mothers.":[34],"The":[35,59,121],"highest":[36],"malformation":[37,115,125],"rate":[38,60],"(61":[39],"per":[40,71],"1000)":[41],"was":[42,61,74],"observed":[43],"98":[45],"exposed":[47,81,100,129],"during":[48,133],"early":[50,134],"months":[51],"pregnancy":[53],"daily":[55],"diphenylhydantoin":[56,132],"(phenytoin)":[57],"use.":[58],"lowest":[62],"50,591":[64],"women":[69,106],"(25":[70],"1000).":[72],"It":[73],"intermediate":[75],"before":[82],"delivery":[83],"sporadic":[85],"or":[86,109,153],"late":[87],"use":[88],"diphenylhydantoin,":[90,113],"such":[95],"who":[97],"not":[99,118],"drug.":[103],"Among":[104],"with":[107],"varying":[108],"no":[110],"exposure":[111],"rates":[116,126],"did":[117],"differ":[119],"significantly.":[120],"difference":[122],"regularly":[130],"gestation":[135],"could":[142],"reflect":[143],"teratogenic":[145],"effect":[146],"drug,":[149],"epilepsy":[151],"itself":[152],"both":[155],"factors.":[156],"(N":[157],"Engl":[158],"J":[159],"Med":[160],"289:1049\u20131052,":[161],"1973)":[162]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
