{"id":"https://openalex.org/W2339811333","doi":"https://doi.org/10.1056/nejm199503093321004","title":"Treatment of Severe Colchicine Overdose with Colchicine-Specific Fab Fragments","display_name":"Treatment of Severe Colchicine Overdose with Colchicine-Specific Fab Fragments","publication_year":1995,"publication_date":"1995-03-09","ids":{"openalex":"https://openalex.org/W2339811333","doi":"https://doi.org/10.1056/nejm199503093321004","mag":"2339811333","pmid":"https://pubmed.ncbi.nlm.nih.gov/7845428"},"language":"en","primary_location":{"id":"doi:10.1056/nejm199503093321004","doi":"https://doi.org/10.1056/nejm199503093321004","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199503093321004","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199503093321004?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199503093321004?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021744927","display_name":"Fr\u00e9d\u00e9ric Joseph Baud","orcid":"https://orcid.org/0000-0002-2377-4709","observed_orcids":["https://orcid.org/0000-0002-2377-4709","https://orcid.org/0009-0007-5816-9238","https://orcid.org/0000-0002-3088-5765"]},"institutions":[{"id":"https://openalex.org/I4210111631","display_name":"H\u00f4pital Fernand-Widal","ror":"https://ror.org/01zkyzz15","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210111631"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric J. Baud","raw_affiliation_strings":["H\u00f4pital Fernand Widal, Paris, France","R\u00e9animation Toxicologique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Fernand Widal, Paris, France","institution_ids":["https://openalex.org/I4210111631"]},{"raw_affiliation_string":"R\u00e9animation Toxicologique","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051335180","display_name":"Alain E. Sabouraud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Sabouraud","raw_affiliation_strings":["INSERM Unit\u00e9 26"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 26","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088096181","display_name":"\u00c9ric Vicaut","orcid":"https://orcid.org/0000-0001-6303-8557","observed_orcids":["https://orcid.org/0000-0001-6303-8557"]},"institutions":[{"id":"https://openalex.org/I4210111631","display_name":"H\u00f4pital Fernand-Widal","ror":"https://ror.org/01zkyzz15","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210111631"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Vicaut","raw_affiliation_strings":["D\u00e9partement de Biophysique, H\u00f4pital Fernand Widal, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biophysique, H\u00f4pital Fernand Widal, Paris","institution_ids":["https://openalex.org/I4210111631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058485558","display_name":"Pierre Taboulet","orcid":"https://orcid.org/0000-0003-0843-9758","observed_orcids":["https://orcid.org/0000-0003-0843-9758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Taboulet","raw_affiliation_strings":["R\u00e9animation Toxicologique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R\u00e9animation Toxicologique","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111459902","display_name":"Jean Lang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Lang","raw_affiliation_strings":["Pasteur-M\u00e9rieux S\u00e9rums et Vaccins, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur-M\u00e9rieux S\u00e9rums et Vaccins, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078331900","display_name":"C Bismuth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chantal Bismuth","raw_affiliation_strings":["R\u00e9animation Toxicologique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R\u00e9animation Toxicologique","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067416903","display_name":"J M Rouzioux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean Marc Rouzioux","raw_affiliation_strings":["Pasteur-M\u00e9rieux S\u00e9rums et Vaccins, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pasteur-M\u00e9rieux S\u00e9rums et Vaccins, Lyon, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108778722","display_name":"Jean\u2010Michel Scherrmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Michel Scherrmann","raw_affiliation_strings":["INSERM Unit\u00e9 26"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 26","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.2955,"has_fulltext":true,"cited_by_count":228,"citation_normalized_percentile":{"value":0.99563914,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"332","issue":"10","first_page":"642","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colchicine-overdose","display_name":"colchicine overdose","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hemodynamic-collapse","display_name":"hemodynamic collapse","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tubulin-binding","display_name":"tubulin binding","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-poisoning-treatment","display_name":"drug poisoning treatment","score":0.621999979019165},{"id":"https://openalex.org/keywords/suicide-attempts","display_name":"suicide attempts","score":0.8730000257492065},{"id":"https://openalex.org/keywords/antidote-therapy","display_name":"antidote therapy","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.9919442534446716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.799075722694397},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5320696830749512},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5201552510261536},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.490850031375885},{"id":"https://openalex.org/C2776315796","wikidata":"https://www.wikidata.org/wiki/Q3505252","display_name":"Drug overdose","level":3,"score":0.43785709142684937},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4284197688102722},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.4252467155456543},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.4121435284614563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29782283306121826},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28160449862480164},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.23169571161270142},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.12166893482208252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12123218178749084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11222919821739197},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.09976086020469666},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm199503093321004","doi":"https://doi.org/10.1056/nejm199503093321004","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199503093321004","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199503093321004?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:7845428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7845428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1056/nejm199503093321004","doi":"https://doi.org/10.1056/nejm199503093321004","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199503093321004","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199503093321004?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2339811333.pdf","grobid_xml":"https://content.openalex.org/works/W2339811333.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W124118079","https://openalex.org/W194252323","https://openalex.org/W1488098727","https://openalex.org/W1526012266","https://openalex.org/W1553253964","https://openalex.org/W1971908565","https://openalex.org/W1978570255","https://openalex.org/W1983147658","https://openalex.org/W1985808251","https://openalex.org/W1988931987","https://openalex.org/W1990953531","https://openalex.org/W1991683656","https://openalex.org/W1996877405","https://openalex.org/W1998626084","https://openalex.org/W1998699416","https://openalex.org/W2006486542","https://openalex.org/W2007546493","https://openalex.org/W2031530169","https://openalex.org/W2032080427","https://openalex.org/W2033902214","https://openalex.org/W2042100002","https://openalex.org/W2046997361","https://openalex.org/W2063907370","https://openalex.org/W2080725434","https://openalex.org/W2083932001","https://openalex.org/W2092694799","https://openalex.org/W2125454893","https://openalex.org/W2170411152","https://openalex.org/W2182411840","https://openalex.org/W2257171361","https://openalex.org/W2414256785","https://openalex.org/W2502670554","https://openalex.org/W4241895195"],"related_works":["https://openalex.org/W2089975506","https://openalex.org/W2083932001","https://openalex.org/W2024627375","https://openalex.org/W2032080427","https://openalex.org/W2471675334","https://openalex.org/W4317434487","https://openalex.org/W1824554073","https://openalex.org/W2984218759","https://openalex.org/W4220668586","https://openalex.org/W7045983899"],"abstract_inverted_index":{"T":[0],"HE":[1],"use":[2,103],"of":[3,44,64,78,83,91,104,115],"colchicine":[4,12,27,46,85,116],"is":[5,14,89],"limited":[6],"by":[7],"its":[8],"toxicity,":[9],"1":[10],"and":[11,34,54],"overdose":[13,28],"associated":[15],"with":[16,21],"a":[17,108,118],"high":[18],"mortality":[19],"rate.Patients":[20],"early":[22],"hemodynamic":[23],"collapse":[24],"due":[25],"to":[26,51,60],"have":[29,57],"particularly":[30],"poor":[31],"prognoses,":[32],"2,3":[33],"there":[35],"has":[36],"been":[37,58],"no":[38],"effective":[39],"treatment":[40,82,106],"for":[41],"this":[42,105],"complication":[43],"severe":[45],"intoxication.":[47],"4olchicine":[48],"binds":[49],"reversibly":[50],"tubulin,":[52],"5":[53],"colchicine-specific":[55,73],"antibodies":[56],"shown":[59],"restore":[61],"the":[62,81,101],"activity":[63],"tubulin":[65],"in":[66,80,95,107,117],"vitro.":[67],"6,7][10][11]":[68],"These":[69],"findings":[70],"suggested":[71],"that":[72],"Fab":[74,93],"fragments":[75,94],"could":[76],"be":[77],"value":[79],"life-threatening":[84],"poisoning,":[86],"such":[87],"as":[88],"true":[90],"digoxin-specific":[92],"digitalis":[96],"poisoning.":[97],"12e":[98],"here":[99],"describe":[100],"successful":[102],"woman":[109],"who":[110],"had":[111],"ingested":[112],"60":[113],"mg":[114],"suicide":[119],"attempt.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}